-
1
المصدر: IBRO Neuroscience Reports
IBRO Neuroscience Reports, Vol 11, Iss, Pp 73-80 (2021)مصطلحات موضوعية: CP, cortical plate, Neurogenesis, medicine.medical_treatment, Intraperitoneal injection, NPCs, neural progenitor cells, Polyriboinosinic–polyribocytidylic acid, MIA, Maternal immune activation, SVZ, subventricular zone, Neurosciences. Biological psychiatry. Neuropsychiatry, Activating transcription factor 4, Atf4, activating transcription factor 4, VZ, ventricular zone, Unfolded protein response, Andrology, Integrated stress response, UPR, unfolded protein response, DEG, differentially expressed gene, Maternal immune activation, medicine, ASD, autism spectrum disorders, ISR, integrated stress response, Fetus, biology, General Neuroscience, Neural stem cell, Cytokine, [polyI:C], polyriboinosinic–polyribocytidylic acid, biology.protein, TBR1, PAX6, RC321-571, Research Paper
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a70992b8c2cebaacf973902b65edbeb
https://doi.org/10.1016/j.ibneur.2021.07.003 -
2
المؤلفون: Marie D. Ralff, Benedito A. Carneiro, Lanlan Zhou, Wen-I Chang, Rohinton Tarapore, Varun V. Prabhu, Joshua N. Honeyman, Attila A. Seyhan, Isacco Ferrarini, Alexander G. Raufi, Lindsey Carlsen, Martin Stogniew, Lee Schalop, Robyn Borsuk, Joshua E. Allen, Aakash Jhaveri, Cassandra Parker, Sara Morrow, Young Lee, Fabio Tavora, Wolfgang Oster, Jocelyn E. Ray, Kelsey E. Huntington, Howard Safran, Anna D Louie, Abed Rahman Kawakibi, Yiqun Zhang, Wafik S. El-Deiry
المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 725-744 (2020)مصطلحات موضوعية: DRD4, dopamine receptor D4, SCLC, small-cell lung cancer, Pyridines, medicine.medical_treatment, OXPHOS, oxidative phosphorylation, GIRK, G protein-coupled inwardly rectifying potassium channel, GnRH, gonadotropin-releasing hormone receptor, Receptors, G-Protein-Coupled, TNF-Related Apoptosis-Inducing Ligand, 0302 clinical medicine, NOAEL, no-observed-adverse-event-level, DSRCT, desmoplastic small round cell tumor, RECIST, Response Evaluation Criteria in Solid Tumors, Antineoplastic Combined Chemotherapy Protocols, ATRT, atypical teratoid rhabdoid tumor, AML, acute myeloid leukemia, DRD2, dopamine receptor D2, CLL, chronic lymphocytic leukemia, Clinical Studies as Topic, A2A, Adenosine 2A receptor, ONC201, RANO, Response Assessment in Neuro-Oncology, MTD, maximum tolerated dose, HGG, high-grade glioma, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, PFS, progression-free survival, DRD5, dopamine receptor D5, DRD3, dopamine receptor D3, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, CRC, colorectal cancer, Neoplastic Stem Cells, NK, natural killer, IHC, immunohistochemistry, cAMP, cyclic AMP, EC, endometrial cancer, Antineoplastic Agents, lcsh:RC254-282, TNBC, triple-negative breast cancer, WHO, World Health Organization, 03 medical and health sciences, DRD1, dopamine receptor D1, Review article, Cancer stem cell, Glioma, MCL, mantle cell lymphoma, SAR, structure–activity relationship, Humans, Protein kinase B, ISR, integrated stress response, Tumor microenvironment, TMZ, temozolomide, cCK18, caspase-cleaved cytokeratin 18, GDSC, Genomics of Drug Sensitivity in Cancer, medicine.disease, DNA-PKcs, DNA-activated protein kinase catalytic subunit, FLAIR, fluid-attenuated inversion recovery, 030104 developmental biology, DIPG, diffuse intrinsic pontine glioma, 0301 basic medicine, Cancer Research, ClpX, caseinolytic mitochondrial matrix peptidase chaperone subunit X, Drug Evaluation, Preclinical, CTCL, cutaneous T-cell lymphoma, NHL, non-Hodgkin’s lymphoma, Targeted therapy, Prostate cancer, AUC, area under the curve, Neoplasms, CML, chronic myelogenous leukemia, Clinical Trials as Topic, AMPK, AMP kinase, Chemistry, CK18, cytokeratin 18, MM, multiple myeloma, Imidazoles, TIC10, TRAIL-inducing compound 10, Endopeptidase Clp, TRAIL, TNF-associated apoptosis-inducing ligand, Mitochondria, Treatment