المؤلفون: Jérôme Loc'h, Magali Blaud, Stéphane Réty, Simon Lebaron, Patrick Deschamps, Joseph Bareille, Julie Jombart, Julien Robert-Paganin, Lila Delbos, Florian Chardon, Elodie Zhang, Clément Charenton, David Tollervey, Nicolas Leulliot

المصدر: PLoS Biology, Vol 12, Iss 5, p e1001860 (2014)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24823650/?tool=EBI; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

URL الوصول: https://doaj.org/article/b5bc28e3f7a5415191a558049d3855ae

المؤلفون: Ahmed Haouz, Simonetta Gribaldo, Pierre Simon Garcia, Najwa Taib, Pascal Röthlisberger, Pierre Alexandre Kaminski, Marion Lagune, Philippe Marliere, Jérôme Loc’h, Dona Sleiman

المساهمون: Biologie des Bactéries pathogènes à Gram-positif - Biology of Gram-Positive Pathogens, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Biologie Evolutive de la Cellule Microbienne - Evolutionary Biology of the Microbial Cell, Adaptation au stress et Métabolisme chez les entérobactéries - Stress adaptation and metabolism in enterobacteria (SAMe), Dynamique structurale des Macromolécules / Structural Dynamics of Macromolecules, Cristallographie (Plateforme) - Crystallography (Platform), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Chimie bioorganique des acides nucléiques - Bioorganic chemistry of nucleic acids, Génomique métabolique (UMR 8030), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), D.S. and P.S.G. were supported by an ERASynBio 'TNA episome' and by an ERACoBioTech 'Iron Plug’n Play' fellowship, respectively. S.G. acknowledges funding from the French National Agency for research grant Archaevol (ANR-16-CE02-0005-01). This study was funded from the French government’s Investissement d’Avenir program, Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases (grant no. ANR-10-LABX-62-IBEID)., ANR-16-CE02-0005,Arch-Evol,Approches phylogenomiques pour étudier l'origine et évolution des Archées(2016), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université d'Évry-Val-d'Essonne (UEVE)

المصدر: Science
Science, 2021, 372 (6541), pp.516-520. ⟨10.1126/science.abe6494⟩
Science, American Association for the Advancement of Science, 2021, 372 (6541), pp.516-520. ⟨10.1126/science.abe6494⟩

مصطلحات موضوعية: Purine, DNA polymerase, Guanine, Genome, Viral, Viral Nonstructural Proteins, Crystallography, X-Ray, Genome, 03 medical and health sciences, chemistry.chemical_compound, Adenylosuccinate Synthase, MESH: 2-Aminopurine, A-DNA, MESH: Adenylosuccinate Synthase, Bacteriophages, MESH: Bacteriophages, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], MESH: Phylogeny, 2-Aminopurine, Phylogeny, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Multidisciplinary, biology, ATP synthase, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], 030302 biochemistry & molecular biology, MESH: Crystallography, X-Ray, MESH: DNA, Viral, Biosynthetic Pathways, Enzyme, chemistry, Biochemistry, DNA, Viral, biology.protein, MESH: Viral Nonstructural Proteins, MESH: Biosynthetic Pathways, MESH: Genome, Viral, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8758f0aeb77cb3f97a12f3e0e04478
https://pubmed.ncbi.nlm.nih.gov/33926938

المؤلفون: Marc Delarue, Sandrine Rosario, Michael R. Lieber, Jérôme Loc’h, Christina A. Gerodimos, Mustafa Tekpinar

المساهمون: Institut Pasteur [Paris], University of Southern California (USC), Dynamique structurale des Macromolécules / Structural Dynamics of Macromolecules, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), This work was supported by the 'Fondation ARC pour la recherche sur la cancer' through a post-doctoral fellowship to J.L. MT is supported by the PAUSE program (Collège de France, IP). Work in the lab of MRL is supported by NIH, Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

المصدر: J Biol Chem
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, pp.jbc.RA119.008739. ⟨10.1074/jbc.RA119.008739⟩
Journal of Biological Chemistry, 2019, pp.jbc.RA119.008739. ⟨10.1074/jbc.RA119.008739⟩

مصطلحات موضوعية: 0301 basic medicine, DNA End-Joining Repair, DNA polymerase, DNA repair, DNA damage, Stereochemistry, Recombinant Fusion Proteins, Eukaryotic DNA replication, DNA-Directed DNA Polymerase, DNA and Chromosomes, Biochemistry, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Mice, Isomerism, DNA Nucleotidylexotransferase, Catalytic Domain, [CHIM.CRIS]Chemical Sciences/Cristallography, structural biology, Animals, DNA Breaks, Double-Stranded, Amino Acid Sequence, Molecular Biology, Polymerase, X-ray crystallography, 030102 biochemistry & molecular biology, biology, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], V(D)J recombination, Cell Biology, DNA, Protein Structure, Tertiary, 030104 developmental biology, Terminal deoxynucleotidyl transferase, chemistry, biology.protein, Sequence Alignment, non-homologous DNA end joining

