المؤلفون: Tingting Wang, Kirstine L. Nielsen, Kim Frisch, Johan K. Lassen, Camilla B. Nielsen, Charlotte U. Andersen, Palle Villesen, Mette F. Andreasen, Jørgen B. Hasselstrøm, Mogens Johannsen

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: Gamma-hydroxybutyrate, retrospective study, metabolomics, biomaker discovery, whole blood samples, driving under the influence of drugs (DUID), Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.816376/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/6fc776acff2045f5b8faf8dbdf372247

المؤلفون: Kata W. Pedersen, Jakob Hansen, Jørgen B. Hasselstrøm, Jakob R. Jornil

المصدر: Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)

مصطلحات موضوعية: CYP1A2, CYP2D25, CYP2E1, CYP3A29, cytochrome P450, drug metabolism, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2052-1707

URL الوصول: https://doaj.org/article/582ec299dd6a4b45822c779ccfcbe8c8

المؤلفون: Johan K. Lassen, Tingting Wang, Kirstine L. Nielsen, Jørgen B. Hasselstrøm, Mogens Johannsen, Palle Villesen

المصدر: Aging Cell. 22

مصطلحات موضوعية: Aging, Cell Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bc167121940cd243e7d13b63c99520e9
https://doi.org/10.1111/acel.13813

المؤلفون: Lambert K Sørensen, Mette F Andreasen, Jakob R Jornil, Charlotte U Andersen, Jørgen B Hasselstrøm

المصدر: Sørensen, L K, Andreasen, M F, Jornil, J R, Andersen, C U & Hasselstrøm, J B 2023, ' Stability of Lisdexamfetamine in Sampled Whole Blood – Implications of Sampling Tube Additives and Storage Temperature for Interpretation of Impairment ', Journal of Analytical Toxicology, vol. 47, no. 1, pp. 33-42 . https://doi.org/10.1093/jat/bkac025

مصطلحات موضوعية: Fluorides, Chemical Health and Safety, Dextroamphetamine, Treatment Outcome, Double-Blind Method, Health, Toxicology and Mutagenesis, Temperature, Environmental Chemistry, Central Nervous System Stimulants, Lisdexamfetamine Dimesylate, Toxicology, Analytical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7b22f85e665dd651e39b83fd86d50b
https://pure.au.dk/portal/da/publications/stability-of-lisdexamfetamine-in-sampled-whole-blood--implications-of-sampling-tube-additives-and-storage-temperature-for-interpretation-of-impairment(a8f8611d-35dd-404f-9185-ea278d3e0358).html

المؤلفون: Kata W. Pedersen, Jakob Hansen, Jytte Banner, Jørgen B. Hasselstrøm, Jakob R. Jornil

المصدر: Drug Metabolism and Disposition. :DMD-AR

مصطلحات موضوعية: Pharmacology, Pharmaceutical Science

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e72c780a4f8fe03211ab87fb2de3dc68
https://doi.org/10.1124/dmd.122.001125

المؤلفون: Tingting Wang, Kirstine L. Nielsen, Kim Frisch, Johan K. Lassen, Camilla B. Nielsen, Charlotte U. Andersen, Palle Villesen, Mette F. Andreasen, Jørgen B. Hasselstrøm, Mogens Johannsen

المصدر: Wang, T, Nielsen, K L, Frisch, K, Lassen, J K, Nielsen, C B, Andersen, C U, Villesen, P, Andreasen, M F, Hasselstrøm, J B & Johannsen, M 2022, ' A Retrospective Metabolomics Analysis of Gamma-Hydroxybutyrate in Humans : New Potential Markers and Changes in Metabolism Related to GHB Consumption ', Frontiers in Pharmacology, vol. 13, 816376 . https://doi.org/10.3389/fphar.2022.816376

مصطلحات موضوعية: Pharmacology, Gamma-hydroxybutyrate, retrospective study, whole blood samples, Pharmacology (medical), UPLC-QTOF analysis, metabolomics, driving under the influence of drugs (DUID), drug metabolism, biomaker discovery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb498f451b5863a843a1d00777e96985
https://pure.au.dk/portal/da/publications/a-retrospective-metabolomics-analysis-of-gammahydroxybutyrate-in-humans(c7b319ca-23da-4e65-86ce-1e3c9f191771).html

