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1
المؤلفون: Olivier Rogel, Tommasi Ruben A, J. R. Doughty, James Fang, Robert Goldstein, Raviraj Kulathila, Clayton Springer, Kirk Clark, Vishwas Ganu, Sven Weiler, Lijuan Zhu, Mark Chambers, Marc Walker, Stacey LaVoie, Jonathan E. Grob, Leslie Wighton Mcquire, Michael Shultz, Ronald L. Goldberg, Richard Melton, William Macchia, Jing Zhang
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6440-6445
مصطلحات موضوعية: Models, Molecular, Matrix metalloproteinase inhibitor, Clinical Biochemistry, Type II collagen, Pharmaceutical Science, Arthritis, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, Crystallography, X-Ray, Hydroxamic Acids, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Structure–activity relationship, Protease Inhibitors, Molecular Biology, Sulfonamides, Metalloproteinase, Hydroxamic acid, biology, Chemistry, Organic Chemistry, medicine.disease, Enzyme inhibitor, biology.protein, Molecular Medicine
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2
المؤلفون: David Farley, Leslie Wighton Mcquire, Karen Toscano, Noela Reel, Song Xue, James Fang, Elizabeth Quadros, Ronald L. Goldberg, J. R. Doughty, Siyuan Zhou, Robert Goldstein, Raviraj Kulathila, Joseph Somers, Gary Pastor, V. Blancuzzi, H. N. Singh, Stacey LaVoie, Robert A. Doti, Lauren G. Monovich, Kirk Clark, Tommasi Ruben A, Dennis M. Roland, John Fitt, Lijuan Zhu, Elizabeth O'Byrne, Vishwas Ganu, Jerry W. Skiles, Wen-Chung Shieh, David Thomas Parker, Theodore C. Pellas, Yumi Sakane, Andrew Wigg, Wendy D. Cornell, Richard Melton, William Macchia, Roger Aki Fujimoto
المصدر: Journal of Medicinal Chemistry. 52:3523-3538
مصطلحات موضوعية: Matrix metalloproteinase inhibitor, Carboxylic acid, Type II collagen, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, Pharmacology, Crystallography, X-Ray, Inhibitory Concentration 50, Structure-Activity Relationship, Piperidines, In vivo, Drug Discovery, medicine, Animals, Protease Inhibitors, Collagen Type II, chemistry.chemical_classification, Sulfonamides, Biological activity, Rats, Cartilage, Enzyme, chemistry, Biochemistry, Collagenase, Molecular Medicine, Cattle, Proteoglycans, medicine.drug
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3
المؤلفون: Ronald L. Goldberg, V. Blancuzzi, Michael R. Justice, Lijuan Zhu, Michael Paul Capparelli, Salvatore Spirito, L R Fryer, Brian J Carroll, J. R. Doughty, Erol K. Bayburt, Elizabeth O'Byrne, Robert Goldstein, Vishwas Ganu, Doug Wilson, Macpherson Lawrence J, David Thomas Parker, Richard Melton, Shou-Ih Hu
المصدر: Journal of Medicinal Chemistry. 40:2525-2532
مصطلحات موضوعية: Matrix metalloproteinase inhibitor, Administration, Oral, Enzyme-Linked Immunosorbent Assay, Cartilage metabolism, In Vitro Techniques, Matrix Metalloproteinase Inhibitors, Substance P, Pharmacology, Hydroxamic Acids, Stromelysin 1, Structure-Activity Relationship, chemistry.chemical_compound, stomatognathic system, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Protease Inhibitors, Chromatography, High Pressure Liquid, Sulfonamides, Binding Sites, Hydroxamic acid, biology, Chemistry, Recombinant Proteins, Rats, Kinetics, Cartilage, Models, Chemical, Enzyme inhibitor, Pyrazines, biology.protein, Molecular Medicine, Rabbits, Ex vivo
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4
المؤلفون: Ying Qiao, Richard Melton, Charles Boehm, J. Eric Carlson, Vishwas Ganu, J. R. Doughty, Cynthia A. Fink, Ronald L. Goldberg, Patricia McTaggart
المصدر: ChemInform. 30
مصطلحات موضوعية: chemistry.chemical_classification, Drug levels, Chemistry, Thiol, General Medicine, Matrix metalloproteinase, Pharmacology, Selectivity
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5
المؤلفون: B. Kotyuk, Ronald L. Goldberg, J. R. Doughty, A. Raychaudhuri, Vishwas Ganu
المصدر: Acta Orthopaedica Scandinavica. 66:145-147
مصطلحات موضوعية: medicine.medical_specialty, Pyridinoline, business.industry, Urinary system, Cartilage, Type II collagen, Arthritis, Pannus, medicine.disease, Excretion, chemistry.chemical_compound, medicine.anatomical_structure, Endocrinology, chemistry, Internal medicine, Rheumatoid arthritis, Immunology, medicine, Orthopedics and Sports Medicine, Surgery, business
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6
المؤلفون: David Farley, J. R. Doughty, Scott Douglas Cowen, Elizabeth Quadros, Tommasi Ruben A, Leslie Wighton Mcquire, Andrew Wigg, Huanghai Zhou, Karen Toscano, David E. Coppa, Zheng Fang, Zengming Du, Siyuan Zhou, Paul D. Greenspan, Kirk Clark
