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المؤلفون: Santo R. Cortina, R. J. Griffiths, Marcie L. Vaughn-Bowser, Arturo Lopez-Anaya, Lori L. Lopresti-Morrow, Kim F. McClure, Kathleen M. Donahue, Shunda M. McGahee, Mary E. Lame, Christopher S. Jones, James D. Eskra, Ralph P. Robinson, Ivan G. Otterness, Jennifer L. Liras, Matthew R. Reese, Lisa M. Tobiassen, Sue A. Yocum, Gary J. Martinelli, Peter G. Mitchell, Lawrence A. Reiter, Marcia L. Bliven
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:3389-3395
مصطلحات موضوعية: Matrix metalloproteinase inhibitor, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Matrix Metalloproteinase Inhibitors, Hydroxamic Acids, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Matrix Metalloproteinase 13, Drug Discovery, Humans, Structure–activity relationship, Protease Inhibitors, Molecular Biology, Pyrans, chemistry.chemical_classification, Sulfonamides, Hydroxamic acid, integumentary system, biology, Bicyclic molecule, Chemistry, Organic Chemistry, Matrix Metalloproteinases, Sulfonamide, Pyran, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Matrix Metalloproteinase 1
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2
المؤلفون: Sue A. Yocum, Gary J. Martinelli, James D. Eskra, Lawrence A. Reiter, Lori L. Lopresti-Morrow, Peter G. Mitchell
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:2331-2336
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, Biochemistry, Chemical synthesis, Substrate Specificity, Structure-Activity Relationship, Isomerism, Matrix Metalloproteinase 13, Drug Discovery, Protease Inhibitors, Collagenases, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Phosphinic Acids, In vitro, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Indicators and Reagents, Matrix Metalloproteinase 3, Matrix Metalloproteinase 1
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3
المؤلفون: Margaret A. Rushing, James D. Eskra, Robert J. Noveck, Ramon Vargas, Keith D. Wilner, Rebecca Adler, Catherine Walden
المصدر: Journal of Clinical Pharmacology. 42:1027-1030
مصطلحات موضوعية: Adult, Male, Adolescent, Platelet Aggregation, Thromboxane, Arthritis, Pharmacology, Placebo, chemistry.chemical_compound, Double-Blind Method, medicine, Humans, Cyclooxygenase Inhibitors, Drug Interactions, Platelet, Pharmacology (medical), Sulfonamides, Aspirin, Arachidonic Acid, Cyclooxygenase 2 Inhibitors, business.industry, Membrane Proteins, Middle Aged, medicine.disease, Adenosine Diphosphate, Isoenzymes, Thromboxane B2, chemistry, Celecoxib, Cyclooxygenase 2, Prostaglandin-Endoperoxide Synthases, Pyrazoles, Platelet aggregation inhibitor, Female, business, Platelet Aggregation Inhibitors, medicine.drug
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4
المؤلفون: Ivan G. Otterness, Jean-Pierre Pelletier, Marcia L. Bliven, Anthony J. Milici, James D. Eskra, Anne K. Shay
المصدر: Arthritis & Rheumatism. 41:2068-2076
مصطلحات موضوعية: Pathology, medicine.medical_specialty, business.industry, Cartilage, Immunology, Hamster, Physical exercise, Osteoarthritis, medicine.disease, chemistry.chemical_compound, Hydroxyproline, medicine.anatomical_structure, Rheumatology, chemistry, Hyaluronic acid, medicine, Immunology and Allergy, Synovial fluid, Pharmacology (medical), business, Sedentary lifestyle
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::09f97b8141f4f5262dad404ec0b3a3d9
https://doi.org/10.1002/1529-0131(199811)41:11<2068::aid-art23>3.0.co;2-l -
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المؤلفون: Marcia L. Bliven, James D. Eskra, Ivan G. Otterness
المصدر: Inflammation Research. 46:491-495
مصطلحات موضوعية: medicine.medical_specialty, Indoles, Lipopolysaccharide, Indomethacin, Immunology, Arthritis, Hamster, Motor Activity, Pharmacology, Piroxicam, Injections, Intra-Articular, chemistry.chemical_compound, Cricetinae, Internal medicine, Animals, Medicine, Chromatography, High Pressure Liquid, Mesocricetus, biology, business.industry, Anti-Inflammatory Agents, Non-Steroidal, biology.organism_classification, medicine.disease, Rheumatology, Oxindoles, Disease Models, Animal, chemistry, Acute Disease, biology.protein, Female, Cyclooxygenase, Tenidap, business, medicine.drug
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المؤلفون: Peter F. Moore, A. Nagahisa, Saul B. Kadin, Francis J. Sweeney, Thomas J. Carty, P. P. Pazoles, M. J. Ernest, J. D. Cheng, J.S. Pillar, Leland D. Loose, P. A. Joseph, R. J. Griffiths, S. Murase, James D. Eskra
