المؤلفون: Qu W; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Lam M; Department of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA., McInvale JJ; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Mares JA; Department of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA., Kwon S; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Humala N; Department of Neurosurgery, Columbia University, New York, NY, USA., Mahajan A; Department of Neurosurgery, Columbia University, New York, NY, USA., Nguyen T; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Jakubiak KA; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Mun JY; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Tedesco TG; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Al-Dalahmah O; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Hussaini SA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Sproul AA; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Siegelin MD; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., De Jager PL; Department of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Canoll P; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Menon V; Department of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA. vm2545@cumc.columbia.edu.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. vm2545@cumc.columbia.edu., Hargus G; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA. gh2374@cumc.columbia.edu.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. gh2374@cumc.columbia.edu.

المصدر: Acta neuropathologica [Acta Neuropathol] 2024 Jun 25; Vol. 147 (1), pp. 107. Date of Electronic Publication: 2024 Jun 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE

مواضيع طبية MeSH: Induced Pluripotent Stem Cells* , Alzheimer Disease*/genetics , Alzheimer Disease*/pathology , Alzheimer Disease*/metabolism , Neurons*/metabolism , Neurons*/pathology , Transcriptome* , Amyloid beta-Protein Precursor*/genetics , Amyloid beta-Protein Precursor*/metabolism, Humans ; Animals ; Mice ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Mutation ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Synapses/pathology ; Synapses/metabolism ; Amyloid beta-Peptides/metabolism ; Signal Transduction/genetics ; Signal Transduction/physiology

المؤلفون: Al-Dalahmah O; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease & the Aging Brain, Columbia University, New York, NY 10032, USA., Lam M; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA., McInvale JJ; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Qu W; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Nguyen T; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Mun JY; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Kwon S; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Ifediora N; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Mahajan A; Department of Neurosurgery, Columbia University, New York, NY 10032, USA., Humala N; Department of Neurosurgery, Columbia University, New York, NY 10032, USA., Winters T; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Angeles E; Taub Institute for Research on Alzheimer's Disease & the Aging Brain, Columbia University, New York, NY 10032, USA., Jakubiak KA; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Kühn R; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Kim YA; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., De Rosa MC; Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY 10032, USA., Doege CA; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Paryani F; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA., Flowers X; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Dovas A; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Mela A; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Lu H; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., DeTure MA; Department of Neuroscience, The Mayo Clinic Florida, Jacksonville, FL 32224, USA., Vonsattel JP; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Wszolek ZK; Department of Neurology, The Mayo Clinic Florida, Jacksonville, FL 32224, USA., Dickson DW; Department of Neuroscience, The Mayo Clinic Florida, Jacksonville, FL 32224, USA., Kuhlmann T; Institute of Neuropathology, University Hospital Münster, Münster 48149, Germany., Zaehres H; Institute of Anatomy, Ruhr University Bochum, Medical Faculty, Bochum 44801, Germany; Max Planck Institute for Molecular Biomedicine, Münster 48149, Germany., Schöler HR; Max Planck Institute for Molecular Biomedicine, Münster 48149, Germany., Sproul AA; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease & the Aging Brain, Columbia University, New York, NY 10032, USA., Siegelin MD; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., De Jager PL; Taub Institute for Research on Alzheimer's Disease & the Aging Brain, Columbia University, New York, NY 10032, USA; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA., Goldman JE; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease & the Aging Brain, Columbia University, New York, NY 10032, USA., Menon V; Taub Institute for Research on Alzheimer's Disease & the Aging Brain, Columbia University, New York, NY 10032, USA; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA., Canoll P; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA., Hargus G; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease & the Aging Brain, Columbia University, New York, NY 10032, USA. Electronic address: gh2374@cumc.columbia.edu.

المصدر: Cell stem cell [Cell Stem Cell] 2024 May 02; Vol. 31 (5), pp. 676-693.e10. Date of Electronic Publication: 2024 Apr 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

مواضيع طبية MeSH: Osteopontin*/metabolism , Osteopontin*/genetics , Frontotemporal Dementia*/genetics , Frontotemporal Dementia*/pathology , Frontotemporal Dementia*/metabolism , Neurons*/metabolism , Neurons*/pathology , tau Proteins*/metabolism, Humans ; Animals ; Mice ; Neuroinflammatory Diseases/metabolism ; Neuroinflammatory Diseases/pathology ; Microglia/metabolism ; Microglia/pathology ; Mutation/genetics