المؤلفون: Manning A; Welsh Medicines Advice Service, Cardiff and Vale University Health Board, Cardiff, South Glamorgan, UK Abigail.Manning@wales.nhs.uk., Burgess A; Welsh Medicines Advice Service, Cardiff and Vale University Health Board, Cardiff, South Glamorgan, UK.

المصدر: Archives of disease in childhood. Education and practice edition [Arch Dis Child Educ Pract Ed] 2024 Sep 19; Vol. 109 (5), pp. 242-246. Date of Electronic Publication: 2024 Sep 19.

نوع المنشور: Journal Article; Review; Comparative Study

بيانات الدورية: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101220684 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-0593 (Electronic) Linking ISSN: 17430585 NLM ISO Abbreviation: Arch Dis Child Educ Pract Ed Subsets: MEDLINE

مواضيع طبية MeSH: Aminoglycosides*/administration & dosage , Aminoglycosides*/therapeutic use , Anti-Bacterial Agents*/administration & dosage, Humans ; Infusions, Intravenous ; Child ; Injections, Intravenous ; Pediatrics/standards ; Infant ; Child, Preschool ; Male ; Female ; Internationality

المؤلفون: Bhatt LK; Department of Pharmacology & Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India., Shah CR; Department of Pharmacology & Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India., Patel JH; Department of Pharmacology & Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India., Rajwadi VI; Department of Pharmacology & Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India., Dwivedi P; Department of Pharmacology & Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India., Patel RJ; Department of Pharmacology & Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India., Ranvir RK; Department of Pharmacology & Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India., Patel H; Department of Pharmacology & Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India., Sundar R; Department of Pharmacology & Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India., Jain MR; Department of Pharmacology & Toxicology, Zydus Research Centre, Zydus Lifesciences Limited, Ahmedabad, India.

المصدر: International journal of toxicology [Int J Toxicol] 2024 Sep-Oct; Vol. 43 (5), pp. 491-502. Date of Electronic Publication: 2024 Jun 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9708436 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1092-874X (Electronic) Linking ISSN: 10915818 NLM ISO Abbreviation: Int J Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Diclofenac*/toxicity , Diclofenac*/pharmacokinetics , Diclofenac*/administration & dosage , Rats, Wistar* , Anti-Inflammatory Agents, Non-Steroidal*/toxicity , Anti-Inflammatory Agents, Non-Steroidal*/administration & dosage , Anti-Inflammatory Agents, Non-Steroidal*/pharmacokinetics, Animals ; Male ; Female ; Rats ; Excipients/toxicity ; Excipients/pharmacokinetics ; Excipients/chemistry ; Povidone/toxicity ; Povidone/chemistry ; Povidone/pharmacokinetics ; Administration, Intravenous ; Dose-Response Relationship, Drug ; Injections, Intravenous

المؤلفون: Costa RS; Department of Specialty Medicine, Midwestern University Companion Animal Hospital, Glendale, AZ, USA. Electronic address: renata.costa@murdoch.edu.au., Winslow CM; Department of Specialty Medicine, Midwestern University Companion Animal Hospital, Glendale, AZ, USA., Veltri CA; Department of Pharmaceutical Science, College of Pharmacy, Midwestern University, Glendale, AZ, USA., Lozoya M; Department of Pharmaceutical Science, College of Pharmacy, Midwestern University, Glendale, AZ, USA., Norris JW; Department of Pharmacology, College of Graduate Studies, Midwestern University, Glendale, AZ, USA.

المصدر: Veterinary anaesthesia and analgesia [Vet Anaesth Analg] 2024 Sep-Oct; Vol. 51 (5), pp. 539-547. Date of Electronic Publication: 2024 Jun 18.

نوع المنشور: Journal Article; Clinical Trial, Veterinary

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 100956422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-2995 (Electronic) Linking ISSN: 14672987 NLM ISO Abbreviation: Vet Anaesth Analg Subsets: MEDLINE

مواضيع طبية MeSH: Gabapentin*/administration & dosage , Gabapentin*/pharmacokinetics , Goats* , Cross-Over Studies*, Animals ; Female ; Administration, Oral ; Injections, Intravenous/veterinary ; Analgesics/pharmacokinetics ; Analgesics/administration & dosage ; Half-Life ; Heart Rate/drug effects ; Prospective Studies ; Administration, Intravenous/veterinary

المؤلفون: Shabani M; Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran., Khezri S; Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran., Salimi A; Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran. salimikd@yahoo.com.; Arthropod-Borne Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran. salimikd@yahoo.com.

