-
1
المؤلفون: Matthew Bogyo, Sanjay K. Jain, Charles S. Craik, Florencia La Greca, Anthony J. O’Donoghue, Alvaro A. Ordonez, Christian S. Lentz, James C. Powers, Marcin Drag, Christopher J. Schulze, Paulina Kasperkiewicz
المصدر: ACS Infectious Diseases
مصطلحات موضوعية: 0301 basic medicine, Proteases, medicine.medical_treatment, Antitubercular Agents, Virulence, hydrolase important for pathogenesis 1 (Hip1), 01 natural sciences, Article, Substrate Specificity, Mycobacterium tuberculosis, Serine, 03 medical and health sciences, Bacterial Proteins, Hydrolase, medicine, activity-based probe, Animals, Humans, Tuberculosis, Enzyme Inhibitors, Serine protease, chemistry.chemical_classification, Protease, biology, Molecular Structure, 010405 organic chemistry, protease, biology.organism_classification, substrate profiling, 0104 chemical sciences, 3. Good health, Kinetics, 030104 developmental biology, Infectious Diseases, Enzyme, Biochemistry, chemistry, Drug Design, biology.protein, fluorogenic substrate, Serine Proteases
-
2
المؤلفون: Sarina Gloeckl, Charles W. Armitage, Melisa Merdanovic, Joel D. A. Tyndall, Kenneth W. Beagley, Cynthia B. Whitchurch, Józef Oleksyszyn, Lynne Turnbull, Peter Timms, Pooja Patel, Vanissa A. Ong, Michael Ehrmann, Wilhelmina M. Huston, Matthew Bogyo, John A. Allan, James C. Powers, Martijn Verdoes
المصدر: Molecular Microbiology. 89:676-689
مصطلحات موضوعية: Proteases, Chlamydia, biology, Intracellular parasite, urologic and male genital diseases, medicine.disease, medicine.disease_cause, biology.organism_classification, Cell morphology, Microbiology, female genital diseases and pregnancy complications, In vitro, Cell biology, medicine, Chlamydia trachomatis, Molecular Biology, Pathogen, Chlamydia muridarum
-
3
المؤلفون: Amy J. Campbell, Victoria E. Albrow, James C. Powers, Elizabeth L. Ponder, Junpeng Xiao, Miklós Békés, Edgar Deu, Urša Pečar Fonović, Marcin Drag, Jowita Mikolajczyk, Brittany A. Leader, Matthew Bogyo, Aimee Shen, Guy S. Salvesen
المصدر: Chemistry & Biology. 18:711-721
مصطلحات موضوعية: medicine.medical_treatment, Molecular Sequence Data, Plasmodium falciparum, Clinical Biochemistry, Phthalic Acids, Protozoan Proteins, SUMO protein, SUMO enzymes, Biochemistry, Article, Substrate Specificity, 03 medical and health sciences, Transcription (biology), Small Ubiquitin-Related Modifier Proteins, Catalytic Domain, Endopeptidases, parasitic diseases, Drug Discovery, medicine, Humans, Protease Inhibitors, Amino Acid Sequence, Molecular Biology, Peptide sequence, 030304 developmental biology, Pharmacology, 0303 health sciences, Protease, biology, 030302 biochemistry & molecular biology, General Medicine, biology.organism_classification, Small molecule, Recombinant Proteins, 3. Good health, Cysteine Endopeptidases, Hydrazines, Molecular Medicine
-
4
المؤلفون: Michelle Brouner, Crystal Fagan, Asli Ovat, Jan Dvorák, Daniel Sojka, Petr Kopáček, Conor R. Caffrey, Elizabeth Hansell, James C. Powers, Fanuel Muindi, James H. McKerrow
المصدر: Journal of Medicinal Chemistry. 52:7192-7210
مصطلحات موضوعية: Stereochemistry, Biological Availability, Epoxide, Tripeptide, Chemical synthesis, chemistry.chemical_compound, Drug Discovery, Peptide synthesis, Animals, Amino Acid Sequence, Enzyme Inhibitors, chemistry.chemical_classification, Aza Compounds, Ixodes, biology, Schistosoma mansoni, biology.organism_classification, Cysteine Endopeptidases, Kinetics, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Drug Design, Michael reaction, biology.protein, Epoxy Compounds, Molecular Medicine, Oligopeptides
-
5
المؤلفون: Victoria E. Albrow, Aimee Shen, Andrew Guzzetta, K. Christopher Garcia, James C. Powers, Patrick J. Lupardus, Matthew Bogyo
المصدر: Nature chemical biology
مصطلحات موضوعية: Models, Molecular, Cholera Toxin, Proteases, medicine.medical_treatment, Blotting, Western, Molecular Sequence Data, education, Allosteric regulation, Virulence, Cysteine Proteinase Inhibitors, Biology, Crystallography, X-Ray, medicine.disease_cause, Article, Protein Structure, Secondary, Substrate Specificity, Allosteric Regulation, Cysteine Proteases, Catalytic Domain, Spectroscopy, Fourier Transform Infrared, medicine, Amino Acid Sequence, Vibrio cholerae, Molecular Biology, Protease, Effector, Cell Biology, Cysteine protease, Enzyme Activation, Biochemistry, Antitoxin, Sequence Alignment, Protein Binding
