المؤلفون: Todd, John A., Evangelou, Marina, Cutler, Antony J., Pekalski, Marcin L., Walker, Neil M., Stevens, Helen E., Porter, Linsey, Smyth, Deborah J., Rainbow, Daniel B., Ferreira, Ricardo C., Esposito, Laura, Hunter, Kara M. D., Loudon, Kevin, Irons, Kathryn, Yang, Jennie H., Bell, Charles J. M., Schuilenburg, Helen, Heywood, James, Challis, Ben, Neupane, Sankalpa, Clarke, Pamela, Coleman, Gillian, Dawson, Sarah, Goymer, Donna, Anselmiova, Katerina, Kennet, Jane, Brown, Judy, Caddy, Sarah L., Lu, Jia, Greatorex, Jane, Goodfellow, Ian, Wallace, Chris, Tree, Tim I., Evans, Mark, Mander, Adrian P., Bond, Simon, Wicker, Linda S., Waldron-Lynch, Frank

المساهمون: Goodfellow, Ian Gordon [0000-0002-9483-510X], Wallace, Chris [0000-0001-9755-1703], Waldron-Lynch, Frank [0000-0002-0597-4328], Apollo - University of Cambridge Repository, Evangelou, Marina [0000-0003-0789-8944], Esposito, Laura [0000-0003-3246-7855], Hunter, Kara MD [0000-0002-8089-0693], Loudon, Kevin [0000-0001-9055-6894], Irons, Kathryn [0000-0002-7843-7080], Heywood, James [0000-0002-2499-3663], Neupane, Sankalpa [0000-0001-9519-0940], Anselmiova, Katerina [0000-0002-9533-100X], Caddy, Sarah L [0000-0002-9790-7420], Lu, Jia [0000-0003-3995-324X], Tree, Tim I [0000-0002-6973-5377]

المصدر: PLoS Medicine
PLoS Medicine, Vol 13, Iss 10, p e1002139 (2016)
Todd, J A, Evangelou, M, Cutler, A J, Pekalski, M L, Walker, N M, Stevens, H E, Porter, L, Smyth, D J, Rainbow, D B, Ferreira, R C, Esposito, L, Hunter, K M D, Loudon, K, Irons, K, Yang, J H, Bell, C J M, Schuilenburg, H, Heywood, J, Challis, B, Neupane, S, Clarke, P, Coleman, G, Dawson, S, Goymer, D, Anselmiova, K, Kennet, J, Brown, J, Caddy, S L, Lu, J, Greatorex, J, Goodfellow, I, Wallace, C, Tree, T I, Evans, M, Mander, A P, Bond, S, Wicker, L S & Waldron-Lynch, F 2016, ' Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2 : A Non-Randomised, Open Label, Adaptive Dose-Finding Trial ', PL o S Medicine, vol. 13, no. 10, e1002139 . https://doi.org/10.1371/journal.pmed.1002139

مصطلحات موضوعية: Adult, Male, lymphocytes, Cell biology, Blood cells, Adolescent, Physiology, Immunology, T cells, T-Lymphocytes, Regulatory, regulatory T cells, Immunophenotyping, Young Adult, blood, memory T cells, Cellular types, Humans, Lymphocyte Count, Medicine and health sciences, blood counts, Biology and life sciences, Dose-Response Relationship, Drug, Immune cells, Hematology, Middle Aged, Recombinant Proteins, Body Fluids, Killer Cells, Natural, Diabetes Mellitus, Type 1, Animal cells, Medicine, White blood cells, Interleukin-2, Female, eosinophils, Anatomy, Chemokines, Inflammation Mediators, Biomarkers, Research Article, blood plasma

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e1c8df238f9bd0b4b509e1bf7c865862
https://ora.ox.ac.uk/objects/uuid:01a52af1-ff42-4256-99be-80df2bfa4ad6

المؤلفون: Waldron-Lynch, Frank, Kareclas, Paula, Irons, Kathryn, Walker, Neil M, Mander, Adrian, Wicker, Linda S, Todd, John A, Bond, Simon

المصدر: BMJ Open

مصطلحات موضوعية: Diabetes and Endocrinology, Diabetes Mellitus, Type 1, Research Design, Protocol, Humans, Interleukin-2, Drug Dosage Calculations, T-Lymphocytes, Regulatory

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::a73396054b6bc83f04516bbe2cf69600
http://europepmc.org/articles/PMC4054640

المؤلفون: Todd, John A, Evangelou, Marina, Cutler, Antony J, Pekalski, Marcin L, Walker, Neil M, Stevens, Helen E, Porter, Linsey, Smyth, Deborah J, Rainbow, Daniel B, Ferreira, Ricardo C, Esposito, Laura, Hunter, Kara MD, Loudon, Kevin, Irons, Kathryn, Yang, Jennie H, Bell, Charles JM, Schuilenburg, Helen, Heywood, James, Challis, Ben, Neupane, Sankalpa, Clarke, Pamela, Coleman, Gillian, Dawson, Sarah, Goymer, Donna, Anselmiova, Katerina, Kennet, Jane, Brown, Judy, Caddy, Sarah L, Lu, Jia, Greatorex, Jane, Goodfellow, Ian, Wallace, Chris, Tree, Tim I, Evans, Mark, Mander, Adrian P, Bond, Simon, Wicker, Linda S, Waldron-Lynch, Frank

