المؤلفون: Collins VJ; Translational Sarcoma Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Ludwig KR; Functional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Nelson AE; Translational Sarcoma Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Sundara Rajan S; Functional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Yeung C; Translational Sarcoma Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Vulikh K; Molecular Histopathology Lab, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Isanogle KA; Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Mendoza A; Translational Sarcoma Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Difilippantonio S; Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Karim BO; Molecular Histopathology Lab, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Caplen NJ; Functional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Heske CM; Translational Sarcoma Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2024 Aug 01; Vol. 23 (8), pp. 1109-1123.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: DNA-Activated Protein Kinase*/antagonists & inhibitors , DNA-Activated Protein Kinase*/metabolism , Sarcoma, Ewing*/drug therapy , Sarcoma, Ewing*/pathology, Animals ; Humans ; Mice ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA Damage ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Standard of Care ; Xenograft Model Antitumor Assays

المؤلفون: Stauffer S; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, NIH, 8560 Progress Drive, Frederick, MD 21701, USA., Roth JS; Early Translation Branch, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, 9800 Medical Center Drive, Rockville, MD 20850, USA., Hernandez ER; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA., Kowalczyk JT; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA., Sealover NE; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Services, Bethesda, MD 20814, USA., Hebron KE; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, NIH, 8560 Progress Drive, Frederick, MD 21701, USA., James A; Animal Research Technical Support, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Isanogle KA; Animal Research Technical Support, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Riffle LA; Small Animal Imaging Program, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Ileva L; Small Animal Imaging Program, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Luo X; Collaborative Protein Technology Resource, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Chen JQ; Collaborative Protein Technology Resource, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Kedei N; Collaborative Protein Technology Resource, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Kortum RL; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Services, Bethesda, MD 20814, USA., Lei H; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA., Shern JF; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA., Kalen JD; Small Animal Imaging Program, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Edmondson EF; Molecular Histopathology Laboratory, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Hall MD; Early Translation Branch, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, 9800 Medical Center Drive, Rockville, MD 20850, USA., Difilippantonio S; Animal Research Technical Support, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Thiele CJ; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA., Yohe ME; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, NIH, 8560 Progress Drive, Frederick, MD 21701, USA.; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA.

المصدر: Cancers [Cancers (Basel)] 2024 Jun 25; Vol. 16 (13). Date of Electronic Publication: 2024 Jun 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Hebron KE; Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, Frederick, Maryland., Wan X; Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Roth JS; Early Translation Branch, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville, Maryland., Liewehr DJ; Biostatistics and Data Management Section, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Sealover NE; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Services, Bethesda, Maryland., Frye WJE; Laboratory of Cell Biology, Center for Cancer Research, NCI, Bethesda, Maryland., Kim A; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, Frederick, Maryland., Stauffer S; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, Frederick, Maryland., Perkins OL; Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Sun W; Laboratory of Pathology, Center for Cancer Research, NCI, Bethesda, Maryland., Isanogle KA; Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland., Robinson CM; Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland., James A; Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland., Awasthi P; Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland., Shankarappa P; Genitourinary Malignancies Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Luo X; Collaborative Protein Technology Resource, NCI, NIH, Bethesda, Maryland., Lei H; Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Butcher D; Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland., Smith R; Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland., Edmondson EF; Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland., Chen JQ; Collaborative Protein Technology Resource, NCI, NIH, Bethesda, Maryland., Kedei N; Collaborative Protein Technology Resource, NCI, NIH, Bethesda, Maryland., Peer CJ; Genitourinary Malignancies Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Shern JF; Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Figg WD; Genitourinary Malignancies Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Chen L; Early Translation Branch, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville, Maryland., Hall MD; Early Translation Branch, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Rockville, Maryland., Difilippantonio S; Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland., Barr FG; Laboratory of Pathology, Center for Cancer Research, NCI, Bethesda, Maryland., Kortum RL; Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Services, Bethesda, Maryland., Robey RW; Laboratory of Cell Biology, Center for Cancer Research, NCI, Bethesda, Maryland., Vaseva AV; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, Texas., Khan J; Genetics Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland., Yohe ME; Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, Frederick, Maryland.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Jan 17; Vol. 29 (2), pp. 472-487.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Rhabdomyosarcoma*/drug therapy , Rhabdomyosarcoma*/genetics , Rhabdomyosarcoma*/pathology, Humans ; Animals ; Mice ; Child ; Cell Line, Tumor ; Mice, SCID ; Protein Kinase Inhibitors/pharmacology ; Mitogen-Activated Protein Kinase Kinases

