المؤلفون: MRH DUNSTAN, C TATE, RT PROCTER, LH MCCURRICH, ES DAWSON, SJ WOOD, KM BROOK, PGK KNIGHT, D MACLEOD, AC ALLEN, JD LLEWELLIN, PL OWENS, WE MURPHY, A HOOPER, JE THORPE, JDC OSORIO, DC NORMAN

المصدر: Proceedings of the Institution of Civil Engineers. 78:413-434

مصطلحات موضوعية: General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::46cfd122c2b6631ec9a6f7070fb5f08c
https://doi.org/10.1680/iicep.1985.1011

المؤلفون: Xia D; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China; Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Lai DV; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Wu W; Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Webb ZD; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Yang Q; Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Zhao L; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Yu Z; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Thorpe JE; Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma College of Pharmacy, OKC, OK 73117, USA., Disch BC; Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma College of Pharmacy, OKC, OK 73117, USA., Ihnat MA; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma College of Pharmacy, OKC, OK 73117, USA., Jayaraman M; Stephenson Cancer Center, University of Oklahoma, Oklahoma City, OK 73104, USA., Dhanasekaran DN; Stephenson Cancer Center, University of Oklahoma, Oklahoma City, OK 73104, USA; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Stratton KL; Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Cookson MS; Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Fung KM; Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Pathology, Veterans Affairs Medical Center, Oklahoma City, Oklahoma, OK 73104, USA., Lin HK; Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Electronic address: hk-lin@ouhsc.edu.

المصدر: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2018 Apr; Vol. 178, pp. 89-98. Date of Electronic Publication: 2017 Nov 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Pergamon Country of Publication: England NLM ID: 9015483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1220 (Electronic) Linking ISSN: 09600760 NLM ISO Abbreviation: J Steroid Biochem Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Aldo-Keto Reductase Family 1 Member C3/*metabolism , Anabolic Agents/*pharmacology , Androstane-3,17-diol/*pharmacology , Prostatic Neoplasms/*pathology , Receptors, GABA-A/*metabolism, Aldo-Keto Reductase Family 1 Member C3/genetics ; Cell Proliferation ; Disease Progression ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Humans ; Male ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Receptors, GABA-A/genetics ; Signal Transduction ; Tumor Cells, Cultured

