المؤلفون: Leszek Lisowski, Sophia H.Y. Liao, Szun S. Tay, Ian E. Alexander, Grant J Logan, Samantha L. Ginn, Claus V. Hallwirth, Markus Grompe, Anais K. Amaya, Erhua Zhu, Hilda A. Pickett, Kimberley L. Dilworth, Anthony J. Cesare, Sharon C. Cunningham, Michael Lee

المصدر: JHEP Reports, Vol 2, Iss 1, Pp-(2020)
JHEP Reports

مصطلحات موضوعية: Genetic enhancement, ITR, inverted terminal repeats, medicine.disease_cause, RTA, Real Time Analysis, BrdU, bromodeoxyuridine, AAV, adeno-associated virus, 0302 clinical medicine, Genome editing, 7 NGS, next-generation sequencing, recombinant AAV, Immunology and Allergy, CRISPR, Adeno-associated virus, HDR, homology-directed repair, 0303 health sciences, NP59 capsid, Gastroenterology, humanised FRG mice, rAAV, recombinant adeno-associated virus, 3. Good health, homology-directed repair, U6, RNA polymerase III promoter for human U6 snRNA, 030220 oncology & carcinogenesis, SaCas9, Staphylococcus aureus Cas9 nuclease, CRISPR-Cas9, Research Article, TBG, human thyroxine binding globulin promoter, Ornithine transcarbamylase, Computational biology, Biology, LSP1, liver-specific promoter, Homology directed repair, 03 medical and health sciences, synthetic capsid, PRE, mutant form of the Woodchuck hepatitis virus posttranscriptional regulatory element, InDels, insertions and deletions, PAM, protospacer adjacent motif, Internal Medicine, medicine, genome editing, lcsh:RC799-869, Gene, 030304 developmental biology, Hepatology, OTC deficiency, sgRNA, single guide RNA, WT, wild-type, FRG, Fah-/-Rag2-/-Il2rg, primary human hepatocytes, NHEJ, non-homologous end joining, lcsh:Diseases of the digestive system. Gastroenterology, pA, bovine growth hormone polyadenylation signal sequence, SV40 pA, SV40 polyadenylation signal sequence, Minigene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db43f1b07a8924ee43c66eaf654d9a6b
https://pubmed.ncbi.nlm.nih.gov/32039406

المؤلفون: Quchang Ouyang, Xin Yi, Xiaohong Yang, Jianxiang Gao, Zheyu Hu, Xuming Hu, Can Tian, Lianpeng Chang, Xuefeng Xia, Yu Tang, Qianjin Liao, Mengjia Xiao, Qiongzhi He, Liping Liu, Hui Wu, Jing Li, Jun Lu, Ning Xie, Huawu Xiao, Min Cao, Zhengrong Shui

المصدر: EBioMedicine
EBioMedicine, Vol 32, Iss, Pp 111-118 (2018)

مصطلحات موضوعية: 0301 basic medicine, Oncology, MBC, metastatic breast cancer, ER, estrogen receptor, Receptor, ErbB-2, Gene mutation pattern, Estrogen receptor, lcsh:Medicine, Drug resistance, SNV, Single nucleotide variants, Gene mutation, medicine.disease_cause, Circulating Tumor DNA, SEER, Surveillance Epidemiology and End Results, AUC, area under the curve, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, HER2, human epidermal growth factor receptor 2, ctDNA, circulating tumor DNA, Indels, insertions and deletions, Neoplasm Metastasis, skin and connective tissue diseases, Triple-negative breast cancer, TNBC, triple negative breast cancer, Mutation, lcsh:R5-920, Mediator Complex, BRCA1 Protein, Progression-free survival, General Medicine, Middle Aged, Metastatic breast cancer, PFS, progression-free survival, Drug Resistance, Multiple, Gene Expression Regulation, Neoplastic, GX, gemcitabine+capecitabine, 030220 oncology & carcinogenesis, Disease Progression, Female, lcsh:Medicine (General), Circulating tumor DNA (ctDNA), WES, whole exome sequencing, IHC, immunohistochemistry, Research Paper, Adult, medicine.medical_specialty, Class I Phosphatidylinositol 3-Kinases, Breast Neoplasms, General Biochemistry, Genetics and Molecular Biology, Disease-Free Survival, 03 medical and health sciences, Internal medicine, medicine, Biomarkers, Tumor, Humans, neoplasms, AI, aromatase inhibitor, Aged, HR/HER2 subtype, TMB, Tumor mutation burden, business.industry, lcsh:R, Cancer, HR, hormone receptor, PR, progesterone receptor, cfDNA, cell-free DNA, medicine.disease, HR, hazard ratio, ROC, receiver operating characteristic, CI, confidence interval, 030104 developmental biology, Drug Resistance, Neoplasm, gDNA, genomic DNA, Tumor Suppressor Protein p53, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ba2a916d616434f8644bf3d44cb54d
http://europepmc.org/articles/PMC6020712

