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المؤلفون: Alice Kaganovich, Kelechi Ndukwe, Allissa Dillman, Ravindran Kumaran, Iakov N. Rudenko, Ruth Chia, Rebekah G. Langston, Aleksandra Beilina, Mark R. Cookson
المصدر: Biochemical Journal. 474:1547-1558
مصطلحات موضوعية: 0301 basic medicine, Proteasome Endopeptidase Complex, Ubiquitin-Protein Ligases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Biochemistry, Article, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Mutant protein, Heat shock protein, Humans, Genetic Predisposition to Disease, Kinase activity, Molecular Biology, biology, Protein turnover, Parkinson Disease, Cell Biology, Hsp90, Molecular biology, LRRK2, nervous system diseases, HEK293 Cells, 030104 developmental biology, Gene Knockdown Techniques, Chaperone (protein), Mutation, Proteolysis, biology.protein, 030217 neurology & neurosurgery, Intracellular
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb662eb6765939f3a976a677fc652bf
https://doi.org/10.1042/bcj20160909 -
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المؤلفون: Allissa Dillman, Rebekah G. Langston, Alice Kaganovich, Adamantios Mamais, Iakov N. Rudenko, Ravindran Kumaran, Mark R. Cookson, David N. Hauser, Luis Bonet Ponce, Aleksandra Beilina, Amr M. Al-Saif, Kelechi Ndukwe
المصدر: Neurochem Res
مصطلحات موضوعية: 0301 basic medicine, Biology, Leucine-rich repeat, Mouse Protein, medicine.disease_cause, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Biochemistry, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, Mice, 0302 clinical medicine, medicine, Animals, Humans, Gene Knock-In Techniques, HSP90 Heat-Shock Proteins, Kinase activity, Phosphorylation, Gene, Genetics, Mutation, Kinase, Protein Stability, HSC70 Heat-Shock Proteins, General Medicine, LRRK2, In vitro, nervous system diseases, rab1 GTP-Binding Proteins, 030104 developmental biology, HEK293 Cells, rab GTP-Binding Proteins, 030217 neurology & neurosurgery
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المؤلفون: Mark R. Cookson, Iakov N. Rudenko
المصدر: Neurotherapeutics. 11:738-750
مصطلحات موضوعية: Review, GTPase, Protein Serine-Threonine Kinases, Leucine-rich repeat, Biology, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, medicine.disease_cause, Risk Factors, Genetic variation, medicine, Animals, Humans, Pharmacology (medical), Kinase activity, Gene, Neurons, Pharmacology, Genetics, Mutation, Kinase, Genetic Variation, Parkinson Disease, LRRK2, nervous system diseases, Cancer research, Neurology (clinical)
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المؤلفون: Mina Ryten, Daniah Trabzuni, J. Ding, Bart Post, Albert Hofman, Jean-Charles Lambert, Olaf Riess, Michele T.M. Hu, Andrew B. Singleton, Stephen Sawcer, X. Huang, Caroline H. Williams-Gray, H. R. Zielke, C Smith, Peter Lichtner, B.P.C. van de Warrenburg, Bernard Ravina, F. Durif, Ellen Sidransky, Mike A. Nalls, Karen E. Morrison, J. R. Gibbs, Robert L. Johnson, Peter Heutink, David J. Burn, Michael Bonin, Sarah Edkins, T. Gasser, Luigi Ferrucci, H. Chau, Sampath Arepalli, Chris C. A. Spencer, Yoav Ben-Shlomo, Honglei Chen, Caroline M. Tanner, Zoltán Bochdanovits, Ruth Chia, Heiko Huber, Kari Stefansson, Dena G. Hernandez, Jean-Marc Taymans, Veerle Baekelandt, Iakov N. Rudenko, Evy Lobbestael, Huw R. Morris, A. Goate, C. Moorby, Lois E. Greene, Manu Sharma, Emma Gray, Ira Shoulson, Janet Brooks, Juan C. Troncoso, K. Shaw, Laura Civiero, Alessandra Biffi, Hans Scheffer, Matthew Moore, Alan B. Zonderman, S. Sveinbjornsdottir, Avazeh Tashakkori-Ghanbaria, Jean-Christophe Corvol, Vincent