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المؤلفون: Christopher L. Carpenter, Eldridge N. Nartey, Dominic Suarez, Elisabeth A. Minthorn, Jesus R. Medina, Louis V. LaFrance, Ralph A. Rivero, James F. Mack, Charles F. McHugh, Xinrong Tian, Dirk A. Heerding, Christina Ng Di Marco, Thomas J. Berrodin, Aishwarya Bhaskar, Biju Mangatt, William Hoi Hong Li, Brackley James, Martyr Cuthbert, Lorena A. Kallal, Michael Butticello, Jacob Rubin
المصدر: Journal of Medicinal Chemistry. 64:16056-16087
مصطلحات موضوعية: Gene knockdown, Oncogene, Drug discovery, Chemistry, Drug Discovery, Molecular Medicine, Structure–activity relationship, Computational biology, Small molecule binding, Pharmacophore, Small molecule, Function (biology)
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المؤلفون: Jesús R, Medina, Xinrong, Tian, William H, Li, Dominic, Suarez, James F, Mack, Louis, LaFrance, Cuthbert, Martyr, James, Brackley, Christina, Di Marco, Ralph, Rivero, Dirk A, Heerding, Charles, McHugh, Elisabeth, Minthorn, Aishwarya, Bhaskar, Jacob, Rubin, Michael, Butticello, Christopher, Carpenter, Eldridge N, Nartey, Thomas J, Berrodin, Lorena A, Kallal, Biju, Mangatt
المصدر: Journal of medicinal chemistry. 64(21)
مصطلحات موضوعية: Proto-Oncogene Proteins c-myc, Small Molecule Libraries, Structure-Activity Relationship, Area Under Curve, Cell Line, Tumor, Drug Discovery, Animals, Humans, Xenograft Model Antitumor Assays, Half-Life, Rats
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المؤلفون: Mary Ann Hardwicke, Hong Lin, Karl F. Erhard, John D. Martin, Ren Xie, Kaushik Raha, Rosanna Tedesco, Jin Zeng, Yanqiu Qian, Patricia M. Kratz, Yong Jiang, Ted Cecconie, Stan F. Martens, Angela Smallwood, Patrick McDevitt, James F. Mack, Baoguang Zhao, Stephenie B. Chen, Anthony J. Jurewicz, Juan I. Luengo, Mark J. Schulz, Nino Campobasso, Catherine A. Oleykowski, Lawrence M. Szewczuk, Alan R. Rendina, Cynthia M. Rominger, Benjamin J. Schwartz, Leng Nickels, Junya Qu, Jacques Briand
المصدر: ACS Medicinal Chemistry Letters. 7:217-222
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Biology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Hexokinase-2, Enzyme, chemistry, Cell culture, Glucosamine, 030220 oncology & carcinogenesis, Drug Discovery, Bladder tumor, Glycolysis, Selectivity
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المؤلفون: Manca Logar, James F. Mack, Hitoshi Iwadate, Yonas T. Yemane, Philip B. Van Stockum, Fritz B. Prinz
المصدر: Chemistry of Materials. 24:4357-4362
مصطلحات موضوعية: In situ, Materials science, Morphology (linguistics), General Chemical Engineering, Analytical chemistry, Nucleation, Nanotechnology, General Chemistry, Zinc sulfide, Grain size, law.invention, Atomic layer deposition, chemistry.chemical_compound, chemistry, law, Phase (matter), Materials Chemistry, Scanning tunneling microscope
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5Abstract 2919: Discovery of small-molecule compounds targeting c-MYC using a novel cell-based screen
المؤلفون: Stuart Paul Romeril, Gopinath Ganji, Dirk A. Heerding, George P. Livi, Anna Rutkowska-Klute, William Hoi Hong Li, James F. Mack, Elisabeth A. Minthorn, Derrick W. Meinhold, Carolyn A. Buser, Jesus R. Medina, Lorena A. Kallal, Shanker K. Sundaram, Biju Mangatt, Anthony Della Pietra, Sonja Ghidelli-Disse, Anna Waszkiewicz, Jon-Paul Jaworski, Thomas J. Berrodin, Rakesh Kumar, Wendy S. Halsey, Christian S. Sherk, Gerard Drewes
المصدر: Cancer Research. 78:2919-2919
