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المؤلفون: Sebastian Dekkers, Kirsten Visser, Ilze Adlere, Iwan J. P. de Esch, Michael J. Stocks, Stephen J. Briddon, Barrie Kellam, Marta Arimont, Birgit Caspar, Stephen J. Hill, Jeffrey Stuijt, Rob Leurs, Chris de Graaf, Maikel Wijtmans
المصدر: Adlere, I, Caspar, B, Arimont, M, Dekkers, S, Visser, K, Stuijt, J, de Graaf, C, Stocks, M, Kellam, B, Briddon, S, Wijtmans, M, de Esch, I, Hill, S & Leurs, R 2019, ' Modulators of CXCR4 and CXCR7/AckR3 function ', Molecular pharmacology, vol. 96, no. 6, pp. 737-752 . https://doi.org/10.1124/mol.119.117663
مصطلحات موضوعية: 0301 basic medicine, Benzylamines, Receptors, CXCR4, Chemokine, Computational biology, Cyclams, CXCR4, Protein Structure, Secondary, 03 medical and health sciences, Chemokine receptor, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Heterocyclic Compounds, Animals, Humans, Amino Acid Sequence, Receptor, Structural motif, G protein-coupled receptor, Receptors, CXCR, Pharmacology, biology, Drug discovery, Chemistry, Ligand (biochemistry), Protein Structure, Tertiary, 030104 developmental biology, biology.protein, Molecular Medicine, 030217 neurology & neurosurgery, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2edb3426bf2a9db659622fecf53151c
http://www.scopus.com/inward/record.url?scp=85075090368&partnerID=8YFLogxK -
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المؤلفون: I.J.P. de Esch, Rob Leurs, Stephen J. Hill, M. Gozelle, Marta Arimont, Henry F. Vischer, Birgit Caspar, Aurélien Zarca, Ilze Adlere, Luc Roumen, Stephen J. Briddon, Maikel Wijtmans, Martine J. Smit, Shanliang Sun, C. Perpiñá Viciano, J.P. Bebelman, Carsten Hoffmann, C de Graaf
المساهمون: Medicinal chemistry, AIMMS, Chemistry and Pharmaceutical Sciences
المصدر: European Journal of Medicinal Chemistry, 162, 631-649. Elsevier Masson SAS
Adlere, I, Sun, S, Zarca, A, Roumen, L, Gozelle, M, Viciano Perpiñá, C, Caspar, B, Arimont, M, Bebelman, J P, Briddon, S J, Hoffmann, C, Hill, S J, Smit, M J, Vischer, H F, Wijtmans, M, de Graaf, C, de Esch, I J P & Leurs, R 2019, ' Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists ', European Journal of Medicinal Chemistry, vol. 162, pp. 631-649 . https://doi.org/10.1016/j.ejmech.2018.10.060
European Journal of Medicinal Chemistryمصطلحات موضوعية: Models, Molecular, Receptors, CXCR4, Stereochemistry, Quantitative Structure-Activity Relationship, Ligands, 01 natural sciences, CXCR4, Hydrophobic effect, Methylamines, 03 medical and health sciences, Chemokine receptor, CXCR4 chemokine receptor, Piperidines, G protein-coupled receptors, SDG 3 - Good Health and Well-being, Drug Discovery, Structure–activity relationship, Binding site, 030304 developmental biology, G protein-coupled receptor, 3D-QSAR, Pharmacology, 0303 health sciences, Virtual screening, Binding Sites, 010405 organic chemistry, Chemistry, Organic Chemistry, General Medicine, Ligand (biochemistry), Structure-activity relationship, Chemokine CXCL12, Peptide Fragments, Structure-based fragment virtual screening, 0104 chemical sciences, Antagonists, Protein Binding
وصف الملف: application/pdf
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المؤلفون: Berend J. H. Huisman, Marie Ranson, Dong Guo, Ilze Adlere, Corine van Veen, Arnault Massink, Eelke B. Lenselink, Gabrielle S. Dijksteel, Michael J. Kelso, Hayden Matthews, Benjamin J. Buckley, Adriaan P. IJzerman, Julien Louvel
المصدر: Journal of Medicinal Chemistry. 59:4769-4777