المؤلفون: Bastian A; Department of Pharmaceutical Sciences (A.B., J.E.T., B.C.D., M.A.I.), Department of Physiology (A.B.), Flow Cytometry and Imaging Laboratory (J.H.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; DormaTarg, Inc., Oklahoma City, Oklahoma (B.C.D., L.C.B.D., M.A.I.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (A.G., R.K.V.D.); and Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma (K.M.H., S.S.V.)., Thorpe JE; Department of Pharmaceutical Sciences (A.B., J.E.T., B.C.D., M.A.I.), Department of Physiology (A.B.), Flow Cytometry and Imaging Laboratory (J.H.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; DormaTarg, Inc., Oklahoma City, Oklahoma (B.C.D., L.C.B.D., M.A.I.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (A.G., R.K.V.D.); and Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma (K.M.H., S.S.V.)., Disch BC; Department of Pharmaceutical Sciences (A.B., J.E.T., B.C.D., M.A.I.), Department of Physiology (A.B.), Flow Cytometry and Imaging Laboratory (J.H.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; DormaTarg, Inc., Oklahoma City, Oklahoma (B.C.D., L.C.B.D., M.A.I.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (A.G., R.K.V.D.); and Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma (K.M.H., S.S.V.)., Bailey-Downs LC; Department of Pharmaceutical Sciences (A.B., J.E.T., B.C.D., M.A.I.), Department of Physiology (A.B.), Flow Cytometry and Imaging Laboratory (J.H.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; DormaTarg, Inc., Oklahoma City, Oklahoma (B.C.D., L.C.B.D., M.A.I.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (A.G., R.K.V.D.); and Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma (K.M.H., S.S.V.)., Gangjee A; Department of Pharmaceutical Sciences (A.B., J.E.T., B.C.D., M.A.I.), Department of Physiology (A.B.), Flow Cytometry and Imaging Laboratory (J.H.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; DormaTarg, Inc., Oklahoma City, Oklahoma (B.C.D., L.C.B.D., M.A.I.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (A.G., R.K.V.D.); and Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma (K.M.H., S.S.V.)., Devambatla RK; Department of Pharmaceutical Sciences (A.B., J.E.T., B.C.D., M.A.I.), Department of Physiology (A.B.), Flow Cytometry and Imaging Laboratory (J.H.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; DormaTarg, Inc., Oklahoma City, Oklahoma (B.C.D., L.C.B.D., M.A.I.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (A.G., R.K.V.D.); and Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma (K.M.H., S.S.V.)., Henthorn J; Department of Pharmaceutical Sciences (A.B., J.E.T., B.C.D., M.A.I.), Department of Physiology (A.B.), Flow Cytometry and Imaging Laboratory (J.H.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; DormaTarg, Inc., Oklahoma City, Oklahoma (B.C.D., L.C.B.D., M.A.I.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (A.G., R.K.V.D.); and Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma (K.M.H., S.S.V.)., Humphries KM; Department of Pharmaceutical Sciences (A.B., J.E.T., B.C.D., M.A.I.), Department of Physiology (A.B.), Flow Cytometry and Imaging Laboratory (J.H.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; DormaTarg, Inc., Oklahoma City, Oklahoma (B.C.D., L.C.B.D., M.A.I.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (A.G., R.K.V.D.); and Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma (K.M.H., S.S.V.)., Vadvalkar SS; Department of Pharmaceutical Sciences (A.B., J.E.T., B.C.D., M.A.I.), Department of Physiology (A.B.), Flow Cytometry and Imaging Laboratory (J.H.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; DormaTarg, Inc., Oklahoma City, Oklahoma (B.C.D., L.C.B.D., M.A.I.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (A.G., R.K.V.D.); and Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma (K.M.H., S.S.V.)., Ihnat MA; Department of Pharmaceutical Sciences (A.B., J.E.T., B.C.D., M.A.I.), Department of Physiology (A.B.), Flow Cytometry and Imaging Laboratory (J.H.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; DormaTarg, Inc., Oklahoma City, Oklahoma (B.C.D., L.C.B.D., M.A.I.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (A.G., R.K.V.D.); and Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma (K.M.H., S.S.V.) michael-ihnat@ouhsc.edu.

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2015 May; Vol. 353 (2), pp. 392-404. Date of Electronic Publication: 2015 Feb 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Indoles/*pharmacology , Mitochondria/*drug effects , Necrosis/*chemically induced , Pyrimidines/*pharmacology , Triple Negative Breast Neoplasms/*pathology, Animals ; Antineoplastic Agents/toxicity ; Apoptosis/drug effects ; Calcium/metabolism ; Cell Line, Tumor ; Cell Membrane Permeability/drug effects ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Female ; Homeostasis/drug effects ; Humans ; Indoles/toxicity ; Male ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Mitochondria/metabolism ; Neoplasm Metastasis ; Pyrimidines/toxicity ; Rats ; Superoxides/metabolism ; Time Factors ; Xenograft Model Antitumor Assays