Outcome, RP2D, recommended phase II dose, Disease Susceptibility, DLBCL, diffuse large B-cell lymphoma, PD, pharmacodynamic, Signal Transduction, imipridones, PC-PG, pheochromocytoma-paraganglioma, rhTRAIL, recombinant human TRAIL, ClpP, caseinolytic protease P, PK, pharmacokinetic, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, OS, overall survival, Immune system, PLC, phospholipase C, DR5, death receptor 5, NSCLC, non-small cell lung cancer, medicine, BRD, bromodomain, cancer, Animals, ALCL, anaplastic large cell lymphoma, PDX, patient-derived xenograft, Cancer, GBM, glioblastoma multiforme, ALL, acute lymphoblastic leukemia, CSC, cancer stem cell, GPCR, G protein coupled receptor, EGFR, epidermal growth factor receptor, Pyrimidines, Cancer research, 5-FU, 5-fluorouracil, HCC, hepatocellular carcinoma, ONC201, imipridones, cancer
-
3
المؤلفون: Karin Musier-Forsyth, Ronald C. Wek, Sheree A. Wek, Marina Bakhtina, William A. Cantara, Nathan T. Kudlapur, Danni Jin
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Male, multisynthetase complex, ATF4, activating transcription factor 4, aminoacyl-tRNA synthetases, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, RNA, Transfer, enzyme kinetics, AIMP, ARS-complex interacting multifunctional protein, PERK, PKR-like endoplasmic reticulum kinase, glutamyl-prolyl-tRNA synthetase, Protein biosynthesis, Amino Acids, CD, circular dichroism, Amino acid activation, chemistry.chemical_classification, Mutation, FA, fluorescence anisotropy, Editors' Pick, integrated stress response, ARS, aminoacyl-tRNA synthetase, Amino acid, Cell biology, GAIT, gamma interferon-activated inhibition of translation, Bone Diseases, compound-heterozygous mutations, Research Article, SEC, size-exclusion chromatography, PRS, prolyl-tRNA synthetase, Mutation, Missense, tRNA charging, Amino Acyl-tRNA Synthetases, Editors' Pick Highlight, MSC, multisynthetase complex, Stress, Physiological, genetic disease, aaRSs, aminoacyl-tRNA synthetases, GST, glutathione-S-transferase, Diabetes Mellitus, medicine, Integrated stress response, Humans, EPRS, glutamyl-prolyl-tRNA synthetase, Molecular Biology, CHOP, C/EBP-homologous protein, ISR, integrated stress response, MALS, multiangle laser light scattering, GCN2, general control nonderepressible 2, Aminoacyl tRNA synthetase, Genetic Diseases, Inborn, Cell Biology, stress response, EPRS, TRNA binding, WT, wild-type, compound heterozygous mutations, Glutamate-tRNA Ligase, HEK293 Cells, Amino Acid Substitution, chemistry, DTT, dithiothreitol, Protein Biosynthesis, Aminoacyl-tRNA synthetase, endoplasmic reticulum stress (ER stress), ERS, glutamyl-tRNA synthetase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce97fb563092e3b298c457fe5bda992
http://europepmc.org/articles/PMC8511952 -
4
المؤلفون: Gustavo M. Silva, Nathan A. Snyder
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: translation, Ubiquitin C-Terminal Hydrolase, CYLD, conserved cylindromatosis, SUMO, small ubiquitin-like modifier, Biochemistry, MJD, Machado–Josephin domain, Deubiquitinating enzyme, TRAF6, tumor necrosis factor (TNF) receptor associated factor 6, RTU, redox control of translation by ubiquitin, USP, ubiquitin-specific protease, Ubiquitin, oxidative stress, Homeostasis, deubiquitination, BER, base excision repair, TNF, tumor necrosis factor, biology, Deubiquitinating Enzymes, Chemistry, OTU, ovarian tumor domain, Cell biology, AMSH, associated molecule with the SH3 domain of STAM, Mdm2, Polβ, DNA polymerase beta, Ubp, ubiquitin-binding protein, Oxidation-Reduction, Deubiquitination, Signal Transduction, TRAF2, tumor necrosis factor (TNF) receptor associated factor 2, PCNA, proliferating cell nuclear antigen, OTUB, varian tumor deubiquitinase, ubiquitin aldehyde binding, DUB, A20, tumor necrosis factor alpha–induced protein 3, MIC-CAP, microcephaly-capillary malformation, ROS, reactive oxygen species, ESCRT, endosomal sorting complexes required