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d071df0610392eb7c9f8393ac491f2
https://europepmc.org/articles/PMC6615693/

المؤلفون: Marc Delarue, Jérôme Loc’h

المساهمون: Dynamique structurale des Macromolécules / Structural Dynamics of Macromolecules, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), JL was supported by an ARC post-doctoral fellowship., Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris]

المصدر: Current Opinion in Structural Biology
Current Opinion in Structural Biology, 2018, 53, pp.22-31. ⟨10.1016/j.sbi.2018.03.019⟩
Current Opinion in Structural Biology, Elsevier, 2018, 53, pp.22-31. ⟨10.1016/j.sbi.2018.03.019⟩

مصطلحات موضوعية: 0301 basic medicine, MESH: V(D)J Recombination, DNA Repair, DNA polymerase, DNA repair, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], [SDV.BC]Life Sciences [q-bio]/Cellular Biology, DNA-Directed DNA Polymerase, MESH: DNA Nucleotidylexotransferase, 03 medical and health sciences, chemistry.chemical_compound, Structural Biology, DNA Nucleotidylexotransferase, MESH: DNA-Directed DNA Polymerase, [CHIM.CRIS]Chemical Sciences/Cristallography, Animals, Humans, MESH: Animals, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Molecular Biology, MESH: DNA Repair, MESH: Humans, DNA synthesis, biology, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Chemistry, V(D)J recombination, Synapsis, Molecular biology, V(D)J Recombination, 030104 developmental biology, MESH: DNA Repair Enzymes, DNA Repair Enzymes, biology.protein, Trans-acting, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], Recombination, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e19d14b948d910a5557cf7e372df3bf
https://pubmed.ncbi.nlm.nih.gov/29656238

المؤلفون: Sandrine Rosario, Jérôme Loc’h, Marc Delarue

المساهمون: Dynamique structurale des Macromolécules / Structural Dynamics of Macromolecules, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Structure
Structure, Elsevier (Cell Press), 2016, 24 (9), pp.1452-1463. ⟨10.1016/j.str.2016.06.014⟩
Structure, 2016, 24 (9), pp.1452-1463. ⟨10.1016/j.str.2016.06.014⟩

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Protein Conformation, alpha-Helical, MESH: V(D)J Recombination, MESH: Sequence Homology, Amino Acid, Gene Expression, Eukaryotic DNA replication, MESH: Amino Acid Sequence, DNA-Directed DNA Polymerase, MESH: Base Sequence, Crystallography, X-Ray, Substrate Specificity, MESH: Recombinant Proteins, chemistry.chemical_compound, 0302 clinical medicine, Structural Biology, MESH: DNA-Directed DNA Polymerase, Transferase, Polymerase, Nucleotides, V(D)J recombination, Synapsis, MESH: DNA, Recombinant Proteins, MESH: Protein Conformation, beta-Strand, Recombination, MESH: Models, Molecular, Protein Binding, endocrine system, MESH: Gene Expression, MESH: Sequence Alignment, Biology, MESH: DNA Nucleotidylexotransferase, 03 medical and health sciences, DNA Nucleotidylexotransferase, [CHIM.CRIS]Chemical Sciences/Cristallography, MESH: Protein Binding, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Protein Interaction Domains and Motifs, Amino Acid Sequence, double-strand-break DNA repair, Molecular Biology, X-ray crystallography, MESH: Protein Conformation, alpha-Helical, MESH: Protein Interaction Domains and Motifs, MESH: Humans, Binding Sites, Base Sequence, Sequence Homology, Amino Acid, DNA, MESH: Crystallography, X-Ray, Molecular biology, V(D)J Recombination, MESH: Nucleotides, stomatognathic diseases, 030104 developmental biology, Terminal deoxynucleotidyl transferase, chemistry, MESH: Binding Sites, biology.protein, MESH: Substrate Specificity, Protein Conformation, beta-Strand, Sequence Alignment, 030217 neurology & neurosurgery, micro-homology base pair

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25dce4551e4d792e5f10e9f943fbe26
https://pubmed.ncbi.nlm.nih.gov/27499438

