المؤلفون: Charles Jacob HK; Department of Surgery, University of Miami, Miller School of Medicine, Miami, USA. harryskcjacob@miami.edu.; Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, USA. harryskcjacob@miami.edu., Signorelli R; Department of Biology, University of Miami, Miami, USA., Charles Richard JL; Institute of Engineering in Medicine, University of California San Diego, San Diego, USA., Kashuv T; Department of Biochemistry and Molecular Biology, University of Miami, Miami, USA.; Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine, Stanford University School of Medicine, Stanford, USA., Lavania S; Department of Surgery, University of Miami, Miller School of Medicine, Miami, USA.; Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, USA., Middleton A; Department of Surgery, University of Miami, Miller School of Medicine, Miami, USA.; Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, USA., Gomez BA; Department of Surgery, University of Miami, Miller School of Medicine, Miami, USA.; Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, USA., Ferrantella A; Department of Surgery, University of Miami, Miller School of Medicine, Miami, USA.; Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, USA., Amirian H; Department of Surgery, University of Miami, Miller School of Medicine, Miami, USA.; Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, USA., Tao J; Department of Surgery, University of Miami, Miller School of Medicine, Miami, USA.; Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, USA., Ergonul AB; Biospecimen Shared Resource, University of Miami, Miami, USA., Boone MM; Biospecimen Shared Resource, University of Miami, Miami, USA., Hadisurya M; Department of Biochemistry, Purdue University, West Lafayette, USA., Tao WA; Department of Biochemistry, Purdue University, West Lafayette, USA., Iliuk A; Tymora Analytical Operations, Innovations, West Lafayette, USA., Kashyap MK; Amity Stem Cell Institute, Amity Medical School, Amity University, Haryana, India., Garcia-Buitrago M; Sylvester Comprehensive Cancer Center, Cancer Modeling Shared Resource, University of Miami, Miller School of Medicine, Miami, USA.; Department of Pathology and Laboratory Medicine, University of Miami, Miller School of Medicine, Miami, USA., Dawra R; Department of Surgery, University of Miami, Miller School of Medicine, Miami, USA.; Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, USA., Saluja AK; Department of Surgery, University of Miami, Miller School of Medicine, Miami, USA. asaluja@miami.edu.; Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, USA. asaluja@miami.edu.

المصدر: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2022 Aug 24; Vol. 41 (1), pp. 258. Date of Electronic Publication: 2022 Aug 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Kinesins* , Membrane Proteins* , Pancreatic Neoplasms*/pathology , Tumor Microenvironment*, Animals ; Biomarkers, Tumor/metabolism ; Humans ; Matrix Metalloproteinase 3 ; Mice ; Proteome/metabolism ; Proteomics/methods ; Pancreatic Neoplasms

المؤلفون: Signorelli R; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Department of Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Giret TM; Department of Radiation Oncology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Umland O; Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Hadisurya M; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA., Lavania S; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Charles Richard JL; Institute of Engineering in Medicine, University of California San Diego, San Diego, CA 92093, USA., Middleton A; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Boone MM; Biospecimen Shared Resource, University of Miami, Miami, FL 33136, USA., Ergonul AB; Biospecimen Shared Resource, University of Miami, Miami, FL 33136, USA., Tao WA; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA., Amirian H; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Iliuk A; Tymora Analytical Operations, Innovations, West Lafayette, IN 47906, USA., Khan A; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Diaz R; Sylvester Comprehensive Cancer Center, Cancer Modeling Shared Resource, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Cortes DB; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Cancer Modeling Shared Resource, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Garcia-Buitrago M; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Cancer Modeling Shared Resource, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Charles Jacob HK; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

المصدر: Biomedicines [Biomedicines] 2022 Aug 16; Vol. 10 (8). Date of Electronic Publication: 2022 Aug 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE

المؤلفون: Palathingal Bava E; Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA., George J; Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA., Tarique M; Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA., Iyer S; Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA., Sahay P; Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA., Gomez Aguilar B; Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA., Edwards DB; Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA., Giri B; Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA., Sethi V; Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA., Jain T; Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA., Sharma P; Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA., Vaish U; Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA., C Jacob HK; Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA., Ferrantella A; Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA., Maynard CL; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Saluja AK; Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA., Dawra RK; Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, USA., Dudeja V; Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Birmingham Veteran Affairs Medical Center, Birmingham, Alabama, USA.