المؤلفون: Asger Granfeldt, Lars W. Andersen, Mikael F. Vallentin, Ole Hilberg, Jørgen B. Hasselstrøm, Lambert K. Sørensen, Susie Mogensen, Steffen Christensen, Anders M. Grejs, Bodil S. Rasmussen, Klaus T. Kristiansen, Thomas Strøm, Isik S. Johansen, Olav L. Schjørring, Ulf Simonsen

المصدر: Granfeldt, A, Andersen, L W, Vallentin, M F, Hilberg, O, Hasselstrøm, J B, Sørensen, L K, Mogensen, S, Christensen, S, Grejs, A M, Rasmussen, B S, Kristiansen, K T, Strøm, T, Johansen, I S, Schjørring, O L & Simonsen, U 2022, ' Senicapoc treatment in COVID-19 Patients with Severe Respiratory Insufficiency-A Randomized, Open-Label, Phase II Trial ', Acta Anaesthesiologica Scandinavica, vol. 66, no. 7, pp. 838-846 . https://doi.org/10.1111/aas.14072
Granfeldt, A, Andersen, L W, Fink Vallentin, M, Hilberg, O, Hasselstrøm, J B, Sørensen, L K, Mogensen, S, Christensen, S, Grejs, A M, Rasmussen, B S, Kristiansen, K T, Strøm, T, Johansen, I S, Schjørring, O L & Simonsen, U 2022, ' Senicapoc treatment in COVID-19 patients with severe respiratory insufficiency : A randomized, open-label, phase II trial ', Acta Anaesthesiologica Scandinavica, vol. 66, no. 7, pp. 838-846 . https://doi.org/10.1111/aas.14072
Granfeldt, A, Andersen, L W, Vallentin, M F, Hilberg, O, Hasselstrøm, J B, Sørensen, L K, Mogensen, S, Christensen, S, Grejs, A M, Rasmussen, B S, Kristiansen, K T, Strøm, T, Johansen, I S, Schjørring, O L & Simonsen, U 2022, ' Senicapoc treatment in COVID-19 patients with severe respiratory insufficiency — A randomized, open-label, phase II trial ', Acta Anaesthesiologica Scandinavica, vol. 66, no. 7, pp. 838-846 . https://doi.org/10.1111/aas.14072

مصطلحات موضوعية: Adult, Adolescent, SARS-CoV-2, Senicapoc, COVID-19, Trityl Compounds, General Medicine, Respiration, Artificial, Respiratory Insufficiency/therapy, Anesthesiology and Pain Medicine, respiratory insufficiency, Acetamides, Humans, ARDS, Respiratory Insufficiency

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d49b3edf95f03deea6619f8d8ac46ea
https://pubmed.ncbi.nlm.nih.gov/35403225

المؤلفون: Jørgen B. Hasselstrøm, Jakob Hansen, Kata Wolff Pedersen, Jakob Ross Jornil

المصدر: Pedersen, K W, Hansen, J, Hasselstrøm, J B & Jornil, J R 2021, ' Stability investigations of cytochrome P450 (CYP) enzymes immediately after death in a pig model support the applicability of postmortem hepatic CYP quantification ', Pharmacology research & perspectives, vol. 9, no. 5, e00860 . https://doi.org/10.1002/prp2.860
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)

مصطلحات موضوعية: PBPK, Time Factors, Swine, cytochrome P450, Sus scrofa, CYP1A2, RM1-950, Postmortem Changes, Cytochrome P-450 Enzyme System, Pharmacokinetics, Tandem Mass Spectrometry, CYP3A29, Animals, CYP2E1, General Pharmacology, Toxicology and Pharmaceutics, chemistry.chemical_classification, postmortem, biology, Protein Stability, Chemistry, Cytochrome P450, Original Articles, Molecular biology, Enzyme assay, drug metabolism, enzyme, Enzyme, Liver, Neurology, CYP2D25, biology.protein, Original Article, Therapeutics. Pharmacology, Drug metabolism, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d156ea1999e6adfca59abe5993ee73d
https://pure.au.dk/portal/da/publications/stability-investigations-of-cytochrome-p450-cyp-enzymes-immediately-after-death-in-a-pig-model-support-the-applicability-of-postmortem-hepatic-cyp-quantification(22643fa9-318e-40e4-946a-edb9ac17edca).html

