المؤلفون: Ji Zhang, Eric S. Muise, Seongah Han, Peter S. Kutchukian, Philippe Costet, Yonghua Zhu, Yanqing Kan, Haihong Zhou, Vinit Shah, Yongcheng Huang, Ashmita Saigal, Taro E. Akiyama, Xiao-Lan Shen, Tian-Quan Cai, Kashmira Shah, Ester Carballo-Jane, Emanuel Zycband, Lan Yi, Ye Tian, Ying Chen, Jason Imbriglio, Elizabeth Smith, Kristine Devito, James Conway, Li-Jun Ma, Maarten Hoek, Iyassu K. Sebhat, Andrea M. Peier, Saswata Talukdar, David G. McLaren, Stephen F. Previs, Kristian K. Jensen, Shirly Pinto

المصدر: Cell Reports Medicine, Vol 1, Iss 4, Pp 100056- (2020)

مصطلحات موضوعية: fibrosis, metabolism, fatty acid oxidation, TGF-β, PGC1α, MK-8722, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666379120300720; https://doaj.org/toc/2666-3791

URL الوصول: https://doaj.org/article/063a70c64d8f4793abcfad76e4a93d9a

المؤلفون: David G. McLaren, Lan Yi, Shirly Pinto, Ye Tian, Kristian K. Jensen, Kristine Devito, Elizabeth Smith, Philippe Costet, Iyassu K. Sebhat, Stephen F. Previs, Emanuel Zycband, James Conway, Eric S. Muise, Seongah Han, Yongcheng Huang, Kashmira Shah, Ying Chen, Jason E. Imbriglio, Ji Zhang, Vinit Shah, Peter S. Kutchukian, Haihong Zhou, Tian-Quan Cai, Li-Jun Ma, Yonghua Zhu, Yanqing Kan, Taro E. Akiyama, Ester Carballo-Jane, Maarten Hoek, Xiaolan Shen, Saswata Talukdar, Andrea M. Peier, Ashmita Saigal

المصدر: Cell Reports Medicine
Cell Reports Medicine, Vol 1, Iss 4, Pp 100056-(2020)

مصطلحات موضوعية: TGF-β, AMPK, Male, MK-8722, Pyridines, Phenotypic screening, Peroxisome proliferator-activated receptor, Gene Expression, Biology, Kidney, PPAR, General Biochemistry, Genetics and Molecular Biology, Article, Extracellular matrix, Transcriptome, Rats, Sprague-Dawley, Mice, Downregulation and upregulation, Fibrosis, Transforming Growth Factor beta, PGC1α, medicine, Animals, Humans, Beta oxidation, fatty acid oxidation, Cells, Cultured, chemistry.chemical_classification, MK-4074, lcsh:R5-920, Gene Expression Profiling, fibrosis, Adenylate Kinase, medicine.disease, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Extracellular Matrix, Rats, Mice, Inbred C57BL, chemistry, Organ Specificity, Cancer research, Benzimidazoles, lcsh:Medicine (General), metabolism, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfdffc0cd9c8343fd1d503ee93abf772
http://europepmc.org/articles/PMC7659620

المؤلفون: F. Anthony Romero, Robert W. Myers, Hong-Ping Guan, Anantha Gollapudi, Gaochao Zhou, Ku Lu, James F. Dropinski, Marc M. Kurtz, Xiaodong Yang, Cai Li, Iyassu K. Sebhat, Tesfaye Biftu, Danqing Feng, Ahmet Kekec, Ann E. Weber, Qing Shao, Daniel M. Kemp, Andrew Kassick, Shiyao Xu, Maria E. Trujillo

المصدر: ACS Medicinal Chemistry Letters. 9:39-44

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, biology, Activator (genetics), Organic Chemistry, Regulator, AMPK, Type 2 Diabetes Mellitus, Biochemistry, Energy homeostasis, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Enzyme, chemistry, AMP-activated protein kinase, Drug Discovery, biology.protein, Protein kinase A, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523ed2d42da00835ac297ba9e01c4ffe
https://doi.org/10.1021/acsmedchemlett.7b00417

المؤلفون: Sandra C. Souza, Shirly Pinto, Franklin Liu, Xiaoyan Zhou, Yanqing Kan, Robin E. Haimbach, David E. Kelley, Yonghua Zhu, Iyassu K. Sebhat, Eric S. Muise, Maarten Hoek

المصدر: The Journal of pharmacology and experimental therapeutics. 371(1)

