المؤلفون: Ke F; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing., Wang N; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing., Zhang X; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing., Liu R; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing., Ren T; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing., Ke J; Department of Pharmacy., Yang J; Institute of Clinical Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, China., Yan H; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing., Ma J; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing.

المصدر: Anti-cancer drugs [Anticancer Drugs] 2024 Aug 01; Vol. 35 (7), pp. 615-622. Date of Electronic Publication: 2024 May 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9100823 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5741 (Electronic) Linking ISSN: 09594973 NLM ISO Abbreviation: Anticancer Drugs Subsets: MEDLINE

مواضيع طبية MeSH: Retinoblastoma*/drug therapy , Retinoblastoma*/pathology , Nitriles*/pharmacology , Pyrimidines*/pharmacology , Vincristine*/pharmacology , Pyrazoles*/pharmacology , Janus Kinase 1*/antagonists & inhibitors , Janus Kinase 1*/metabolism , Drug Resistance, Neoplasm*/drug effects, Animals ; Humans ; Mice ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase 2/metabolism ; Janus Kinase Inhibitors/pharmacology ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Retinal Neoplasms/drug therapy ; Retinal Neoplasms/pathology ; Drug Synergism ; Cell Proliferation/drug effects ; Antineoplastic Combined Chemotherapy Protocols/pharmacology

المؤلفون: Wang Z; West China Hospital, Sichuan University, Chendu, Sichuan, China., Jin X; West China Hospital, Sichuan University, Chendu, Sichuan, China., Zeng J; West China Hospital, Sichuan University, Chendu, Sichuan, China., Xiong Z; West China Hospital, Sichuan University, Chendu, Sichuan, China., Chen X; West China Hospital, Sichuan University, Chendu, Sichuan, China. xinchuan_chen@163.com.

المصدر: Annals of hematology [Ann Hematol] 2024 Sep; Vol. 103 (9), pp. 3293-3301. Date of Electronic Publication: 2024 Mar 18.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE

مواضيع طبية MeSH: Primary Myelofibrosis*/therapy , Primary Myelofibrosis*/drug therapy , Hematopoietic Stem Cell Transplantation* , Janus Kinase Inhibitors*/therapeutic use , Nitriles*/therapeutic use , Pyrimidines*/therapeutic use , Pyrazoles*/therapeutic use, Humans ; Allografts ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase 1/antagonists & inhibitors

المؤلفون: Harrison CN; Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK. claire.harrison@gstt.nhs.uk., Vannucchi AM; University of Florence, Florence, Italy., Recher C; University Hospital Center (CHU) of Toulouse, Toulouse, France., Passamonti F; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Dipartimento di Oncologia ed Onco-Ematologia, Università degli Studi di Milano, Milan, Italy., Gerds AT; Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA., Hernandez-Boluda JC; Hospital Clìnico de Valencia-INCLIVA, University of Medicine, Valencia, Spain., Yacoub A; University of Kansas, Kansas City, KS, USA., Sirhan S; Jewish General Hospital, McGill University, Montreal, QC, Canada., Ellis C; GSK plc, Philadelphia, PA, USA., Patel B; GSK plc, Philadelphia, PA, USA., Strouse B; GSK plc, Philadelphia, PA, USA., Platzbecker U; University Hospital Leipzig, Leipzig, Germany.

المصدر: Advances in therapy [Adv Ther] 2024 Sep; Vol. 41 (9), pp. 3722-3735. Date of Electronic Publication: 2024 Jul 11.

