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1دورية أكاديمية
المؤلفون: Zachary A. Gurard-Levin, Brian McMillan, Douglas A. Whittington, Brian Doyon, Michael D. Scholle, Jacques Ermolieff, Madhavi Bandi, Mu-Sen Liu, Alvaro Amor, William D. Mallender
المصدر: SLAS Technology, Vol 29, Iss 5, Pp 100173- (2024)
مصطلحات موضوعية: Screening, Label-free, Drug discovery, Multiplex, ASMS, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5
وصف الملف: electronic resource
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المؤلفون: Leanne Ahronian, Xinyuan Wu, Minjie Zhang, Chengyin Min, Alice Tsai, Jacques Ermolieff, Patrick McCarren, Margaret Wyman, Ye Wang, Alborz Bejnood, Kenjie Amemiya, Brian McMillan, Nikitha Das, Brian Doyon, Andre Mignault, Colin Liang, Vassil Elitzin, Yi Yu, Samuel Meier, Ashley Choi, John Maxwell, Alan Huang
المصدر: Regular and Young Investigator Award Abstracts.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8c641c1f38c41673cca4d6cb7ca020f7
https://doi.org/10.1136/jitc-2022-sitc2022.0444 -
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المؤلفون: Paul Tanis, Urmi Banerjee, Ron de Jong, Charles E. Grimshaw, Mark Sabat, Chris Proffitt, Walter Keung, Petro Halkowycz, Kim Peacock, Jacques Ermolieff
المصدر: SLAS Discovery. 26:676-683
مصطلحات موضوعية: 0301 basic medicine, Protein subunit, Regulator, Protein Serine-Threonine Kinases, Biology, Biochemistry, Analytical Chemistry, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Humans, Protein Kinase Inhibitors, Transcription factor, Drug discovery, Kinase, RELB, Cell biology, 030104 developmental biology, Cytoplasm, 030220 oncology & carcinogenesis, Molecular Medicine, Drug Screening Assays, Antitumor, Signal transduction, Protein Binding, Signal Transduction, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461b487527afd747e2f0032556040ba0
https://doi.org/10.1177/2472555220964450 -
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المؤلفون: Paul Rolzin, Jennifer Matuszkiewicz, James Bilakovics, Alok Pachori, Christopher J. Zopf, Pamela Farrell, Huey-Jing Huang, Artur Plonowski, Urmi Banerjee, Andrea Fanjul, Christopher McBride, Christopher J. Larson, Corine Holub, Zacharia Cheruvallath, Jacques Ermolieff, Darian Bartkowski, Crystal Mazur, Deepika Balakrishna
المصدر: Journal of Pharmacology and Experimental Therapeutics. 371:299-308
مصطلحات موضوعية: Male, 0301 basic medicine, Drug, media_common.quotation_subject, Angiogenesis Inhibitors, Pharmacology, Chlorobenzenes, Mice, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Cyclohexanes, Predictive Value of Tests, Weight loss, Human Umbilical Vein Endothelial Cells, Animals, Humans, Methionyl Aminopeptidases, Medicine, media_common, Dose-Response Relationship, Drug, business.industry, Biological activity, Mice, Inbred C57BL, Clinical trial, Treatment Outcome, 030104 developmental biology, Drug development, Cinnamates, Pharmacodynamics, Epoxy Compounds, Molecular Medicine, Biomarker (medicine), medicine.symptom, business, Sesquiterpenes, Biomarkers, 030217 neurology & neurosurgery, HeLa Cells
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190c881ee391f64b555b89dd5b10a54a
https://doi.org/10.1124/jpet.119.259028 -
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المؤلفون: Simone V, Bigi-Botterill, Anthony, Ivetac, Erica L, Bradshaw, Derek, Cole, Douglas R, Dougan, Jacques, Ermolieff, Petro, Halkowycz, Ben, Johnson, Christopher, McBride, Jason, Pickens, Mark, Sabat, Steven, Swann
المصدر: Bioorganicmedicinal chemistry letters. 30(17)
مصطلحات موضوعية: Inhibitory Concentration 50, Mice, Binding Sites, Catalytic Domain, Drug Design, Imidazoles, Animals, Humans, Myocardial Reperfusion Injury, Molecular Dynamics Simulation, Crystallography, X-Ray, MAP Kinase Kinase Kinase 5, Protein Kinase Inhibitors
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المؤلفون: Loui Madakamutil, Ewan Taylor, Phong H. Vu, Mark Sabat, Deepika Balakrishna, Beverly Knight, Haixia Wang, Corey Wyrick, Mark S. Hixon, Nicholas Scorah, Christopher Ronald Smith, Donavon McConn, Petro Halkowycz, Douglas R. Dougan, J. David Lawson, Jacques Ermolieff
