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المؤلفون: Michael Lahn, Faming Zhang, William T. McMillen, Jeremy R. Graff, Rikke B. Holmgaard, Chandrasekar V. Iyer, Jason Manro, Bryan D. Anderson, Douglas W. Beight, Maria Jose Lallena, Kyla Driscoll, Lei Yan, J. Scott Sawyer, Michael Kalos, Karen S. Britt, David K. Clawson, Philip W. Iversen, Rolf A. Brekken, Karim A. Benhadji, Xiaohong Xu, Durisala Desaiah, Jonathan Michael Yingling, Huocong Huang
المصدر: Oncotarget
مصطلحات موضوعية: 0301 basic medicine, Chemistry, Cancer, SMAD, medicine.disease, Peripheral blood mononuclear cell, 03 medical and health sciences, 030104 developmental biology, galunisertib, Oncology, In vivo, Cancer research, medicine, Galunisertib, Phosphorylation, TGFβ receptor I, Receptor, LY2157299, Priority Research Paper, Transforming growth factor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d8441d71dc2f3af0b1cfba12364fde
https://doi.org/10.18632/oncotarget.23795 -
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المؤلفون: Karen L. Huss, Charles R. Heap, William T. McMillen, David K. Clawson, Jonathan M. Yingling, J. Scott Sawyer, Robert M. Campbell, Matthew D. Voss, Bryan D. Anderson, Chi Hsin R. King, Elizabeth A. Dierks, Hong Yu Li, Wang Yan, Lei Yan, Sreenivasa Reedy Mundla, Karen S. Britt, Denis J. McCann
المصدر: Journal of Medicinal Chemistry. 51:2302-2306
مصطلحات موضوعية: Models, Molecular, Molecular Conformation, Receptor, Transforming Growth Factor-beta Type I, Administration, Oral, Biological Availability, Mice, Nude, Antineoplastic Agents, Protein Serine-Threonine Kinases, Pharmacology, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Growth factor receptor, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Pyrroles, Receptor, Protein Kinase Inhibitors, Cell Proliferation, biology, Chemistry, Stereoisomerism, Xenograft Model Antitumor Assays, Rats, Biochemistry, Protein kinase domain, Enzyme inhibitor, Drug Design, biology.protein, Pyrazoles, Molecular Medicine, Signal transduction, Receptors, Transforming Growth Factor beta, Transforming growth factor
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المؤلفون: John E. Toth, Matthew Ernst Voss, Robert D. Boyer, Hong-Yu Li, Sreenivasa R. Mundla, Yan Wang, Arindam Chatterjee, J. Scott Sawyer, William Thomas Mcmillen
المصدر: Tetrahedron. 63:11763-11770
مصطلحات موضوعية: Analog synthesis, Methanesulfonyl chloride, Organic Chemistry, Biochemistry, chemistry.chemical_compound, chemistry, Microwave heating, Amide, Yield (chemistry), Intramolecular force, Drug Discovery, Organic chemistry, Quinazolinone, Boronic acid
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المؤلفون: Xiaoling Xia, William Thomas Mcmillen, Jonathan Michael Yingling, David Kent Herron, J. Scott Sawyer, Michael L. Jones, Scott A. Watkins, Mort Nicholas A, John W. Lampe, Beight Douglas W, Brooks Harold Burns, Sheng-Bin Peng, Lei Yan
المصدر: Biochemistry. 44:2293-2304
مصطلحات موضوعية: Molecular Sequence Data, Smad2 Protein, Mitogen-activated protein kinase kinase, Binding, Competitive, Biochemistry, Mass Spectrometry, Cell Line, Substrate Specificity, MAP2K7, Mesoderm, Mice, Adenosine Triphosphate, Transforming Growth Factor beta, Serine, Animals, Humans, ASK1, Amino Acid Sequence, Smad3 Protein, Phosphorylation, Protein Kinase Inhibitors, Chromatography, High Pressure Liquid, biology, MAP kinase kinase kinase, Cyclin-dependent kinase 4, Cyclin-dependent kinase 2, Epithelial Cells, Transforming growth factor beta, MAP Kinase Kinase Kinases, Growth Inhibitors, Peptide Fragments, Cell biology, DNA-Binding Proteins, Kinetics, Trans-Activators, biology.protein, Pyrazoles, Cyclin-dependent kinase 9, HeLa Cells
