المؤلفون: Jiang L; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Sun XY; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Wang SQ; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Liu YL; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Lu LJ; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Wu WH; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Zhi H; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Wang ZY; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Liu XD; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. xdliu@cpu.edu.cn., Liu L; Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. liulee@cpu.edu.cn.

المصدر: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2024 Jul; Vol. 45 (7), pp. 1406-1424. Date of Electronic Publication: 2024 Apr 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE

مواضيع طبية MeSH: Indican* , Acute Kidney Injury*/metabolism , Tumor Necrosis Factor-alpha*/metabolism , Cisplatin*, Animals ; Humans ; Mice ; Male ; RAW 264.7 Cells ; Rats ; Mice, Inbred C57BL ; Organic Anion Transporters, Sodium-Independent/metabolism ; Rats, Sprague-Dawley ; Synaptophysin/metabolism ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/drug effects ; Uremia/metabolism ; Uremia/complications ; Cell Line, Tumor

المؤلفون: Imamura R; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan., Sugimoto M; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan., Horike SI; Research Center for Experimental Modeling of Human Disease, Kanazawa University, Kanazawa 920-0934, Japan., Terakawa J; Laboratory of Toxicology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201, Japan., Fujita K; Faculty of Pharmaceutical Science, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan., Tamai I; Faculty of Pharmaceutical Science, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan., Daikoku T; Research Center for Experimental Modeling of Human Disease, Kanazawa University, Kanazawa 920-0934, Japan., Kato Y; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan., Arakawa H; Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan. Electronic address: arakawa@p.kanazawa-u.ac.jp.

المصدر: Journal of pharmaceutical sciences [J Pharm Sci] 2024 Jul; Vol. 113 (7), pp. 1996-2000. Date of Electronic Publication: 2024 Apr 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

مواضيع طبية MeSH: Indican*/metabolism , Mice, Knockout* , Oocytes*/metabolism , Uremic Toxins*/metabolism, Animals ; Male ; Mice ; Kidney/metabolism ; Metabolomics/methods ; Mice, Inbred C57BL ; Organic Anion Transporters/metabolism ; Organic Anion Transporters/genetics ; Xenopus laevis

المؤلفون: Hung TW; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan; Division of Nephrology, Department of Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan., Hsieh YH; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan., Lee HL; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan; Deptartment of Surgery, Chung Shan Medical University Hospital, Taichung 40201, Taiwan., Ting YH; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan., Lin CL; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan., Chao WW; Department of Nutrition and Health Sciences, Kainan University, Taoyuan 33857, Taiwan. Electronic address: wwchao@mail.knu.edu.tw.

المصدر: International immunopharmacology [Int Immunopharmacol] 2024 Jun 30; Vol. 135, pp. 112314. Date of Electronic Publication: 2024 May 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Rosmarinic Acid* , Depsides*/pharmacology , Depsides*/therapeutic use , Cinnamates*/pharmacology , Cinnamates*/therapeutic use , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Fibrosis* , Inflammasomes*/metabolism , Signal Transduction*/drug effects , Kidney*/pathology , Kidney*/drug effects , Kidney*/metabolism , Indican* , Mice, Inbred C57BL*, Animals ; Male ; Cell Line ; Mice ; Interleukin-1beta/metabolism ; Ureteral Obstruction/drug therapy ; Ureteral Obstruction/pathology ; Reactive Oxygen Species/metabolism ; Disease Models, Animal ; Smad2 Protein/metabolism ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/chemically induced ; Renal Insufficiency, Chronic/pathology ; Renal Insufficiency, Chronic/metabolism ; Smad3 Protein/metabolism ; Caspase 1/metabolism ; Kidney Diseases/drug therapy ; Kidney Diseases/chemically induced ; Kidney Diseases/pathology

المؤلفون: Cladis DP; Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA.; Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.; Department of Food Science and Technology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA., Burstad KM; Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA.; Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA., Biruete A; Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.; Department of Nutrition and Dietetics, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA.; Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Jannasch AH; Bindley Bioscience Center, Purdue University, West Lafayette, IN 47906, USA., Cooper BR; Bindley Bioscience Center, Purdue University, West Lafayette, IN 47906, USA., Hill Gallant KM; Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA.; Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.; Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

المصدر: Nutrients [Nutrients] 2024 Jun 08; Vol. 16 (12). Date of Electronic Publication: 2024 Jun 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

مواضيع طبية MeSH: Rats, Sprague-Dawley* , Nephrectomy* , Phosphorus, Dietary* , Renal Insufficiency, Chronic* , Indican*/blood , Uremic Toxins* , Sulfuric Acid Esters*/blood, Animals ; Male ; Rats ; Methylamines/blood ; Cresols/blood ; Gastrointestinal Microbiome/drug effects

المؤلفون: Wakamatsu T; Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.; Ohgo Clinic, Maebashi 371-0232, Japan., Yamamoto S; Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan., Yoshida S; Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan., Narita I; Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