for transport, MDM2, Mouse double minute 2, ubiquitin, TGF-β, transforming growth factor beta, Endopeptidases, ATXN, ataxin, Integrated stress response, UPS, ubiquitin-proteasome system, Animals, Humans, redox signaling, Molecular Biology, enzymatic regulation, ISR, integrated stress response, BAP1, BRCA1-associated protein 1, JBC Reviews, Ubiquitination, WDR48, WD repeat domain 48, Tumor Necrosis Factor alpha-Induced Protein 3, Cell Biology, RPN11, regulatory particle non-ATPase 11, EGFR, epidermal growth factor receptor, CK2, casein kinase 2, QC, quality control, MINDY, motif interacting with Ub-containing novel DUB, FOXO4, forkhead box O4, Proteasome, DTT, dithiothreitol, NLS, nuclear localization signal, UCH, ubiquitin C-terminal hydrolase, biology.protein, RQC, ribosome-associated quality control, PTM, posttranslational modification, UIM, ubiquitin interacting motif, OTUD, ovarian tumor deubiquitinase, Reactive Oxygen Species, Protein Processing, Post-Translational, DUB, deubiquitinating enzyme or deubiquitinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c743630c2855f90492c29a0b696db4
http://europepmc.org/articles/PMC8424594 -
5
المؤلفون: Xupeng Bai, Ying Zhu, Shanping Wang, Yong Li, Julia Beretov, Valerie C. Wasinger, Jie Ni, Peter Graham
المصدر: Redox Biology, Vol 43, Iss, Pp 101993-(2021)
Redox Biologyمصطلحات موضوعية: 0301 basic medicine, Medicine (General), Clinical Biochemistry, Eukaryotic Initiation Factor-2, Triple Negative Breast Neoplasms, SLC7A11, Biochemistry, chemistry.chemical_compound, 0302 clinical medicine, DEP, Differentially expressed proteins, ATF4, Biology (General), Triple-negative breast cancer, biology, Radioresistance, Glutathione, CRE, Cis-regulatory element, GCLC, CHIP, Chromatin immunoprecipitation, Signal transduction, TNBC, Research Paper, Signal Transduction, QH301-705.5, eIF2α, TSS, Transcription start site, CTH, Cystathionine gamma-lyase, 03 medical and health sciences, Integrated stress response, R5-920, 0601 Biochemistry and Cell Biology, 1101 Medical Biochemistry and Metabolomics, 1115 Pharmacology and Pharmaceutical Sciences, Cell Line, Tumor, ARE, Antioxidant responsive element, IR, Irradiation, GSH, Humans, AARE, Amino acid response element, HE, Hematoxylin and eosin, IF, Immunofluorescence, Organic Chemistry, Activating Transcription Factor 4, AP-1, Active protein-1 binding site, 030104 developmental biology, chemistry, OS, Overall survival, biology.protein, Cancer research, ISR, Integrated stress response, AMBIC, Ammonium bicarbonate, 030217 neurology & neurosurgery
وصف الملف: Print-Electronic; application/pdf
-
6
المؤلفون: Philip J. Smaldino, Amy Krans, Yi-Ju Tseng, Yuh-Hwa Wang, Adam E. Richardson, Katelyn M. Green, James P. Vaughn, Meredith E. Sharlow, Eric D. Routh, Peter K. Todd, Melissa A. Smaldino, Siara N. Sandwith, Antonio E. Chambers, Michael A. Reisinger, Heather M Raimer
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, fragile X, NLuc, nanoluciferase, FFLuc, firefly luciferase, Biochemistry, DEAD-box RNA Helicases, C9orf72, rDHX36, recombinant DHX36, dipeptide repeat proteins, DNA Repeat Expansion, G-quadruplex, doxy, doxycycline, Translation (biology), RNA Helicase A, Cell biology, FTD, frontal temporal dementia, Frontotemporal Dementia, G4C2, GGGGCC, RNA Helicases, Research Article, RAN, repeat-associated non-AUG, RNA helicase, repeat-associated non-AUG translation, DNA helicase, Biology, 03 medical and health sciences, Stress granule, DHX36, Cell Line, Tumor, HRE, hexanucleotide repeat expansion, Humans, Molecular Biology, ALS (Lou Gehrig's disease), ISR, integrated stress response, KD, knockdown, 030102 biochemistry & molecular biology, C9orf72 Protein, C9-NLuc, C9RAN translation–specific NLuc reporter, Amyotrophic Lateral Sclerosis, RNA, Helicase, Cell Biology, SG, stress granule, Ctrl, control, G-Quadruplexes, 030104 developmental biology, Protein Biosynthesis, Ran, Tg, thapsigargin, biology.protein, DHX36, DEAH-box helicase 36, Trinucleotide repeat expansion, G4, G-quadruplex, DHX36–G4R1–RHAU, DPR, dipeptide repeat protein, KCl, potassium chloride
