المؤلفون: Wang ZY; Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China., Gao ST; Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China., Gou XJ; Central Laboratory, Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine of Shanghai, Shanghai University of Traditional Chinese Medicine, Shanghai, 201999, China., Qiu FR; Laboratory of Clinical Pharmacokinetics, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: furong_qiu@shutcm.edu.cn., Feng Q; Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Central Laboratory, ShuGuang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine, Shanghai, 201203, China; Key Laboratory of Liver and Kidney Diseases, Shanghai University of Traditional Chinese Medicine, Ministry of Education, Shanghai, 201203, China. Electronic address: fengqin@shutcm.edu.cn.

المصدر: European journal of pharmacology [Eur J Pharmacol] 2024 Sep 05; Vol. 978, pp. 176773. Date of Electronic Publication: 2024 Jun 25.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Interleukin-1 Receptor-Associated Kinases*/metabolism , Interleukin-1 Receptor-Associated Kinases*/genetics , Liver Diseases*/metabolism, Humans ; Animals ; Signal Transduction

المؤلفون: Watany MM; Clinical pathology department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt. Electronic address: mona.watany@med.tanta.edu.eg., Elhosary MM; Msc Immunology from Tanta university, Faculty of Science, Tanta 31527, Egypt., El-Horany HE; Medical biochemistry department, Faculty of Medicine. Tanta University, Tanta 31527, Egypt; Biochemistry Department, College of Medicine, Ha'il University, Ha'il 55211, Saudi Arabia., El-Horany ME; Neurology department, Faculty of Medicine. Tanta University, Tanta 31527, Egypt.

المصدر: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2024 Sep; Vol. 266, pp. 110327. Date of Electronic Publication: 2024 Jul 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 100883537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-7035 (Electronic) Linking ISSN: 15216616 NLM ISO Abbreviation: Clin Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Interleukin-1 Receptor-Associated Kinases*/genetics , Interleukin-1 Receptor-Associated Kinases*/metabolism , Multiple Sclerosis*/genetics , Multiple Sclerosis*/blood , Multiple Sclerosis*/immunology , Myeloid Differentiation Factor 88*/genetics, Humans ; Female ; Male ; Adult ; Middle Aged ; Cross-Sectional Studies ; NF-kappa B/metabolism ; NF-kappa B/genetics ; Recurrence ; Retrospective Studies ; DNA Methylation ; Biomarkers/blood ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Young Adult

المؤلفون: Rao Z; Department of Endocrinology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, China., Ao G; Department of Pulmonary and Critical Care Medicine, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, China., Zhang Y; Department of Endocrinology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, China., Jiang Z; Department of Pulmonary and Critical Care Medicine, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, China., Li L; Department of Pulmonary and Critical Care Medicine, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, China., Hua Z; Department of Pulmonary and Critical Care Medicine, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, China. Electronic address: huazhidan@wmu.edu.cn.

المصدر: Immunobiology [Immunobiology] 2024 Sep; Vol. 229 (5), pp. 152835. Date of Electronic Publication: 2024 Jul 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8002742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3279 (Electronic) Linking ISSN: 01712985 NLM ISO Abbreviation: Immunobiology Subsets: MEDLINE

مواضيع طبية MeSH: Podocytes*/metabolism , Podocytes*/pathology , Diabetic Nephropathies*/metabolism , Diabetic Nephropathies*/etiology , Diabetic Nephropathies*/pathology , Apoptosis* , Interleukin-1 Receptor-Associated Kinases*/metabolism , Interleukin-1 Receptor-Associated Kinases*/genetics , Signal Transduction*, Humans ; Proteolysis ; Inflammation ; TOR Serine-Threonine Kinases/metabolism ; Glucose/metabolism ; Heterogeneous Nuclear Ribonucleoprotein A1/metabolism ; Heterogeneous Nuclear Ribonucleoprotein A1/genetics

المؤلفون: Weng P; State Key Laboratory of Biocontrol, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangdong, China.; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, China., Lan M; State Key Laboratory of Biocontrol, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangdong, China., Zhang H; State Key Laboratory of Biocontrol, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangdong, China., Fan H; State Key Laboratory of Biocontrol, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangdong, China., Wang X; State Key Laboratory of Biocontrol, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangdong, China., Ran C; State Key Laboratory of Biocontrol, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangdong, China., Yue Z; State Key Laboratory of Biocontrol, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangdong, China., Hu J; State Key Laboratory of Biocontrol, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangdong, China., Xu A; State Key Laboratory of Biocontrol, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangdong, China., Huang S; State Key Laboratory of Biocontrol, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangdong, China.; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, China.

