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المؤلفون: Timothy A. Springer, Hans Deckmyn, Joshua Muia, Louis Deforche, Elien Roose, J E Sadler, Nele Vandeputte, K. Soejima, Karen Vanhoorelbeke, Li-Zhi Mi, Aline Vandenbulcke, S. F. De Meyer, Hanspeter Rottensteiner, Hendrik B. Feys
المصدر: Journal of Thrombosis and Haemostasis. 13:2063-2075
مصطلحات موضوعية: Protein Folding, Protein Conformation, Molecular Sequence Data, ADAMTS13 Protein, Sequence alignment, Plasma protein binding, Biology, Article, Catalysis, Epitope, Antigen-Antibody Reactions, Thrombospondin 1, Epitopes, Protein structure, Allosteric Regulation, Consensus Sequence, von Willebrand Factor, Humans, Amino Acid Sequence, Sequence Homology, Amino Acid, Ligand binding assay, Antibodies, Monoclonal, Hematology, ADAM Proteins, Molecular biology, Protein Structure, Tertiary, Enzyme Activation, Microscopy, Electron, Biophysics, Protein folding, Protein Processing, Post-Translational, Sequence Alignment, Linker, Allosteric Site, Protein Binding
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المؤلفون: J E Sadler, Tobias Obser, Sonja Schneppenheim, Reinhard Schneppenheim, Florian Oyen, U. Budde, M. Ledford-Kraemer, Rolf Marschalek, Cécile V. Denis, Maria A. Brehm, Robert R. Montgomery
مصطلحات موضوعية: 0301 basic medicine, Adult, Male, congenital, hereditary, and neonatal diseases and abnormalities, Genotype, Mutant, Genes, Recessive, von Willebrand Disease, Type 2, 030204 cardiovascular system & hematology, medicine.disease_cause, Endoplasmic Reticulum, Article, 03 medical and health sciences, Exon, Mice, 0302 clinical medicine, Von Willebrand factor, hemic and lymphatic diseases, von Willebrand Factor, medicine, Von Willebrand disease, Animals, Humans, Deamino Arginine Vasopressin, Protein precursor, Aged, Genes, Dominant, Mutation, biology, Chemistry, Hematology, Middle Aged, medicine.disease, Phenotype, Molecular biology, ADAMTS13, Recombinant Proteins, Mice, Inbred C57BL, 030104 developmental biology, cardiovascular system, biology.protein, Female, circulatory and respiratory physiology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2196a9d1a4989eea0348e64644f4e776
https://europepmc.org/articles/PMC5035592/ -
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المصدر: Journal of Thrombosis and Haemostasis. 7:2088-2095
مصطلحات موضوعية: Protein Denaturation, congenital, hereditary, and neonatal diseases and abnormalities, Immunoprecipitation, Von Willebrand factor type A domain, Blotting, Western, ADAMTS13 Protein, Plasma protein binding, Article, Von Willebrand factor, hemic and lymphatic diseases, von Willebrand Factor, Humans, Binding site, Hemostasis, Binding Sites, biology, Chemistry, ADAMTS, Active site, Thrombosis, Hematology, Molecular biology, ADAM Proteins, Glycoprotein Ib, Multiprotein Complexes, Blood Circulation, cardiovascular system, biology.protein, Stress, Mechanical, Protein Binding, circulatory and respiratory physiology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05eaf70ed501bace81c5715a561ab512
https://doi.org/10.1111/j .1538-7836.2009.03620.x -
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المؤلفون: J E Sadler
المصدر: Journal of Thrombosis and Haemostasis. 7:24-27
مصطلحات موضوعية: Von Willebrand factor type C domain, biology, Protein Conformation, Chemistry, Endoplasmic reticulum, Hematology, Hydrogen-Ion Concentration, Golgi apparatus, Protein Transport, symbols.namesake, Protein structure, Von Willebrand factor, Biochemistry, hemic and lymphatic diseases, von Willebrand Factor, symbols, Extracellular, biology.protein, Weibel–Palade body, Biophysics, Humans, Secretion, Disulfides, Protein Multimerization
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579c53b983ef9fb7f5bf513a4f8211a1
https://doi.org/10.1111/j .1538-7836.2009.03375.x -