المؤلفون: Yichen Meng, Tao Lin, Xuhui Zhou, Shulun Liang, Rui Gao, Fu Yang, Heng Jiang, Wei Shao

المصدر: EBioMedicine

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Research paper, AUC, Area under the ROC curve, Epigenesis, Genetic, 0302 clinical medicine, Copy-number variation, Indels, insertions and deletions, Progression, AIS, adolescent idiopathic scoliosis, General Medicine, Methylation, MZ, monozygotic, Institutional review board, Pedigree, Scoliosis, CpG site, DNA methylation, Disease Progression, Biomarker (medicine), Female, medicine.medical_specialty, Adolescent, CNV, copy number variation, General Biochemistry, Genetics and Molecular Biology, Adolescent idiopathic scoliosis, 03 medical and health sciences, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Curve progression, Epigenetics, Genetic Association Studies, SNV, single-nucleotide variant, Proportional Hazards Models, Whole Genome Sequencing, Receiver operating characteristic, Genome, Human, Proportional hazards model, business.industry, Genetic Variation, Reproducibility of Results, Twins, Monozygotic, DNA Methylation, GATK, Genome Analysis Toolkit, HR, hazard ratio, ROC, receiver operating characteristic, CI, confidence interval, 030104 developmental biology, ROC Curve, CpG Islands, business, 030217 neurology & neurosurgery, Genome-Wide Association Study, Predictor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d214823e41dadedb86680ea9e596b3d2
https://doi.org/10.2139/ssrn.3228880

المؤلفون: Letizia Foroni, Jane F. Apperley, Mary Alikian, Robert Peter Gale

المصدر: Biomolecular Detection and Quantification, Vol 11, Iss C, Pp 4-20 (2017)
Biomolecular Detection and Quantification

مصطلحات موضوعية: Oncology, Pathology, SCT, stem cell transplant, Review Article, Disease, Biochemistry, lcsh:Microbiology, CMR, complete molecular response/remission, ZMW, zero-mode wave-guided, 0302 clinical medicine, LSC, leukemic stem cell, EURO-SKI, European Stop Tyrosine Kinase Inhibitor Study, DESTINY, De-Escalation and Stopping Treatment of Imatinib, Nilotinib or sprYcel in Chronic Myeloid Leukaemia, NTC, No Template Control, PCR, Polymerase Chain Reaction, lcsh:QH301-705.5, ABL, RT, reverse transcription, CP, chronic phase, ALL, acute lymphoblastic leukaemia, CAP, College of American Pathology, KDa, Kilo Dalton, AP, accelerated phase, μg, microgram, RT-dPCR, reverse transcription-digital polymerase chain reaction, 030220 oncology & carcinogenesis, NGS, TKD, tyrosine kinase domain, ARQ, armored RNA Quant, IRIS, interferon and cytarabine versus STI571, medicine.medical_specialty, Cancer therapy, IS, International Scale, cDNA, coding or complimentary DNA, RT-qPCR, reverse transcription-quantitative polymerase chain reaction, Chronic myeloid leukaemia, 03 medical and health sciences, ELN, European Leukaemia Net, STIM, stop imatinib, Molecular Biology, CML, chronic myeloid leukaemia, LPC, leukemic progenitor cells, NGS, next generation sequencing, BMT, bone marrow transplantation, Q-PCR, quantitative polymerase chain reaction, respiratory tract diseases, IC, inhibotory concentration, MMR, major molecular response/remission, SMRT, single-molecule real-time sequencing, Mbp, mega base pair, dPCR, digital polymerase chain reaction, m-bcr, minor-breakpoint cluster region, dMIQE, Minimum Information for Publication of Quantitative Digital PCR Experiments, PFS, Progression Free Survival, lcsh:QR1-502, GUSB, glucuronidase beta gene, Kbp, Kilo Base Pairs, μ-bcr, micro-breakpoint cluster region, ABL1, Abelson murine leukaemia virus, MRD, minimal residual disease, TKI, tyrosine kinase inhibitor, DNA, deoxyribonucleic acid, Structural Biology, hemic and lymphatic diseases, CES, capillary electrophoresis sequencing, CML, μl, microliter, breakpoint cluster region, Myeloid leukemia, allo-SCT, Allogeneic Stem Cell Transplantation, LoQ, limit of quantification, mRNA, messenger RNA, medicine.anatomical_structure, MRD, emPCR, emulsion PCR, Molecular Medicine, Ph, Philadelpia, WHO, World Health Organisation, ATP, adenosine triphosphate, Bp, base pair, NCCN, National Comprehensive Cancer Network, QC, Quality Control, BC, blast crisis, LoD, limit of detection, PB, Peripheral Blood, gDNA, genomic deoxyribonucleic acid, Internal medicine, InDels, insertions and deletions, Molecular monitoring, medicine, EAC, Europe Against Cancer, nM, manomolar, business.industry, dPCR, MR, deep molecular response/remission, M-bcr, major-breakpoint cluster region, Gold standard (test), lcsh:Biology (General), NEQAS, National External Quality Assessement Service, BM, bone marrow, BCR, breakpoint cluster region, Bone marrow, business, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bbd66daeb393841cac660a98150a1a