نوع المنشور: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Comparative Study; Multicenter Study

بيانات الدورية: Publisher: Health Communications Inc Country of Publication: United States NLM ID: 8611864 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-8652 (Electronic) Linking ISSN: 0741238X NLM ISO Abbreviation: Adv Ther Subsets: MEDLINE

مواضيع طبية MeSH: Pyrimidines*/therapeutic use , Nitriles*/therapeutic use , Pyrazoles*/therapeutic use , Primary Myelofibrosis*/drug therapy , Primary Myelofibrosis*/complications , Anemia*/drug therapy , Anemia*/etiology , Janus Kinase Inhibitors*/therapeutic use, Humans ; Male ; Female ; Aged ; Middle Aged ; Benzamides/therapeutic use ; Janus Kinase 1/antagonists & inhibitors ; Erythrocyte Transfusion/statistics & numerical data ; Aged, 80 and over ; Treatment Outcome ; Janus Kinase 2/antagonists & inhibitors

المؤلفون: Zhang X; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, PR China., Wang W; The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), 325 Guohe Road, Shanghai 200433, PR China., Dong G; The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), 325 Guohe Road, Shanghai 200433, PR China., Song Y; School of Pharmaceutical Sciences, Hainan University, Haikou 570228, PR China., Zhai X; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: zhaixin_syphu@126.com., Sheng C; The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), 325 Guohe Road, Shanghai 200433, PR China. Electronic address: shengcq@smmu.edu.cn.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Sep 01; Vol. 109, pp. 129838. Date of Electronic Publication: 2024 Jun 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Janus Kinase 1*/antagonists & inhibitors , Janus Kinase 1*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Proteolysis*/drug effects , Cell Proliferation*/drug effects, Humans ; Structure-Activity Relationship ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Drug Discovery ; Molecular Structure ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase 2/metabolism ; Proteasome Endopeptidase Complex/metabolism

المؤلفون: Poto R; Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità (ISS), Rome, Italy.; World Allergy Organization (WAO) Center of Excellence, Naples, Italy., Cristinziano L; Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.; World Allergy Organization (WAO) Center of Excellence, Naples, Italy.; Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy., Criscuolo G; Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.; World Allergy Organization (WAO) Center of Excellence, Naples, Italy.; Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy., Strisciuglio C; Department of Woman, Child and General and Specialistic Surgery, University of Campania 'Luigi Vanvitelli', Naples, Italy., Palestra F; Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.; World Allergy Organization (WAO) Center of Excellence, Naples, Italy., Lagnese G; Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.; World Allergy Organization (WAO) Center of Excellence, Naples, Italy., Di Salvatore A; Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.; World Allergy Organization (WAO) Center of Excellence, Naples, Italy., Marone G; Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.; World Allergy Organization (WAO) Center of Excellence, Naples, Italy.; Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy.; Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council, Naples, Italy., Spadaro G; Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.; World Allergy Organization (WAO) Center of Excellence, Naples, Italy.; Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy., Loffredo S; Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.; World Allergy Organization (WAO) Center of Excellence, Naples, Italy.; Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy.; Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council, Naples, Italy., Varricchi G; Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.; World Allergy Organization (WAO) Center of Excellence, Naples, Italy.; Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy.; Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council, Naples, Italy.

المصدر: Frontiers in immunology [Front Immunol] 2024 Aug 12; Vol. 15, pp. 1443704. Date of Electronic Publication: 2024 Aug 12 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Basophils*/drug effects , Basophils*/immunology , Basophils*/metabolism , Pyrimidines*/pharmacology , Nitriles*/pharmacology , Mast Cells*/drug effects , Mast Cells*/immunology , Mast Cells*/metabolism , Pyrazoles*/pharmacology , Janus Kinase 1*/antagonists & inhibitors , Janus Kinase 1*/metabolism , Janus Kinase 2*/metabolism , Janus Kinase 2*/antagonists & inhibitors, Humans ; Cells, Cultured ; Janus Kinase Inhibitors/pharmacology ; Cytokines/metabolism ; Immunoglobulin E/immunology ; Immunoglobulin E/metabolism ; Protein Kinase Inhibitors/pharmacology

المؤلفون: Huang S; Shenzhen Chipscreen Biosciences Co., Ltd., Shenzhen, Guangdong 518057, China; Chengdu Chipscreen Pharmaceutical Ltd., Chengdu, Sichuan 610095, China., Yang Q; Shenzhen Chipscreen Biosciences Co., Ltd., Shenzhen, Guangdong 518057, China., Zhou Y; Shenzhen Chipscreen Biosciences Co., Ltd., Shenzhen, Guangdong 518057, China., Li L; Shenzhen Chipscreen Biosciences Co., Ltd., Shenzhen, Guangdong 518057, China., Shan S; Shenzhen Chipscreen Biosciences Co., Ltd., Shenzhen, Guangdong 518057, China. Electronic address: shansong@chipscreen.com.