المصدر: Bioorganicmedicinal chemistry letters. 13(22)
مصطلحات موضوعية: Models, Molecular, Nitrile, Peptidomimetic, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Administration, Oral, Biological Availability, Biochemistry, Cathepsin B, chemistry.chemical_compound, X-Ray Diffraction, Amide, Drug Discovery, Peptide synthesis, Animals, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Dipeptide, biology, Organic Chemistry, Dipeptides, Rats, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
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7
المؤلفون: Yun He, Tanya Shin, Neil S. Ryder, Badry Bursulaya, Kunyong Yang, Andreas Kreusch, J. R. Doughty, Xiaohui He, Valentina Molteni, Perry Gordon, Ronald L. Goldberg, Tanya Biorac, Nabakka Juliet, Ian Warner
المصدر: Bioorganicmedicinal chemistry letters. 14(6)
مصطلحات موضوعية: Staphylococcus aureus, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, medicine.disease_cause, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Amidohydrolases, Peptide deformylase, chemistry.chemical_compound, Bridged Bicyclo Compounds, Drug Discovery, medicine, Protease Inhibitors, Molecular Biology, Antibacterial agent, Hydroxamic acid, biology, Bicyclic molecule, Chemistry, fungi, Organic Chemistry, body regions, nervous system, Enzyme inhibitor, biology.protein, Molecular Medicine, Antibacterial activity
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8
المؤلفون: J. R. Doughty, Shou-Ih Hu, Ronald L. Goldberg, Jane V. Peppard, Fraser Glickman, Yang He
المصدر: Journal of biomolecular screening. 8(2)
مصطلحات موضوعية: musculoskeletal diseases, 0301 basic medicine, High-throughput screening, medicine.medical_treatment, Drug Evaluation, Preclinical, Matrix metalloproteinase, Matrix Metalloproteinase Inhibitors, Cleavage (embryo), 01 natural sciences, Biochemistry, Antibodies, Analytical Chemistry, 03 medical and health sciences, Chondrocytes, Endopeptidases, Disintegrin, medicine, Animals, Humans, Lectins, C-Type, Aggrecans, Enzyme Inhibitors, Aggrecan, Cells, Cultured, Metalloproteinase, Extracellular Matrix Proteins, Protease, biology, Dose-Response Relationship, Drug, Chemistry, Reproducibility of Results, musculoskeletal system, Fluorescence, Matrix Metalloproteinases, 0104 chemical sciences, carbohydrates (lipids), Oxygen, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, biology.protein, Molecular Medicine, Indicators and Reagents, Proteoglycans, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e38d04671f0dc31afb9291c46e06a45
https://pubmed.ncbi.nlm.nih.gov/12844435 -
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المؤلفون: Kirk Clark, Regine Bohacek, Andrew Wigg, Robert Goldstein, Z. Fang, J. R. Doughty, John Fitt, Leslie Wighton Mcquire, Michael Paul Capparelli, David Farley, Zhengming Du, Ronald L. Goldberg, Anna K. Knap, Scott Douglas Cowen, Paul D. Greenspan, William Macchia, David E. Coppa, J. H. van Duzer, Tommasi Ruben A, Lijuan Zhu, Huanghai Zhou
المصدر: Journal of medicinal chemistry. 44(26)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, medicine.medical_treatment, Crystallography, X-Ray, Cathepsin B, Cathepsin C, chemistry.chemical_compound, Structure-Activity Relationship, Cathepsin O, Drug Discovery, Nitriles, medicine, Animals, Enzyme Inhibitors, Cathepsin, Protease, Binding Sites, biology, Active site, Dipeptides, Rats, Papain, chemistry, Biochemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine
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10
المؤلفون: J. R. Doughty, V. Blancuzzi, Ronald L. Goldberg, Elizabeth O'Byrne, Vishwas Ganu, D. Wilson, Richard Melton
المصدر: Agents and Actions. 34:226-228
مصطلحات موضوعية: Cartilage, Articular, medicine.medical_specialty, Triamcinolone acetonide, Keratan sulfate, Immunology, Anti-Inflammatory Agents, Toxicology, Injections, Intra-Articular, law.invention, Plasminogen Activators, chemistry.chemical_compound, Hydroxyproline, law, Internal medicine, Synovial Fluid, medicine, Animals, Pharmacology (medical), Dexamethasone, Pharmacology, biology, Cartilage, Anti-Inflammatory Agents, Non-Steroidal, Anatomy, Stimulation, Chemical, Hindlimb, Endocrinology, medicine.anatomical_structure, chemistry, Proteoglycan, biology.protein, Recombinant DNA, Proteoglycans, Steroids, Rabbits, Joint Diseases, Plasminogen activator, Interleukin-1, medicine.drug