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المؤلفون: Martin Mortensen, Yue Xu, Mohamed A. Shehata, Jacob Krall, Margot Ernst, Bente Frølund, Trevor G. Smart
المصدر: British Journal of Pharmacology.
مصطلحات موضوعية: Pharmacology
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المؤلفون: Yongsong Tian, Mohamed A. Shehata, Stine Juul Gauger, Carolina Veronesi, Louise Hamborg, Louise Thiesen, Jesper Bruus-Jensen, Johanne Schlieper Royssen, Ulrike Leurs, Anne Sofie G. Larsen, Jacob Krall, Sara M.Ø. Solbak, Petrine Wellendorph, Bente Frølund
المصدر: Journal of medicinal chemistry. 65(22)
مصطلحات موضوعية: Mice, Benzocycloheptenes, Binding Sites, Drug Discovery, Molecular Medicine, Animals, Brain, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Protein Binding
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المؤلفون: Yongsong Tian, Mohamed Shehata, Stine Gauger, Carolina Veronesi, Louise Hamborg, Louise Thiesen, Jesper Bruus-Jensen, Johanne Schlieper Royssen, Ulrike Leurs, Anne Sofie Larsen, Jacob Krall, Sara Solbak, Petrine Wellendorph, Bente Frølund
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b93ff7e52f322bbe50e39bfc68636bd5
https://doi.org/10.26434/chemrxiv-2022-54d5q -
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المؤلفون: Yongsong Tian, Mohamed A. Shehata, Stine Juul Gauger, Clarissa K. L. Ng, Sara Solbak, Louise Thiesen, Jesper Bruus-Jensen, Jacob Krall, Christoffer Bundgaard, K. Michael Gibson, Petrine Wellendorph, Bente Frølund
المصدر: Journal of medicinal chemistry. 65(9)
مصطلحات موضوعية: Diclofenac, Drug Discovery, Long-Term Potentiation, Molecular Medicine, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Ligands
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المؤلفون: Nils Ole Dalby, Bente Frølund, Ulrike Leurs, Petrine Wellendorph, Christina Birkedahl Falk-Petersen, Petra Scholze, Jacob Krall
المصدر: British Journal of Pharmacology. 177:3975-3990
مصطلحات موضوعية: Pharmacology, Agonist, GABAA receptor, medicine.drug_class, Dentate gyrus, Gating, chemistry.chemical_compound, chemistry, medicine, Gabazine, Kinase activity, Receptor, Picrotoxin, medicine.drug
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المصدر: Developmental Neurobiology. 80:178-199
مصطلحات موضوعية: Male, 0301 basic medicine, Nicotine, medicine.medical_specialty, Pontine Tegmentum, Stimulation, Biology, GABAB receptor, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, Sex Factors, 0302 clinical medicine, Calcium imaging, Developmental Neuroscience, GABA receptor, Pregnancy, Internal medicine, medicine, Animals, Nicotinic Agonists, Receptor, GABAA receptor, Smoking, Age Factors, Receptors, GABA-A, Disease Models, Animal, 030104 developmental biology, Endocrinology, Receptors, GABA-B, nervous system, Prenatal Exposure Delayed Effects, GABAergic, Calcium, Female, 030217 neurology & neurosurgery, medicine.drug
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المؤلفون: Birgitte Nielsen, Kenneth T. Kongstad, Barbara Rolando, Bente Frølund, Donatella Boschi, Jacob Krall, Troels E. Sørensen, Alessandro Giraudo, Marco Lucio Lolli
المصدر: European Journal of Medicinal Chemistry. 158:311-321
مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Stereochemistry, Carboxylic acid, Triazole, Hydroxylation, 01 natural sciences, Aminobutyric acid, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, 3-triazole, Animals, Humans, Moiety, Homology modeling, Binding site, gamma-Aminobutyric Acid, Bioisosterism, Pharmacology, chemistry.chemical_classification, Hydroxy-1, Binding Sites, Scaffold hopping, 010405 organic chemistry, Organic Chemistry, GABA(A) receptor, General Medicine, Triazoles, Receptors, GABA-A, Rats, 0104 chemical sciences, 030104 developmental biology, chemistry, Docking (molecular), Hydroxy-1,2,3-triazole, Bioisostere, Protein Binding