المؤلفون: Zhang X; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, United States., Raghavan S; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, United States., Ihnat M; College of Pharmacy, University of Oklahoma Health Science Center, 1110 North Stonewall, Oklahoma City, OK 73117, United States., Thorpe JE; College of Pharmacy, University of Oklahoma Health Science Center, 1110 North Stonewall, Oklahoma City, OK 73117, United States., Disch BC; College of Pharmacy, University of Oklahoma Health Science Center, 1110 North Stonewall, Oklahoma City, OK 73117, United States., Bastian A; College of Pharmacy, University of Oklahoma Health Science Center, 1110 North Stonewall, Oklahoma City, OK 73117, United States., Bailey-Downs LC; College of Pharmacy, University of Oklahoma Health Science Center, 1110 North Stonewall, Oklahoma City, OK 73117, United States., Dybdal-Hargreaves NF; Department of Pharmacology, Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States., Rohena CC; Department of Pharmacology, Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States., Hamel E; Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Institutes of Health, 1050 Boyles Street, Frederick, MD 21702, United States., Mooberry SL; Department of Pharmacology, Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States., Gangjee A; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, United States. Electronic address: gangjee@duq.edu.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2014 Jul 15; Vol. 22 (14), pp. 3753-72. Date of Electronic Publication: 2014 May 14.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Aniline Compounds/*pharmacology , Antineoplastic Agents/*pharmacology , Apoptosis/*drug effects , Microtubules/*drug effects , Neoplasms, Experimental/*drug therapy , Protein Kinase Inhibitors/*pharmacology , Pyrimidines/*pharmacology , Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors , Water/*chemistry, Aniline Compounds/chemical synthesis ; Aniline Compounds/chemistry ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; HeLa Cells ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasms, Experimental/pathology ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Receptor Protein-Tyrosine Kinases/metabolism ; Solubility ; Structure-Activity Relationship

المؤلفون: Bailey-Downs LC; DormaTarg, Inc., Oklahoma City, Oklahoma, United States of America., Thorpe JE; DormaTarg, Inc., Oklahoma City, Oklahoma, United States of America; Department of Pharmaceutical Sciences, University of Oklahoma College of Pharmacy, Oklahoma City, Oklahoma, United States of America., Disch BC; DormaTarg, Inc., Oklahoma City, Oklahoma, United States of America., Bastian A; Department of Pharmaceutical Sciences, University of Oklahoma College of Pharmacy, Oklahoma City, Oklahoma, United States of America., Hauser PJ; DormaTarg, Inc., Oklahoma City, Oklahoma, United States of America; Department of Urology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, United States of America., Farasyn T; DormaTarg, Inc., Oklahoma City, Oklahoma, United States of America., Berry WL; Department of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, United States of America., Hurst RE; DormaTarg, Inc., Oklahoma City, Oklahoma, United States of America; Department of Urology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, United States of America; Department of Biochemistry and Molecular Biology, of Oklahoma College of Medicine, Oklahoma City, Oklahoma, United States of America., Ihnat MA; DormaTarg, Inc., Oklahoma City, Oklahoma, United States of America; Department of Pharmaceutical Sciences, University of Oklahoma College of Pharmacy, Oklahoma City, Oklahoma, United States of America.

المصدر: PloS one [PLoS One] 2014 May 30; Vol. 9 (5), pp. e98624. Date of Electronic Publication: 2014 May 30 (Print Publication: 2014).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms/*pathology , Lung Neoplasms/*pathology , Lung Neoplasms/*secondary , Neoplasm Metastasis/*pathology , Neoplasm Micrometastasis/*pathology, Animals ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Disease Progression ; Doxorubicin/pharmacology ; Female ; Lung Neoplasms/drug therapy ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Neoplasm Metastasis/drug therapy ; Neoplasm Micrometastasis/drug therapy

المؤلفون: Gangjee A; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University , Pittsburgh, Pennsylvania 15282, United States., Pavana RK; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University , Pittsburgh, Pennsylvania 15282, United States., Ihnat MA; Department of Pharmaceutical Sciences, University of Oklahoma College of Pharmacy , Oklahoma City, Oklahoma 73117, United States., Thorpe JE; Department of Pharmaceutical Sciences, University of Oklahoma College of Pharmacy , Oklahoma City, Oklahoma 73117, United States., Disch BC; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University , Pittsburgh, Pennsylvania 15282, United States., Bastian A; Department of Pharmaceutical Sciences, University of Oklahoma College of Pharmacy , Oklahoma City, Oklahoma 73117, United States., Bailey-Downs LC; Department of Pharmaceutical Sciences, University of Oklahoma College of Pharmacy , Oklahoma City, Oklahoma 73117, United States., Hamel E; Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute , Frederick, Maryland 21702, United States., Bai R; Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute , Frederick, Maryland 21702, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2014 Feb 27; Vol. 5 (5), pp. 480-4. Date of Electronic Publication: 2014 Feb 27 (Print Publication: 2014).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Pathuri G; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, 1110 N. Stonewall Avenue, Room 301, Oklahoma City, OK 73117, USA., Thorpe JE, Disch BC, Bailey-Downs LC, Ihnat MA, Gali H

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Jun 15; Vol. 23 (12), pp. 3561-4. Date of Electronic Publication: 2013 Apr 23.