المؤلفون: Kowalczyk JT; National Cancer Institute, Bethesda, Maryland., Wan X; National Cancer Institute, Bethesda, Maryland., Hernandez ER; National Cancer Institute, Bethesda, Maryland., Luo R; National Cancer Institute, Bethesda, Maryland., Lyons GC; National Cancer Institute, Bethesda, Maryland., Wilson KM; National Center for Advancing Translational Sciences, Rockville, Maryland., Gallardo DC; National Cancer Institute, Bethesda, Maryland., Isanogle KA; Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Robinson CM; Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Mendoza A; National Cancer Institute, Bethesda, Maryland., Heske CM; National Cancer Institute, Bethesda, Maryland., Chen JQ; National Cancer Institute, Bethesda, Maryland., Luo X; National Cancer Institute, Bethesda, Maryland., Kelly AE; National Cancer Institute, Bethesda, Maryland., Difilippantinio S; Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Robey RW; National Cancer Institute, Bethesda, Maryland., Thomas CJ; National Center for Advancing Translational Sciences, Rockville, Maryland., Sackett DL; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland., Morrison DK; National Cancer Institute, Frederick, Maryland., Randazzo PA; National Cancer Institute, Bethesda, Maryland., Jenkins LMM; National Cancer Institute, Bethesda, Maryland., Yohe ME; National Cancer Institute, Bethesda, Maryland. yoheme@mail.nih.gov.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2021 Feb; Vol. 20 (2), pp. 307-319. Date of Electronic Publication: 2020 Nov 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Glycine/*analogs & derivatives , Neuroblastoma/*drug therapy , Rhabdomyosarcoma/*drug therapy , Spindle Apparatus/*metabolism , Sulfones/*therapeutic use, Apoptosis ; Glycine/pharmacology ; Glycine/therapeutic use ; Humans ; Sulfones/pharmacology

المؤلفون: Yohe ME; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA. yoheme@mail.nih.gov khanjav@mail.nih.gov.; Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Gryder BE; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA., Shern JF; Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Song YK; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA., Chou HC; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA., Sindiri S; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA., Mendoza A; Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Patidar R; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA., Zhang X; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Bethesda, MD 20892, USA., Guha R; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Bethesda, MD 20892, USA., Butcher D; Pathology/Histotechnology Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, NIH, Frederick, MD 21702, USA., Isanogle KA; Laboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, NIH, Frederick, MD 21701, USA., Robinson CM; Laboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, NIH, Frederick, MD 21701, USA., Luo X; Collaborative Protein Technology Resource, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Chen JQ; Collaborative Protein Technology Resource, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Walton A; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA., Awasthi P; Laboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, NIH, Frederick, MD 21701, USA., Edmondson EF; Pathology/Histotechnology Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, NIH, Frederick, MD 21702, USA., Difilippantonio S; Laboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, NIH, Frederick, MD 21701, USA., Wei JS; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA., Zhao K; Systems Biology Center, National Heart Lung and Blood Institute, NIH, Bethesda, MD 20892, USA., Ferrer M; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Bethesda, MD 20892, USA., Thomas CJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Bethesda, MD 20892, USA., Khan J; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA. yoheme@mail.nih.gov khanjav@mail.nih.gov.

المصدر: Science translational medicine [Sci Transl Med] 2018 Jul 04; Vol. 10 (448).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Genes, ras*, Enhancer Elements, Genetic/*genetics , Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors , Myogenin/*metabolism , Protein Kinase Inhibitors/*pharmacology , Rhabdomyosarcoma/*genetics, Animals ; Cell Differentiation ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Chromatin/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; MAP Kinase Signaling System/drug effects ; Mice ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Muscle Development/drug effects ; Muscle Development/genetics ; Myoblasts/metabolism ; Myoblasts/pathology ; Oncogene Proteins, Fusion/metabolism ; Pyridones/pharmacology ; Pyrimidinones/pharmacology ; Receptor, IGF Type 1/metabolism ; Rhabdomyosarcoma/enzymology ; Rhabdomyosarcoma/pathology ; Transcription, Genetic/drug effects ; Xenograft Model Antitumor Assays