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1
المؤلفون: David Hecht, Kyle Chan, Paul Erdman, Eduardo Torres, yinon Ben-Neriah, Brooke McElwee, Frank Mercurio, Aparajita Chourasia, Leah Fung, Robert Sullivan, Imelda Calderon
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbce36130955bb33ebe35f3bdfe327d
https://doi.org/10.1021/scimeetings.0c07400 -
2
المؤلفون: Andiliy G. Lai, Katherine Nguyen, Gretchen Bain, Lance Goulet, Imelda Calderon, Fei Huang, Deidre A. MacKenna, Kristen E. Shannon, Janice Darlington, Patricia Prodanovich, John H. Hutchinson, David Lonergan, Angelina M. Santini, Gina L. Ma, Jilly F. Evans, Taylor Lasof, Martin W. Rowbottom, Christopher D. King
المصدر: Journal of Medicinal Chemistry. 60:4403-4423
مصطلحات موضوعية: Lung Diseases, Male, Models, Molecular, 0301 basic medicine, Amine oxidase, Halogenation, Pyridines, Stereochemistry, Lysine, Administration, Oral, Lysyl oxidase, Methylation, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Lung, Trifluoromethyl, LOXL2, Oxidative deamination, Fibrosis, Mice, Inbred C57BL, Disease Models, Animal, Hydroxylysine, 030104 developmental biology, chemistry, Biochemistry, 030220 oncology & carcinogenesis, Molecular Medicine, Amino Acid Oxidoreductases, Allysine
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3
المؤلفون: Adam J. Stein, Ranjinder S. Sidhu, Lance Goulet, Jilly F. Evans, Jeffrey M. Schaub, Dave Lonergan, Janice Darlington, Gretchen Bain, Nina M. P. Stelzer, Imelda Calderon, Angelina M. Santini, John H. Hutchinson, Pat Prodanovich
المصدر: Molecular Pharmacology. 88:982-992
مصطلحات موضوعية: Plasma protein binding, Biology, Protein Structure, Secondary, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Lysophosphatidic acid, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, Receptor, Pharmacology, chemistry.chemical_classification, Phosphoric Diester Hydrolases, Cell growth, HEK 293 cells, Protein Structure, Tertiary, HEK293 Cells, Enzyme, Biochemistry, chemistry, Molecular Medicine, lipids (amino acids, peptides, and proteins), Autotaxin, Crystallization, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6791e4072e6e2dc892dc384baa160e6
https://doi.org/10.1124/mol.115.100404 -
4
المؤلفون: Khawja A. Usmani, Dawei Yue, Zhi-Liang Chu, Abu J.M. Sadeque, Chris Carroll, Chuan Chen, Hsin-Hui Shu, Sanju Narayanan, Hussein Al-Sharmma, Dominic P. Behan, Robert M. Jones, Graeme Semple, James N. Leonard, David J. Unett, Daniel J. Buzard, Michael Morgan, Juerg Lehmann, Imelda Calderon, Shiu-Feng Tung, Woo Hyun Yoon, Xiuwen Zhu, Sangdon Han, Andrew M. Kawasaki, Amy Siu-Ting Wong, Sun Hee Kim
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:3034-3038
مصطلحات موضوعية: Blood Glucose, Male, medicine.medical_specialty, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Pharmacology, Biochemistry, Rats sprague dawley, Receptors, G-Protein-Coupled, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cyclohexanes, Internal medicine, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Structure–activity relationship, Gpr119 agonist, Molecular Biology, Glycemic, Organic Chemistry, Rats, Zucker, Endocrinology, Diabetes Mellitus, Type 2, chemistry, Molecular Medicine, Lead compound
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5
المؤلفون: Weichao Chen, Andrew M. Kawasaki, Dominic P. Behan, Jeff Edwards, You-An Ma, Tawfik Gharbaoui, Sun Hee Kim, Jayant Thatte, Hussien A. Al-Shamma, Carleton R. Sage, Jeremy Barden, Anthony C. Blackburn, Michelle Solomon, Xiuwen Zhu, Christopher Ronald J, David Mills, Ibragim Gaidarov, Antonio Garrido Montalban, Sangdon Han, Luis Lopez, Dipanjan Sengupta, Michael Morgan, Juerg Lehmann, Daniel J. Buzard, Graeme Semple, Kevin Whelan, Yinghong Gao, Joel Gatlin, Moody Jeanne, David J. Unett, Imelda Calderon, Lars Thoresen, Robert M. Jones, Brett Ullman, Todd Anthony, Chuan Chen, Minh Le, Khawja A. Usmani, Scott Stirn, Jaimie Karyn Rueter, Lixia Fu, Lorene Calvano, Abu J.M. Sadeque
المصدر: ACS Medicinal Chemistry Letters. 5:1313-1317
مصطلحات موضوعية: business.industry, S1p1 receptor, Multiple sclerosis, Lymphocyte, Organic Chemistry, Experimental autoimmune encephalomyelitis, Antagonist, Pharmacology, medicine.disease, Biochemistry, Fingolimod, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Drug Discovery, medicine, Sphingosine-1-phosphate, business, Receptor, medicine.drug
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6
المؤلفون: Lance Goulet, Fei Huang, Patricia Prodanovich, Dave Lonergan, Gretchen Bain, Janice Darlington, Andiliy G. Lai, Angelina M. Santini, Kristen E. Shannon, Gina L. Ma, Christopher D. King, Jilly F. Evans, Imelda Calderon, Adam J. Stein, John H. Hutchinson
