المؤلفون: Daniel F. Gudbjartsson, H. Marike Boezen, Monica Gavala, Adalbjorg Jonasdottir, Johannes Waage, Klaus A. Deichmann, Aslaug Jonasdottir, Asgeir Sigurdsson, Thorarinn Gislason, Haruki Hasegawa, Olafur Th Magnusson, Pall T. Onundarson, David Gislason, Gisli Masson, Michael Brown, Randal R. Ketchem, James A. Johnston, Kari Stefansson, Celeste Porsbjerg, Vibeke Backer, Unnur S. Bjornsdottir, Andrea Heinzmann, Dora Ludviksdottir, Logan Garrett, Marcus Krueger, Dirk E. Smith, Hans Bisgaard, Tarunveer S. Ahluwalia, Ai Ching Lim, Klaus Bønnelykke, Gardar Sveinbjornsson, Hannes Helgason, Gerard H. Koppelman, Ingileif Jonsdottir, Olof Sigurdardottir, Gudmundur I. Eyjolfsson, Unnur Thorsteinsdottir, Isleifur Olafsson, Bjorn R. Ludviksson, Patrick Sulem

المساهمون: Groningen Research Institute for Asthma and COPD (GRIAC), Life Course Epidemiology (LCE), Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Verkfræði- og náttúruvísindasvið (HÍ), School of Engineering and Natural Sciences (UI), Háskóli Íslands, University of Iceland

المصدر: PLoS genetics, 13(3), 1-24. PUBLIC LIBRARY SCIENCE
PLoS Genetics, Vol 13, Iss 3, p e1006659 (2017)
Smith, D, Helgason, H, Sulem, P, Bjornsdottir, U S, Lim, A C, Sveinbjornsson, G, Hasegawa, H, Brown, M, Ketchem, R R, Gavala, M, Garrett, L, Jonasdottir, A, Jonasdottir, A, Sigurdsson, A, Magnusson, O T, Eyjolfsson, G I, Olafsson, I, Onundarson, P T, Sigurdardottir, O, Gislason, D, Gislason, T, Ludviksson, B R, Ludviksdottir, D, Boezen, H M, Heinzmann, A, Krueger, M, Porsbjerg, C, Ahluwalia, T S, Waage, J, Backer, V, Deichmann, K A, Koppelman, G H, Bønnelykke, K, Bisgaard, H, Masson, G, Thorsteinsdottir, U, Gudbjartsson, D F, Johnston, J A, Jonsdottir, I & Stefansson, K 2017, ' A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma ', P L o S Genetics, vol. 13, no. 3, e1006659 . https://doi.org/10.1371/journal.pgen.1006659
PLoS Genetics

مصطلحات موضوعية: Male, Pulmonology, Genome-wide association study, VARIANTS, Pathology and Laboratory Medicine, Biochemistry, Mice, 0302 clinical medicine, Animal Cells, Asthma/genetics, Child, Immune Response, POPULATION, Aged, 80 and over, Innate Immune System, education.field_of_study, Messenger RNA, LARGE-SCALE, Nucleic acids, Child, Preschool, Cytokines, Biological Assay, Cellular Types, Genotype, Immune Cells, Immunology, 03 medical and health sciences, Signs and Symptoms, Genetics, Humans, GENOME-WIDE ASSOCIATION, education, Molecular Biology, Alleles, Ecology, Evolution, Behavior and Systematics, Asma, POLYMORPHISMS, Aged, Blood Cells, Eosinophils/metabolism, Biology and Life Sciences, Infant, Molecular Development, Eosinophil, Interleukin-33, ST2, Eosinophils, Alternative Splicing, Molecular biology techniques, 030104 developmental biology, 030228 respiratory system, Genetic Loci, Mutation, Developmental Biology, 0301 basic medicine, Cancer Research, AIRWAY INFLAMMATION, Physiology, Denmark, Iceland, IL1RL1, White Blood Cells, Exon, Sequencing techniques, Gene Frequency, Immune Physiology, Medicine and Health Sciences, Genetics (clinical), Netherlands, GENETIC-VARIATION, RNA sequencing, Middle Aged, medicine.anatomical_structure, Female, Haploinsufficiency, Research Article, Adult, Heterozygote, Adolescent, lcsh:QH426-470, Population, Mice, Transgenic, Biology, Young Adult, Diagnostic Medicine, medicine, Animals, Erfðafræði, Genetic Predisposition to Disease, Allele frequency, Inflammation, Binding Sites, Interleukin-33/genetics, RECEPTOR, Infant, Newborn, Intron, Cell Biology, Ofnæmi, Asthma, Introns, Research and analysis methods, lcsh:Genetics, Immune System, IL-33, RNA

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8bf9fd4475bc44e1cefedd75365983
https://research.rug.nl/en/publications/cbb66b9e-bd67-435c-806f-7f301357232f

المؤلفون: Matthias Kreuzaler, Min Lu, Stephanie Darbre, Alfred Zippelius, Daniel D. Pinschewer, Mario Kreutzfeldt, Philipp Müller, Nicolas Page, Weldy V. Bonilla, Stéphanie Favre, Sandra M. Kallert, Max Löhning, Sanjiv A. Luther, Doron Merkler, Florian Kreppel