المصدر: JCI insight [JCI Insight] 2022 Jan 25; Vol. 7 (2). Date of Electronic Publication: 2022 Jan 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

مواضيع طبية MeSH: Fibrosis*/etiology , Fibrosis*/prevention & control , Pancreas*/drug effects , Pancreas*/immunology , Pancreas*/injuries , Pancreas*/pathology , Pancreatitis*/drug therapy , Pancreatitis*/immunology, Acinar Cells/*metabolism , Interleukin-10/*immunology , Macrophages/*metabolism , Pyridones/*pharmacology, Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Cells, Cultured ; Cytokines/classification ; Cytokines/immunology ; Disease Models, Animal ; Mice ; Paracrine Communication/immunology ; Signal Transduction/immunology

المؤلفون: Charles Jacob HK; Departments of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Charles Richard JL; School of Biosciences, Engineering and Technology (SBET), VIT Bhopal University, Madhya Pradesh 466114, India., Signorelli R; Department of Biology, University of Miami, Miami, FL 33146, USA., Kashuv T; Department of Biochemistry and Molecular Biology, University of Miami, Miami, FL 33146, USA., Lavania S; Departments of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Vaish U; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Boopathy R; Department of Life Sciences, Shiv Nadar University, Greater Noida 201304, India., Middleton A; Departments of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Boone MM; Biospecimen Shared Resource, University of Miami, Miami, FL 33136, USA., Sundaram R; Departments of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Dudeja V; Departments of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Department of Life Sciences, Shiv Nadar University, Greater Noida 201304, India., Saluja AK; Departments of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

المصدر: Cancers [Cancers (Basel)] 2021 May 31; Vol. 13 (11). Date of Electronic Publication: 2021 May 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Charles Jacob HK; Department of Surgery and, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, Florida. Electronic address: harryskcjacob@miami.edu., Lavania S; Department of Surgery and, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, Florida., Saluja AK; Department of Surgery and, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, Florida.

المصدر: Gastroenterology [Gastroenterology] 2021 Mar; Vol. 160 (4), pp. 1014-1016. Date of Electronic Publication: 2021 Feb 05.

نوع المنشور: Editorial; Comment

بيانات الدورية: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE

مواضيع طبية MeSH: Cell Nucleus* , Pancreas*, Sequence Analysis, RNA

المؤلفون: Zhang X; From the ‡Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, 20892., Maity T; From the ‡Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, 20892., Kashyap MK; §Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205., Bansal M; ¶Department of System Biology, Columbia University, New York, New York, 10032.; ‖PsychoGenics Inc., Tarrytown, New York, 10591., Venugopalan A; From the ‡Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, 20892., Singh S; From the ‡Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, 20892., Awasthi S; From the ‡Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, 20892., Marimuthu A; §Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205., Charles Jacob HK; §Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205., Belkina N; From the ‡Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, 20892., Pitts S; From the ‡Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, 20892., Cultraro CM; From the ‡Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, 20892., Gao S; From the ‡Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, 20892., Kirkali G; From the ‡Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, 20892., Biswas R; From the ‡Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, 20892., Chaerkady R; §Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205.; *Medimmune LLC, Gaithersburg, Maryland, 20878., Califano A; ¶Department of System Biology, Columbia University, New York, New York, 10032., Pandey A; §Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205., Guha U; From the ‡Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, 20892; udayan.guha@nih.gov.

المصدر: Molecular & cellular proteomics : MCP [Mol Cell Proteomics] 2017 May; Vol. 16 (5), pp. 891-910. Date of Electronic Publication: 2017 Mar 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 101125647 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-9484 (Electronic) Linking ISSN: 15359476 NLM ISO Abbreviation: Mol Cell Proteomics Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma/*drug therapy , Adenocarcinoma/*metabolism , Biomarkers, Tumor/*metabolism , ErbB Receptors/*antagonists & inhibitors , Lung Neoplasms/*drug therapy , Lung Neoplasms/*metabolism , Phosphotyrosine/*metabolism , Protein Kinase Inhibitors/*therapeutic use , Proteomics/*methods, Adenocarcinoma/pathology ; Adenocarcinoma of Lung ; Afatinib ; Cell Line, Tumor ; Cluster Analysis ; ErbB Receptors/metabolism ; Erlotinib Hydrochloride/pharmacology ; Erlotinib Hydrochloride/therapeutic use ; Humans ; Isotope Labeling ; Lung Neoplasms/pathology ; Mass Spectrometry ; Mutation/genetics ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/pharmacology ; Quinazolines/pharmacology ; Quinazolines/therapeutic use ; Reproducibility of Results ; Signal Transduction/drug effects ; Tyrosine/metabolism

المؤلفون: Drosten M; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain. mdrosten@cnio.es mbarbacid@cnio.es., Simón-Carrasco L; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., Hernández-Porras I; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., Lechuga CG; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., Blasco MT; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., Jacob HK; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., Fabbiano S; Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC-Universidad de Salamanca, Salamanca, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Salamanca, Spain., Potenza N; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Second University of Naples, Caserta, Italy., Bustelo XR; Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC-Universidad de Salamanca, Salamanca, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Salamanca, Spain., Guerra C; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., Barbacid M; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain. mdrosten@cnio.es mbarbacid@cnio.es.

