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1
المؤلفون: Hannah Dou, Songli Wang, Hilary Plake Beck, Hantao Liu, Steven H. Olson, Toni Williamson, Philip Roveto, James J. S. Treanor, Frank Kayser, Guifen Xu, Ji Ma, Brian M. Fox, Qingwen Cheng, Lixia Jin
المصدر: Journal of Medicinal Chemistry. 58:5256-5273
مصطلحات موضوعية: Pyridones, Amyloid beta, medicine.medical_treatment, Prostaglandin E2 receptor, Plaque, Amyloid, Pharmacology, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Phagocytosis, Drug Discovery, medicine, Animals, Structure–activity relationship, Tissue Distribution, Receptor, Molecular Structure, biology, CYP3A4, Chemistry, Macrophages, Antagonist, Brain, Receptors, Prostaglandin E, EP2 Subtype, Rats, Mice, Inbred C57BL, Oxazepines, Microsomes, Liver, biology.protein, Molecular Medicine, Biological Assay, Ex vivo, Prostaglandin E
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2
المؤلفون: Essa Hu, Samer Chmait, Thomas T. Nguyen, Amy Porter, Kristin L. Andrews, Silke Miller, Carl Davis, Jennifer R. Allen, Robert M. Rzasa, James J. S. Treanor, Alexander J. Pickrell, Adrie D. Jones, Roxanne Kunz, Daniel B. Horne, Xiaoning Zhao, Matthew R. Kaller, Holger Monenschein, Ning Chen, Heather Eastwood, Jeffrey Clarine, Michael J. Frohn, Andreas Reichelt
المصدر: Bioorganic & Medicinal Chemistry. 22:6570-6585
مصطلحات موضوعية: Models, Molecular, Phosphodiesterase Inhibitors, Stereochemistry, Clinical Biochemistry, Azetidine, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Structure–activity relationship, Solubility, Molecular Biology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Phosphoric Diester Hydrolases, Chemistry, Organic Chemistry, Bioavailability, Enzyme, Quinolines, Alkoxy group, Molecular Medicine, Lead compound, Ex vivo
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3
المؤلفون: Jianxia Shi, Xiaoning Zhao, Samer Chmait, Mary Dovlatyan, Silke Miller, Kristin L. Andrews, Geraldine Hill Della Puppa, James J. S. Treanor, Dianna Lester-Zeiner, Carl Davis, Essa Hu, Christopher Biorn, Jessica Able, Hang Chen, Jennifer R. Allen, Ji Ma
المصدر: ACS Medicinal Chemistry Letters. 5:700-705
مصطلحات موضوعية: Stereochemistry, Organic Chemistry, Phosphodiesterase, Biochemistry, Cocrystal, Bioavailability, chemistry.chemical_compound, chemistry, Morpholine, Drug Discovery, Pyridine, Potency, PDE10A, Receptor
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4
المؤلفون: Dah-Ren Hwang, John Castrillon, Shannon Rumfelt, Jennifer R. Allen, Essa Hu, Anissa Abi-Dargham, Carl Davis, Balu Easwaramoorthy, James J. S. Treanor, Hang Chen, Mark Slifstein
المصدر: Nuclear Medicine and Biology. 41:343-349
مصطلحات موضوعية: Male, Cancer Research, Central nervous system, Aminopyridines, Striatum, Nuclear magnetic resonance, medicine, Animals, Radiology, Nuclear Medicine and imaging, Carbon Radioisotopes, Radiochemistry, medicine.diagnostic_test, Phosphoric Diester Hydrolases, Chemistry, business.industry, Putamen, Brain, Phosphodiesterase, Pyridazines, Kinetics, Globus pallidus, medicine.anatomical_structure, Positron emission tomography, Positron-Emission Tomography, Feasibility Studies, Molecular Medicine, PDE10A, Bolus (digestion), Nuclear medicine, business, Papio
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e513d78ed165d00a8bcf84edd85dfd4d
https://doi.org/10.1016/j .nucmedbio.2014.01.007 -
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المؤلفون: Dianna Lester-Zeiner, Christopher Biorn, Essa Hu, Jianxia Shi, James J. S. Treanor, Sharon Zhao, Jennifer R. Allen, Amy Porter, Kristin L. Andrews, Samer Chmait, Shannon Rumfelt, Aaron C. Siegmund, Roxanne Kunz, Ning Chen, Hang Chen, Carl Davis, Ji Ma
المصدر: Journal of Medicinal Chemistry. 56:8781-8792
مصطلحات موضوعية: Male, Models, Molecular, Phosphodiesterase Inhibitors, Swine, Pharmacology, Rats, Sprague-Dawley, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Humans, Potency, Receptor, Cells, Cultured, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Phosphoric Diester Hydrolases, Phosphodiesterase, Ketones, Rats, Bioavailability, Enzyme, chemistry, Biochemistry, Drug Design, Molecular Medicine, Benzimidazoles, Efflux, PDE10A
