نتائج البحث - "Isabelle Lamrissi-Garcia"

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دورية أكاديمية

CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/3a225f969b444010a97c3369c573fb50

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CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells

المؤلفون: Jean-Marc Blouin, F. Prat, J. Rosier, Jean-Philippe Merlio, J. Bouron, Emmanuel Richard, Cécile Ged, Julian Boutin, Isabelle Lamrissi-Garcia, Aurélie Bedel, Sandrine Dabernat, François Moreau-Gaudry, G. Cullot, J. Toutain, Caroline Rooryck, Perrine Pennamen, Véronique Guyonnet-Dupérat, D. Cappellen, Samuel Amintas

المساهمون: Biothérapies des maladies génétiques et cancers, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) (U1211 INSERM/MRGM), Université de Bordeaux (UB)-Groupe hospitalier Pellegrin-Institut National de la Santé et de la Recherche Médicale (INSERM), Bordeaux Research In Translational Oncology [Bordeaux] (BaRITOn), Université de Bordeaux (UB)-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Association Française contre les Myopathies, ANR-21-CE18-0002,CRISPR-genotox,Génotoxicité induite par CRISPR-CAS9(2021), Admin, Oskar, Génotoxicité induite par CRISPR-CAS9 - - CRISPR-genotox2021 - ANR-21-CE18-0002 - AAPG2021 - VALID

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-25190-6⟩
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-25190-6⟩

مصطلحات موضوعية: CRISPR-Cas9 genome editing, Genetic enhancement, Science, General Physics and Astronomy, Gene Expression, Loss of Heterozygosity, Biology, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Article, Loss of heterozygosity, 03 medical and health sciences, 0302 clinical medicine, Genome editing, Insulin-Like Growth Factor II, medicine, CRISPR, Humans, Globin, Cells, Cultured, 030304 developmental biology, Sequence Deletion, Genetics, Gene Editing, 0303 health sciences, Multidisciplinary, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Chromosomes, Human, Pair 11, Chromosome, General Chemistry, DNA Methylation, medicine.disease, Hematopoietic Stem Cells, Uniparental disomy, 3. Good health, Telomere, Globins, Targeted gene repair, HEK293 Cells, 030220 oncology & carcinogenesis, RNA, Long Noncoding, CRISPR-Cas Systems, Chromosome Deletion, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb74bfd20b4608945b76780551b62ec
https://doaj.org/article/e2a0368b510f4b0f8a6f33bea02556ca

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3

Spleen route accelerates engraftment of human hematopoietic stem cells

المؤلفون: Aurélie Bedel, Isabelle Lamrissi-Garcia, S. Poglio, Julian Boutin, Benoit Rousseau, Jean-Marc Blouin, Isabelle Moranvillier, Samuel Amintas, Sandrine Dabernat, Emmanuel Richard, P. Brunet de la Grange, François Moreau-Gaudry

المصدر: Biochemical and biophysical research communications. 569

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd09855520b0c2c346acf8b95dba60d9
https://pubmed.ncbi.nlm.nih.gov/34216994

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Iron chelation rescues hemolytic anemia and skin photosensitivity in congenital erythropoietic porphyria

المؤلفون: Jean-Marc Blouin, Raed Daher, Zoubida Karim, Cécile Ged, Aurélie Bedel, Fanny Morice-Picard, Laurent Gouya, Magalie Lalanne, Hervé Puy, François Moreau-Gaudry, Pierre Costet, Isabelle Lamrissi-Garcia, Emmanuel Richard

المساهمون: Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)

المصدر: Blood
Blood, American Society of Hematology, 2020, 136 (21), pp.2457-2468. ⟨10.1182/blood.2020006037⟩

مصطلحات موضوعية: Hemolytic anemia, Porphyria, Erythropoietic, Uroporphyrinogen III synthase, Congenital erythropoietic porphyria, Pharmacology, Biochemistry, Mice, chemistry.chemical_compound, 0302 clinical medicine, Deferiprone, Gene Knock-In Techniques, RNA, Small Interfering, Heme, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, biology, Skin photosensitivity, Hematology, Hemolysis, 3. Good health, 030220 oncology & carcinogenesis, Female, RNA Interference, BLOOD Commentary, 5-Aminolevulinate Synthetase, Adult, Anemia, Hemolytic, Iron Overload, Porphyrins, Iron, Immunology, Iron Chelating Agents, Cell Line, 03 medical and health sciences, Erythroid Cells, Cell Line, Tumor, medicine, Animals, Humans, Photosensitivity Disorders, 030304 developmental biology, Cell Biology, medicine.disease, ALAS2, Disease Models, Animal, chemistry, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Porphyria, Acute Intermittent, Peripheral Blood Stem Cells, biology.protein, Leukemia, Erythroblastic, Acute, CRISPR-Cas Systems

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b910936d3819515eac5c040e5dad1e9
https://hal.archives-ouvertes.fr/hal-03045807

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Mutation-Specific Guide RNA for Compound Heterozygous Porphyria On-target Scarless Correction by CRISPR/Cas9 in Stem Cells