المصدر: Transplant immunology [Transpl Immunol] 2024 Aug; Vol. 85, pp. 102075. Date of Electronic Publication: 2024 Jun 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9309923 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5492 (Electronic) Linking ISSN: 09663274 NLM ISO Abbreviation: Transpl Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Bone Marrow Transplantation* , Graft vs Host Disease*/drug therapy , Janus Kinase 3*/antagonists & inhibitors , Janus Kinase 3*/metabolism, Animals ; Humans ; Mice ; Acute Disease ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/drug effects ; Cells, Cultured ; Disease Models, Animal ; Interferon-gamma/metabolism ; Janus Kinase Inhibitors/therapeutic use ; Janus Kinase Inhibitors/pharmacology ; Lymphocyte Culture Test, Mixed ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Nitriles/therapeutic use ; Pyrimidines/therapeutic use ; Pyrimidines/pharmacology ; Transplantation, Homologous ; Tumor Necrosis Factor-alpha/metabolism

المؤلفون: Gobbo F; Department of Veterinary Medical Sciences, Alma Mater Studiorum University, 40126 Bologna, Italy., Martelli F; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, 00161 Rome, Italy., Di Virgilio A; National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, 00161 Rome, Italy., Demaria E; Department of Medical and Surgical Sciences, Alma Mater Studiorum University, 40126 Bologna, Italy., Sarli G; Department of Veterinary Medical Sciences, Alma Mater Studiorum University, 40126 Bologna, Italy., Migliaccio AR; Altius Institute for Biomedical Sciences, Seattle, WA 98121, USA.; Institute of Nanotechnology, National Research Council (Cnr-NANOTEC), c/o Campus Ecotekne, 73100 Lecce, Italy.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 13; Vol. 25 (14). Date of Electronic Publication: 2024 Jul 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Primary Myelofibrosis*/drug therapy , Primary Myelofibrosis*/metabolism , Primary Myelofibrosis*/pathology , Transforming Growth Factor beta*/metabolism , Janus Kinase 1*/antagonists & inhibitors , Janus Kinase 1*/metabolism , P-Selectin*/metabolism , Receptors, Interleukin-8B*/antagonists & inhibitors , Receptors, Interleukin-8B*/metabolism , Pyrimidines*/pharmacology , Pyrimidines*/therapeutic use, Animals ; Receptors, Interleukin-8A/antagonists & inhibitors ; Receptors, Interleukin-8A/metabolism ; Mice ; Janus Kinase 2/metabolism ; Janus Kinase 2/antagonists & inhibitors ; Nitriles/therapeutic use ; Nitriles/pharmacology ; Disease Models, Animal ; Drug Therapy, Combination ; GATA1 Transcription Factor/metabolism ; GATA1 Transcription Factor/genetics ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; Humans

المؤلفون: Wei Q; MD Anderson Cancer Center., Xu J; MD Anderson Cancer Center.

المصدر: Blood [Blood] 2024 Jul 11; Vol. 144 (2), pp. 238.