المصدر: Cardiovascular toxicology [Cardiovasc Toxicol] 2024 Sep; Vol. 24 (9), pp. 929-941. Date of Electronic Publication: 2024 Jul 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 101135818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0259 (Electronic) Linking ISSN: 15307905 NLM ISO Abbreviation: Cardiovasc Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Phosphines*/toxicity , Oxidative Stress*/drug effects , Mitochondria, Heart*/metabolism , Mitochondria, Heart*/drug effects , Mitochondria, Heart*/pathology , Aluminum Compounds*/toxicity , Rats, Wistar* , Cardiotoxicity*, Animals ; Male ; Disease Models, Animal ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/pathology ; Myocytes, Cardiac/metabolism ; Injections, Intravenous ; Reactive Oxygen Species/metabolism ; Rats ; Antioxidants/pharmacology ; Time Factors

المؤلفون: Merhav G; Neuroradiology Unit, Department of Radiology, Rambam Health Care Campus, Haifa, Israel. Electronic address: goni.merhav@gmail.com., Yahav-Dovrat A; Departement of Medical Imaging, Neuroradiology, University of Toronto, Toronto, Canada. Electronic address: Anat.yahav.dovrat@gmail.com., Klein E; Department of Medical Imaging and Interventional Radiology, Moffitt Cancer Center, Tampa, Fl, USA. Electronic address: Erezklein@gmail.com., Nitai B; Neuroradiology Unit, Department of Radiology, Rambam Health Care Campus, Haifa, Israel. Electronic address: Yourfriendnitai@gmail.com., Saban M; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: Morsab1608@gmail.com., Katson M; Neurology Department, Rambam Health Care Campus, Haifa, Israel. Electronic address: hmerkp@gmail.com., Ronen G; Neuroradiology Unit, Department of Radiology, Rambam Health Care Campus, Haifa, Israel. Electronic address: galiaronen@gmail.com., Eran A; Neuroradiology Unit, Department of Radiology, Rambam Health Care Campus, Haifa, Israel; Rappaport Faculty of Medicine, Technion, Haifa, Israel. Electronic address: a_eran@rambam.health.gov.il., Javitt MC; Department of Radiology, University of Miami, Miami, FL, USA. Electronic address: marcia.javitt@gmail.com.

المصدر: European journal of radiology [Eur J Radiol] 2024 Sep; Vol. 178, pp. 111635. Date of Electronic Publication: 2024 Jul 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ireland Ltd Country of Publication: Ireland NLM ID: 8106411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7727 (Electronic) Linking ISSN: 0720048X NLM ISO Abbreviation: Eur J Radiol Subsets: MEDLINE

مواضيع طبية MeSH: Contrast Media*/administration & dosage , Tomography, X-Ray Computed*/methods, Humans ; Male ; Female ; Middle Aged ; Prospective Studies ; Reproducibility of Results ; Aged ; Adult ; Injections, Intravenous ; Brain/diagnostic imaging ; Iodine/administration & dosage ; Radiographic Image Enhancement/methods

