يعرض 1 - 4 نتائج من 4 نتيجة بحث عن '"Ivan William Hemeon"', وقت الاستعلام: 0.97s تنقيح النتائج
  1. 1
    Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310

    المؤلفون: Sultan Chowdhury, Christoph Martin Dehnhardt, Tao Sheng, Clint Young, Rainbow Kwan, Michael Scott Wilson, Jun Chen, Matthew Waldbrook, Dinah Misner, C. Lee Robinette, Rebecca M. Reese, Elaine Chang, Henry Verschoof, Tanja S. Zabka, Girish Bankar, Philippe Bergeron, Luis Sojo, Karen Nelkenbrecher, Daniel P. Sutherlin, Amy Kim, Ivan William Hemeon, Andrea Lindgren, Jae H. Chang, Alla Yurevna Zenova, Shaoyi Sun, Jonathan Maher, Shannon D. Shields, Jun Li, Daniel F. Ortwine, David H. Hackos, Zhiwei Xie, Thilo Focken, Charles J. Cohen, Richard T. Dean, Shannon Decker, Janette Mezeyova, Kuldip Khakh, Antonio G. DiPasquale, Chien-An Chen, Andrew D. White, Brian Safina, Jodie Pang, Qi Jia, Sophia Lin, Jean-Christophe Andrez, J. P. Johnson, Steven J. McKerrall

    المصدر: Journal of Medicinal Chemistry. 64:2953-2966

    مصطلحات موضوعية: 0303 health sciences, Chemistry, Sulfonamide (medicine), Phase 1 trials, Pharmacology, Metabolic stability, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Pharmacokinetics, Drug Discovery, NAV1, medicine, Molecular Medicine, Dosing, 030304 developmental biology, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1a8a9431d81bf8ca2eed0fbbfbb36905
    https://doi.org/10.1021/acs.jmedchem.1c00049

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  2. 2
    Identification of Selective Acyl Sulfonamide–Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity

    المؤلفون: Qi Jia, Jean-Christophe Andrez, Charles J. Cohen, Jae H. Chang, Kuldip Khakh, J. P. Johnson, Chien-An Chen, Jun Li, Karen Nelkenbrecher, Thilo Focken, Zhiwei Xie, Daniel F. Ortwine, Brian Safina, Michael Edward Grimwood, Andrew D. White, Christoph Martin Dehnhardt, Shannon Decker, Ivan William Hemeon, David H. Hackos, Sophia Lin, Jodie Pang, Luis Sojo, Girish Bankar, Andrea Lindgren, Matthew Waldbrook, Elaine Chang, C. Lee Robinette, Shaoyi Sun, Antonio G. DiPasquale, Tao Sheng, Clint Young, Rainbow Kwan, Benjamin D. Sellers, Sultan Chowdhury, Michael Scott Wilson, Lunbin Deng, Daniel P. Sutherlin, Alla Yurevna Zenova

    المصدر: Journal of Medicinal Chemistry. 62:908-927

    مصطلحات موضوعية: 0303 health sciences, Chemistry, Sodium channel, Pharmacology, 01 natural sciences, Molecular Docking Simulation, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Pharmacokinetics, In vivo, Docking (molecular), Drug Discovery, Microsome, Molecular Medicine, Structure–activity relationship, Potency, 030304 developmental biology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7f65c95248ff36af0807edf4a8f95cad
    https://doi.org/10.1021/acs.jmedchem.8b01621

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  3. 3
    Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain

    المؤلفون: Girish Bankar, Charles J. Cohen, Bowen Li, Kuldip Khakh, Sultan Chowdhury, Elaine Chang, Paul Robert Bichler, Christoph Martin Dehnhardt, Daniel P. Sutherlin, Jodie Pang, Michael D. Wilson, Yi Zhang, Zhiwei Xie, Matthew Waldbrook, C. Lee Robinette, Jae H. Chang, Karen Nelkenbrecher, Ivan William Hemeon, Alla Yurevna Zenova, Tao Sheng, Samuel J. Goodchild, Clint Young, Navjot Chahal, Rainbow Kwan, Daniel F. Ortwine, Brian Safina, Sophia Lin, Andrew D. White, Parisa Karimi Tari, Qi Jia, J. P. Johnson, Thilo Focken, Chien-An Chen, David H. Hackos, Shannon Decker, Noah G. Shuart, Luis Sojo, Christine Chabot, Shaoyi Sun, Michael Edward Grimwood

    المصدر: Journal of Medicinal Chemistry. 61:4810-4831

    مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Genetically modified mouse, Stereochemistry, Aryl, Sodium channel, In vitro, Sulfonamide, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, In vivo, Drug Discovery, Lipophilicity, Molecular Medicine, Potency, 030217 neurology & neurosurgery

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::301a3d7aee1781be0e40a336f69ca411
    https://doi.org/10.1021/acs.jmedchem.7b01826

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  4. 4
    Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models

    المؤلفون: Charles J. Cohen, Brian Safina, Daniel P. Sutherlin, Michael Edward Grimwood, Thilo Focken, J. P. Johnson, Shifeng Liu, Maxim Dauphinais, Matthew Waldbrook, C. Lee Robinette, Girish Bankar, Ivan William Hemeon, Noah G. Shuart, Jae H. Chang, Sultan Chowdhury, David Bogucki, Luis Sojo, Clint Young, Rainbow Kwan, Paul Robert Bichler, Renata Oballa, Tarek S. Mansour, Sophia Lin, Christoph Martin Dehnhardt, Jodie Pang, Navjot Chahal

    المصدر: ACS Medicinal Chemistry Letters. 7:277-282

    مصطلحات موضوعية: 0301 basic medicine, Drug, Gene isoform, biology, Aryl, Sodium channel, media_common.quotation_subject, Organic Chemistry, Analgesic, Pharmacology, Nav1.5, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, In vivo, Drug Discovery, biology.protein, Potency, 030217 neurology & neurosurgery, media_common

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2edc92a10b757ea1080ec9a9cb99aa
    https://doi.org/10.1021/acsmedchemlett.5b00447

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