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المؤلفون: Lars Holmberg, J E Sadler, A. Srivastava, Christine A. Lee, Ian R. Peake, M. Nishino, Emmanuel J. Favaloro, Augusto B. Federici, Dominique Meyer, U. Budde, P. M. Mannucci, F. Rodeghiero, Zaverio M. Ruggeri, Jørgen Ingerslev, Jeroen Eikenboom, Reinhard Schneppenheim, Frank Hill, Robert R. Montgomery, David Lillicrap, William L. Nichols, Claudine Mazurier
المصدر: Journal of Thrombosis and Haemostasis. 4:2103-2114
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, ADAMTS13 Protein, Review, Gene mutation, Platelet membrane glycoprotein, Models, Biological, Von Willebrand factor, hemic and lymphatic diseases, Internal medicine, von Willebrand Factor, Von Willebrand disease, Humans, Medicine, Clinical significance, Vwf multimers, biology, business.industry, Hematology, medicine.disease, Phenotype, Pathophysiology, Protein Structure, Tertiary, ADAM Proteins, von Willebrand Diseases, Endocrinology, Immunology, biology.protein, business, circulatory and respiratory physiology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5891803e5da91c825bd131b286b8f4d
https://doi.org/10.1111/j .1538-7836.2006.02146.x -
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المؤلفون: John Richardson, Pablo Fuentes-Prior, Robert Huber, Wolfram Bode, J E Sadler
المصدر: Biochemistry. 41:2535-2542
مصطلحات موضوعية: Models, Molecular, Invertebrate Hormones, Protein Conformation, Stereochemistry, Binding energy, Ionic bonding, Crystallography, X-Ray, Biochemistry, Serine, Thrombin, Leeches, medicine, Animals, Humans, Molecule, Amino Acid Sequence, biology, Chemistry, Osmolar Concentration, Active site, Ionic strength, biology.protein, Diisopropyl fluorophosphate, Protein Binding, medicine.drug
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المؤلفون: J E Sadler, P Ganguly, Joel L. Moake, P. M. Mannucci
المصدر: American Journal of Hematology. 68:122-126
مصطلحات موضوعية: medicine.medical_specialty, biology, Von Willebrand factor type A domain, Chemistry, Integrin, Thrombotic thrombocytopenic purpura, Hematology, medicine.disease, Fibrinogen, Molecular biology, Endocrinology, Von Willebrand factor, hemic and lymphatic diseases, Internal medicine, medicine, biology.protein, Platelet, Binding site, Peptide sequence, medicine.drug
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المؤلفون: Alexander Tulinsky, Raman Krishnan, J E Sadler
المصدر: Acta Crystallographica Section D Biological Crystallography. 56:406-410
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, Proteolysis, Mutant, Crystallography, X-Ray, Cleavage (embryo), Catalysis, Thrombin, Structural Biology, Hydrolase, Serine, medicine, Humans, Point Mutation, Peptide bond, Fibrinopeptide A, Alanine, Binding Sites, biology, medicine.diagnostic_test, Chemistry, Active site, General Medicine, Hirudins, Peptide Fragments, Amino Acid Substitution, biology.protein, Software, medicine.drug
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المؤلفون: U. Budde, Francesco Rodeghiero, Paolo Bucciarelli, Hiroshi Mohri, Jacob H. Rand, P. J. J. Van Genderen, Augusto B. Federici, J E Sadler, Dominique Meyer
المصدر: Thrombosis and Haemostasis. 84:345-349
مصطلحات موضوعية: Bleeding episodes, Pediatrics, medicine.medical_specialty, business.industry, medicine.medical_treatment, Mucocutaneous zone, Hematology, Guideline, medicine.disease, Thrombosis, Surgery, Acquired von Willebrand syndrome, Coagulopathy, medicine, Plasmapheresis, business, Blood coagulation test
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::efe11dd89a73fcf70ddd824d7c7204cc
https://doi.org/10.1055/s-0037-1614018 -
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المؤلفون: Xinglong Zheng, Sergey Korolev, Deshun Lu, J E Sadler, Gabriel Waksman, Klaus Fütterer, Kai Tan
المصدر: Journal of Molecular Biology. 292:361-373
مصطلحات موضوعية: Serine protease, Enteropeptidase, Proteases, biology, Chemistry, Trypsinogen, Serine, chemistry.chemical_compound, Protein structure, Biochemistry, Structural Biology, biology.protein, Binding site, Trypsinogen activation, Molecular Biology