المؤلفون: Applegate CC; Department of Bioengineering, University of Illinois at Urbana-Champaign, 405 N. Mathews Ave, MC-251, Urbana, IL, 61801, USA. cca2@illinois.edu.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. cca2@illinois.edu.; Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. cca2@illinois.edu., Nelappana MB; Department of Bioengineering, University of Illinois at Urbana-Champaign, 405 N. Mathews Ave, MC-251, Urbana, IL, 61801, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Cui Y; Department of Bioengineering, University of Illinois at Urbana-Champaign, 405 N. Mathews Ave, MC-251, Urbana, IL, 61801, USA.; Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Okoro G; Department of Bioengineering, University of Illinois at Urbana-Champaign, 405 N. Mathews Ave, MC-251, Urbana, IL, 61801, USA., Nielsen EA; Department of Bioengineering, University of Illinois at Urbana-Champaign, 405 N. Mathews Ave, MC-251, Urbana, IL, 61801, USA., Dovalovsky NP; Department of Bioengineering, University of Illinois at Urbana-Champaign, 405 N. Mathews Ave, MC-251, Urbana, IL, 61801, USA., Smith AM; Department of Bioengineering, University of Illinois at Urbana-Champaign, 405 N. Mathews Ave, MC-251, Urbana, IL, 61801, USA.; Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.; Department of Biomedical and Translational Sciences, Carle-Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61853, USA.; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Dobrucki IT; Department of Bioengineering, University of Illinois at Urbana-Champaign, 405 N. Mathews Ave, MC-251, Urbana, IL, 61801, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.; Department of Biomedical and Translational Sciences, Carle-Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61853, USA.; Academy of Medical and Social Applied Sciences, Elblag, Poland., Dobrucki LW; Department of Bioengineering, University of Illinois at Urbana-Champaign, 405 N. Mathews Ave, MC-251, Urbana, IL, 61801, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.; Department of Biomedical and Translational Sciences, Carle-Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61853, USA.; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.; Division of Medical Laboratory Diagnostics - Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, Gdansk, Poland.

المصدر: Scientific reports [Sci Rep] 2024 Aug 30; Vol. 14 (1), pp. 20241. Date of Electronic Publication: 2024 Aug 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Jugular Veins*/diagnostic imaging , Jugular Veins*/metabolism , Radiopharmaceuticals*/pharmacokinetics , Radiopharmaceuticals*/administration & dosage , Prostatic Neoplasms*/diagnostic imaging , Prostatic Neoplasms*/metabolism, Animals ; Mice ; Male ; Tissue Distribution ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Injections, Intravenous ; Cell Line, Tumor

المؤلفون: Guirguis F; Neuromuscular and Neurogenetic Disorders of Childhood Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health; The Dubowitz Neuromuscular Centre, Molecular Neurosciences Section, Developmental Neurosciences Research and Teaching Department, Great Ormond Street Institute of Child Health, University College London., Bolduc V; Neuromuscular and Neurogenetic Disorders of Childhood Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health., Slarve MJ; Department of Molecular Microbiology and Immunology, University of Southern California., Zhou H; NIHR Great Ormond Street Hospital Biomedical Research Centre; Genetics and Genomic Medicine Research and Teaching Department, Great Ormond Street Institute of Child Health, University College London., Muntoni F; The Dubowitz Neuromuscular Centre, Molecular Neurosciences Section, Developmental Neurosciences Research and Teaching Department, Great Ormond Street Institute of Child Health, University College London; NIHR Great Ormond Street Hospital Biomedical Research Centre., Bönnemann CG; Neuromuscular and Neurogenetic Disorders of Childhood Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health; carsten.bonnemann@nih.gov.

المصدر: Journal of visualized experiments : JoVE [J Vis Exp] 2024 Aug 23 (210). Date of Electronic Publication: 2024 Aug 23.

نوع المنشور: Journal Article; Video-Audio Media

بيانات الدورية: Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE

مواضيع طبية MeSH: Dependovirus*/genetics , Tail*, Animals ; Mice ; Injections, Intravenous ; Genetic Vectors/administration & dosage

المؤلفون: Cho HS; Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Korea., Song WJ; Laboratory of Veterinary Internal Medicine, Research Institute of Veterinary Science, College of Veterinary Medicine, Jeju National University, Jeju, 63243, Korea. ssong@jejunu.ac.kr., Nam A; Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, 05029, Korea. aryung@konkuk.ac.kr., Li Q; Department of Veterinary Medicine, College of Agriculture, YanBian University, YanJi, JiLin, China., An JH; College of Veterinary Medicine, Institute of Veterinary Science, Kangwon National University, Chuncheon, 24321, Korea., Ahn JO; College of Veterinary Medicine, Institute of Veterinary Science, Kangwon National University, Chuncheon, 24321, Korea., Kim HT; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA., Park SM; Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Korea., Ryu MO; Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Korea., Kim MC; Laboratory of Veterinary Internal Medicine, Research Institute of Veterinary Science, College of Veterinary Medicine, Jeju National University, Jeju, 63243, Korea., Kim JH; BioApplications Inc., Seoul, 04174, Korea., Youn HY; Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Korea.