المصدر: Journal of Medicinal Chemistry. 64:16318-16318
مصطلحات موضوعية: Drug, Chemistry, Drug discovery, Stereochemistry, medicine.drug_class, media_common.quotation_subject, Tyrosine-kinase inhibitor, chemistry.chemical_compound, Fragment (logic), Ibrutinib, Drug Discovery, medicine, Molecular Medicine, Bruton's tyrosine kinase inhibitor, media_common
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المؤلفون: Haixia Wang, Marion Lanier, Jacques Ermolieff, Jason Pickens, Tony Gibson, Steve Swann, Joanne Miura, Anthony Ivetac, Erica L. Bradshaw-Pierce, Mark Sabat, Petro Halkowycz, Tyhonas John, Douglas R. Dougan, Derek C. Cole, Simone V. Bigi, Evan Nunez, Xiaolun Wang, Alison Chambers, Zacharia Cheruvallath, Aki Hirokawa
المصدر: ACS Medicinal Chemistry Letters. 8:316-320
مصطلحات موضوعية: 0301 basic medicine, MAP kinase kinase kinase, Kinase, Organic Chemistry, Pharmacology, Biology, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Apoptosis, Heart failure, Drug Discovery, medicine, ASK1, Protein kinase A, Reperfusion injury, Lead compound
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المؤلفون: Petro Halkowycz, Douglas R. Dougan, Simone V. Bigi-Botterill, Derek C. Cole, Ben Johnson, Erica L. Bradshaw, Christopher McBride, Mark Sabat, Steven Swann, Anthony Ivetac, Jacques Ermolieff, Jason Pickens
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127405
مصطلحات موضوعية: MAP kinase kinase kinase, 010405 organic chemistry, Kinase, p38 mitogen-activated protein kinases, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, computer.file_format, Protein Data Bank, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Biophysics, Molecular Medicine, Kinome, ASK1, Protein kinase A, Molecular Biology, computer, Lead compound
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المؤلفون: Charles E. Grimshaw, Isabelle Tcholakov, Lihong Shi, Kiryanov Andre A, Artur Plonowski, Murphy Sean, Jacques Ermolieff, Christopher J. Larson
المصدر: Bioscience Reports
مصطلحات موضوعية: 0301 basic medicine, hypoxia inducible factor, Cell, Biophysics, Biochemistry, Hypoxia-Inducible Factor-Proline Dioxygenases, Small Molecule Libraries, 03 medical and health sciences, Dissociation rate constant, Catalytic Domain, medicine, Humans, Proline, liquid chromatography-tandem mass spectrometry, time-dependent inhibition, Enzyme Inhibitors, Molecular Biology, Research Articles, residence time, biology, Chemistry, hypoxia, Active site, Cell Biology, prolyl hydroxylase 2, Hypoxia (medical), Small molecule, Kinetics, 030104 developmental biology, medicine.anatomical_structure, Hypoxia-inducible factors, biology.protein, Ketoglutaric Acids, medicine.symptom, Hypoxic stress, Research Article, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df965c862d79fda155242ac015bbda5d
http://europepmc.org/articles/PMC6434079 -
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المؤلفون: Deepak Dalvie, Yong Wang, Theodore O. Johnson, Michael Siu, Cripps Stephan James, Klaus Ruprecht Dress, Jacqui Elizabeth Hoffman, Taylor Wendy Dianne, Stanley William Kupchinsky, Ping Kang, Sue Zhou, Jacques Ermolieff, Andrea Fanjul, Sajiv Krishnan Nair, Arturo Castro, Jennifer E. Vogel, Jean Joo Matthews, Amy LaPaglia, Cheng Hengmiao, Paul A. Rejto, Christopher Ronald Smith, Martin Paul Edwards, Natilie Hosea
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:2344-2348
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Aminopyridines, Pharmaceutical Science, Dehydrogenase, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, 11β-hydroxysteroid dehydrogenase type 1, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, Humans, Structure–activity relationship, Molecular Biology, Sulfonamides, biology, Chemistry, Organic Chemistry, HEK 293 cells, Glutathione, HEK293 Cells, Reactive metabolite, Risk-benefit analysis, biology.protein, Molecular Medicine