المصدر: The Journal of pharmacology and experimental therapeutics. 360(1)
مصطلحات موضوعية: 0301 basic medicine, Liver Cirrhosis, Male, Inflammation, Pharmacology, Biology, Piperazines, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Non-competitive inhibition, Fibrosis, Lysophosphatidic acid, medicine, Animals, Humans, Enzyme Inhibitors, Kidney, Phosphoric Diester Hydrolases, medicine.disease, Disease Models, Animal, 030104 developmental biology, Lysophosphatidylcholine, medicine.anatomical_structure, chemistry, Biochemistry, 030220 oncology & carcinogenesis, Molecular Medicine, lipids (amino acids, peptides, and proteins), Female, medicine.symptom, Autotaxin, Steatosis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07cf278a0329f302e73eee640438c30
https://pubmed.ncbi.nlm.nih.gov/27754931 -
7Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease
المؤلفون: Joel Gatlin, Kevin Whelan, Michael Morgan, Juerg Lehmann, Lixia Fu, Yinghong Gao, Moody Jeanne, Minh Le, Hussien A. Al-Shamma, Jeremy Barden, Khawja A. Usmani, Jeff Edwards, Chuan Chen, Jayant Thatte, Dipanjan Sengupta, Xiuwen Zhu, Abu J.M. Sadeque, Imelda Calderon, Michelle Solomon, Lars Thoresen, Tawfik Gharbaoui, Robert M. Jones, Ling Liu, Luis Lopez, Daniel J. Buzard, Brett Ullman, Krishnan Ashwin M, Sheryll Espinola, Charles Xing, Sangdon Han, Andrew M. Kawasaki
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:4404-4409
مصطلحات موضوعية: Autoimmune disease, chemistry.chemical_classification, Chemistry, Sphingosine-1-phosphate receptor, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, medicine.disease, Biochemistry, In vitro, Sprague dawley, In vivo, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, lipids (amino acids, peptides, and proteins), Receptor, Molecular Biology, Tricyclic
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8
المؤلفون: Luis Lopez, Daniel J. Buzard, Abu J.M. Sadeque, David J. Unett, Ching-Fen Chuang, Hsin-Hui Shu, Rohit Bhat, James N. Leonard, Sanju Narayanan, Dawei Yue, Robert M. Jones, Amy Siu-Ting Wong, Michael Morgan, Zhi-Liang Chu, Juerg Lehmann, Sun Hee Kim, Hussien A. Al-Shamma, Imelda Calderon, Kevin Whelan, Steve Chang, Shiu-Feng Tung, Tawfik Gharbaoui, Andrew M. Kawasaki, Sangdon Han
المصدر: Bioorganicmedicinal chemistry letters. 24(17)
مصطلحات موضوعية: Agonist, Inhibitory potential, Glucose control, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, medicine.drug_class, Pyridines, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, In vitro, Receptors, G-Protein-Coupled, Structure-Activity Relationship, GPR119, Piperidines, Drug Discovery, medicine, Molecular Medicine, Humans, Molecular Biology, CYP2C9
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9Fused tricyclic indoles as S1P₁ agonists with robust efficacy in animal models of autoimmune disease
المؤلفون: Daniel J, Buzard, Sangdon, Han, Luis, Lopez, Andrew, Kawasaki, Jeanne, Moody, Lars, Thoresen, Brett, Ullman, Juerg, Lehmann, Imelda, Calderon, Xiuwen, Zhu, Tawfik, Gharbaoui, Dipanjan, Sengupta, Ashwin, Krishnan, Yinghong, Gao, Jeff, Edwards, Jeremy, Barden, Michael, Morgan, Khawja, Usmani, Chuan, Chen, Abu, Sadeque, Jayant, Thatte, Michelle, Solomon, Lixia, Fu, Kevin, Whelan, Ling, Liu, Hussien, Al-Shamma, Joel, Gatlin, Minh, Le, Charles, Xing, Sheryll, Espinola, Robert M, Jones
المصدر: Bioorganicmedicinal chemistry letters. 22(13)
مصطلحات موضوعية: Male, Indoles, Autoimmune Diseases, Rats, Mice, Inbred C57BL, Rats, Sprague-Dawley, Disease Models, Animal, Mice, Receptors, Lysosphingolipid, Structure-Activity Relationship, Microsomes, Animals, Humans, Immunologic Factors, Female, Lymphocytes
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10
المؤلفون: Guillherme Pereira, Michael Morgan, Yin Liang, Tawfik Gharbaoui, Robert M. Jones, Fioravanti Beatriz, Charles Xing, Karoline Choi, Hussien A. Al-Shamma, Carleton R. Sage, Albert S. Ren, Graeme Semple, James N. Leonard, Young-Jun Shin, Andrew J. Grottick, Yifeng Xiong, Zhi-Liang Chu, Imelda Calderon, Keith T. Demarest
المصدر: Bioorganicmedicinal chemistry letters. 21(10)
مصطلحات موضوعية: Agonist, Blood Glucose, medicine.medical_specialty, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Pyrazolopyrimidine, Receptors, G-Protein-Coupled, chemistry.chemical_compound, In vivo, Internal medicine, Drug Discovery, medicine, Animals, Hypoglycemic Agents, Receptor, Molecular Biology, G protein-coupled receptor, Glucose tolerance test, Oxadiazoles, medicine.diagnostic_test, Molecular Structure, Organic Chemistry, Bridged Bicyclo Compounds, Heterocyclic, Rats, Rats, Zucker, Disease Models, Animal, Endocrinology, Glucose, Pyrimidines, Mechanism of action, chemistry, Molecular Medicine, Pyrazoles, Glycated hemoglobin, medicine.symptom