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المؤلفون: Tianyuan Zhang, Richard A. G. Smith, Rohinton Edalji, Yu-Gui Gu, John L. Baranowski, William J. Sanders, Bruce A. Beutel, Liping Yu, Philip J. Hajduk, Annapur Gurulingappa Shivakumar, Stephan J. Kakavas, Frank L. Wagenaar, Darlene J. Balli, Steven F. Betz, Richard F. Clark, Kenneth M. Comess, Eric J. Hebert, J. Owen McCall, Jamey Mack, Linda E. Chovan, Randy E. Metzger, Thomas F. Holzman, Anne Y. Saiki, Sarah A. Dorwin, Niru B. Soni, Mai Bui, Angela M. Nilius, Susan J. Thornewell, Cooper Curt S, Mark E. Schurdak, Michael L. Coen, Rolf Wagner, Alan S. Florjancic, Philip J. Merta, Claude G. Lerner, Charlotte Woodall, Candace Black-Schaefer, John E. Harlan, Mengli Cai, Karl A. Walter, Xenia B. Searle, Stephen W. Fesik
المصدر: Chemical Biology & Drug Design. 69:395-404
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Chemistry, Pharmaceutical, Molecular Sequence Data, Plasma protein binding, Bacterial genome size, medicine.disease_cause, Biochemistry, Mass Spectrometry, Microbiology, Haemophilus influenzae, Structure-Activity Relationship, Bacterial Proteins, Drug Discovery, medicine, Animals, Amino Acid Sequence, Adenosine Triphosphatases, Pharmacology, B-Lymphocytes, biology, Drug discovery, Organic Chemistry, Genomics, biology.organism_classification, Anti-Bacterial Agents, Mechanism of action, Essential gene, Drug Design, Molecular Medicine, medicine.symptom, Antibacterial activity, Genome, Bacterial, Bacteria, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5518c2506c2d9a00a67d68a32abac6
https://doi.org/10.1111/j .1747-0285.2007.00521.x -
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المؤلفون: Stephen F. Betz, Kevin Ronald Condroski, John E. Harlan, Bruce A. Beutel, Jean M. Severin, Sean M. Merrick, Vicki L. Nienaber, Susan J. Swanson, Rolf Wagner, Vincent S. Stoll, Karl A. Walter, J. Owen McCall, Peter Magdalinos, Claude G. Lerner, William J. Sanders, Geoffrey F. Stamper, Clarissa G. Jakob, Robert P. Meadows
المصدر: Journal of Medicinal Chemistry. 47:1709-1718
مصطلحات موضوعية: Models, Molecular, Guanine, Databases, Factual, Molecular model, Stereochemistry, Dihydroneopterin aldolase, Crystallography, X-Ray, Benzoates, Neopterin, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Enzyme Inhibitors, Aldehyde-Lyases, chemistry.chemical_classification, Binding Sites, Molecular Structure, biology, Chemistry, Aldolase A, Active site, Triazoles, Lyase, Crystallography, Pyrimidines, Enzyme, Purines, Enzyme inhibitor, biology.protein, Molecular Medicine
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المؤلفون: Katrin E. Rhodes, Patrick A. Marcotte, Yujia Dai, Eric F. Johnson, Jun Guo, Michael R. Michaelides, Saul J. Priceman, Lori J. Pease, Niru B. Soni, Theodore B. Moore, Jenny Chang, Kathleen M. Sakamoto, Steven K. Davidsen, Ru-Qi Wei, Keith B. Glaser, Deepa B. Shankar, Jennifer J. Bouska, Junling Li, Paul Tapang, Daniel H. Albert, Neil P. Shah, Kresna Hartandi, J. Owen McCall, Donald J. Osterling
مصطلحات موضوعية: Indazoles, Myeloid, Immunology, Apoptosis, Biology, Resting Phase, Cell Cycle, Biochemistry, Mice, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, STAT5 Transcription Factor, medicine, Animals, Humans, Phosphorylation, Kinase activity, Extracellular Signal-Regulated MAP Kinases, Protein Kinase Inhibitors, Tumor Stem Cell Assay, Cell Proliferation, Dose-Response Relationship, Drug, Neoplasia, Phenylurea Compounds, G1 Phase, Myeloid leukemia, U937 Cells, Cell Biology, Hematology, Hematopoietic Stem Cells, medicine.disease, Molecular biology, Leukemia, Myeloid, Acute, Leukemia, Ki-67 Antigen, medicine.anatomical_structure, fms-Like Tyrosine Kinase 3, Fms-Like Tyrosine Kinase 3, Cancer research, K562 Cells, Protein Processing, Post-Translational, Tyrosine kinase, K562 cells
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c83ec4de1219dc2e704f8d60cb6299
https://resolver.caltech.edu/CaltechAUTHORS:20100219-111915402 -
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المؤلفون: Mark E. Schurdak, Lan Gao, Claude G. Lerner, Houjun Yang, Jonathan D. Trumbull, Hua Tang, David J. Burns, Xueheng Cheng, Bruce A. Beutel, J. Owen McCall, Michael L. Coen, Kenneth M. Comess, Martin J. Voorbach
المصدر: Journal of biomolecular screening. 11(7)
مصطلحات موضوعية: chemistry.chemical_classification, Drug Evaluation, Preclinical, Microbial Sensitivity Tests, Biology, Ligand (biochemistry), Biochemistry, Bacterial cell structure, Mass Spectrometry, Analytical Chemistry, Organic molecules, Anti-Bacterial Agents, chemistry.chemical_compound, Enzyme, Streptococcus pneumoniae, chemistry, Biosynthesis, Cell wall biosynthesis, Cell Wall, Screening method, Molecular Medicine, Peptide Synthases, Protein target, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bb69a48eb3022e567651e240c43c5e