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, Pyridines, Renal function, Blood Pressure, Pharmacology, Kidney, Diabetic nephropathy, 03 medical and health sciences, 0302 clinical medicine, AMP-Activated Protein Kinase Kinases, medicine, Animals, Humans, Hypoglycemic Agents, Diabetic Nephropathies, Cells, Cultured, Triglycerides, Aged, business.industry, Imidazoles, AMPK, Kidney metabolism, Middle Aged, medicine.disease, Mitochondria, Rats, Rats, Zucker, 030104 developmental biology, medicine.anatomical_structure, Lipotoxicity, Mitochondrial biogenesis, Molecular Medicine, Benzimidazoles, Female, business, Protein Kinases, 030217 neurology & neurosurgery, Kidney disease, Glomerular Filtration Rate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c83fdaf2a7c7d97a1864080dd6aa21
https://pubmed.ncbi.nlm.nih.gov/31300612

المؤلفون: Hong-Ping Guan, Wen Feng, Daniel M. Kemp, Judith N. Gorski, Shiyao Xu, Ying Li, Dan Zhou, Ku Lu, Tesfaye Biftu, David E. Kelley, Chuanlin Wang, Sandra C. Souza, Lan Wei, Danqing Feng, Robert R. Wilkening, Andrea R. Nawrocki, Iyassu K. Sebhat, Mark J. Rosenbach, Margaret van Heek, Carlos G. Rodriguez, Eric S. Muise, Xiaodong Yang, Mark D. Erion, Jinqi Liu, Stephen F. Previs, James M. Apgar, Marc M. Kurtz, Huaibing He, Robert W. Myers, Xiaolan Shen, Kenneth J. Leavitt

المصدر: PLoS ONE, Vol 14, Iss 2, p e0211568 (2019)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Glycogens, Glycobiology, Adipose tissue, Cardiovascular Medicine, AMP-Activated Protein Kinases, Biochemistry, Transcriptome, chemistry.chemical_compound, 0302 clinical medicine, Medicine and Health Sciences, Hyperinsulinemia, Homeostasis, Public and Occupational Health, Musculoskeletal System, Multidisciplinary, Glycogen, Organic Compounds, Pharmaceutics, Muscles, Monosaccharides, Fatty Acids, Cardiac muscle, Heart, Sports Science, Chemistry, medicine.anatomical_structure, Adipose Tissue, Liver, Physical Sciences, Medicine, Anatomy, Oxidation-Reduction, Research Article, medicine.medical_specialty, Drug Administration, Science, DNA transcription, Carbohydrates, Cardiovascular Pharmacology, 03 medical and health sciences, Drug Therapy, Physical Conditioning, Animal, Internal medicine, Genetics, medicine, Animals, Sports and Exercise Medicine, Muscle, Skeletal, Exercise, Pharmacology, business.industry, Myocardium, Organic Chemistry, Chemical Compounds, Biology and Life Sciences, Skeletal muscle, AMPK, Physical Activity, medicine.disease, Enzyme Activation, Mice, Inbred C57BL, Glucose, 030104 developmental biology, Endocrinology, Skeletal Muscles, Gene Expression Regulation, chemistry, Physical Fitness, Cardiovascular Anatomy, Gene expression, Energy Metabolism, business, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e74f669b91225dbd7a81a386f22662b
https://doaj.org/article/f28b2c263a184739b47d79a0d7b9272a

المؤلفون: Iyassu K. Sebhat, Sylvain Celanire, Stephan Schann, Silvia Gatti, Stanislas Mayer, Juergen Wichmann

المصدر: Expert Opinion on Therapeutic Patents. 25:69-90

مصطلحات موضوعية: Pharmacology, Drug Industry, Molecular Structure, business.industry, Group ii, Glutamate receptor, General Medicine, Receptors, Metabotropic Glutamate, Glutamate antagonists, Review article, Patents as Topic, Structure-Activity Relationship, Central Nervous System Diseases, Metabotropic glutamate receptor, Drug Design, Drug Discovery, Animals, Humans, Medicine, Metabotropic glutamate receptor 2, business, Excitatory Amino Acid Antagonists, Neuroscience, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95050884ccfe28dd20f93bf0710c2067
https://doi.org/10.1517/13543776.2014.983899

المؤلفون: Aleksandr Petrov, Wen Feng, Ann E. Weber, Effie Tozzo, Lisa LaFranco Scheuch, Shiyao Xu, Wei Zhu, Nancy A. Thornberry, Dinko Gonzalez Trotter, Rory J. Rohm, Franklin Liu, Ku Lu, Michelle Bunzel, David E. Kelley, Stacey Conarello, Jinqi Liu, Corin O. Miller, Xiaoda Niu, Huaibing He, Ronald E. Painter, Ying Li, Daniel M. Kemp, Ying Qian, Maria E. Trujillo, Mark D. Erion, Liyang Wang, Iyassu K. Sebhat, Gaochao Zhou, Michael Klimas, Marie A. Holahan, Marc M. Kurtz, George J. Eiermann, Guillermo Fernandez, Bindu Bennet, Juliann Ehrhart, Tesfaye Biftu, Aimie Ogawa, Sandra C. Souza, Cai Li, Srinivasa Prahalada, James A. Milligan, Hong-Ping Guan, Danqing Feng, Robert W. Myers, Douglas Wisniewski, Xiaodong Yang, Daniel Rubins, Hongwu Wang, Margaret van Heek