المؤلفون: Clément Charenton, Elodie Zhang, Julie Jombart, Simon Lebaron, Joseph Bareille, Nicolas Leulliot, Julien Robert-Paganin, Stéphane Réty, Florian Chardon, David Tollervey, Lila Delbos, Jérôme Loc'h, Magali Blaud, Patrick Deschamps

المساهمون: Centre National de la Recherche Scientifique (CNRS), Biologie Cellulaire et Cancer, Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

المصدر: PLoS Biology, Vol 12, Iss 5, p e1001860 (2014)
PLoS Biology
PLoS Biology, Public Library of Science, 2014, 12 (5), pp.e1001860. ⟨10.1371/journal.pbio.1001860⟩

مصطلحات موضوعية: Models, Molecular, Pyrococcus abyssi, [SDV]Life Sciences [q-bio], Ribosome biogenesis, Biochemistry, Ribosome, Adenosine Triphosphate, Nucleic Acids, Gene Expression Regulation, Fungal, Biomacromolecule-Ligand Interactions, Biology (General), Enzyme Chemistry, ComputingMilieux_MISCELLANEOUS, Ribonucleoprotein, General Neuroscience, Nuclear Proteins, Ribosome Subunits, Large, Eukaryotic, Nucleoside-Triphosphatase, Recombinant Proteins, Enzymes, Adenosine Diphosphate, General Agricultural and Biological Sciences, Research Article, Ribosomal Proteins, Protein Structure, Saccharomyces cerevisiae Proteins, QH301-705.5, Molecular Sequence Data, Biophysics, Adenylate kinase, Saccharomyces cerevisiae, Biology, General Biochemistry, Genetics and Molecular Biology, Enzyme Regulation, Transferases, Ribosomal protein, Escherichia coli, RNA, Ribosomal, 18S, Humans, Amino Acid Sequence, Protein Interactions, Molecular Biology, Ribosome Subunits, Small, Eukaryotic, General Immunology and Microbiology, Eukaryotic Large Ribosomal Subunit, Adenylate Kinase, Molecular Mimicry, Biology and Life Sciences, Proteins, RNA, Chaperone Proteins, Ribosome Subunits, Enzyme Structure, Enzymology, Molecular Complexes, Sequence Alignment

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9b7234e003256d7ae67d14f2cd4b3a
https://doi.org/10.1371/journal.pbio.1001860

المؤلفون: Marc Delarue, Catherine Van Renterghem, Zaineb Fourati, Pierre-Jean Corringer, Ludovic Sauguet, Haidai Hu, Ákos Nemecz

المساهمون: Dynamique structurale des Macromolécules / Structural Dynamics of Macromolecules, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Récepteurs Canaux - Channel Receptors, Á.N. and Z.F. were supported by Agence Nationale de Recherches Grant 13-BSV8-0020 'Pentagate.' H.H. was sponsored by the China Scholarship Council and Institut Pasteur., We thank Anaïs Menny for sharing expertise on plasmid constructions, the staff of the Crystallography Platform (PF6) in the Institut Pasteur for initial crystal screens, Reinis Reinholds Ruza for help in data collection, Jérôme Loc’h for help during structural refinement and picture preparation, Stacy Gellenoncourt for help in purification and crystallization of the sTeLIC R86A mutant, the staff of synchrotron beamlines in Soleil (Orsay) and European Synchrotron Radiation Facility (Grenoble) for data collection, Pierre Legrand (Soleil synchrotron) for suggestions on refinement in Buster, and Marc Gielen for suggestions during the paper preparation, ANR-13-BSV8-0020,Pentagate,Mécanismes d'activation et de désensibilisation d'un récepteur-canal pentamérique(2013), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

المصدر: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (17), pp.E3959-E3968. ⟨10.1073/pnas.1717700115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (17), pp.E3959-E3968. ⟨10.1073/pnas.1717700115⟩

مصطلحات موضوعية: 0301 basic medicine, Gating, Crystallography, X-Ray, Divalent, 03 medical and health sciences, chemistry.chemical_compound, Allosteric Regulation, Bacterial Proteins, [CHIM.CRIS]Chemical Sciences/Cristallography, structural biology, Binding site, crystallography, Ion channel, Tetramethylammonium, chemistry.chemical_classification, Multidisciplinary, ligand-gated ion channel, druggable cavity, Hydrogen-Ion Concentration, Ligand-Gated Ion Channels, electrophysiology, Transmembrane protein, Quaternary Ammonium Compounds, 030104 developmental biology, chemistry, Structural biology, PNAS Plus, Biophysics, Ligand-gated ion channel, Gammaproteobacteria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcfb1cd8cd8b1c42c53246247271278
https://hal-pasteur.archives-ouvertes.fr/pasteur-02174579