المصدر: Inflammation Research. 46:168-179
مصطلحات موضوعية: Erythrocytes, Indoles, Neutrophils, Intracellular pH, Immunology, Radioimmunoassay, 6-Ketoprostaglandin F1 alpha, Leukotriene B4, Neutrophil Activation, Cyclooxygenase pathway, Immunoenzyme Techniques, Rats, Sprague-Dawley, chemistry.chemical_compound, In vivo, Hydroxyeicosatetraenoic Acids, medicine, Animals, Humans, Cyclooxygenase Inhibitors, Lipoxygenase Inhibitors, Calcimycin, Chromatography, High Pressure Liquid, Leukotriene E4, Pharmacology, Leukotriene, Arachidonate 5-Lipoxygenase, Arachidonic Acid, Chemotactic Factors, Ionophores, biology, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Zymosan, Oxindoles, Rats, Thromboxane B2, Cytosol, Leukemia, Basophilic, Acute, Biochemistry, Arachidonate 5-lipoxygenase, biology.protein, Arachidonic acid, Rabbits, Tenidap, medicine.drug
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7
المؤلفون: Ethan J. Stam, R. J. Griffiths, Anthony J. Milici, Mary Alice Smith, Jeffrey L. Stock, Deborah N. Scampoli, Robert S. Byrum, James D. Eskra, John D. McNeish, Marsha L. Roach, Beverly H. Koller
المصدر: The Journal of Experimental Medicine
مصطلحات موضوعية: Male, Heterozygote, Leukotrienes, Immunology, Leukotriene Production, 5-Lipoxygenase-Activating Proteins, Arthritis, Article, Pathogenesis, chemistry.chemical_compound, Peritoneal cavity, Mice, medicine, Immunology and Allergy, Animals, Humans, 5-lipoxygenase-activating protein, Peritoneal Cavity, Mice, Knockout, biology, Stem Cells, Zymosan, Membrane Proteins, Articles, Blood Proteins, medicine.disease, Arthritis, Experimental, medicine.anatomical_structure, chemistry, Mice, Inbred DBA, Antibody Formation, biology.protein, Chronic inflammatory response, Female, Joints, Collagen, Stem cell, Carrier Proteins
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80cb45f1797ad1aec7c112551e0d9fd
http://europepmc.org/articles/PMC2196231 -
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المؤلفون: M. Sakakibara, Saul B. Kadin, A. Nagahisa, Ivan G. Otterness, David L. Larson, James D. Eskra, Francis J. Sweeney, Peter F. Moore, Albert Weissman, Thomas J. Carty
المصدر: Inflammation Research. 45:54-61
مصطلحات موضوعية: Male, Indoles, Guinea Pigs, Immunology, Analgesic, Pharmacology, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, Dogs, Oral administration, Animals, Humans, Medicine, Cyclooxygenase Inhibitors, IC50, ED50, Arachidonic Acid, biology, business.industry, Arthritis, Anti-Inflammatory Agents, Non-Steroidal, Haplorhini, Analgesics, Non-Narcotic, Oxindoles, Rats, chemistry, biology.protein, Cyclooxygenase, Prostaglandin D2, Tenidap, business, Ex vivo, medicine.drug
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المؤلفون: G.W. Antognoli, J.T. Shirley, A. Marfat, C.F. Wright, Thomas J. Carty, Frank W. Rusek, J. W. Watson, J. Delehunt, B. A. Naclerio, James F. Eggler, J.S. Pillar, Herbert Sherman, E.G. Andrews, Francis J. Sweeney, K. W. Freiert, R. Breslow, C. J. Mularski, V. L. Cohan, C J Pazoles, Lawrence S. Melvin, L.A. Rappach, John B. Cheng, David B. Damon, Jeanene E. Tickner, Judith L. Collins, P. Reiche, Hiroko Masamune, M. P. Carta, James D. Eskra, Hada William Andrew, R. J. Chambers
المصدر: Bioorganic & Medicinal Chemistry Letters. 5:1365-1370
مصطلحات موضوعية: LTD4 receptor, Chemistry, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Antagonist, Pharmaceutical Science, Molecular Medicine, Pharmacology, Receptor, Molecular Biology, Biochemistry, First generation
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المؤلفون: Louis W. Heck, Leland D. Loose, T. J. Carty, Warren D. Blackburn, James D. Eskra
المصدر: Arthritis & Rheumatism. 34:204-210
مصطلحات موضوعية: medicine.medical_specialty, Indoles, Neutrophils, Leukotriene B4, Immunology, Radioimmunoassay, Cell Degranulation, Dinoprostone, Arthritis, Rheumatoid, chemistry.chemical_compound, Rheumatology, Internal medicine, Synovial Fluid, medicine, Humans, Immunology and Allergy, Synovial fluid, Cyclooxygenase Inhibitors, Pharmacology (medical), Lipoxygenase Inhibitors, Prostaglandin E2, Cells, Cultured, Chromatography, High Pressure Liquid, Aged, Pancreatic Elastase, biology, Lactoferrin, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Elastase, Degranulation, Middle Aged, Oxindoles, Endocrinology, chemistry, biology.protein, Neutrophil degranulation, Tenidap, business, medicine.drug