المصدر: BMC veterinary research [BMC Vet Res] 2024 Aug 22; Vol. 20 (1), pp. 375. Date of Electronic Publication: 2024 Aug 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101249759 Publication Model: Electronic Cited Medium: Internet ISSN: 1746-6148 (Electronic) Linking ISSN: 17466148 NLM ISO Abbreviation: BMC Vet Res Subsets: MEDLINE

مواضيع طبية MeSH: Mesenchymal Stem Cell Transplantation*/veterinary , Mesenchymal Stem Cell Transplantation*/adverse effects , Mesenchymal Stem Cell Transplantation*/methods , Dog Diseases*/therapy, Animals ; Dogs ; Female ; Male ; Retrospective Studies ; Mesenchymal Stem Cells ; Transplantation, Homologous/veterinary ; Injections, Intravenous/veterinary ; Adipose Tissue/cytology

المؤلفون: Di J; Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China. wudaocheng@mail.xjtu.edu.cn., Huang C; Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China. wudaocheng@mail.xjtu.edu.cn., Zhao C; Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China. wudaocheng@mail.xjtu.edu.cn., Luo S; Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China. wudaocheng@mail.xjtu.edu.cn., Wang R; Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China. wudaocheng@mail.xjtu.edu.cn., Zhang S; Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China. wudaocheng@mail.xjtu.edu.cn., Zhu H; Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China. wudaocheng@mail.xjtu.edu.cn., Wu D; Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China. wudaocheng@mail.xjtu.edu.cn.

المصدر: Journal of materials chemistry. B [J Mater Chem B] 2024 Aug 14; Vol. 12 (32), pp. 7934-7945. Date of Electronic Publication: 2024 Aug 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101598493 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-7518 (Electronic) Linking ISSN: 2050750X NLM ISO Abbreviation: J Mater Chem B Subsets: MEDLINE

مواضيع طبية MeSH: Metformin*/chemistry , Metformin*/pharmacology , Metformin*/administration & dosage , Nanoparticles*/chemistry , Copper*/chemistry , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/administration & dosage , Polymers*/chemistry, Animals ; Mice ; Humans ; Injections, Intravenous ; Particle Size ; Mice, Inbred BALB C ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Cell Line, Tumor

المؤلفون: Connolly K; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D AstraZeneca Cambridge UK., George R; Development, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D AstraZeneca Gaithersburg MD., Omar S; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D AstraZeneca Cambridge UK., Matsson E; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden., Åstrand M; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden., Althage M; Translational Science and Experimental Medicine, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden., Pettersen D; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden., Mohamed E; Early Biometrics, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden., Fang K; Early Biometrics, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D AstraZeneca Gaithersburg MD., Lima JAC; Cardiology Division, Department of Medicine Johns Hopkins Hospital Baltimore MD., Kujacic M; Global Patient Safety, BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden., Ödesjö H; Global Patient Safety, BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden., Turton M; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D AstraZeneca Cambridge UK., Johannesson P; Global Patient Safety, BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden., Gabrielsen A; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D AstraZeneca Gothenburg Sweden., Ufnal M; Early Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D AstraZeneca Warsaw Poland.

المصدر: Journal of the American Heart Association [J Am Heart Assoc] 2024 Aug 06; Vol. 13 (15), pp. e034067. Date of Electronic Publication: 2024 Jul 26.

نوع المنشور: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE

مواضيع طبية MeSH: Heart Failure*/drug therapy , Heart Failure*/physiopathology , Receptors, G-Protein-Coupled*/agonists, Humans ; Male ; Female ; Single-Blind Method ; Middle Aged ; Adult ; Aged ; Treatment Outcome ; Receptors, Peptide/agonists ; Stroke Volume/drug effects ; Injections, Subcutaneous ; Ventricular Function, Left/drug effects ; Young Adult ; Relaxin/pharmacokinetics ; Relaxin/administration & dosage ; Relaxin/adverse effects ; Relaxin/therapeutic use ; Dose-Response Relationship, Drug ; Injections, Intravenous