المؤلفون: Frank Noé, Heike Hofmann-Winkler, Joan C. Smith, Katsura Yamatsuta, Ole S. Søgaard, Lluís Raich, Hirotaka Mizuno, Simon Olsson, Lambert K. Sørensen, Olga Danov, Takashi Yamazoe, Stephan Ludwig, Jason M. Sheltzer, Jørgen B. Hasselstrøm, Michael Winkler, Armin Braun, Danny Jonigk, Tim Hempel, Stefan Pöhlmann, Markus Hoffmann, Mads Kjolby, Nadine Krüger, Prerna Arora

المساهمون: Publica

المصدر: EBioMedicine
bioRxiv
article-version (status) pre
article-version (number) 1
Hoffmann, M, Hofmann-Winkler, H, Smith, J C, Krüger, N, Arora, P, Sørensen, L K, Søgaard, O S, Hasselstrøm, J B, Winkler, M, Hempel, T, Raich, L, Olsson, S, Danov, O, Jonigk, D, Yamazoe, T, Yamatsuta, K, Mizuno, H, Ludwig, S, Noé, F, Kjolby, M, Braun, A, Sheltzer, J M & Pöhlmann, S 2021, ' Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity ', EBioMedicine, vol. 65, 103255 . https://doi.org/10.1016/j.ebiom.2021.103255

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Metabolite, Pharmacology, Guanidines, law.invention, chemistry.chemical_compound, 0302 clinical medicine, Camostat, law, Cricetinae, Chlorocebus aethiops, FOY-251, Lung, Serine Endopeptidases, Esters, General Medicine, 030220 oncology & carcinogenesis, Recombinant DNA, Research Paper, Proteases, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Molecular Dynamics Simulation, Antiviral Agents, TMPRSS2, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, 03 medical and health sciences, Viral entry, medicine, Animals, Humans, Protease Inhibitors, Protease inhibitor (pharmacology), Vero Cells, Protease, SARS-CoV-2, fungi, GBPA, Membrane Proteins, 500 Naturwissenschaften und Mathematik::570 Biowissenschaften, Biologie::570 Biowissenschaften, Biologie, Virus Internalization, COVID-19 Drug Treatment, HEK293 Cells, 030104 developmental biology, chemistry, Cell culture, Virus Activation, Serine Proteases, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c912b34a71338cc57ee5fcf28cf375e
http://europepmc.org/articles/PMC7930809

المؤلفون: Mads Kjolby, Jørgen B. Hasselstrøm, Lambert K. Sørensen, Jesper Damsgaard Gunst, Ole S. Søgaard

المصدر: Sørensen, L K, Hasselstrøm, J B, Gunst, J D, Søgaard, O S & Kjolby, M 2021, ' Determination of camostat and its metabolites in human plasma – Preservation of samples and quantification by a validated UHPLC-MS/MS method ', Clinical Biochemistry . https://doi.org/10.1016/j.clinbiochem.2021.07.007
Sørensen, L K, Hasselstrøm, J B, Damsgaard Gunst, J, Søgaard, O S & Kjolby, M 2021, ' Determination of camostat and its metabolites in human plasma – Preservation of samples and quantification by a validated UHPLC-MS/ MS method ', Clinical Biochemistry, vol. 96, pp. 56-62 . https://doi.org/10.1016/j.clinbiochem.2021.07.007

مصطلحات موضوعية: Camostat, Isoflurophate, Clinical Biochemistry, Phenylacetic acid, Mass spectrometry, Guanidines, Paraoxon, chemistry.chemical_compound, Hydrolysis, Tandem Mass Spectrometry, medicine, FOY-251, Humans, LC-MS/MS, Enzyme Inhibitors, Chromatography, High Pressure Liquid, Whole blood, Reproducibility, Blood Specimen Collection, Chromatography, FOY-305, SARS-CoV-2, GBPA, Esterases, COVID-19, Reproducibility of Results, Esterase inhibitors, Esters, General Medicine, COVID-19 Drug Treatment, chemistry, GBA, Esterase inhibitor, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddb28762eac949e8fc1a0fb9c6348fe
https://pubmed.ncbi.nlm.nih.gov/34252447