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3ff8599557e7269f89d5bb5b0f3c3c
http://europepmc.org/articles/PMC8326427 -
7
المؤلفون: Moshe Arditi, Roberta A. Gottlieb, Jon Sin, Ozlem Tufanli, Ebru Erbay, Prediman K. Shah, Asli D. Yildirim, Zehra Veli, Umut Inci Onat, Begüm Kocatürk, Kenichi Shimada, Ismail Çimen, Shuang Chen, Syed M. Hamid
المساهمون: Onat, Umut I., Yıldırım, Aslı D., Tufanlı, Özlem, Çimen, İsmail, Kocatürk, Begüm, Veli, Zehra, Erbay, Ebru
المصدر: Journal of the American College of Cardiology
مصطلحات موضوعية: ATF4, activating transcription factor 4, Metabolic inflammation, interleukin-1β, Inflammasomes, Eukaryotic Initiation Factor-2, Interleukin-1beta, CCL2, C-D motif ligand-2, 030204 cardiovascular system & hematology, Endoplasmic Reticulum, PA, palmitate, siRNA, silencer RNA, Inflammasome, Mice, UPR, unfolded protein response, 0302 clinical medicine, BMDM, bone marrow–derived macrophages, GAS, Group A Streptococcus, 030212 general & internal medicine, Phosphorylation, Dietary fats, TNF, tumor necrosis factor, CHOP, CCAT/enhancer-binding protein beta homologous protein, food and beverages, integrated stress response, Lipids, Interleukin-1β, Plaque, Atherosclerotic, metabolic inflammation, Mitochondria, Cell biology, Interleukin 1β, eIF2α, eukaryotic initiation factor 2 alpha, Inflammation Mediators, IRE1, inositol-requiring enzyme-1, Cardiology and Cardiovascular Medicine, eIF2B, eukaryotic initiation factor 2B, Signal Transduction, medicine.drug, CVD, cardiovascular disease(s), PERK, protein kinase R-like endoplasmic reticulum kinase/eIF2α kinase, SFA, saturated fatty acid, Alpha (ethology), Article, ER, endoplasmic reticulum, Integrated stress response, 03 medical and health sciences, inflammasome, Stress, Physiological, medicine, Animals, Humans, PINK1, phosphatase and tensin-induced putative kinase1, lipid-induced inflammation, LONP1, Lon protease 1, ISR, integrated stress response, Parkin, Parkinson juvenile disease protein 2, Lipid-induced inflammation, business.industry, NLRP3, Nod-like receptor family, pyrin domain-containing protein-3, Atherosclerosis, Mationmetabolic inflammation, Dietary Fats, IL, interleukin, mtROS, mitochondrial reactive oxygen species, Oxidative Stress, ASKA, ATP-analog sensitive kinase allele, business, human activities
وصف الملف: application/pdf
-
8
المؤلفون: Cheng Luo, Jianpeng Liu, Ming Liu, Quan Zhao, Xinyu Li, Yichen Xu, Xiaming Pang, Jingru Ge, Ying Wang
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, translation control, HRI, Heme-Regulated Inhibitor, Protein-Arginine N-Methyltransferases, Methyltransferase, SCD, Sickle Cell Disease, Five prime untranslated region, Gene Expression, beta-Globins, Biochemistry, ATF4, Activating Transcription Factor 4, Transcription (biology), hemic and lymphatic diseases, DDX3, Dead-Box Polypetide 3, PRMT1, Protein Arginine Methyltransferase 1, gamma-Globins, Fetal Hemoglobin, Translation (biology), Cell biology, HbA, Adult Hemoglobin, 5’UTR, 5’ Untranslated Region, Research Article, PABP1, Polyadenylate-Binding Protein 1, uORF, upstream Open Reading Frame, ISR, Integrated Stress Response, Activating Transcription Factor 4, Biology, γ-globin, 03 medical and health sciences, Upstream open reading frame, Integrated stress response, Humans, ATIS, Alternative Translation Initiation Sites, protein arginine methyltransferase 1 (PRMT1), Molecular Biology, ATP2A2, ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2, 030102 biochemistry & molecular biology, ATF4, Cell Biology, Methyltransferases, PIC, Preinitiation Complex, β-hemoglobinopathies, Repressor Proteins, upstream open reading frame (uORF), 030104 developmental biology, HEK293 Cells, Gene Expression Regulation, Protein Biosynthesis, eIF2α, Translation Initiation Factor 2, HbF, Fetal Hemoglobin, K562 Cells