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المؤلفون: Xu PF; Scientific Research Center, The 7th Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong 510275, PR China.; Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, PR China.; School of Medical, Sun Yat-Sen University, Shenzhen, Guandong 510275, PR China., Li C; Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, PR China.; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province Hospital of Chinese Medical, Guangzhou, Guandong 510120, PR China., Xi SY; Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, PR China., Chen FR; Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, PR China., Wang J; Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, PR China., Zhang ZQ; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province Hospital of Chinese Medical, Guangzhou, Guandong 510120, PR China., Liu Y; Scientific Research Center, The 7th Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong 510275, PR China., Li X; School of Medical, Sun Yat-Sen University, Shenzhen, Guandong 510275, PR China.; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518107, PR China., Chen ZP; Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, PR China.

المصدر: Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2022 Apr 29; Vol. 20, pp. 2235-2246. Date of Electronic Publication: 2022 Apr 29 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology Country of Publication: Netherlands NLM ID: 101585369 Publication Model: eCollection Cited Medium: Print ISSN: 2001-0370 (Print) Linking ISSN: 20010370 NLM ISO Abbreviation: Comput Struct Biotechnol J Subsets: PubMed not MEDLINE

المؤلفون: Ginn SL; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia., Amaya AK; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia., Liao SHY; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia., Zhu E; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia., Cunningham SC; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia., Lee M; Telomere Length Regulation Group, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Hallwirth CV; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia., Logan GJ; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia., Tay SS; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia., Cesare AJ; Genome Integrity Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Pickett HA; Telomere Length Regulation Group, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Grompe M; School of Medicine, Oregon Health & Science University, Portland, Oregon., Dilworth K; Translational Vectorology Group and Vector & Genome Engineering Facility, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Lisowski L; Translational Vectorology Group and Vector & Genome Engineering Facility, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia.; Military Institute of Hygiene and Epidemiology, Pulway, Poland., Alexander IE; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, Australia.; Discipline of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia.

المصدر: JHEP reports : innovation in hepatology [JHEP Rep] 2019 Dec 27; Vol. 2 (1), pp. 100065. Date of Electronic Publication: 2019 Dec 27 (Print Publication: 2020).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101761237 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5559 (Electronic) Linking ISSN: 25895559 NLM ISO Abbreviation: JHEP Rep Subsets: PubMed not MEDLINE

المؤلفون: Alikian M; Centre for Haematology, Department of Medicine, Imperial College London Hammersmith Hospital, London UK; Imperial Molecular Pathology, Imperial College Healthcare Trust, Hammersmith Hospital, London, UK., Gale RP; Centre for Haematology, Department of Medicine, Imperial College London Hammersmith Hospital, London UK., Apperley JF; Centre for Haematology, Department of Medicine, Imperial College London Hammersmith Hospital, London UK., Foroni L; Centre for Haematology, Department of Medicine, Imperial College London Hammersmith Hospital, London UK.

المصدر: Biomolecular detection and quantification [Biomol Detect Quantif] 2017 Feb 14; Vol. 11, pp. 4-20. Date of Electronic Publication: 2017 Feb 14 (Print Publication: 2017).

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101667177 Publication Model: eCollection Cited Medium: Print ISSN: 2214-7535 (Print) Linking ISSN: 22147535 NLM ISO Abbreviation: Biomol Detect Quantif Subsets: PubMed not MEDLINE