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1دورية أكاديمية
المؤلفون: Irina V. Shelukhina, Maxim N. Zhmak, Alexander V. Lobanov, Igor A. Ivanov, Alexandra I. Garifulina, Irina N. Kravchenko, Ekaterina A. Rasskazova, Margarita A. Salmova, Elena A. Tukhovskaya, Vladimir A. Rykov, Gulsara A. Slashcheva, Natalya S. Egorova, Inessa S. Muzyka, Victor I. Tsetlin, Yuri N. Utkin
المصدر: Toxins, Vol 10, Iss 1, p 34 (2018)
مصطلحات موضوعية: nicotinic acetylcholine receptor, azemiopsin, preclinical studies, toxicity, pharmacokinetics, myorelaxant, Key Contribution, Investigation of the preclinical profile of azemiopsin demonstrated its high affinity and specificity for muscle type nicotinic acetylcholine receptor as well as good muscle relaxant capacity. Toxicology studies in mice indicated that azemiopsin was well tolerated during chronic dosing and showed no immunotoxicity, allergenic or mutagenic activity, which made it a good candidate for application as a local muscle relaxant., Medicine
وصف الملف: electronic resource
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2
المؤلفون: Margarita A Salmova, A. V. Lobanov, Natalya S. Egorova, G. A. Slashcheva, Victor I. Tsetlin, Maxim N. Zhmak, Elena A Tukhovskaya, Inessa S. Muzyka, Igor Ivanov, I. N. Kravchenko, Irina V. Shelukhina, Alexandra I. Garifulina, Ekaterina A Rasskazova, Yuri N. Utkin, V. A. Rykov
المصدر: Toxins
Toxins; Volume 10; Issue 1; Pages: 34
Toxins, Vol 10, Iss 1, p 34 (2018)مصطلحات موضوعية: 0301 basic medicine, Male, medicine.drug_class, Health, Toxicology and Mutagenesis, Xenopus, lcsh:Medicine, Investigation of the preclinical profile of azemiopsin demonstrated its high affinity and specificity for muscle type nicotinic acetylcholine receptor as well as good muscle relaxant capacity. Toxicology studies in mice indicated that azemiopsin was well tolerated during chronic dosing and showed no immunotoxicity, allergenic or mutagenic activity, which made it a good candidate for application as a local muscle relaxant, CHO Cells, Nicotinic Antagonists, Viper Venoms, Pharmacology, Receptors, Nicotinic, Toxicology, Article, nicotinic acetylcholine receptor, azemiopsin, preclinical studies, toxicity, pharmacokinetics, myorelaxant, Key Contribution, Rats, Sprague-Dawley, 03 medical and health sciences, Cricetulus, Cell Line, Tumor, Toxicity Tests, medicine, Animals, Humans, Receptor, Mice, Inbred ICR, GABAA receptor, Chemistry, lcsh:R, Antagonist, Muscle relaxant, Effective dose (pharmacology), Nicotinic acetylcholine receptor, 030104 developmental biology, Neuromuscular Agents, Toxicity, Oocytes, Female, Peptides, Acetylcholine, medicine.drug
وصف الملف: application/pdf
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3دورية أكاديمية
المؤلفون: Shelukhina IV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russia. shelukhina.iv@yandex.ru., Zhmak MN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russia. mzhmak@gmail.com., Lobanov AV; Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia., Ivanov IA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russia. chai.mail0@gmail.com., Garifulina AI; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russia. garifulinaai@gmail.com., Kravchenko IN; Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia. ikravchenko@bibch.ru., Rasskazova EA; Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia. katyarass@mail.ru., Salmova MA; Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia. mak401@gmail.com., Tukhovskaya EA; Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia. elentuk@mail.ru., Rykov VA; Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia. vladimirrykov@email.su., Slashcheva GA; Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia. slashcheva_ga@mail.ru., Egorova NS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russia. natalyegorov@yandex.ru., Muzyka IS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russia. mis_kou@mail.ru., Tsetlin VI; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russia. vits@mx.ibch.ru., Utkin YN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russia. Yutkin@yandex.ru.
المصدر: Toxins [Toxins (Basel)] 2018 Jan 07; Vol. 10 (1). Date of Electronic Publication: 2018 Jan 07.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE
مواضيع طبية MeSH: Neuromuscular Agents/*pharmacology , Nicotinic Antagonists/*pharmacology , Peptides/*pharmacology , Viper Venoms/*pharmacology, Animals ; CHO Cells ; Cell Line, Tumor ; Cricetulus ; Female ; Humans ; Male ; Mice, Inbred ICR ; Oocytes/drug effects ; Oocytes/physiology ; Rats, Sprague-Dawley ; Receptors, Nicotinic/physiology ; Toxicity Tests ; Xenopus
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