المصدر: Toxins [Toxins (Basel)] 2024 May 31; Vol. 16 (6). Date of Electronic Publication: 2024 May 31.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE

مواضيع طبية MeSH: Indican*/toxicity , Atherosclerosis* , Macrophages*/drug effects , Uremia* , Renal Insufficiency, Chronic*, Humans ; Animals ; Uremic Toxins ; Gastrointestinal Microbiome/drug effects ; Oxidative Stress/drug effects

المؤلفون: Lu W; Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Shanghai Medical Center of Kidney Disease, China; Kidney and Dialysis Institute of Shanghai, China; Kidney and Blood Purification Key Laboratory of Shanghai, China., Cheng S; Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Shanghai Medical Center of Kidney Disease, China; Kidney and Dialysis Institute of Shanghai, China; Kidney and Blood Purification Key Laboratory of Shanghai, China., Xu J; Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Shanghai Medical Center of Kidney Disease, China; Kidney and Dialysis Institute of Shanghai, China; Kidney and Blood Purification Key Laboratory of Shanghai, China., Xiao Z; Division of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China., Yu Y; Division of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China., Xie Q; Department of Nephrology, Xiamen Branch, Zhongshan hospital, Fudan University; Nephrology, China; Clinical Quality Control Center of Xiamen, No.668 Jinhu Road, Xiamen, Fujian 361006, China., Fang Y; Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Shanghai Medical Center of Kidney Disease, China; Kidney and Dialysis Institute of Shanghai, China; Kidney and Blood Purification Key Laboratory of Shanghai, China., Chen R; Division of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China., Shen B; Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Shanghai Medical Center of Kidney Disease, China; Kidney and Dialysis Institute of Shanghai, China; Kidney and Blood Purification Key Laboratory of Shanghai, China. Electronic address: shen.bo@zs-hospital.sh.cn., Xie Y; Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Shanghai Medical Center of Kidney Disease, China; Kidney and Dialysis Institute of Shanghai, China; Kidney and Blood Purification Key Laboratory of Shanghai, China. Electronic address: xie.yeqing@zs-hospital.sh.cn., Ding X; Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Shanghai Medical Center of Kidney Disease, China; Kidney and Dialysis Institute of Shanghai, China; Kidney and Blood Purification Key Laboratory of Shanghai, China. Electronic address: ding.xiaoqiang@zs-hospital.sh.cn.

المصدر: Toxicology letters [Toxicol Lett] 2024 May 15; Vol. 396, pp. 81-93. Date of Electronic Publication: 2024 Apr 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol Lett Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Aryl Hydrocarbon*/metabolism , Receptors, Aryl Hydrocarbon*/genetics , Reactive Oxygen Species*/metabolism , Uremia*/metabolism , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/drug effects , Myocytes, Cardiac*/pathology , Signal Transduction* , Indican*/toxicity , Cardiomyopathies*/metabolism , Cardiomyopathies*/pathology , Rats, Sprague-Dawley*, Animals ; Humans ; Rats ; Male ; Cell Line ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Oxidative Stress ; Disease Models, Animal ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/pathology

المؤلفون: Barisione C; Department of Surgical and Integrated Diagnostic Sciences, University of Genova, Genova, Italy.; Cardiac, Thoracic and Vascular Department, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Verzola D; Department of Internal Medicine, University of Genova, Genova, Italy., Garibaldi S; Department of Internal Medicine, University of Genova, Genova, Italy., Altieri P; Department of Internal Medicine, University of Genova, Genova, Italy., Furfaro AL; Department of Experimental Medicine, University of Genova, Genova, Italy., Nitti M; Department of Experimental Medicine, University of Genova, Genova, Italy., Pratesi G; Department of Surgical and Integrated Diagnostic Sciences, University of Genova, Genova, Italy.; Cardiac, Thoracic and Vascular Department, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Palombo D; Department of Surgical and Integrated Diagnostic Sciences, University of Genova, Genova, Italy., Ameri P; Cardiac, Thoracic and Vascular Department, IRCCS Ospedale Policlinico San Martino, Genova, Italy.; Department of Internal Medicine, University of Genova, Genova, Italy.

المصدر: Journal of cellular and molecular medicine [J Cell Mol Med] 2024 Apr; Vol. 28 (7), pp. e18192.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE

مواضيع طبية MeSH: Indican*/pharmacology , Indican*/metabolism , Signal Transduction*, Mice ; Animals ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Toll-Like Receptor 4/genetics ; Fibroblasts/metabolism

