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المؤلفون: David A. Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W. Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Gunaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul Ciaccio, Jennifer A. Piesvaux, Karin M. Otte, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller, J. Michael Ellis
المصدر: Journal of Medicinal Chemistry. 65:16801-16817
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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2
المؤلفون: Thomas W. Rosahl, Lynn A. Hyde, Patrick T. Reilly, Marie-France Champy, Kirstine J. Belongie, Benoit Petit-Demouliere, Tania Sorg, Hugues Jacobs, Robert Terry, Jack D. Scott, Jared N. Cumming, Eric M. Parker, Matthew E. Kennedy
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a3d85e28d56edb9af63d9775fa8f6931
https://doi.org/10.1101/2021.12.20.473491 -
3Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors
المؤلفون: Blair T. Lapointe, Jack D. Scott, Xin Cindy Yan, Haiqun Tang, Janice D Woodhouse, Kaleen Konrad Childers, Robert Faltus, Erin F. DiMauro, Solomon Kattar, Charles S. Yeung, Ravi Kurukulasuriya, Vladimir Simov, Hakan Gunaydin, Anmol Gulati, Joey L. Methot, Rachel L. Palte, Ellen C. Minnihan, Greg Morriello, J. Michael Ellis, Harold B. Wood, Santhosh Neelamkavil, Karin M. Otte, Michael J. Ardolino, Barbara Pio, Ping Liu, Laxminarayan G Hegde, Matthew J. Fell, Vanessa L. Rada, Peter Fuller, Paul J Ciaccio
المصدر: RSC Med Chem
مصطلحات موضوعية: Pharmacology, 0303 health sciences, Trifluoromethyl, Chemistry, Metabolite, Organic Chemistry, Pharmaceutical Science, Pyrazole, Leucine-rich repeat, Biochemistry, LRRK2, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, 030220 oncology & carcinogenesis, Drug Discovery, Molecular Medicine, Kinome, Penetrant (biochemical), Linker, 030304 developmental biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8d45ea7dd7adda70471298a4476afa
https://europepmc.org/articles/PMC8292993/ -
4
المؤلفون: Mark S. Forman, Peter Orth, Ulrich Iserloh, Yusheng Wu, Hongwu Wang, William J. Greenlee, Reshma Kuvelkar, Xia Chen, Jack D. Scott, John Meredith, Lana M. Rossiter, Lynn A. Hyde, Robert A. Hodgson, Andrew Stamford, Julie A. Stone, Irina Kazakevich, Ganfeng Wang, Eric M. Parker, Eric J. Gilbert, Kathleen Cox, Corey O. Strickland, Sarah W. Li, Meagan Slater, Qin Jiang, Johannes H. Voigt, Hong Mei, Andrew Brunskill, Matthew E. Kennedy, Misiaszek Jeffrey A, Jared N. Cumming
المصدر: Journal of Medicinal Chemistry. 59:10435-10450
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, High selectivity, Cathepsin D, Rats, Sprague-Dawley, Amyloid beta-Protein Precursor, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Aspartate protease, Alzheimer Disease, Drug Discovery, Amyloid precursor protein, Animals, Humans, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Thiadiazines, biology, Cyclic S-Oxides, Rats, Macaca fascicularis, 030104 developmental biology, Enzyme, Biochemistry, chemistry, biology.protein, Molecular Medicine, Verubecestat, Clinical evaluation, Derivative (chemistry)
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المؤلفون: Hong Liu, Shawn P. Walsh, Yan Qi, Jiaqiang Cai, Jack D. Scott, Xin-Jie Chu, Cuizhi Mu, Brandon M. Taoka, Yaxian Cai, Jinsong Hao, Quang Truong, Zhong Lai, Xing Dai, Wen-Lian Wu, Jeffrey T. Kuethe, Eric J. Gilbert, Andrew Brunskill, Jared N. Cumming
المصدر: Tetrahedron. 72:6011-6020
مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Stereochemistry, Organic Chemistry, 010402 general chemistry, Ring (chemistry), Oxetane, 01 natural sciences, Biochemistry, Pyrrolidine, 0104 chemical sciences, Stereocenter, chemistry.chemical_compound, Cascade reaction, Intramolecular force, Drug Discovery, Proline
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المؤلفون: Jack D. Scott, William J. Morris, David A. Thaisrivongs
المصدر: ACS Symposium Series ISBN: 9780841233980
ACS Symposium Seriesمصطلحات موضوعية: Chemistry, Verubecestat, Disease, Bioinformatics
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b62690ca4aeaaa528269dc343def46e8
https://doi.org/10.1021/bk-2018-1307.ch003 -
7كتاب إلكتروني
المؤلفون: Ahmed F. Abdel-Magid, Jaan A. Pesti, Rajappa Vaidyanathan, Xin Linghu, Nicholas Wong, James F. Blake, John J. Gaudino, John G. Moffat, Steven M. Mennen, John Stellwagen, Ryan D. White, David A. Thaisrivongs, William J. Morris, Jack D. Scott, Harrie J. M. Gijsen, Jinguang Lin, Yannis Houpis, Ling Tong, Joseph A. Kozlowski, Louis-Charles Campeau, Jingjun Yin, Staffan Karlsson, Daniel Pettersen, Henrik Sörensen, Darren McKerrecher, Alan Steven, Fredrik Zetterberg, Carl-Johan Aurell, James W. Leahy, Sriram Naganathan, Denise L. Andersen, Neil G. Andersen, Stephen Lau
نوع المادة: eBook.