نوع المنشور: Case Reports; Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Hypereosinophilic Syndrome*/genetics , Hypereosinophilic Syndrome*/drug therapy , Hypereosinophilic Syndrome*/pathology , Janus Kinase 1*/genetics , Janus Kinase 1*/antagonists & inhibitors , Mutation* , Nitriles*/therapeutic use , Pyrazoles*/therapeutic use , Pyrimidines*/therapeutic use, Humans ; Janus Kinase 2/genetics ; Janus Kinase 2/antagonists & inhibitors ; Leukemia ; Protein Kinase Inhibitors/therapeutic use ; Female ; Aged

SCR Disease Name: Pdgfra-Associated Chronic Eosinophilic Leukemia

المؤلفون: Isfort S; Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, Hannover, 30625, Germany., von Bubnoff N; Department of Hematology and Oncology, University Hospital Lübeck, Lübeck, Germany., Al-Ali HK; University Hospital Halle (Saale), Krukenberg Cancer Center Halle, Halle, Germany., Becker H; Department of Medicine I - Medical Center - University of Freiburg, Faculty of Medicine, University of , Freiburg, Freiburg, Germany., Götze T; Krankenhaus Nordwest, University Cancer Center (UCT), Frankfurt, Germany.; Institut für Klinische Krebsforschung IKF Am Krankenhaus Nordwest, Frankfurt, Germany., le Coutre P; Department of Hematology, Oncology and Stem Cell Transplantation, Charite Berlin, Germany., Griesshammer M; Mühlenkreisklinikum Minden, Universitätsklinikum Bochum, Minden, Germany., Moskwa C; Internal Medicine C, Hematology, Oncology, Stem Cell Transplantation and Palliative Care, University Medicine Greifswald, Greifswald, Germany., Wohn L; Institut für Klinische Krebsforschung IKF Am Krankenhaus Nordwest, Frankfurt, Germany., Riedel J; Institut für Klinische Krebsforschung IKF Am Krankenhaus Nordwest, Frankfurt, Germany., Palandri F; IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Istituto Di Ematologia 'Seràgnoli', Bologna, Italy., Manz K; Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, Hannover, 30625, Germany.; Institute for Community Medicine - SHIP-KEF, Universitätsmedizin Greifswald, Greifswald, Germany., Hochhaus A; Klinik für Innere Medizin II, Abteilung Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Jena, Germany., Döhner K; Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany., Heidel FH; Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, Hannover, 30625, Germany. heidel.florian@mh-hannover.de.; Internal Medicine C, Hematology, Oncology, Stem Cell Transplantation and Palliative Care, University Medicine Greifswald, Greifswald, Germany. heidel.florian@mh-hannover.de.

المصدر: Annals of hematology [Ann Hematol] 2024 Aug; Vol. 103 (8), pp. 2775-2785. Date of Electronic Publication: 2024 Jul 05.

نوع المنشور: Journal Article; Clinical Trial, Phase II; Clinical Trial Protocol; Multicenter Study

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE

مواضيع طبية MeSH: Primary Myelofibrosis*/drug therapy , Janus Kinase Inhibitors*/therapeutic use , Pyrrolidines*/therapeutic use , Nivolumab*/therapeutic use , Nivolumab*/administration & dosage, Humans ; Sulfonamides/therapeutic use ; Sulfonamides/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Male ; Middle Aged ; Aged ; Germany ; Myeloproliferative Disorders/drug therapy ; Nitriles/therapeutic use ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase 2/genetics ; Pyrimidines/therapeutic use ; Pyrazoles/therapeutic use ; Benzenesulfonamides

المؤلفون: Hunter AM; Department of Hematology and Medical oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Bose P; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

المصدر: Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2024 Jul; Vol. 25 (10), pp. 1391-1404. Date of Electronic Publication: 2024 Aug 01.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 100897346 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-7666 (Electronic) Linking ISSN: 14656566 NLM ISO Abbreviation: Expert Opin Pharmacother Subsets: MEDLINE

مواضيع طبية MeSH: Janus Kinase Inhibitors*/therapeutic use , Janus Kinase Inhibitors*/pharmacology , Myeloproliferative Disorders*/drug therapy , Primary Myelofibrosis*/drug therapy, Humans ; Janus Kinases/antagonists & inhibitors ; Nitriles/therapeutic use ; Animals ; Drug Development ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology ; Pyrazoles/therapeutic use ; Pyrazoles/pharmacology ; Polycythemia Vera/drug therapy ; Polycythemia Vera/genetics ; Pyrimidines/therapeutic use ; Pyrimidines/pharmacology