Plagnol, H. Petursson, Alice Kaganovich, M M Wickremaratchi, Nigel Williams, Thomas Foltynie, Henk W. Berendse, P. Damier, A. Strange, J. M. Cooper, Simon C. Potter, Patricia Limousin, Jiali Gao, Sophie Winder-Rhodes, M. Van Der Brug, Marie Vidailhet, Elisa Greggio, Nicholas W. Wood, Kevin Talbot, M. R. Cookson, Johanna Huttenlocher, J.J. van Hilten, Dan L. Longo, Alisdair McNeill, François Tison, K.D. van Dijk, David N. Hauser, Allissa Dillman, Suneil K. Kalia, Lorraine V. Kalia, Patrick F. Chinnery, Alexis Brice, Kelechi Ndukwe, J. F. Dartigues, M. Gardner, Mohamad Saad, Palmi V. Jonsson, Kailash P. Bhatia, Roger A. Barker, André G. Uitterlinden, Maria Martinez, R. Walker, Elisa Majounie, Fernando Rivadeneira, Joel S. Perlmutter, Panagiotis Deloukas, Bryan J. Traynor, Ese E. Mudanohwo, Grisel Lopez, UM Sheerin, Joanne D. Stockton, Thomas Illig, Andres M. Lozano, Rita Guerreiro, David T. Dexter, Andrew J. Lees, Sean Chong, Gavin Hudson, Cordelia Langford, Günther Deuschl, Ravindran Kumaran, Janice L. Holton, Tamas Revesz, B.R. Bloem, Alexandra Beilina, Clare Elizabeth Harris, Daniela Berg, Anthony H.V. Schapira, Suzanne Lesage, Sean S. O'Sullivan, Albert R. Hollenbeck, James A. Pearson, R. M. A. de Bie, Delia Lorenz, Sarah E. Hunt, Richard O'Brien, Gavin Charlesworth, Maciej B. Olszewski, Stacy Steinberg, Kathrin Brockmann, Carl E Clarke, Patrizia Rizzu, Claudia Schulte, Hreinn Stefansson, Daan C. Velseboer, Omar Gustafsson, Jonathan R. Evans, Alexandra Durr, Javier Simón-Sánchez, Pierre Pollak, H. Z. Munchen, Jose Bras, Carl Counsell, John Hardy
المساهمون: ANS - Amsterdam Neuroscience, Neurology, Graduate School
المصدر: Proceedings of the National Academy of Sciences, 111(7), 2626-2631
Proceedings of the National Academy of Sciences USA, 111, 2626-31
Proceedings of the National Academy of Sciences of the United States of America, 111(7), 2626-2631. National Academy of Sciences
Proc. Natl. Acad. Sci. U.S.A. 111, 2626-2631 (2014)
Proceedings of the National Academy of Sciences USA, 111, 7, pp. 2626-31مصطلحات موضوعية: Candidate gene, autophagy, Blotting, Western, Golgi Apparatus, Genome-wide association study, Protein Serine-Threonine Kinases, Biology, Leucine-rich repeat, Cell Fractionation, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Mass Spectrometry, Commentaries, Protein Interaction Mapping, Humans, Immunoprecipitation, Genetic Predisposition to Disease, Transport Vesicles, Gene, Adaptor Proteins, Signal Transducing, DNA Primers, Genetics, Analysis of Variance, Microscopy, Confocal, Multidisciplinary, Kinase, HEK 293 cells, BAG5, Intracellular Signaling Peptides and Proteins, Brain, rab7 GTP-Binding Proteins, Signal transducing adaptor protein, Parkinson Disease, Biological Sciences, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], GAK, LRRK2, nervous system diseases, HEK293 Cells, Genetic Loci, rab GTP-Binding Proteins, Multiprotein Complexes, trans-Golgi, Genome-Wide Association Study, Plasmids
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f039110c8ce3d814891d0913e28b739c
https://doi.org/10.1073/pnas.1318306111 -
5دورية أكاديمية
المؤلفون: Ruth Chia, Sara Haddock, Alexandra Beilina, Iakov N. Rudenko, Adamantios Mamais, Alice Kaganovich, Yan Li, Ravindran Kumaran, Michael A. Nalls, Mark R. Cookson
المصدر: Nature, Nature Communications. 5(1):1-11
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المؤلفون: David N. Hauser, Iakov N. Rudenko, J. Raphael Gibbs, Mike A. Nalls, Mark R. Cookson, Melissa K. McCoy, Dagmar Galter, Allissa Dillman
المصدر: Nature neuroscience