مصطلحات موضوعية: 0301 basic medicine, Receptor, Adenosine A2A, Stereochemistry, Sodium, Mutant, Allosteric regulation, chemistry.chemical_element, Adenosine A2A receptor, Amiloride, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Allosteric Regulation, Drug Discovery, Radioligand, medicine, Humans, Receptor, G protein-coupled receptor, Molecular Structure, Chemistry, Adenosine A2 Receptor Antagonists, 3. Good health, Molecular Docking Simulation, 030104 developmental biology, Biochemistry, 030220 oncology & carcinogenesis, Molecular Medicine, Allosteric Site, medicine.drug
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المؤلفون: Elina Sokolova, Gunars Duburs, Aivars Krauze, Ilona Domracheva, S. Grinberga, I. Shestakova, L. Krasnova, Ilze Adlere, Z. Andzans
المصدر: Bioorganic & Medicinal Chemistry. 22:5860-5870
مصطلحات موضوعية: Thienopyridines, Abcg2, Cell Survival, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Inhibitory postsynaptic potential, Biochemistry, Cell Line, Mice, Structure-Activity Relationship, Drug Discovery, ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, MDR Modulators, Cytotoxicity, Molecular Biology, P-glycoprotein, biology, Chemistry, Organic Chemistry, Antagonist, Muscle, Smooth, Calcium Channel Blockers, Drug Resistance, Multiple, Neoplasm Proteins, Rats, Multiple drug resistance, Toxicity, NIH 3T3 Cells, biology.protein, Molecular Medicine, ATP-Binding Cassette Transporters, Calcium, Calcium Channels, Multidrug Resistance-Associated Proteins, Protein Binding
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المؤلفون: S. Grinberga, Ilze Adlere, Gunars Duburs, Z. Andzans, Ilona Domracheva, L. Krasnova, Aivars Krauze, S. K. Germane
المصدر: Chemistry of Heterocyclic Compounds. 49:566-573
مصطلحات موضوعية: Agonist, Cerebrocrast, Carbachol, medicine.drug_class, Stereochemistry, Organic Chemistry, chemistry.chemical_element, Calcium, Related derivatives, chemistry.chemical_compound, chemistry, Pyridine, medicine, Neuroblastoma cell line, Enhancer, medicine.drug
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المؤلفون: A. Krauze, Ilze Adlere, G. Duburs
المصدر: Latvian Journal of Chemistry. 51:257-263
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Aryl, Aril, Pyridine, Medicinal chemistry
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المؤلفون: Aleksandrs Versilovskis, L. Krasnova, Ilze Adlere, S. Grinberga, Z. Andzans, Aivars Krauze, Gunars Duburs
المصدر: ChemInform. 45
مصطلحات موضوعية: biology, Leaving group, General Medicine, Alkylation, biology.organism_classification, Kinetic resolution, chemistry.chemical_compound, chemistry, Sulfanyl, Diisopropyl ether, Organic chemistry, Candida antarctica, Protecting group, Enantiomeric excess
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المؤلفون: Z. Andzans, Ilze Adlere, L. Krasnova, Aivars Krauze, Gunars Duburs
المصدر: ChemInform. 44
مصطلحات موضوعية: biology, Chemistry, Enantioselective synthesis, Dihydropyridine, General Medicine, Catalysis, Kinetic resolution, chemistry.chemical_compound, Sulfanyl, biology.protein, medicine, Organic chemistry, Lipase, medicine.drug
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المؤلفون: Gunars Duburs, Z. Andzans, Ilze Adlere, L. Krasnova, Aivars Krauze, S. Grinberga, Aleksandrs Versilovskis
المصدر: HETEROCYCLES. 89:43
مصطلحات موضوعية: Pharmacology, biology, Organic Chemistry, Leaving group, Alkylation, biology.organism_classification, Medicinal chemistry, Analytical Chemistry, Kinetic resolution, chemistry.chemical_compound, chemistry, Sulfanyl, Diisopropyl ether, Candida antarctica, Enantiomeric excess, Protecting group
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5e93cdc6728b7052dbcd0cc636c6692a
https://doi.org/10.3987/com-13-12839
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