المصدر: Nature Communications, Vol. 8 (2017) P. 15327
Nature Communications
Nature communications, vol. 8, pp. 15327
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

مصطلحات موضوعية: 0301 basic medicine, Viral vectors, Live attenuated vaccines, medicine.medical_treatment, General Physics and Astronomy, Priming (immunology), ddc:616.07, Virus Replication, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit, Mice, Cancer immunotherapy, Neoplasms, Tumor Microenvironment, Alarmins, Lymphocytic choriomeningitis virus, Cytotoxic T cell, Mice, Knockout, Mice, Inbred BALB C, Multidisciplinary, 3. Good health, Mice, Inbred DBA, Immunotherapy, Genetic Engineering, Vaccines, Live, Unattenuated, Science, Genetic Vectors, Biology, Lymphocytic choriomeningitis, Cancer Vaccines, Article, General Biochemistry, Genetics and Molecular Biology, Viral vector, Effector T-Lymphocyte, 03 medical and health sciences, Alarmins/immunology, Animals, Antigens, Neoplasm/immunology, Cancer Vaccines/immunology, Cancer Vaccines/therapeutic use, Cell Line, Tumor, Dendritic Cells/immunology, Gene Expression Profiling, Genetic Vectors/genetics, Genetic Vectors/immunology, Genetic Vectors/therapeutic use, HEK293 Cells, Humans, Immunotherapy/methods, Interleukin-33/genetics, Interleukin-33/immunology, Lymphocyte Activation/immunology, Lymphocytic choriomeningitis virus/genetics, Mesocricetus, Mice, Inbred C57BL, Neoplasms/immunology, Neoplasms/therapy, T-Lymphocytes, Cytotoxic/immunology, Tumor Microenvironment/immunology, Vaccines, Live, Unattenuated/immunology, Virus Replication/genetics, Virus Replication/immunology, Xenograft Model Antitumor Assays, Antigens, Neoplasm, medicine, Lymphocyte activation, Dendritic Cells, General Chemistry, Interleukin-33, medicine.disease, CTL, 030104 developmental biology, Tumour vaccines, Immunology, Cancer research, T-Lymphocytes, Cytotoxic

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cecd39857413817068e6b7d5865400
https://archive-ouverte.unige.ch/unige:98397

المصدر: Poulsen , N N , Bjerregaard , A , Khoo , S-K , Laing , I A , Le Souëf , P , Backer , V , Rapley , L , Cohen , S E , Barrett , L , Thompson , P , Baltic , S & Porsbjerg , C 2018 , ' Airway Interleukin-33 and type 2 cytokines in adult patients with acute asthma ' , Respiratory Medicine , vol. 140 , pp. 50-56 .

مصطلحات الفهرس: Acute Disease, Adult, Asthma/immunology, Cytokines/genetics, Eosinophils/immunology, Female, Follow-Up Studies, Gene Expression/immunology, Humans, Inflammation Mediators/metabolism, Interleukin-13/genetics, Interleukin-33/genetics, Interleukin-5/genetics, Male, Middle Aged, Nasal Mucosa/immunology, RNA, Messenger/genetics, Severity of Illness Index, Sputum/immunology, Young Adult, article

URL: https://curis.ku.dk/portal/da/publications/airway-interleukin33-and-type-2-cytokines-in-adult-patients-with-acute-asthma(d61126e1-6f58-4aad-b355-4520e0a12e19).html
https://doi.org/10.1016/j.rmed.2018.05.016

المصدر: Smith , D , Helgason , H , Sulem , P , Bjornsdottir , U S , Lim , A C , Sveinbjornsson , G , Hasegawa , H , Brown , M , Ketchem , R R , Gavala , M , Garrett , L , Jonasdottir , A , Jonasdottir , A , Sigurdsson , A , Magnusson , O T , Eyjolfsson , G I , Olafsson , I , Onundarson , P T , Sigurdardottir , O , Gislason , D , Gislason , T , Ludviksson , B R , Ludviksdottir , D , Boezen , H M , Heinzmann , A , Krueger , M , Porsbjerg , C , Ahluwalia , T S , Waage , J , Backer , V , Deichmann , K A , Koppelman , G H , Bønnelykke , K , Bisgaard , H , Masson , G , Thorsteinsdottir , U , Gudbjartsson , D F , Johnston , J A , Jonsdottir , I & Stefansson , K 2017 , ' A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma ' , P L o S Genetics , vol. 13 , no. 3 , e1006659 .

مصطلحات الفهرس: Adolescent, Adult, Aged, Aged, 80 and over, Alternative Splicing, Animals, Asthma/genetics, Binding Sites, Biological Assay, Child, Child, Preschool, Denmark, Eosinophils/metabolism, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Heterozygote, Humans, Iceland, Infant, Infant, Newborn, Interleukin-33/genetics, Introns, Male, Mice, Mice, Transgenic, Middle Aged, Mutation, Netherlands, Young Adult, article