المصدر: Science (New York, N.Y.). 357(6350)

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, medicine.medical_specialty, Pyridines, Glucose uptake, Cardiomegaly, Biology, AMP-Activated Protein Kinases, Energy homeostasis, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Internal medicine, medicine, Glucose homeostasis, Animals, Homeostasis, Insulin, Glycogen synthase, Protein kinase A, Muscle, Skeletal, Multidisciplinary, Glycogen, Activator (genetics), Imidazoles, AMPK, Fasting, Macaca mulatta, Hypoglycemia, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Glucose, chemistry, biology.protein, Benzimidazoles, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2391508ed314a4efb53e289ff8766448
https://pubmed.ncbi.nlm.nih.gov/28774917

المؤلفون: Palucki Brenda, Patrick G. Pollard, Liangqin Guo, Tung M. Fong, Matthew J. Wyvratt, Randy R. Miller, Shuwen He, Constantin Tamvakopoulos, Iyassu K. Sebhat, Qianping Peng, Ravi P. Nargund, Zhixiong Ye, Airu S. Chen, Doreen E. Cashen, David H. Weinberg, Min K. Park, Raman K. Bakshi, D. Euan MacIntyre, Howard Y. Chen, Rui Tang, Tanya MacNeil, Qingmei Hong, Alison M. Strack, Ralph A. Stearns, Jian Liu, William J. Martin

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2330-2334

مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmaceutical Science, Carboxamide, Pharmacology, Biochemistry, Partial agonist, Piperazines, Rats, Sprague-Dawley, Eating, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Oral administration, In vivo, Drug Discovery, medicine, Animals, Urea, Obesity, Receptor, Molecular Biology, Organic Chemistry, Haplorhini, Rats, Disease Models, Animal, Piperazine, chemistry, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99aea0aa624d82cc9bc8f3cfa4bdb369
https://doi.org/10.1016/j.bmcl.2011.02.090

المؤلفون: Oksana C. Palyha, Terry D. Faidley, Joseph M. Metzger, Xiao-Ming Guan, Sheng-Ping Wang, Jennifer A. Kosinski, Ravi P. Nargund, Stephanie K. Spann, Marc L. Reitman, Liming Yang, Linus S. Lin, Lauren P. Shearman, Kate A. Raustad, Donald J. Marsh, Kathy Lyons, Theresa M. Kelly, Stephanie Craw, Alison M. Strack, Yanqing Kan, Hong Yu, Jasminka Dragovic, Iyassu K. Sebhat

المصدر: Journal of Pharmacology and Experimental Therapeutics. 336:356-364

مصطلحات موضوعية: Male, Agonist, medicine.medical_specialty, medicine.drug_class, Blood Pressure, Pharmacology, Energy homeostasis, Rats, Sprague-Dawley, Eating, Mice, Dogs, Heart Rate, Weight loss, Internal medicine, medicine, Animals, Receptor, Dose-Response Relationship, Drug, Chemistry, Body Weight, Imidazoles, Rats, Bombesin receptor, Mice, Inbred C57BL, Receptors, Bombesin, Dose–response relationship, Blood pressure, Endocrinology, Pyrazoles, Molecular Medicine, Bombesin Receptor Subtype-3, Anti-Obesity Agents, medicine.symptom, Energy Metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f83aba6c5ca83619726b27f1351081f
https://doi.org/10.1124/jpet.110.174763

المؤلفون: Yingjie Lai, Ralph A. Stearns, Qianping Peng, Ravi P. Nargund, Qingmei Hong, Jian Liu, Rui Tang, Matthew J. Wyvratt, Raman K. Bakshi, Randy R. Miller, Tianying Jian, Alison M. Strack, Tanya MacNeil, Liangqin Guo, Howard Y. Chen, James Dellureficio, Iyassu K. Sebhat, Peter H. Dobbelaar, Airu S. Chen, Constantin Tamvakopoulos, David H. Weinberg, Tung M. Fong, Christopher L. Franklin, Shuwen He, Zhixiong Ye

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4399-4405

مصطلحات موضوعية: Agonist, medicine.medical_specialty, Pyrrolidines, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Anti-Obesity Agents, Internal medicine, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Spiro Compounds, Obesity, Molecular Biology, Mice, Knockout, Chemistry, Body Weight, Organic Chemistry, Amides, Rats, Endocrinology, Drug development, Anorectic, Receptor, Melanocortin, Type 4, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04db1e6e6855a321002bb787613d21e
https://doi.org/10.1016/j.bmcl.2010.06.062