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المؤلفون: Troels E. Sørensen, Kenneth T. Kongstad, Martin Mortensen, Anders A. Jensen, Birgitte Nielsen, Trevor G. Smart, Jacob Krall, Benjamin M. Brygger, Bente Frølund, Pierre Francotte, Ombretta Lenzi
المصدر: Mortensen, M, Krall, J, Kongstad, K T, Brygger, B M, Lenzi, O, Francotte, P, Sørensen, T E, Nielsen, B, Jensen, A A, Smart, T G & Frølund, B 2019, ' Developing New 4-PIOL and 4-PHP Analogues for Photoinactivation of γ-Aminobutyric Acid Type A Receptors ', ACS Chemical Neuroscience, vol. 10, no. 11, pp. 4669-4684 . https://doi.org/10.1021/acschemneuro.9b00478
مصطلحات موضوعية: Nervous system, Physiology, Cognitive Neuroscience, Central nervous system, Photoaffinity Labels, Inhibitory postsynaptic potential, Biochemistry, Aminobutyric acid, Protein Structure, Secondary, 03 medical and health sciences, 0302 clinical medicine, Piperidines, medicine, Humans, Binding site, Receptor, 030304 developmental biology, 0303 health sciences, Chemistry, GABAA receptor, Cell Biology, General Medicine, Isoxazoles, Receptors, GABA-A, medicine.anatomical_structure, HEK293 Cells, nervous system, Neuroscience, 030217 neurology & neurosurgery, Function (biology)
وصف الملف: application/pdf
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المؤلفون: Rasmus P. Clausen, Claus H. Jensen, Sara Björk Sigurdardóttir, Kenneth T. Kongstad, David E. Gloriam, Petrine Wellendorph, Mia Nittegaard-Nielsen, Christina Birkedahl Falk-Petersen, Francesco Bavo, Yongsong Tian, Jan Kehler, Kasper Harpsøe, Jacob Krall, Stine B. Vogensen, Bente Frølund, Anne S. Haugaard
المصدر: Journal of Medicinal Chemistry. 60:9022-9039
مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Carboxylic Acids, Molecular Conformation, Hydroxybutyrates, Cyclopentanes, Ligands, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, γ-Hydroxybutyric acid, Drug Discovery, T-HCA, Binding site, Binding Sites, 010405 organic chemistry, Chemistry, Ligand, 0104 chemical sciences, Molecular hybridization, Design synthesis, Crotonates, Drug Design, Molecular Medicine, Pharmacophore, 030217 neurology & neurosurgery
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المؤلفون: Toke Bek, Christoffer Bundgaard, Birgitte Nielsen, Bente Frølund, Jacob Krall, Benjamin M. Brygger, Jan Kehler, Clarissa K. L. Ng, Sara B. Sigurðardóttir, Anders A. Jensen
المصدر: Krall, J, Brygger, B M, Sigurðardóttir, S B, Ng, C K L, Bundgaard, C, Kehler, J, Nielsen, B, Bek, T, Jensen, A A & Frølund, B 2016, ' Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ1 γ-Aminobutyric Acid Type A Receptor Antagonists with Effect on Retinal Vascular Tone ', ChemMedChem, vol. 11, no. 20, pp. 2299-2310 . https://doi.org/10.1002/cmdc.201600356
مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.drug_class, Stereochemistry, Biochemistry, Aminobutyric acid, 03 medical and health sciences, chemistry.chemical_compound, Acetic acid, 0302 clinical medicine, Drug Discovery, Journal Article, medicine, Structure–activity relationship, General Pharmacology, Toxicology and Pharmaceutics, Receptor, Pharmacology, Chemistry, GABAA receptor, Ligand binding assay, Organic Chemistry, 030104 developmental biology, nervous system, Muscimol, Molecular Medicine, 030217 neurology & neurosurgery
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