نوع المنشور: Letter; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Angiogenesis Inhibitors/*chemical synthesis , Angiogenesis Inhibitors/*pharmacology , Oligopeptides/*chemical synthesis , Oligopeptides/*pharmacology, Angiogenesis Inhibitors/chemistry ; Animals ; Breast Neoplasms/blood supply ; Breast Neoplasms/drug therapy ; CD13 Antigens/antagonists & inhibitors ; Cell Line, Tumor ; Chick Embryo ; Chorioallantoic Membrane/blood supply ; Female ; Humans ; Mice, Inbred BALB C ; Neovascularization, Physiologic/drug effects ; Oligopeptides/chemistry ; Solid-Phase Synthesis Techniques/methods ; Xenograft Model Antitumor Assays

المؤلفون: Gangjee A; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, United States. gangjee@duq.edu, Zaware N, Raghavan S, Disch BC, Thorpe JE, Bastian A, Ihnat MA

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2013 Apr 01; Vol. 21 (7), pp. 1857-64. Date of Electronic Publication: 2013 Jan 31.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Angiogenesis Inhibitors/*chemistry , Diamines/*chemistry , Indoles/*chemistry , Vascular Endothelial Growth Factor Receptor-2/*antagonists & inhibitors, Angiogenesis Inhibitors/chemical synthesis ; Angiogenesis Inhibitors/pharmacology ; Cell Line, Tumor ; Diamines/chemical synthesis ; Diamines/pharmacology ; Halogenation ; Humans ; Indoles/chemical synthesis ; Indoles/pharmacology ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Vascular Endothelial Growth Factor Receptor-2/metabolism

المؤلفون: Gangjee A; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA. gangjee@duq.edu, Namjoshi OA, Yu J, Ihnat MA, Thorpe JE, Bailey-Downs LC

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2013 Mar 01; Vol. 21 (5), pp. 1312-23. Date of Electronic Publication: 2013 Jan 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Angiogenesis Inhibitors/*chemistry , Antineoplastic Agents/*chemistry , Protein Kinase Inhibitors/*chemistry , Pyrimidines/*chemistry , Pyrroles/*chemistry , Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors, Angiogenesis Inhibitors/therapeutic use ; Angiogenesis Inhibitors/toxicity ; Animals ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/toxicity ; Cell Line, Tumor ; Cell Survival/drug effects ; Disease Models, Animal ; Humans ; Melanoma, Experimental/drug therapy ; Mice ; Mice, Nude ; Microwaves ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinase Inhibitors/toxicity ; Pyrimidines/therapeutic use ; Pyrimidines/toxicity ; Pyrroles/therapeutic use ; Pyrroles/toxicity ; Receptor Protein-Tyrosine Kinases/metabolism ; Structure-Activity Relationship

المؤلفون: Gangjee A; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, United States. gangjee@duq.edu, Zhao Y, Ihnat MA, Thorpe JE, Bailey-Downs LC, Kisliuk RL

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2012 Jul 15; Vol. 20 (14), pp. 4217-25. Date of Electronic Publication: 2012 Jun 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Angiogenesis Inhibitors/*chemistry , Antineoplastic Agents/*chemistry , Indenes/*chemistry , Pyrimidines/*chemistry, Angiogenesis Inhibitors/therapeutic use ; Angiogenesis Inhibitors/toxicity ; Animals ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/toxicity ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chick Embryo ; Drug Screening Assays, Antitumor ; Humans ; Indenes/therapeutic use ; Indenes/toxicity ; Melanoma, Experimental/drug therapy ; Mice ; Pyrimidines/therapeutic use ; Pyrimidines/toxicity ; Receptor, Platelet-Derived Growth Factor beta/antagonists & inhibitors ; Receptor, Platelet-Derived Growth Factor beta/metabolism