المصدر: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2024 Aug 01; Vol. 213 (3), pp. 362-372.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Zebrafish* , Interleukin-1 Receptor-Associated Kinases*/metabolism , Interleukin-1 Receptor-Associated Kinases*/genetics , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/genetics , TNF Receptor-Associated Factor 6*/metabolism , TNF Receptor-Associated Factor 6*/genetics , Signal Transduction*/immunology , Zebrafish Proteins*/metabolism , Zebrafish Proteins*/genetics, Animals ; Humans ; HEK293 Cells

المؤلفون: Zhang F; Department of Prenatal Diagnosis, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu 222000, People's Republic of China., Wang Z; Department of Prenatal Diagnosis, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu 222000, People's Republic of China., Men S; Department of Prenatal Diagnosis, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu 222000, People's Republic of China., Zhang J; Department of Prenatal Diagnosis, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu 222000, People's Republic of China., Wang L; Department of Prenatal Diagnosis, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu 222000, People's Republic of China. Electronic address: wangleileiok@hotmail.com.

المصدر: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2024 Aug; Vol. 265, pp. 110268. Date of Electronic Publication: 2024 Jun 03.

نوع المنشور: Case Reports; Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 100883537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-7035 (Electronic) Linking ISSN: 15216616 NLM ISO Abbreviation: Clin Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Interleukin-1 Receptor-Associated Kinases*/genetics , Interleukin-1 Receptor-Associated Kinases*/deficiency , Pseudomonas aeruginosa*/genetics , Pseudomonas Infections*/genetics , Sepsis*/genetics , Sepsis*/microbiology, Humans ; Male ; Infant ; Primary Immunodeficiency Diseases/genetics ; Loss of Function Mutation ; Heterozygote ; Exome Sequencing ; Immunologic Deficiency Syndromes/genetics

SCR Disease Name: IRAK4 Deficiency

المؤلفون: Ménoret A; Department of Immunology, UConn Health, 263 Farmington Ave, Farmington, CT, 06030, USA. menoret@uchc.edu., Agliano F; Department of Immunology, UConn Health, 263 Farmington Ave, Farmington, CT, 06030, USA., Karginov TA; Department of Immunology, UConn Health, 263 Farmington Ave, Farmington, CT, 06030, USA., Hu X; Department of Neuroscience, UConn Health, 263 Farmington Ave, Farmington, CT, 06030, USA., Vella AT; Department of Immunology, UConn Health, 263 Farmington Ave, Farmington, CT, 06030, USA. vella@uchc.edu.

المصدر: Scientific reports [Sci Rep] 2024 Jul 16; Vol. 14 (1), pp. 16393. Date of Electronic Publication: 2024 Jul 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Interleukin-1 Receptor-Associated Kinases*/metabolism , Interleukin-1 Receptor-Associated Kinases*/genetics , Lupus Vasculitis, Central Nervous System*/immunology , Lupus Vasculitis, Central Nervous System*/metabolism, Animals ; Mice ; Disease Models, Animal ; Female ; Signal Transduction

المؤلفون: Weiss MM; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Zheng X; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Ji N; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Browne CM; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Campbell V; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Chen D; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Enerson B; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Fei X; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Huang X; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Klaus CR; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Li H; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Mayo M; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., McDonald AA; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Paul A; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Rong H; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Sharma K; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Shi Y; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Slavin A; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Walther DM; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Yuan K; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Zhang Y; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Zhu X; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Kelleher J; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Walker D; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States., Mainolfi N; Kymera Therapeutics, 200 Arsenal Yards Boulevardd, Watertown, Massachusetts 02472, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 10548-10566. Date of Electronic Publication: 2024 Jun 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Interleukin-1 Receptor-Associated Kinases*/metabolism , Interleukin-1 Receptor-Associated Kinases*/antagonists & inhibitors , Myeloid Differentiation Factor 88*/metabolism , Lymphoma, Large B-Cell, Diffuse*/drug therapy , Lymphoma, Large B-Cell, Diffuse*/genetics , Lymphoma, Large B-Cell, Diffuse*/metabolism , Lymphoma, Large B-Cell, Diffuse*/pathology , Mutation*, Humans ; Animals ; Cell Line, Tumor ; Drug Discovery ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Mice ; Imidazoles/chemistry ; Imidazoles/pharmacology ; Imidazoles/metabolism ; Proteolysis/drug effects ; Structure-Activity Relationship