مصطلحات موضوعية: Adult, Male, Adolescent, Dose-Response Relationship, Drug, Middle Aged, T-Lymphocytes, Regulatory, Recombinant Proteins, 3. Good health, Immunophenotyping, Eosinophils, Killer Cells, Natural, Young Adult, Diabetes Mellitus, Type 1, Humans, Interleukin-2, Female, Lymphocyte Count, Chemokines, Inflammation Mediators, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5116d1b5807968bbe212eda6d0abd7e8

المؤلفون: Todd, John A, Evangelou, Marina, Cutler, Antony J, Pekalski, Marcin L, Walker, Neil M, Stevens, Helen E, Porter, Linsey, Smyth, Deborah J, Rainbow, Daniel B, Ferreira, Ricardo C, Esposito, Laura, Hunter, Kara MD, Loudon, Kevin, Irons, Kathryn, Yang, Jennie H, Bell, Charles JM, Schuilenburg, Helen, Heywood, James, Challis, Ben, Neupane, Sankalpa, Clarke, Pamela, Coleman, Gillian, Dawson, Sarah, Goymer, Donna, Anselmiova, Katerina, Kennet, Jane, Brown, Judy, Caddy, Sarah, Lu, Jia, Greatorex, Jane, Goodfellow, Ian Gordon, Wallace, Chris, Tree, Tim I, Evans, Mark, Mander, Adrian Paul, Bond, Simon, Wicker, Linda S, Waldron-Lynch, Frank

مصطلحات موضوعية: lymphocytes, blood counts, blood, memory T cells, T cells, eosinophils, regulatory T cells, 3. Good health, blood plasma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a7ac5e0157048ebeaafb6a5473ef8283

المؤلفون: Todd JA; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Evangelou M; Department of Mathematics, Imperial College London, London, United Kingdom., Cutler AJ; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Pekalski ML; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Walker NM; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Stevens HE; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Porter L; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Smyth DJ; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Rainbow DB; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Ferreira RC; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Esposito L; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Hunter KM; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Loudon K; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Irons K; National Institute for Health Research Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom., Yang JH; Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, National Institute of Health Research Biomedical Research Centre, Guy's and St Thomas' National Health Service Foundation Trust and King's College London, London, United Kingdom., Bell CJ; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Schuilenburg H; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Heywood J; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Challis B; Wellcome Trust/MRC Institute of Metabolic Science, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, United Kingdom., Neupane S; Wellcome Trust/MRC Institute of Metabolic Science, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, United Kingdom., Clarke P; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Coleman G; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Dawson S; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Goymer D; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Anselmiova K; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Kennet J; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Brown J; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Caddy SL; Division of Virology, Department of Pathology, Addenbrooke's Hospital, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Lu J; Division of Virology, Department of Pathology, Addenbrooke's Hospital, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Greatorex J; Public Health England, Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom., Goodfellow I; Division of Virology, Department of Pathology, Addenbrooke's Hospital, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Wallace C; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.; MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge, United Kingdom., Tree TI; Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, National Institute of Health Research Biomedical Research Centre, Guy's and St Thomas' National Health Service Foundation Trust and King's College London, London, United Kingdom., Evans M; Wellcome Trust/MRC Institute of Metabolic Science, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, United Kingdom., Mander AP; MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge, United Kingdom., Bond S; National Institute for Health Research Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom.; MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge, United Kingdom., Wicker LS; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom., Waldron-Lynch F; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.

المصدر: PLoS medicine [PLoS Med] 2016 Oct 11; Vol. 13 (10), pp. e1002139. Date of Electronic Publication: 2016 Oct 11 (Print Publication: 2016).

نوع المنشور: Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101231360 Publication Model: eCollection Cited Medium: Internet ISSN: 1549-1676 (Electronic) Linking ISSN: 15491277 NLM ISO Abbreviation: PLoS Med Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 1/*prevention & control , Interleukin-2/*analogs & derivatives , T-Lymphocytes, Regulatory/*drug effects, Adolescent ; Adult ; Biomarkers ; Chemokines/biosynthesis ; Dose-Response Relationship, Drug ; Eosinophils/drug effects ; Female ; Humans ; Immunophenotyping ; Inflammation Mediators/metabolism ; Interleukin-2/adverse effects ; Interleukin-2/pharmacology ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Lymphocyte Count ; Male ; Middle Aged ; Recombinant Proteins/adverse effects ; Recombinant Proteins/pharmacology ; Young Adult