المؤلفون: Jian Sun, Jacques J. Kessl

المصدر: Viruses, Vol 16, Iss 2, p 200 (2024)

مصطلحات موضوعية: HIV, integrase, virus maturation, allosteric integrase inhibitor, ALLINI, quinoline, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1999-4915/16/2/200; https://doaj.org/toc/1999-4915

URL الوصول: https://doaj.org/article/8be272e2c5b8483b93db95e9e02e3edb

المؤلفون: Long Phi Dinh, Jian Sun, Courtney D. Glenn, Krunal Patel, Julie A. Pigza, Matthew G. Donahue, Larry Yet, Jacques J. Kessl

المصدر: Viruses, Vol 14, Iss 7, p 1466 (2022)

مصطلحات موضوعية: HIV-1, integrase, ALLINI, quinolines, multimerization, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1999-4915/14/7/1466; https://doaj.org/toc/1999-4915

URL الوصول: https://doaj.org/article/f2d416b3b3bc4289b2abab616bc72f4e

المؤلفون: Nicholas G. Jentsch, Jared D. Hume, Emily B. Crull, Samer M. Beauti, Amy H. Pham, Julie A. Pigza, Jacques J. Kessl, Matthew G. Donahue

المصدر: Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2529-2536 (2018)

مصطلحات موضوعية: cyclodehydration, HIV integrase, isatoic anhydride, masked acyl cyanide, quinoline, Science, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1860-5397

URL الوصول: https://doaj.org/article/fbd91e864cd84c9da84a118b40063aa4

المؤلفون: Xue Zhi Zhao, Mathieu Métifiot, Evgeny Kiselev, Jacques J. Kessl, Kasthuraiah Maddali, Christophe Marchand, Mamuka Kvaratskhelia, Yves Pommier, Terrence R. Burke

المصدر: Molecules, Vol 23, Iss 8, p 1858 (2018)

مصطلحات موضوعية: HIV-1 integrase, viral protein R, photoaffinity probe, inhibitor, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/23/8/1858; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/4c907d36f6b14c509e53863d153aad7a

المؤلفون: Mamuka Kvaratskhelia, Ari Katz, Nikolozi Shkriabai, Jocelyn O. Eidahl, Christopher J. McKee, Jacques J. Kessl

المصدر: Viruses, Vol 1, Iss 3, Pp 713-736 (2009)

مصطلحات موضوعية: HIV, retroviruses, DNA, integrase, crosslinking, footprinting, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1999-4915/1/3/713/; https://doaj.org/toc/1999-4915

URL الوصول: https://doaj.org/article/f358cbf67f2c43f8aa48b368a2e64b13

المؤلفون: Jian Sun, Jacques J. Kessl, Kaitlin A McNeely, Julie A. Pigza, Nicholas G. Jentsch, Chiyang Lama, Jared D. Hume, Alison P Hart, Matthew Garrett Donahue

المصدر: ACS Medicinal Chemistry Letters. 9:1007-1012

مصطلحات موضوعية: 0301 basic medicine, biology, Stereochemistry, Aryl, 030106 microbiology, Organic Chemistry, Quinoline, Biochemistry, In vitro, Integrase, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, ANTIRETROVIRAL AGENTS, chemistry, Viral replication, Drug Discovery, biology.protein, Hiv 1 integrase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ff79914f4d441c9d2d1e09908647b7
https://doi.org/10.1021/acsmedchemlett.8b00269

المؤلفون: James R. Fuchs, Arthur J. Olson, Mamuka Kvaratskhelia, Stefano Forli, Lei Feng, Janet Antwi, D. Patel, Ronald M. Levy, Pratibha C. Koneru, Joseph D. Bauman, Erik Serrao, Nanjie Deng, Alan Engelman, Jacques J. Kessl, Eddy Arnold

المصدر: Journal of Biological Chemistry. 291:23569-23577

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Stereochemistry, Mutant, Allosteric regulation, Carboxylic Acids, HIV Infections, HIV Integrase, Thiophenes, Biology, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Allosteric Regulation, Catalytic Domain, Drug Discovery, Humans, HIV Integrase Inhibitors, Molecular Biology, 030102 biochemistry & molecular biology, Drug discovery, Quinoline, HEK 293 cells, Cell Biology, Integrase, Molecular Docking Simulation, Crystallography, HEK293 Cells, 030104 developmental biology, chemistry, Viral replication, Protein Structure and Folding, HIV-1, biology.protein, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9bfb32bbfe4818cb1bb991e7d9c8e8
https://doi.org/10.1074/jbc.m116.753384