المؤلفون: Zou Y; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325024, China., Wang X; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325024, China., Chen P; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325024, China.; Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China., Zheng Z; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325024, China.; College of Pharmacy, Chonnam National University, Gwangju 61186, Korea., Li X; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325024, China., Chen Z; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325024, China., Guo M; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325024, China., Zhou Y; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325024, China., Sun C; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325024, China., Wang R; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China., Zhu W; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China., Zheng P; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China., Cho WJ; College of Pharmacy, Chonnam National University, Gwangju 61186, Korea., Cho YC; College of Pharmacy, Chonnam National University, Gwangju 61186, Korea., Liang G; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.; School of Pharmacy, Hangzhou Medical College, Hangzhou 311399, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325024, China.; Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China., Tang Q; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325024, China.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 10687-10709. Date of Electronic Publication: 2024 Jun 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Interleukin-1 Receptor-Associated Kinases*/antagonists & inhibitors , Interleukin-1 Receptor-Associated Kinases*/metabolism , Colitis, Ulcerative*/drug therapy , Acute Lung Injury*/drug therapy , Acute Lung Injury*/metabolism, Humans ; Animals ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/therapeutic use ; Drug Design ; Mice ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/chemistry ; Drug Discovery ; Male ; NF-kappa B/metabolism ; NF-kappa B/antagonists & inhibitors ; Structure-Activity Relationship ; THP-1 Cells

المؤلفون: Maino E; Program in Genetics and Genome Biology, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Scott O; Program in Genetics and Genome Biology, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Division of Clinical Immunology and Allergy, Department of Pediatrics, the Hospital for Sick Children and University of Toronto, Toronto, ON M5G 1E8, Canada., Rizvi SZ; Program in Genetics and Genome Biology, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Chan WS; Program in Genetics and Genome Biology, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Visuvanathan S; Program in Genetics and Genome Biology, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Zablah YB; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Program in Neuroscience and Mental Health, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Li H; Program in Neuroscience and Mental Health, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Sengar AS; Program in Neuroscience and Mental Health, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Salter MW; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Program in Neuroscience and Mental Health, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Jia Z; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Program in Neuroscience and Mental Health, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Rossant J; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Program in Developmental and Stem Cell Biology, the Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada., Cohn RD; Program in Genetics and Genome Biology, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Division of Clinical Immunology and Allergy, Department of Pediatrics, the Hospital for Sick Children and University of Toronto, Toronto, ON M5G 1E8, Canada.; Division of Clinical and Metabolic Genetics, Department of Pediatrics, the Hospital for Sick Children and University of Toronto, Toronto, ON M5G 1X8, Canada., Gu B; Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, East Lansing, MI 48824, USA.; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA., Ivakine EA; Program in Genetics and Genome Biology, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada.

المصدر: Disease models & mechanisms [Dis Model Mech] 2024 Jul 01; Vol. 17 (7). Date of Electronic Publication: 2024 Jul 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101483332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1754-8411 (Electronic) Linking ISSN: 17548403 NLM ISO Abbreviation: Dis Model Mech Subsets: MEDLINE

مواضيع طبية MeSH: Methyl-CpG-Binding Protein 2*/genetics , Methyl-CpG-Binding Protein 2*/metabolism , Interleukin-1 Receptor-Associated Kinases*/genetics , Interleukin-1 Receptor-Associated Kinases*/metabolism , Disease Models, Animal* , Gene Duplication* , Mental Retardation, X-Linked*/genetics , Mental Retardation, X-Linked*/pathology, Animals ; Humans ; Mice, Inbred C57BL ; Mice ; CRISPR-Cas Systems/genetics ; Behavior, Animal ; Male

SCR Disease Name: Lubs X-linked mental retardation syndrome

المؤلفون: Zhao T; Department of Neurology and Basic Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China., Zhang X; Department of Neurology and Basic Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China., Cui X; Department of Neurology and Basic Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China., Su S; Department of Neurology and Basic Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China., Li L; Department of Neurology and Basic Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China., Chen Y; Department of Neurology and Basic Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China., Wang N; Department of Neurology and Basic Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China., Sun L; Department of Neurology and Basic Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China., Zhao J; Institute for Developmental and Regenerative Cardiovascular Medicine, MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. Electronic address: zhaojy@vip.163.com., Zhang J; Department of Neurology and Basic Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China. Electronic address: zhangjiewen@zzu.edu.cn., Han X; Department of Neurology and Basic Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China. Electronic address: hanxiong@zzu.edu.cn., Cao J; Department of Neurology and Basic Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China. Electronic address: caojing@zzu.edu.cn.

المصدر: Experimental neurology [Exp Neurol] 2024 Jul; Vol. 377, pp. 114794. Date of Electronic Publication: 2024 Apr 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

مواضيع طبية MeSH: Interleukin-1 Receptor-Associated Kinases*/metabolism , Interleukin-1 Receptor-Associated Kinases*/genetics , Hippocampus*/metabolism , Hippocampus*/drug effects , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Pyroptosis*/drug effects , Pyroptosis*/physiology , Signal Transduction*/drug effects , Signal Transduction*/physiology , NF-kappa B*/metabolism , Seizures*/metabolism , Seizures*/chemically induced , Neurons*/metabolism , Neurons*/drug effects , Epilepsy*/metabolism , Epilepsy*/chemically induced, Animals ; Mice ; Humans ; Male ; Female ; Mice, Inbred C57BL ; Adult ; Pentylenetetrazole/toxicity ; Young Adult ; Adolescent ; Child