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المؤلفون: J. Scott Sawyer, Jonathan M. Yingling, Kerry L. Blanchard
المصدر: Nature Reviews Drug Discovery. 3:1011-1022
مصطلحات موضوعية: Pharmacology, Drug discovery, Cancer therapy, Cancer, Antineoplastic Agents, SUPERFAMILY, General Medicine, Biology, medicine.disease, Cell biology, Pathogenesis, Signalling, Transforming Growth Factor beta, Fibrosis, Drug Design, Neoplasms, Drug Discovery, TGF beta signaling pathway, Cancer research, medicine, Animals, Humans, Signal Transduction
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المؤلفون: Edward C R Smith, William Thomas Mcmillen, Mccowan Jefferson Ray, Lei Yan, Mort Nicholas A, Michael L. Jones, Bryan D. Anderson, Robert M. Campbell, Faming Zhang, John W. Lampe, Leonard C Weir, David Kent Herron, Stephen Parsons, Jonathan Michael Yingling, Beight Douglas W, J. Scott Sawyer, Michal Vieth
المصدر: Journal of Medicinal Chemistry. 46:3953-3956
مصطلحات موضوعية: Models, Molecular, Stereochemistry, MAPK7, Protein Serine-Threonine Kinases, Spodoptera, Pyrazole, Crystallography, X-Ray, p38 Mitogen-Activated Protein Kinases, Cell Line, MAP2K7, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Adenosine Triphosphate, Growth factor receptor, Drug Discovery, Benzene Derivatives, Animals, Humans, Enzyme Inhibitors, Binding Sites, Kinase, 3T3 Cells, Protein Structure, Tertiary, chemistry, Protein kinase domain, Biochemistry, Mink, Pyrazoles, Molecular Medicine, Mitogen-Activated Protein Kinases, Signal transduction, Receptors, Transforming Growth Factor beta, Transforming growth factor
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المؤلفون: J. Scott Sawyer
المصدر: Tetrahedron. 56:5045-5065
مصطلحات موضوعية: Diaryl ether, Chemistry, Organic Chemistry, Drug Discovery, Organic chemistry, Biochemistry
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المؤلفون: J. Scott Sawyer, Sandra L. Cockerham, K. Jeff Thrasher, Larry L. Froelich, Carlos R. Roman, Bach Nicholas J, Peter W. Stengel, Jerome H. Fleisch, Steven A. Silbaugh
المصدر: Bioorganic & Medicinal Chemistry Letters. 6:249-252
مصطلحات موضوعية: LTD4 receptor, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Quinoline, Pharmaceutical Science, Pharmacology, Biochemistry, In vitro, Guinea pig, chemistry.chemical_compound, Membrane, Orally active, chemistry, In vivo, Drug Discovery, Molecular Medicine, Receptor, Molecular Biology
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المؤلفون: J. Scott Sawyer, William J. Smith
المصدر: Tetrahedron Letters. 37:299-302
مصطلحات موضوعية: Reaction conditions, Indole test, chemistry.chemical_compound, chemistry, Aryl, Yield (chemistry), Organic Chemistry, Drug Discovery, Electrophile, Biochemistry, Medicinal chemistry, Catalysis
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المؤلفون: J Scott Sawyer
المصدر: Expert Opinion on Investigational Drugs. 5:73-77
مصطلحات موضوعية: Pharmacology, Leukotriene B4, business.industry, Leukotriene B4 receptor, Arthritis, Inflammation, General Medicine, Zileuton, medicine.disease, Inflammatory bowel disease, chemistry.chemical_compound, chemistry, Rheumatoid arthritis, Immunology, medicine, Pharmacology (medical), Arachidonic acid, medicine.symptom, business, medicine.drug