-
6
المؤلفون: Jin Qian, Zhaozhao Li, Dominic Cuerrier, Robert L. Campbell, James C. Powers, Peter L. Davies
المصدر: Journal of Medicinal Chemistry. 51:5264-5270
مصطلحات موضوعية: Proteases, Protein Conformation, medicine.medical_treatment, Proteolysis, Crystallography, X-Ray, Article, Amino Acids, Aromatic, Structure-Activity Relationship, Protein structure, Drug Discovery, medicine, Animals, Structure–activity relationship, Glycoproteins, Protease, biology, medicine.diagnostic_test, Calpain, Chemistry, Dipeptides, Rats, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Carbamates, Cysteine
-
7
المؤلفون: Karen Ellis James, Maia M. Cherney, Jie Liu, Ting-Wai Lee, James C. Powers, Michael N.G. James, Lindsay D. Eltis
المصدر: Journal of Molecular Biology
مصطلحات موضوعية: Models, Molecular, Coronavirus M Proteins, Stereochemistry, CoV, coronavirus, Static Electricity, Peptide, Protomer, Plasma protein binding, Crystallography, X-Ray, Article, Substrate Specificity, Viral Matrix Proteins, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Structural Biology, Hydrolase, SARS, severe acute respiratory syndrome, Binding site, Molecular Biology, X-ray crystallography, 030304 developmental biology, induced-fit binding, chemistry.chemical_classification, 0303 health sciences, Binding Sites, Chemistry, aza-peptide epoxide, APE, aza-peptide epoxide, SARS coronavirus main peptidase, Protein Structure, Tertiary, CMK, chloromethyl ketone, N-terminus, Crystallography, Severe acute respiratory syndrome-related coronavirus, Catalytic cycle, 030220 oncology & carcinogenesis, structure-based drug design, Epoxy Compounds, Protons, Peptides, Protein Binding
-
8Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors
المؤلفون: Stjepan Jelakovic, Juliana L. Asgian, Markus G. Grütter, Rajkumar Ganesan, Zhao Zhao Li, Amy J. Campbell, James C. Powers
المصدر: Biochemistry. 45:9059-9067
مصطلحات موضوعية: Stereochemistry, Epoxide, Crystallography, X-Ray, Biochemistry, Substrate Specificity, Residue (chemistry), chemistry.chemical_compound, Humans, Moiety, Enzyme Inhibitors, Binding site, Caspase, Histidine, Aza Compounds, Binding Sites, biology, Caspase 3, Caspase Inhibitors, Recombinant Proteins, chemistry, Caspases, biology.protein, Epoxy Compounds, Oxyanion hole, Oligopeptides, Cysteine
-
9
المؤلفون: James C. Powers, Tex T. X. Lu, Ijaz S. Jamall
المصدر: Remediation Journal. 16:71-80
مصطلحات موضوعية: Environmental Engineering, Chemistry, Environmental remediation, Soil vapor extraction, Extraction (chemistry), Environmental engineering, chemistry.chemical_element, Pulp and paper industry, Pollution, chemistry.chemical_compound, Air stripping, Hydrogen peroxide, Waste Management and Disposal, Effluent, Carbon, Groundwater
-
10
المؤلفون: Carly Huitema, Karen Ellis James, Ting-Wai Lee, Maia M. Cherney, Jie Liu, James C. Powers, Michael N.G. James, Lindsay D. Eltis
المصدر: Journal of Molecular Biology
مصطلحات موضوعية: SARS coronavirus, Stereochemistry, CoV, coronavirus, Mpro, the main peptidase from CoV, Epoxide, Peptide, Crystal structure, Crystallography, X-Ray, medicine.disease_cause, 01 natural sciences, Article, Catalysis, 03 medical and health sciences, chemistry.chemical_compound, Structural Biology, Hydrolase, medicine, Protease Inhibitors, SARS, severe acute respiratory syndrome, Molecular Biology, Coronavirus 3C Proteases, X-ray crystallography, 030304 developmental biology, Coronavirus, chemistry.chemical_classification, main peptidase, 0303 health sciences, Binding Sites, Molecular Structure, 010405 organic chemistry, aza-peptide epoxide, Space group, APE, aza-peptide epoxide, Hydrogen-Ion Concentration, 3. Good health, 0104 chemical sciences, CMK, chloromethyl ketone, Cysteine Endopeptidases, Crystallography, Severe acute respiratory syndrome-related coronavirus, chemistry, Covalent bond, structure-based drug design, Epoxy Compounds, Severe acute respiratory syndrome coronavirus, Peptides