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b50ecafa6c83189ae743f3dabb1c034
http://europepmc.org/articles/PMC7966866 -
9
المؤلفون: Tawni Dornelles, Rachel E Hodgson, Mark P. Ashe, Susan G. Campbell, Benjamin Abell, Karl Norris, K Elizabeth Allen
المصدر: The Journal of Biological Chemistry
Norris, K, Hodgson, R E, Dornelles, T, Allen, K E, Abell, B M, Ashe, M P & Campbell, S G 2020, ' Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease ', The Journal of biological chemistry . https://doi.org/10.1074/jbc.RA120.014956مصطلحات موضوعية: 0301 basic medicine, VWM, vanishing white matter, DNA Mutational Analysis, Eukaryotic Initiation Factor-2, Mutation, Missense, Saccharomyces cerevisiae, Biochemistry, translation initiation, eIF2, eukaryotic initiation factor 2, GEF, guanine nucleotide exchange factor, 03 medical and health sciences, Eukaryotic translation, NIH, National Institutes of Health, Leukoencephalopathy with vanishing white matter, Leukoencephalopathies, Translational regulation, medicine, Integrated stress response, Humans, Molecular Biology, G alpha subunit, ISR, integrated stress response, eIF2, SCD, synthetic complete media, 030102 biochemistry & molecular biology, biology, VWM, FRAP, fluorescence recovery after photobleaching, Cell Biology, medicine.disease, Cell biology, 030104 developmental biology, Protein Biosynthesis, eIF2B, Mutation, biology.protein, Mutagenesis, Site-Directed, Protein Processing, Post-Translational, Research Article, eIF2B, eukaryotic initiation factor 2B
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bbe2734e8e96bd8429c56aebca073a
http://europepmc.org/articles/PMC7948505 -
10
المؤلفون: Mena Abdel-Nour, Jennifer L. Gommerman, Stephen E. Girardin, Valeria Ramaglia, Tapas Mukherjee, J J Chen, Lorraine V. Kalia, Hien Chau, Dana J. Philpott, Suneil K. Kalia, Jessica Tsalikis, Athanasia A. Bianchi, Damien Arnoult
المساهمون: INSERM U1197
المصدر: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, pp.jbc.RA120.014415. ⟨10.1074/jbc.RA120.014415⟩
The Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 296, pp.100050. ⟨10.1074/jbc.RA120.014415⟩مصطلحات موضوعية: 0301 basic medicine, ATF4, activating transcription factor 4, CASA, chaperone-assisted selective autophagy, CASA, alpha-synuclein, Parkinson's disease, Protein aggregation, BAG3-HSPB8 complex, Biochemistry, Mice, eIF-2 Kinase, 0302 clinical medicine, SC, scramble sequence, BAG3, B-cell lymphoma-2 associated athanogene 3, protein misfolding, unfolded protein response (UPR), ComputingMilieux_MISCELLANEOUS, Heat-Shock Proteins, cUPR, cytosolic unfolded protein response, Mice, Knockout, 0303 health sciences, Microglia, Chaperone-assisted selective autophagy, Chemistry, BAG3–HSPB8 complex, HSPB8, heat shock protein 8, Cell biology, Parkinson disease, medicine.anatomical_structure, Aggresome, Spinal Cord, HSP, heat shock protein, eIF2alpha, Research Article, Programmed cell death, autophagy, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Protein Serine-Threonine Kinases, BAG3, Integrated Stress Response, protein aggregation, Protein Aggregates, 03 medical and health sciences, synuclein, medicine, Animals, Humans, Molecular Biology, Adaptor Proteins, Signal Transducing, 030304 developmental biology, ISR, integrated stress response, 030102 biochemistry & molecular biology, Autophagy, Cell Biology, Cytosol, 030104 developmental biology, Proteostasis, shHRI, small hairpin RNA directed against HRI sequence, HEK293 Cells, HRI, proteasome, Proteotoxicity, ubiquitin-dependent protease, Parkinson’s disease, Unfolded Protein Response, Unfolded protein response, Apoptosis Regulatory Proteins, HRI, heme-regulated inhibitory, 030217 neurology & neurosurgery, HeLa Cells, Molecular Chaperones
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9e22cd1c55dbbcd882b64d0aa0c616
https://hal.archives-ouvertes.fr/hal-03001543/document
Full Text via ClinicalKey