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المؤلفون: Wang L; Center for Individualized Medicine, Mayo Clinic, Rochester, MN; Division of Clinical Pharmacology, Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN., Scherer SE; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX., Bielinski SJ; Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN., Muzny DM; Human Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX., Jones LA; Center for Individualized Medicine, Mayo Clinic, Rochester, MN., Black JL 3rd; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Moyer AM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Giri J; Center for Individualized Medicine, Mayo Clinic, Rochester, MN., Sharp RR; Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN., Matey ET; Department of Pharmacy, Mayo Clinic, Rochester, MN., Wright JA; Department of Pharmacy, Mayo Clinic, Rochester, MN., Oyen LJ; Department of Pharmacy, Mayo Clinic, Rochester, MN., Nicholson WT; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN., Wiepert M; Department of Information Technology, Mayo Clinic, Rochester, MN., Sullard T; Center for Individualized Medicine, Mayo Clinic, Rochester, MN., Curry TB; Center for Individualized Medicine, Mayo Clinic, Rochester, MN; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN., Rohrer Vitek CR; Center for Individualized Medicine, Mayo Clinic, Rochester, MN., McAllister TM; Center for Individualized Medicine, Mayo Clinic, Rochester, MN., St Sauver JL; Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN., Caraballo PJ; Division of General Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN., Lazaridis KN; Center for Individualized Medicine, Mayo Clinic, Rochester, MN; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN., Venner E; Human Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX., Qin X; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX., Hu J; Human Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX., Kovar CL; Human Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX., Korchina V; Human Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX., Walker K; Human Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX., Doddapaneni H; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX., Wu TJ; Human Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX., Raj R; Human Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX., Denson S; Human Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX., Liu W; Human Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX., Chandanavelli G; Human Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX., Zhang L; Human Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX., Wang Q; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX., Kalra D; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX., Karow MB; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Harris KJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Sicotte H; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Peterson SE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Barthel AE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Moore BE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Skierka JM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Kluge ML; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Kotzer KE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Kloke K; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Vander Pol JM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Marker H; Center for Individualized Medicine, Mayo Clinic, Rochester, MN., Sutton JA; Department of Information Technology, Mayo Clinic, Rochester, MN., Kekic A; Department of Pharmacy, Mayo Clinic, Phoenix, AZ., Ebenhoh A; Department of Pharmacy, Mayo Clinic, Rochester, MN., Bierle DM; Division of General Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN., Schuh MJ; Department of Pharmacy, Mayo Clinic, Jacksonville, FL., Grilli C; Department of Pharmacy, Mayo Clinic, Phoenix, AZ., Erickson S; Supply Chain Management, Mayo Clinic, Rochester, MN., Umbreit A; Department of Pharmacy, Mayo Clinic Health System, Mankato, MN., Ward L; Department of Pharmacy, Mayo Clinic, Jacksonville, FL., Crosby S; Department of Pharmacy, Mayo Clinic, Jacksonville, FL., Nelson EA; Department of Pharmacy, Mayo Clinic, Phoenix, AZ., Levey S; Department of Clinical Genomics, Mayo Clinic, Scottsdale, AZ., Elliott M; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN., Peters SG; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN., Pereira N; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN., Frye M; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN., Shamoun F; Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ., Goetz MP; Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN., Kullo IJ; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN., Wermers R; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN., Anderson JA; Department of Pharmacy, Mayo Clinic, Rochester, MN., Formea CM; Department of Pharmacy, Mayo Clinic, Rochester, MN., El Melik RM; Department of Pharmacy, Mayo Clinic, Rochester, MN., Zeuli JD; Department of Pharmacy, Mayo Clinic, Rochester, MN., Herges JR; Department of Pharmacy, Mayo Clinic, Rochester, MN., Krieger CA; Department of Pharmacy, Mayo Clinic, Rochester, MN., Hoel RW; Department of Pharmacy, Mayo Clinic, Rochester, MN., Taraba JL; Department of Pharmacy, Mayo Clinic, Rochester, MN., St Thomas SR; Center for Individualized Medicine, Mayo Clinic, Rochester, MN., Absah I; Division of Pediatric Gastroenterology and Hepatology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN., Bernard ME; Department of Family Medicine, Mayo Clinic, Rochester, MN., Fink SR; Division of Community Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN., Gossard A; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN., Grubbs PL; Department of Nursing, Mayo Clinic, Rochester, MN., Jacobson TM; Department of Nursing, Mayo Clinic, Rochester, MN., Takahashi P; Division of Community Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN., Zehe SC; Legal Department, Mayo Clinic, Rochester, MN., Buckles S; Department of Public Affairs, Mayo Clinic, Rochester, MN., Bumgardner M; Department of Nursing, Mayo Clinic, Rochester, MN., Gallagher C; Department of Public Affairs, Mayo Clinic, Rochester, MN., Fee-Schroeder K; Center for Individualized Medicine, Mayo Clinic, Rochester, MN., Nicholas NR; Center for Individualized Medicine, Mayo Clinic, Rochester, MN., Powers ML; Biospecimens Accessioning and Processing Laboratory, Mayo Clinic, Rochester, MN., Ragab AK; Center for Individualized Medicine, Mayo Clinic, Rochester, MN., Richardson DM; Center for Individualized Medicine, Mayo Clinic, Rochester, MN., Stai A; Department of Information Technology, Mayo Clinic, Rochester, MN., Wilson J; Center for Individualized Medicine, Mayo Clinic, Rochester, MN., Pacyna JE; Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN., Olson JE; Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN; Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN., Sutton EJ; Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN., Beck AT; Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN., Horrow C; Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN., Kalari KR; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN., Larson NB; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN., Liu H; Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN., Wang L; Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN., Lopes GS; Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN., Borah BJ; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN; Division of Health Care Policy and Research, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN., Freimuth RR; Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN., Zhu Y; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN., Jacobson DJ; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN., Hathcock MA; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN., Armasu SM; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN., McGree ME; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN., Jiang R; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN., Koep TH; OneOme, LLC, Minneapolis, MN., Ross JL; OneOme, LLC, Minneapolis, MN., Hilden MG; OneOme, LLC, Minneapolis, MN., Bosse K; OneOme, LLC, Minneapolis, MN., Ramey B; OneOme, LLC, Minneapolis, MN., Searcy I; OneOme, LLC, Minneapolis, MN., Boerwinkle E; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX; Human Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX; School of Public Health, University of Texas Health Science Center at Houston (UTHealth), Houston, TX., Gibbs RA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX. Electronic address: agibbs@bcm.edu., Weinshilboum RM; Center for Individualized Medicine, Mayo Clinic, Rochester, MN; Division of Clinical Pharmacology, Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. Electronic address: weinshilboum.richard@mayo.edu.

المصدر: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2022 May; Vol. 24 (5), pp. 1062-1072. Date of Electronic Publication: 2022 Mar 21.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 9815831 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0366 (Electronic) Linking ISSN: 10983600 NLM ISO Abbreviation: Genet Med Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 CYP2D6*/genetics , Pharmacogenetics*/methods, Academic Medical Centers ; Base Sequence ; Genotype ; Humans