https://pubmed.ncbi.nlm.nih.gov/16973923 -
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المؤلفون: Nayereh S. Ghoreishi-Haack, Junling Li, Baole Wang, J. Owen McCall, Steven K. Davidsen, Lori J. Pease, Paul Tapang, Daniel H. Albert, Yi-Chun Wang, Nirupama B. Soni, Peter F. Bousquet, Amanda Niquette, David R. Reuter, Cherrie K. Donawho, Patrick A. Marcotte, Yanping Luo, Kresna Hartandi, Eric F. Johnson, Gail Bukofzer, Jason Stavropoulos, Jun Guo, Michael R. Michaelides, Jennifer J. Bouska, Terrance J. Magoc, Ru-Qi Wei, Keith B. Glaser, Yujia Dai
المصدر: Molecular cancer therapeutics. 5(4)
مصطلحات موضوعية: Cancer Research, Indazoles, medicine.medical_treatment, Neovascularization, Physiologic, Biology, Pharmacology, Receptor tyrosine kinase, Cornea, chemistry.chemical_compound, Mice, medicine, Animals, Edema, Receptors, Platelet-Derived Growth Factor, Enzyme Inhibitors, Phosphorylation, Kinase, Growth factor, Phenylurea Compounds, Cell Cycle, Uterus, Receptor Protein-Tyrosine Kinases, Retinal Vessels, 3T3 Cells, Vascular endothelial growth factor, Linifanib, Receptors, Vascular Endothelial Growth Factor, Oncology, chemistry, Epidermoid carcinoma, biology.protein, Female, Tyrosine kinase, Platelet-derived growth factor receptor, Cell Division
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb38d2236e55542477a01ad526a84c9a
https://pubmed.ncbi.nlm.nih.gov/16648571 -
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المؤلفون: J. Owen McCall, Bruce A. Beutel, Philip J. Hajduk, Geoffrey F. Stamper, Richard F. Clark, Yingna Cia, Kenton L. Longenecker, Elizabeth H. Fry, Candace Black-Schaefer, Clarissa G. Jakob, Cooper Curt S, Alan S. Florjancic, Claude G. Lerner, Vincent S. Stoll, Yu-Gui Gu, David D. Anderson, Tianyuan Zhang
المصدر: Chemical biologydrug design. 67(1)
مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Models, Molecular, Sulfonamides, Magnetic Resonance Spectroscopy, Chemistry, Organic Chemistry, Crystallography, X-Ray, Ligands, Biochemistry, Cocrystal, Bacterial cell structure, Substrate Specificity, Inhibitory Concentration 50, Structure-Activity Relationship, Enzyme, Drug Discovery, Molecular Medicine, Structure based, Enzyme Inhibitors, Peptide Synthases, Crystallization, Function (biology)
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المؤلفون: J. Owen McCall, Claude G. Lerner, Tianyuan Zhang, Cooper Curt S, Richard F. Clark, Geoffrey F. Stamper, Yingna Cai, Candace Black-Schaefer, David D. Anderson, Philip J. Hajduk, Yu Gui Gu, Alan S. Florjancic, Bruce A. Beutel
المصدر: Bioorganicmedicinal chemistry letters. 14(1)
مصطلحات موضوعية: Chemistry, Organic Chemistry, Clinical Biochemistry, Sulfonamide (medicine), Pharmaceutical Science, Peptidoglycan, Biochemistry, Chemical synthesis, In vitro, chemistry.chemical_compound, Structure-Activity Relationship, Biosynthesis, Bacterial Proteins, Drug Discovery, medicine, Molecular Medicine, Enzyme Inhibitors, Peptide Synthases, Antibacterial activity, Molecular Biology, medicine.drug
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المؤلفون: J. Owen McCall, Leonard Katz, Sunil Kadam
المصدر: Bio/Technology (Nature Publishing Company)
مصطلحات موضوعية: Tetracycline, medicine.medical_treatment, Recombinant Fusion Proteins, Molecular Sequence Data, Gene Expression, Biology, medicine.disease_cause, Antiporters, Article, law.invention, Viral Proteins, Plasmid, Bacterial Proteins, law, Gene expression, medicine, Escherichia coli, Protease Inhibitors, Amino Acid Sequence, chemistry.chemical_classification, Protease, Autoanalysis, 3C Viral Proteases, Tetracycline Resistance, Molecular biology, Arabinose, Citrinin, Cysteine Endopeptidases, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Pyrones, Recombinant DNA, biology.protein, Oligopeptides, Biotechnology, medicine.drug, Naphthoquinones, Plasmids
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المصدر: Moleculargeneral genetics : MGG. 185(1)
مصطلحات موضوعية: DNA damage, Ultraviolet Rays, Mutant, Repressor, Biology, medicine.disease_cause, law.invention, Bacterial Proteins, law, Transduction, Genetic, Genetics, medicine, Escherichia coli, Molecular Biology, Gene, Prophage, Recombination, Genetic, Temperature, biochemical phenomena, metabolism, and nutrition, Molecular biology, Bacteriophage lambda, enzymes and coenzymes (carbohydrates), Rec A Recombinases, Phenotype, Gene Expression Regulation, Genes, Bacterial, Mutation, Recombinant DNA, bacteria, Virus Activation, Repressor lexA
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