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6
المؤلفون: Samer Chmait, Adrie D. Jones, Amy Porter, Kristin L. Andrews, Xiaoning Zhao, Jennifer R. Allen, Shannon Rumfelt, Wenge Zhong, Essa Hu, James R. Falsey, Robert M. Rzasa, Steven W. Louie, James J. S. Treanor, Ning Chen
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:7371-7375
مصطلحات موضوعية: Models, Molecular, Phosphodiesterase Inhibitors, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, Drug Discovery, Humans, Potency, Structure–activity relationship, ATP Binding Cassette Transporter, Subfamily B, Member 1, Molecular Biology, P-glycoprotein, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, biology, Phosphoric Diester Hydrolases, Drug discovery, Organic Chemistry, Phosphodiesterase, Enzyme, chemistry, biology.protein, Molecular Medicine, PDE10A, Efflux, Ethers
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7
المؤلفون: Randall W. Hungate, Jennifer R. Allen, Roxanne Kunz, James J. S. Treanor, Ji Ma, Carl Davis, Jianxia Shi, Essa Hu, Ning Chen, Dianna Lester-Zeiner, Dah-Ren Hwang, Hang Chen, Klaus Michelsen
المصدر: ACS medicinal chemistry letters. 7(7)
مصطلحات موضوعية: medicine.diagnostic_test, 010405 organic chemistry, Chemistry, Organic Chemistry, Phosphodiesterase, Binding potential, Pharmacology, 01 natural sciences, Biochemistry, In vitro, 0104 chemical sciences, 03 medical and health sciences, 0302 clinical medicine, In vivo, Positron emission tomography, 030220 oncology & carcinogenesis, TRACER, Drug Discovery, medicine, PDE10A, Pet tracer
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المؤلفون: Dah-Ren Hwang, Geraldine Hill Della Puppa, Jamie Wong, Essa Hu, Thomas Nixey, Silke Miller, Hang Chen, Jessica Able, Dianna Lester-Zeiner, James J. S. Treanor, Robert Cho, Santosh Talreja, Roxanne Kunz, Jianxia Shi, Ji Ma, David C. Immke, Jennifer R. Allen, Christopher Biorn, Amy Porter, Klaus Michelsen, Shannon Rumfelt, Stephen Hitchcock
المصدر: Journal of Medicinal Chemistry. 55:4776-4787
مصطلحات موضوعية: Male, Phosphodiesterase Inhibitors, Aminopyridines, Striatum, In Vitro Techniques, Tritium, Permeability, Cell Line, Rats, Sprague-Dawley, Dogs, Tandem Mass Spectrometry, In vivo, TRACER, Drug Discovery, Animals, Humans, Tissue Distribution, ATP Binding Cassette Transporter, Subfamily B, Member 1, Radionuclide Imaging, Phosphoric Diester Hydrolases, Drug discovery, Chemistry, Brain, Phosphodiesterase, Stereoisomerism, Surface Plasmon Resonance, Molecular biology, Small molecule, Rats, Pyridazines, Rapid identification, Quinolines, Pyrazoles, Molecular Medicine, PDE10A, Radiopharmaceuticals, Chromatography, Liquid, Protein Binding
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المؤلفون: Jeffrey H. Kogan, Samer Chmait, Chun Li, Essa Hu, Michelle Lindstrom, Jiandong Zhang, Kristin L. Andrews, Roland Burli, Roxanne Kunz, Stephen Hitchcock, James J. S. Treanor, Ning Chen, Shannon Rumfelt
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2262-2265
مصطلحات موضوعية: Models, Molecular, Phosphodiesterase Inhibitors, Metabolite, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Coumarins, In vivo, Drug Discovery, Avoidance Learning, Animals, Humans, Potency, Molecular Biology, chemistry.chemical_classification, Psychotropic Drugs, Binding Sites, Behavior, Animal, Phosphoric Diester Hydrolases, Organic Chemistry, Phosphodiesterase, Metabolism, Rats, Enzyme, chemistry, Molecular Medicine, PDE10A, Selectivity, Protein Binding
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المؤلفون: Mqhele Ncube, Lillian Liao, Rami Tamir, Yunxin Bo, Narender R. Gavva, James J. S. Treanor, Partha P. Chakrabarti, Markian Stec, Nuria A. Tamayo, Mark H. Norman
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:5118-5122
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, TRPV Cation Channels, Pharmaceutical Science, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Combinatorial Chemistry Techniques, Potency, Structure–activity relationship, Benzothiazoles, Solubility, Molecular Biology, Molecular Structure, Bicyclic molecule, Aryl, Organic Chemistry, Antagonist, Rats, Bioavailability, Pyrimidines, chemistry, Molecular Medicine