مصطلحات موضوعية: RNA Splicing, Biology, Article, Transcriptome, 03 medical and health sciences, Mice, 0302 clinical medicine, Pregnancy, Gene expression, medicine, Animals, RNA, Messenger, 030304 developmental biology, Regulation of gene expression, Genetics, Cerebral Cortex, 0303 health sciences, Sequence Analysis, RNA, General Neuroscience, Alternative splicing, Age Factors, Gene Expression Regulation, Developmental, Cell biology, Mice, Inbred C57BL, medicine.anatomical_structure, RNA editing, Cerebral cortex, Regulatory sequence, RNA splicing, Female, RNA Editing, Neuroscience, 030217 neurology & neurosurgery
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المؤلفون: Mark R. Cookson, Iakov N. Rudenko, Rebekah G. Langston
مصطلحات موضوعية: 0301 basic medicine, Biomedical Research, Druggability, Disease, Computational biology, Protein Serine-Threonine Kinases, Biochemistry, Article, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Caenorhabditis elegans, Molecular Biology, Gene, Genetics, biology, Neurodegeneration, Parkinson Disease, Cell Biology, biology.organism_classification, medicine.disease, LRRK2, nervous system diseases, Disease Models, Animal, 030104 developmental biology, Drosophila melanogaster, 030217 neurology & neurosurgery, Function (biology)
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c3dad034c18e8e303da629767773af
https://europepmc.org/articles/PMC5165698/ -
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المؤلفون: Ruth Chia, Iakov N. Rudenko, Alice Kaganovich, Aleksandra Beylina, Jinhui Ding, David N. Hauser, Dragan Maric, Mark R. Cookson, Howard Jaffe
المصدر: Biochemical Journal. 446:99-111
مصطلحات موضوعية: Mutation, Missense, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, MAP3K7, Biochemistry, Article, Cell Line, MAP2K7, Microsomes, Neurites, Humans, HSP90 Heat-Shock Proteins, c-Raf, Phosphorylation, Kinase activity, Molecular Biology, Genetics, biology, Cyclin-dependent kinase 4, Cyclin-dependent kinase 2, Parkinson Disease, Cell Biology, LRRK2, nervous system diseases, Amino Acid Substitution, Mutation, Chromatography, Gel, biology.protein, Cyclin-dependent kinase 7
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53edfb10a1afe02bbbc8e3d46976fd2
https://doi.org/10.1042/bj20120637 -
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المصدر: Doklady Biochemistry and Biophysics. 430:45-49
مصطلحات موضوعية: Male, Oligomycin, Potassium, Biophysics, Physiology, chemistry.chemical_element, Lithium, Mitochondrion, Biochemistry, Mitochondria, Heart, chemistry.chemical_compound, Respiration, Animals, Rats, Wistar, Inner mitochondrial membrane, Incubation, Diminution, Membrane potential, Myocardium, General Chemistry, General Medicine, Rats, Oxygen, Spectrometry, Fluorescence, chemistry, Mitochondrial Swelling
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المؤلفون: Aleksandra Beylina, Iakov N. Rudenko, R. Jeremy Nichols, Justin Wetter, Jing Zhao, Jean-Marc Taymans, Veerle Baekelandt, Evy Lobbestael, Mark R. Cookson, Monique Beullens, Mathieu Bollen, Fangye Gao
مصطلحات موضوعية: Phosphatase, Mutant, Biology, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Biochemistry, Article, Cell Line, Dephosphorylation, Mice, Protein Phosphatase 1, Animals, Humans, Kinase activity, Phosphorylation, Molecular Biology, Benzodiazepinones, Kinase, Protein phosphatase 1, Parkinson Disease, Cell Biology, LRRK2, nervous system diseases, Pyrimidines, Mutation
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5dcd032a43eb4d62e5fd0923207f5f
https://europepmc.org/articles/PMC5141581/
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