المؤلفون: Jérôme Toutain, Grégoire Cullot, Samuel Amintas, Emmanuel Richard, Isabelle Moranvillier, François Moreau-Gaudry, Florence Prat, Sandrine Dabernat, Aurélie Bedel, Magalie Lalanne, Isabelle Lamrissi-Garcia, Julian Boutin, Jean-Marc Blouin

المساهمون: Biothérapies des maladies génétiques et cancers, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Université de Bordeaux (UB), Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge (Labex Gr-Ex), Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CCSD, Accord Elsevier

المصدر: Stem Cell Reports
Stem Cell Reports, Elsevier, 2020, 15, pp.677-693. ⟨10.1016/j.stemcr.2020.07.015⟩

مصطلحات موضوعية: 0301 basic medicine, Heterozygote, precise genome editing, [SDV]Life Sciences [q-bio], Induced Pluripotent Stem Cells, Congenital erythropoietic porphyria, iPSCs, Biology, congenital erythropoietic porphyria, Compound heterozygosity, medicine.disease_cause, Biochemistry, Article, 03 medical and health sciences, Porphyrias, 0302 clinical medicine, CRISPR-Associated Protein 9, compound heterozygous recessive disease, Genetics, medicine, CRISPR, Humans, Guide RNA, Allele, Gene, CRISPR/Cas9, Alleles, Gene Editing, Mutation, Base Sequence, mutation specific, Cas9, Stem Cells, Cell Biology, Exons, Genetic Therapy, Uroporphyrinogen III Synthetase, gene therapy, 3. Good health, Clone Cells, [SDV] Life Sciences [q-bio], 030104 developmental biology, Karyotyping, CRISPR-Cas Systems, 030217 neurology & neurosurgery, Developmental Biology, RNA, Guide, Kinetoplastida

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51053ec3d97d81cab94b46e24416bec
https://hal.archives-ouvertes.fr/hal-03492339

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6

Preventing Pluripotent Cell Teratoma in Regenerative Medicine Applied to Hematology Disorders

المؤلفون: Benoit Rucheton, François Béliveau, Aurélie Bedel, Véronique Guyonnet-Duperat, Hubert de Verneuil, Isabelle Moranvillier, Sandrine Dabernat, Benoit Rousseau, Isabelle Lamrissi-Garcia, François Moreau-Gaudry, Bruno Cardinaud

المصدر: Stem Cells Translational Medicine

مصطلحات موضوعية: 0301 basic medicine, Time Factors, Survivin, Cellular differentiation, Mice, SCID, Regenerative Medicine, Hematopoietic stem cell, 0302 clinical medicine, Translational Research Articles and Reviews, Mice, Inbred NOD, Induced pluripotent stem cell, Genes, Transgenic, Suicide, Hematopoietic Stem Cell Transplantation, Imidazoles, Teratoma, Hematology, General Medicine, Caspase 9, Tumor Burden, Gene Expression Regulation, Neoplastic, Haematopoiesis, Cell Transformation, Neoplastic, Phenotype, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Safety, Stem cell, Pluripotent Stem Cells, Induced Pluripotent Stem Cells, Survivin inhibitor, Biology, Risk Assessment, Tacrolimus, Cell Line, iCaspase‐9, 03 medical and health sciences, medicine, Animals, Humans, Cell Proliferation, Dose-Response Relationship, Drug, Cell Biology, Suicide gene, Hematopoietic Stem Cells, medicine.disease, Hematologic Diseases, Xenograft Model Antitumor Assays, Thymidine kinase, 030104 developmental biology, Cancer research, Naphthoquinones, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad259b5f72cfc7fb416483debe0994ce
https://doi.org/10.5966/sctm.2016-0201

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7

Genetic background influences hepcidin response to iron imbalance in a mouse model of hemolytic anemia (Congenital erythropoietic porphyria)

المؤلفون: Emmanuel Richard, Pierre Costet, Said Lyoumi, Cécile Ged, Thibaud Lefebvre, Magalie Lalanne, Hervé Puy, Zoubida Karim, Hubert de Verneuil, François Moreau-Gaudry, Isabelle Lamrissi-Garcia, Jean-Marc Blouin, Sarah Millot, Laurent Gouya

المساهمون: Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)

المصدر: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2019, 520 (2), pp.297-303. ⟨10.1016/j.bbrc.2019.09.141⟩

مصطلحات موضوعية: 0301 basic medicine, Hemolytic anemia, Male, medicine.medical_specialty, Iron Overload, Porphyrins, Anemia, Iron, Porphyria, Erythropoietic, Ferroportin, Biophysics, Congenic, Congenital erythropoietic porphyria, Mice, Inbred Strains, Biochemistry, Hemolysis, 03 medical and health sciences, 0302 clinical medicine, Hepcidins, Hepcidin, hemic and lymphatic diseases, Internal medicine, medicine, Animals, Molecular Biology, Cation Transport Proteins, ComputingMilieux_MISCELLANEOUS, Mice, Inbred BALB C, biology, business.industry, Cell Biology, medicine.disease, Uroporphyrinogen III Synthetase, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Endocrinology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, 030220 oncology & carcinogenesis, biology.protein, Erythropoiesis, Female, business