مصطلحات موضوعية: Cancer Research, Oncogene, Cell, Biology, chemistry.chemical_compound, medicine.anatomical_structure, Oncology, chemistry, Transcription (biology), Gene duplication, medicine, Cancer research, Protein stabilization, Signal transduction, Transcription factor, DNA
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::64bc4d93904423361b095d651579562d
https://doi.org/10.1158/1538-7445.am2018-2919 -
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المصدر: Journal of Labelled Compounds and Radiopharmaceuticals. 44:1025-1033
مصطلحات موضوعية: Chemistry, Hydride, Aryl, Organic Chemistry, Halogenation, Borohydride, Biochemistry, Analytical Chemistry, chemistry.chemical_compound, Deuterium, Drug Discovery, Organic chemistry, Radiology, Nuclear Medicine and imaging, Deuterated methanol, Selective reduction, Ion-exchange resin, Spectroscopy
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7
المؤلفون: Hong Lin, Charles B. Davis, Kaushik Raha, Ralph A. Rivero, Michael D. Schaber, Jeanelle McSurdy-Freed, Mary Ann Hardwicke, Karl F. Erhard, James F. Mack, Ren Xie, Michael D. Spengler, Ramona Plant, Cynthia M. Rominger, Junya Qu, Rosanna Tedesco, Jennifer L. Ariazi, Juan I. Luengo, Mark J. Schulz, Michael D. Squire, Christian S. Sherk, Jin Zeng
مصطلحات موضوعية: business.industry, Organic Chemistry, Rational design, medicine.disease, Bioinformatics, Biochemistry, Prostate cancer, chemistry.chemical_compound, chemistry, Breast cancer cell line, Drug Discovery, Cancer research, Medicine, Structure–activity relationship, Homology modeling, Growth inhibition, business, Beta (finance), PI3K/AKT/mTOR pathway
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace88350b0677b6d5e549d1aab456577
https://europepmc.org/articles/PMC4025772/ -
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المؤلفون: Michael D. Spengler, Rosanna Tedesco, Sanchez Robert, Michael D. Schaber, Ramona Plant, Hong Lin, Mary Ann Hardwicke, Karl F. Erhard, James F. Mack, Kaushik Raha, Ralph A. Rivero, Cynthia M. Rominger, Juan I. Luengo, Mark J. Schulz, Jeanelle McSurdy-Freed, Ren Xie, Jin J. Zeng
المصدر: Bioorganicmedicinal chemistry letters. 22(6)
مصطلحات موضوعية: Gene isoform, Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Breast Neoplasms, Pyrimidinones, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Humans, Homology modeling, Phosphatidylinositol, Molecular Biology, Protein Kinase Inhibitors, Phosphoinositide-3 Kinase Inhibitors, Binding Sites, Kinase, Organic Chemistry, Imidazoles, PTEN Phosphohydrolase, Isoenzymes, Kinetics, chemistry, Docking (molecular), Molecular Medicine, Female, Growth inhibition, Enantiomer, Drug Screening Assays, Antitumor, Phosphatidylinositol 3-Kinase, Gene Deletion, Protein Binding
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المؤلفون: Hitoshi Iwadate, James F. Mack, Fritz B. Prinz, Philip B. Van Stockum
المصدر: Review of Scientific Instruments. 82:123704
مصطلحات موضوعية: Materials science, business.industry, Nanotechnology, Characterization (materials science), law.invention, Atomic layer deposition, Nanolithography, law, Torr, Optoelectronics, Deposition (phase transition), Scanning tunneling microscope, business, Instrumentation, Layer (electronics), Quantum tunnelling
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المصدر: Review of Scientific Instruments. 81:044102
مصطلحات موضوعية: chemistry.chemical_compound, Atomic layer deposition, Materials science, chemistry, Chemical engineering, Hydrogen sulfide, Compressed air, Lead sulfide, Chemical vapor deposition, Chemical reactor, Instrumentation, Zinc sulfide, Leakage (electronics)