نتائج البحث - "Inositol Phosphates pharmacology"

1

Inositol 3,4,5,6-tetrakisphosphate inhibits insulin granule acidification and fusogenic potential.

المؤلفون: Renström, Erik, Ivarsson, Rosita, Shears, Stephen B

المصدر: Journal of Biological Chemistry. 277(30):26717-26720

URL الوصول: https://lup.lub.lu.se/record/109533
http://dx.doi.org/10.1074/jbc.C200314200

2

Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers

المصدر: Schantl, A E, Verhulst, A, Neven, E, Behets, G J, D'Haese, P C, Maillard, M, Mordasini, D, Phan, O, Burnier, M, Spaggiari, D, Decosterd, L A, MacAskill, M G, Alcaide-Corral, C J, Tavares, A A S, Newby, D E, Beindl, V C, Maj, R, Labarre, A, Hedge, C, Castagner, B, Ivarsson, M E & Leroux, J-C 2020, ' Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers ', Nature Communications, vol. 11, 721 . https://doi.org/10.1038/s41467-019-14091-4
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature communications, vol. 11, no. 1, pp. 721
Nature communications
Nature Communications, 11 (1)

مصطلحات موضوعية: 0301 basic medicine, Male, Ethylene Glycol, Drug Evaluation, Preclinical, General Physics and Astronomy, 030204 cardiovascular system & hematology, Pharmacology, Muscle, Smooth, Vascular, Rats, Sprague-Dawley, chemistry.chemical_compound, 0302 clinical medicine, Cardiovascular calcification, X-Ray Diffraction, Inositol, Inositol phosphate, lcsh:Science, Cells, Cultured, chemistry.chemical_classification, 6-Phytase, Multidisciplinary, Drug discovery, 3. Good health, Engineering sciences. Technology, Science, Injections, Subcutaneous, Inositol Phosphates, chemistry.chemical_element, Calcium, General Biochemistry, Genetics and Molecular Biology, Article, Calcification, 03 medical and health sciences, In vivo, medicine, Animals, Humans, Vascular Calcification, Biology, Uremia, 6-Phytase/metabolism, Adenine/adverse effects, Drug Evaluation, Preclinical/methods, Dynamic Light Scattering, Ethylene Glycol/chemistry, Inositol Phosphates/chemistry, Inositol Phosphates/pharmacokinetics, Inositol Phosphates/pharmacology, Muscle, Smooth, Vascular/cytology, Muscle, Smooth, Vascular/drug effects, Uremia/drug therapy, Uremia/physiopathology, Vascular Calcification/chemically induced, Vascular Calcification/drug therapy, Adenine, General Chemistry, Phosphate, medicine.disease, 030104 developmental biology, chemistry, lcsh:Q, Human medicine, Ethylene glycol

وصف الملف: application/pdf; pdf; application/application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb9a8129d650ca324178fbd915550a3
https://www.pure.ed.ac.uk/ws/files/134711722/s41467_019_14091_4.pdf

Find this article in full text from ProQuest

3

A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion

المؤلفون: Riccardo Ferro, Andrew M. Riley, Marco Falasca, Alessandro Fantin, Véronique Calleja, Banafshé Larijani, Barry V. L. Potter, Claudio Raimondi, Tania Maffucci, Caroline H. Brennan

المصدر: Scientific Reports
Raimondi, C, Calleja, V, Ferro, R, Fantin, A, Riley, A M, Potter, B V L, Brennan, C H, Maffucci, T, Larijani, B & Falasca, M 2016, ' A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion ', Scientific Reports, vol. 6, 26142 . https://doi.org/10.1038/srep26142

مصطلحات موضوعية: 0301 basic medicine, Inositol Phosphates/pharmacology, Cell Movement/drug effects, Plasma protein binding, Bioinformatics, Metastasis, 0302 clinical medicine, Cell Movement, Melanoma/drug therapy, Enzyme Inhibitors, Zebrafish, Melanoma, Enzyme Inhibitors/pharmacology, Multidisciplinary, biology, Protein-Serine-Threonine Kinases/antagonists & inhibitors, Chemistry, Hedgehog signaling pathway, 3. Good health, Pleckstrin homology domain, 030220 oncology & carcinogenesis, Phosphorylation, Heterografts, Antineoplastic Agents/pharmacology, Protein Binding, animal structures, Inositol Phosphates, Antineoplastic Agents, Breast Neoplasms, Protein Serine-Threonine Kinases, Article, Cell Line, 03 medical and health sciences, Breast Neoplasms/drug therapy, SDG 3 - Good Health and Well-being, medicine, Phospholipase C gamma/antagonists & inhibitors, Animals, Humans, Protein kinase A, Phospholipase C gamma, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, medicine.disease, biology.organism_classification, Disease Models, Animal, 030104 developmental biology, Cancer cell, Cancer research, Protein Multimerization, Neoplasm Transplantation