المصدر: Cancer research [Cancer Res] 2017 Feb 01; Vol. 77 (3), pp. 707-718. Date of Electronic Publication: 2016 Nov 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Genes, ras/*genetics , Neoplasms/*genetics , ras Proteins/*genetics , ras Proteins/*metabolism, Animals ; Disease Models, Animal ; Immunoblotting ; Immunohistochemistry ; Mice ; Mice, Transgenic ; Regulatory Sequences, Nucleic Acid

المؤلفون: Lechuga CG; Molecular Oncology Programme,, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, Madrid, 28029, Spain., Simón-Carrasco L; Molecular Oncology Programme,, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, Madrid, 28029, Spain., Jacob HK; Molecular Oncology Programme,, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, Madrid, 28029, Spain., Drosten M; Molecular Oncology Programme,, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, Madrid, 28029, Spain. mdrosten@cnio.es.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1487, pp. 269-276.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Association Studies* , Signal Transduction*, Extracellular Signal-Regulated MAP Kinases/*metabolism , Mitogen-Activated Protein Kinase Kinases/*metabolism , Proto-Oncogene Proteins c-raf/*metabolism , ras Proteins/*metabolism, Animals ; Cell Line ; Cell Proliferation ; Extracellular Signal-Regulated MAP Kinases/genetics ; Gene Expression ; Gene Knockout Techniques ; Genetic Vectors/genetics ; Humans ; Mice ; Mitogen-Activated Protein Kinase Kinases/genetics ; Proto-Oncogene Proteins c-raf/genetics ; Reproducibility of Results ; Retroviridae/genetics ; Transduction, Genetic ; ras Proteins/genetics

المؤلفون: Zhang X; Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Belkina N, Jacob HK, Maity T, Biswas R, Venugopalan A, Shaw PG, Kim MS, Chaerkady R, Pandey A, Guha U

المصدر: Proteomics [Proteomics] 2015 Jan; Vol. 15 (2-3), pp. 340-55.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101092707 Publication Model: Print Cited Medium: Internet ISSN: 1615-9861 (Electronic) Linking ISSN: 16159853 NLM ISO Abbreviation: Proteomics Subsets: MEDLINE

مواضيع طبية MeSH: Proteomics* , Signal Transduction*/drug effects, Adenocarcinoma/*metabolism , ErbB Receptors/*metabolism , Lung Neoplasms/*metabolism, Adenocarcinoma/drug therapy ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Adenocarcinoma of Lung ; Autophagy/drug effects ; Cell Line, Tumor ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Erlotinib Hydrochloride ; Humans ; Lung/drug effects ; Lung/metabolism ; Lung/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Mass Spectrometry ; Phosphopeptides/analysis ; Phosphopeptides/metabolism ; Phosphorylation/drug effects ; Point Mutation ; Protein Kinase Inhibitors/pharmacology ; Quinazolines/pharmacology

المؤلفون: Drosten M; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, 28029 Madrid, Spain; and mdrosten@cnio.es mbarbacid@cnio.es., Sum EY; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, 28029 Madrid, Spain; and., Lechuga CG; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, 28029 Madrid, Spain; and., Simón-Carrasco L; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, 28029 Madrid, Spain; and., Jacob HK; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, 28029 Madrid, Spain; and., García-Medina R; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, 28029 Madrid, Spain; and., Huang S; Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Beijersbergen RL; Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Bernards R; Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Barbacid M; Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, 28029 Madrid, Spain; and mdrosten@cnio.es mbarbacid@cnio.es.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Oct 21; Vol. 111 (42), pp. 15155-60. Date of Electronic Publication: 2014 Oct 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Cell Proliferation* , MAP Kinase Signaling System*, Tumor Suppressor Protein p53/*metabolism , ras Proteins/*metabolism, Alleles ; Amino Acid Sequence ; Animals ; Cell Cycle ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Genes, ras ; Humans ; Lysine/chemistry ; Mice ; Microscopy, Fluorescence ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Molecular Sequence Data ; Neoplasms/metabolism ; Sequence Homology, Amino Acid ; raf Kinases/metabolism