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المؤلفون: Chuanchuan Li, Britta Weigelt, Mark Li, Elisa de Stanchina, Yonina R. Murciano-Goroff, Kanika Arora, Lee P. Lim, Jorge S. Reis-Filho, Jenny Y. Xue, Dongsung Kim, Rohan S. Roy, Yulei Zhao, Michael F. Berger, Amber Bahr, Ann E. Sisk, Brian Loomis, Deanna Mohn, Pragathi Achanta, Trang Thi Mai, Agnes Ang, Bob T. Li, Arnaud Da Cruz Paula, Gregory J. Riely, Kathryn C. Arbour, Jessica Lucas, Piro Lito, J. Russell Lipford, Anne Y. Saiki
المصدر: Nature
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, MAPK/ERK pathway, Neuroblastoma RAS viral oncogene homolog, Acetonitriles, Lineage (genetic), endocrine system diseases, MAP Kinase Signaling System, Pyridines, Mutant, Antineoplastic Agents, Biology, medicine.disease_cause, Article, Piperazines, Cell Line, GTP Phosphohydrolases, Cohort Studies, Proto-Oncogene Proteins p21(ras), Mice, Carcinoma, Non-Small-Cell Lung, Neoplasms, medicine, Animals, Humans, Extracellular Signal-Regulated MAP Kinases, neoplasms, Gene, Allele frequency, Multidisciplinary, Membrane Proteins, Cancer, medicine.disease, Xenograft Model Antitumor Assays, digestive system diseases, Pyrimidines, Drug Resistance, Neoplasm, Mutation, Cancer research, Female, KRAS
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المؤلفون: Chendi Li, Mohammed Usman Syed, Yi Shen, Cameron Fraser, Jian Ouyang, Johannes Kreuzer, Sarah E. Clark, Audris Oh, Makeba Walcott, Robert Morris, Christopher Nabel, Sean Caenepeel, Anne Y. Saiki, Karen Rex, J. Russell Lipford, Rebecca S. Heist, Jessica J. Lin, Wilhelm Haas, Kristopher Sarosiek, Paul E. Hughes, Aaron N. Hata
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::35abba6c3c548a2ab22035c3c220edca
https://doi.org/10.1101/2022.09.29.510137 -
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المؤلفون: Deanna Mohn, Anne Y. Saiki, Pragathi Achanta, Andres Plata Stapper, J. Russell Lipford, Rati Verma
المصدر: Cancer Research. 83:3871-3871
مصطلحات موضوعية: Cancer Research, Oncology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::32ba637418e68f35d15a8d683d0b1751
https://doi.org/10.1158/1538-7445.am2023-3871 -
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المؤلفون: Brian A. Lanman, Jennifer R. Allen, John G. Allen, Albert K. Amegadzie, Kate S. Ashton, Shon K. Booker, Jian Jeffrey Chen, Ning Chen, Michael J. Frohn, Guy Goodman, David J. Kopecky, Longbin Liu, Patricia Lopez, Jonathan D. Low, Vu Ma, Ana E. Minatti, Thomas T. Nguyen, Nobuko Nishimura, Alexander J. Pickrell, Anthony B. Reed, Youngsook Shin, Aaron C. Siegmund, Nuria A. Tamayo, Christopher M. Tegley, Mary C. Walton, Hui-Ling Wang, Ryan P. Wurz, May Xue, Kevin C. Yang, Pragathi Achanta, Michael D. Bartberger, Jude Canon, L. Steven Hollis, John D. McCarter, Christopher Mohr, Karen Rex, Anne Y. Saiki, Tisha San Miguel, Laurie P. Volak, Kevin H. Wang, Douglas A. Whittington, Stephan G. Zech, J. Russell Lipford, Victor J. Cee
المصدر: Journal of Medicinal Chemistry. 63:52-65
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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المؤلفون: Timothy J. Price, Victor J. Cee, Tisha San Miguel, Gerald Steven Falchook, Jonathan Werner, Christopher Mohr, Tao Osgood, James Kuo, Kevin Gaida, Xiaochun Zhu, Karen Rex, John D. McCarter, Brian A. Lanman, H. Henary, Roberto Ortiz, Ramaswamy Govindan, Tara Arvedson, Laurie P. Volak, Wenjun Ouyang, J. Russell Lipford, Tyler Holt, Charles G. Knutson, Neelima Koppada, David S. Hong, Aaron S. Rapaport, Anne Y. Saiki, Bert H. O'Neil, Jude Canon, Ji Rong Sun, Marwan Fakih, Brett E. Houk, Dhanashri Bagal, Keegan Cooke, Jayesh Desai
المصدر: Nature. 575:217-223
مصطلحات موضوعية: 0301 basic medicine, Chemotherapy, Multidisciplinary, Oncogene, business.industry, medicine.medical_treatment, Cancer, medicine.disease_cause, medicine.disease, Acquired immune system, Clinical trial, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Antigen, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Medicine, KRAS, business