المؤلفون: Julie A. Pigza, Jared D. Hume, Jacques J. Kessl, Matthew Garrett Donahue, Jian Sun, Krunal Patel

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Integrase inhibitor, HIV Integrase, Virus Replication, Biochemistry, HIV-1, human immunodeficiency virus type 1, quinoline, HTRF, homogeneous time resolved fluorescence, human immunodeficiency virus, biology, Chemistry, CTD, C-terminal domain, DMSAO, dimethyl sulfoxide, Chromatin, Integrase, Cell biology, Quinolines, Intercellular Signaling Peptides and Proteins, CCD, catalytic core domain, I N, integrase, Research Article, Protein Binding, drug design, Virus Integration, Protein subunit, Allosteric regulation, ALLINI, allosteric IN inhibitors, Antiviral Agents, oligomerization, Protein–protein interaction, antiviral agent, 03 medical and health sciences, Allosteric Regulation, Humans, NTD, N-terminal domain, HIV Integrase Inhibitors, Binding site, Molecular Biology, RNP, ribonucleoprotein complex, 030102 biochemistry & molecular biology, Cell Biology, protein–protein interaction, HEK293 Cells, 030104 developmental biology, vDNA, viral cDNA, Viral replication, HIV-1, biology.protein, ALLINI, integrase, Protein Multimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812afed44ebca78da55c911ffeaba508
https://doi.org/10.1016/j.jbc.2021.100363

المؤلفون: Erik Serrao, Frederic D. Bushman, Alan Engelman, Venkatasubramanian Dharmarajan, Ashley C. Hoyte, Alison Slaughter, Jacques J. Kessl, Patrick R. Griffin, James R. Fuchs, Matthew R. Plumb, Ross C. Larue, Mamuka Kvaratskhelia, Amit Sharma, Lei Feng

المصدر: ACS Chemical Biology. 11:1313-1321

مصطلحات موضوعية: 0301 basic medicine, Allosteric regulation, Integrase inhibitor, HIV Infections, HIV Integrase, Virus Replication, Biochemistry, Article, 03 medical and health sciences, Allosteric Regulation, Tetramer, Humans, HIV Integrase Inhibitors, Binding site, 030102 biochemistry & molecular biology, biology, HEK 293 cells, General Medicine, Molecular biology, In vitro, Integrase, HEK293 Cells, 030104 developmental biology, Viral replication, HIV-1, biology.protein, Intercellular Signaling Peptides and Proteins, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0909208d678fa8b0b74fc7dc0a20fb20
https://doi.org/10.1021/acschembio.6b00167

المؤلفون: Jacques J. Kessl, Christophe Marchand, Yves Pommier, Evgeny Kiselev, Mamuka Kvaratskhelia, Terrence R. Burke, Mathieu Métifiot, Kasthuraiah Maddali, Xue Zhi Zhao

المساهمون: Laboratory for Mechanics of Materials and Nanostructures [Thun] (EMPA), Laboratory of Molecular Pharmacology, National Institutes of Health [Bethesda] (NIH)-National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes (LBMCE), Institut de biologie physico-chimique (IBPC (FR_550)), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Molecules
Volume 23
Issue 8
Molecules, Vol 23, Iss 8, p 1858 (2018)
Molecules, MDPI, 2018, 23 (8), pp.1858. ⟨10.3390/molecules23081858⟩
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Magnetic Resonance Spectroscopy, Protein Conformation, Allosteric regulation, Pharmaceutical Science, HIV Infections, Peptide, HIV Integrase, Plasma protein binding, Article, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, Protein structure, lcsh:Organic chemistry, HIV-1 integrase, Drug Discovery, medicine, photoaffinity probe, Protein Interaction Domains and Motifs, Amino Acid Sequence, HIV Integrase Inhibitors, Physical and Theoretical Chemistry, Peptide sequence, ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, biology, Chemistry, Gene Products, vpr, Organic Chemistry, biochemical phenomena, metabolism, and nutrition, viral protein R, 3. Good health, Integrase, inhibitor, 030104 developmental biology, Biochemistry, Mechanism of action, Viral replication, Chemistry (miscellaneous), [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, HIV-1, biology.protein, Molecular Medicine, Protein Multimerization, medicine.symptom, Peptides, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2b90006fbd42f6262d1e28cb52f88d