الموضوعات: Hepatitis C virus--Treatment--Technological innovations, Membrane proteins--Chemical inhibitors--Development, Fibrinolysis--Chemical inhibitors--Development, G proteins--Antagonists--Development, Glucokinase--Regulation--Development, Pharmaceutical industry, Drug development, Pharmaceutical technology, Alzheimer's disease--Treatment--Technological innovations, Protein kinases--Chemical inhibitors--Development, Rapamycin--Chemical inhibitors--Development, Purines--Receptors--Antagonists--Developm
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المؤلفون: Joel M. Harris, Xiaoping Zhou, John A. Morrow, Sue-Ing Lin, Marco A. S. Baptista, John M. Sanders, Xiaoping Zhang, Hong Mei, Mark W. Embrey, Sylvie M. Sur, Duane E. DeMong, Ravi P. Nargund, Alan Hruza, Heather E. Tiscia, Matthew J. Fell, Zhizhang Yin, Gautam Agnihotri, Honglu Zhang, Thomas J. Greshock, Jack D. Scott, Yinghui Lin, Zhi-Cai Shi, John A. Mccauley, Sarah W. Li, Ronald K. Chang, Mark T. Bilodeau, Michael W. Miller, Reshma Kuvelkar, Andrew Stamford, Marc Poirier, Hong Liu, Megan K. Macala, Kallol Basu, Li Xiao, Lynn A. Hyde, Jonathan T. Kern, Xing Dai, Christian Mirescu, Paul L. Walsh, Matthew E. Kennedy, John J. Renger, Zhiyong Hu, John Columbus, Robert E. Drolet, Eric M. Parker
المصدر: Journal of medicinal chemistry. 60(7)
مصطلحات موضوعية: 0301 basic medicine, Male, Indazoles, Leucine-rich repeat, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Animals, Humans, c-Raf, Kinase activity, Enzyme Inhibitors, Rats, Wistar, biology, Cyclin-dependent kinase 4, Kinase, Chemistry, Cyclin-dependent kinase 2, Brain, Parkinson Disease, LRRK2, nervous system diseases, Rats, Molecular Docking Simulation, 030104 developmental biology, Protein kinase domain, Biochemistry, biology.protein, Molecular Medicine, 030217 neurology & neurosurgery
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المؤلفون: Sherry X. Lu, Eric M. Parker, Mario Guzzi, Robert A. Hodgson, Xiaoping Zhang, Michael W. Miller, Andrew Stamford, Carina J. Bleickardt, Geoffrey B. Varty, Jack D. Scott, Deborra Mullins
المصدر: European Journal of Pharmacology. 730:157-163
مصطلحات موضوعية: Male, Receptors, Vasopressin, medicine.medical_specialty, Vasopressin, medicine.drug_class, Guinea Pigs, Anxiety, Mice, Internal medicine, Conditioning, Psychological, medicine, Animals, Receptor, Swimming, Vasopressin receptor, Pharmacology, Arginine vasopressin receptor 1B, Behavior, Animal, Depression, Antagonist, Receptor antagonist, Antidepressive Agents, Rats, Endocrinology, Anti-Anxiety Agents, Female, Vocalization, Animal, Antagonism, Licking, Psychology, Antidiuretic Hormone Receptor Antagonists
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المؤلفون: Huub Jan Kleijn, Jared N. Cumming, Xia Chen, John Palcza, Britta A. Mattson, Michael Tanen, Julie A. Stone, Wei Li, Eric M. Parker, Hong Mei, Reshma Kuvelkar, Stanford Jhee, Robert A. Hodgson, Jack Tseng, Lynn A. Hyde, Andrew Stamford, Matthew E. Kennedy, Kathleen Cox, Michael F. Egan, Larry Ereshefsky, Mark S. Forman, Marissa F. Dockendorf, Jack D. Scott, Matthew D. Troyer
المصدر: Science translational medicine. 8(363)
مصطلحات موضوعية: 0301 basic medicine, Central Nervous System, Magnetic Resonance Spectroscopy, Administration, Oral, Disease, Pharmacology, Crystallography, X-Ray, Toxicology studies, 03 medical and health sciences, Mice, 0302 clinical medicine, Cerebrospinal fluid, β amyloid, Alzheimer Disease, Catalytic Domain, mental disorders, Medicine, Animals, Aspartic Acid Endopeptidases, Myelin Sheath, Amyloid beta-Peptides, Human studies, Thiadiazines, business.industry, Brain, General Medicine, Small molecule, Cyclic S-Oxides, Rats, Macaca fascicularis, 030104 developmental biology, Glucose, Drug Design, Knockout mouse, Verubecestat, Female, Rabbits, Amyloid Precursor Protein Secretases, business, Peptides, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea76cf4560a861dae44bfdba275020bd
https://pubmed.ncbi.nlm.nih.gov/27807285