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المؤلفون: Chendi Li, Mohammed Usman Syed, Yi Shen, Audris Oh, Cameron Fraser, Johannes Kreuzer, Christopher Nabel, Kaitlyn Webster, Robert Morris, Sean Caenepeel, Anne Y. Saiki, Karen Rex, J. Russell Lipford, Wilhelm Hass, Kristopher Sarosiek, Paul E. Hughes, Aaron Hata
المصدر: Cancer Research. 82:2150-2150
مصطلحات موضوعية: Cancer Research, Oncology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::396ab81c0e697fd68b7626f837451b27
https://doi.org/10.1158/1538-7445.am2022-2150 -
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المؤلفون: Jonathan A, Werner, Rhian, Davies, Jan, Wahlstrom, Upendra P, Dahal, Min, Jiang, Jonathan, Stauber, Benjamin, David, William, Siska, Barbara, Thomas, Katsu, Ishida, W Griffith, Humphreys, J Russell, Lipford, Thomas M, Monticello
المصدر: Toxicology and applied pharmacology. 423
مصطلحات موضوعية: Male, Proto-Oncogene Proteins p21(ras), Rats, Sprague-Dawley, Pyrimidines, Dose-Response Relationship, Drug, Pyridines, Animals, Acute Kidney Injury, Piperazines, Acetylcysteine, Rats, Signal Transduction
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المؤلفون: Hui-Ling Wang, Kristin L. Andrews, Shon K. Booker, Jude Canon, Victor J. Cee, Frank Chavez, Yuping Chen, Heather Eastwood, Nadia Guerrero, Brad Herberich, Dean Hickman, Brian A. Lanman, Jimmy Laszlo, Matthew R. Lee, J. Russell Lipford, Bethany Mattson, Christopher Mohr, Yen Nguyen, Mark H. Norman, Liping H. Pettus, David Powers, Anthony B. Reed, Karen Rex, Christine Sastri, Nuria Tamayo, Paul Wang, Jeffrey T. Winston, Bin Wu, Qiong Wu, Tian Wu, Ryan P. Wurz, Yang Xu, Yihong Zhou, Andrew S. Tasker
المصدر: Journal of Medicinal Chemistry. 62:1523-1540
مصطلحات موضوعية: Molecular Structure, Swine, Antineoplastic Agents, Mice, SCID, Xenograft Model Antitumor Assays, Structure-Activity Relationship, Proto-Oncogene Proteins c-pim-1, Hematologic Neoplasms, Drug Discovery, Animals, Humans, Molecular Medicine, Female, Pyrroles, Protein Kinase Inhibitors, Quinazolinones
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المؤلفون: H. Henary, John C. Krauss, Timothy J. Price, Geoffrey I. Shapiro, Marwan Fakih, Timothy F. Burns, Jayesh Desai, Crystal S. Denlinger, John H. Strickler, Keunchil Park, Brett E. Houk, Funda Meric-Bernstam, Ramaswamy Govindan, J. Russell Lipford, Fabrice Barlesi, Andrew L. Coveler, James Kuo, Gregory Friberg, Adrian G. Sacher, Tae Won Kim, Pamela N. Munster, Gataree Ngarmchamnanrith, J. Kim, Jude Canon, David S. Hong, Gerald S. Falchook, Piro Lito, Yung-Jue Bang, Bob T. Li, Yasutoshi Kuboki, J. Ngang, G. Durm, Grace K. Dy, Suresh S. Ramalingam
المصدر: N Engl J Med
مصطلحات موضوعية: Male, Lung Neoplasms, endocrine system diseases, Pyridines, Antineoplastic Agents, 030204 cardiovascular system & hematology, medicine.disease_cause, Article, Piperazines, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Neoplasms, medicine, Carcinoma, Humans, 030212 general & internal medicine, neoplasms, Aged, Mutation, Lung, Dose-Response Relationship, Drug, business.industry, Extramural, Cancer, General Medicine, Middle Aged, medicine.disease, digestive system diseases, respiratory tract diseases, medicine.anatomical_structure, Pyrimidines, Multicenter study, Cancer research, Female, KRAS, business, Colorectal Neoplasms
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المؤلفون: Victor J. Cee, Alla Verlinsky, Anne Y. Saiki, Brian A. Lanman, Marwan Fakih, J. Russell Lipford, Tyler Holt, Patricia McElroy, Karen Rex, Ji-Rong Sun, Jude Canon, Tao Osgood, Upendra P. Dahal, Bernd Bruenner
المصدر: Cancer Research. 81:1057-1057
مصطلحات موضوعية: Antitumor activity, Cancer Research, Oncology, business.industry, Cancer research, Medicine, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d5c9f0f3c8af7ada5b1b3be311e47e2a
https://doi.org/10.1158/1538-7445.am2021-1057
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