المؤلفون: Bidart GN; Novo Nordisk Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, DK-2800, Kgs. Lyngby, Denmark., Teze D; Novo Nordisk Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, DK-2800, Kgs. Lyngby, Denmark., Jansen CU; Department of Chemistry, Technical University of Denmark, Kemitorvet 206, DK-2800, Kgs. Lyngby, Denmark., Pasutto E; Novo Nordisk Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, DK-2800, Kgs. Lyngby, Denmark., Putkaradze N; Novo Nordisk Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, DK-2800, Kgs. Lyngby, Denmark., Sesay AM; Lab for Sustainability and Design, Designskolen Kolding, Ågade 10, DK-6000, Kolding, Denmark., Fredslund F; Novo Nordisk Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, DK-2800, Kgs. Lyngby, Denmark., Lo Leggio L; Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100, Copenhagen, Denmark., Ögmundarson O; Faculty of Food Science and Nutrition, University of Iceland, Aragata 14, 102, Reykjavík, Iceland., Sukumara S; Novo Nordisk Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, DK-2800, Kgs. Lyngby, Denmark., Qvortrup K; Department of Chemistry, Technical University of Denmark, Kemitorvet 206, DK-2800, Kgs. Lyngby, Denmark. kaqvo@kemi.dtu.dk., Welner DH; Novo Nordisk Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, DK-2800, Kgs. Lyngby, Denmark. diwel@biosustain.dtu.dk.

المصدر: Nature communications [Nat Commun] 2024 Feb 27; Vol. 15 (1), pp. 1489. Date of Electronic Publication: 2024 Feb 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Indican* , Indigo Carmine*, Coloring Agents ; Plants ; Environment

المؤلفون: Wu CC; Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.; Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei 11490, Taiwan., Tian YC; Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Taoyuan City 33303, Taiwan., Lu CL; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.; Division of Nephrology, Department of Medicine, Fu Jen Catholic University Hospital, New Taipei City 24352, Taiwan., Wu MJ; Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 40227, Taiwan., Lim PS; Division of Nephrology, Department of Internal Medicine, Tungs’ Taichung Metroharbour Hospital, Taichung 43503, Taiwan., Chiu YW; Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.; Faculty of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Kuo KL; Division of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.; School of Medicine, Buddhist Tzu Chi University, Hualien 97004, Taiwan.; School of Post-Baccalaureate Chinese Medicine, Buddhist Tzu Chi University, Hualien 97004, Taiwan., Liu SH; Department of Nephrology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan City 33303, Taiwan., Chou YC; School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan., Sun CA; Department of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City 24205, Taiwan.; Big Data Research Center, College of Medicine, Fu-Jen Catholic University, New Taipei City 24205, Taiwan., Hou YC; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.; Division of Nephrology, Department of Internal Medicine, Cardinal-Tien Hospital, New Taipei City 23155, Taiwan., Lu KC; Division of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.; Division of Nephrology, Department of Medicine, Fu-Jen Catholic University Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City 24352, Taiwan.

المصدر: Aging [Aging (Albany NY)] 2024 Feb 21; Vol. 16 (5), pp. 4236-4249. Date of Electronic Publication: 2024 Feb 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-4589 (Electronic) Linking ISSN: 19454589 NLM ISO Abbreviation: Aging (Albany NY) Subsets: MEDLINE

مواضيع طبية MeSH: Indican* , Uremia*/complications , Uremia*/metabolism , Carbon* , Oxides*, Humans ; Cytokines ; Tumor Necrosis Factor-alpha ; Renal Dialysis/adverse effects ; Pruritus/drug therapy ; Pruritus/etiology

المؤلفون: Jia M; Department of Nephrology, The People's Hospital of Suzhou New District, Suzhou, China., Lin L; Department of Nephrology, The People's Hospital of Suzhou New District, Suzhou, China., Xun K; Department of Nephrology, The People's Hospital of Suzhou New District, Suzhou, China., Li D; Department of Nephrology, The People's Hospital of Suzhou New District, Suzhou, China., Wu W; Department of Nephrology, The People's Hospital of Suzhou New District, Suzhou, China., Sun S; Department of Nephrology, The People's Hospital of Suzhou New District, Suzhou, China., Qiu H; Department of Nephrology, The People's Hospital of Suzhou New District, Suzhou, China., Jin D; Department of Nephrology, The People's Hospital of Suzhou New District, Suzhou, China.

المصدر: Kidney & blood pressure research [Kidney Blood Press Res] 2024; Vol. 49 (1), pp. 385-396. Date of Electronic Publication: 2024 May 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Karger Country of Publication: Switzerland NLM ID: 9610505 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0143 (Electronic) Linking ISSN: 14204096 NLM ISO Abbreviation: Kidney Blood Press Res Subsets: MEDLINE

مواضيع طبية MeSH: Indican*/toxicity , Indican*/pharmacology , Podocytes*/metabolism , Podocytes*/pathology , Reactive Oxygen Species*/metabolism , Transforming Growth Factor beta1*/metabolism , Signal Transduction* , Diabetic Nephropathies*/metabolism , Diabetic Nephropathies*/pathology, Animals ; Rats ; Smad Proteins/metabolism ; Membrane Proteins/metabolism ; Membrane Proteins/genetics ; Microfilament Proteins/metabolism ; Cells, Cultured ; Adaptor Proteins, Signal Transducing/metabolism ; Cytoskeletal Proteins/metabolism ; Cytoskeletal Proteins/genetics