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المؤلفون: Aranapakam Mudumbai Venkatesan, Christoph Martin Dehnhardt, Osvaldo Dos Santos, Larry Feldberg, Gulnaz Khafizova, Judy Lucas, Robert Mallon, Natasja Brooijmans, Robert T. Abraham, Zecheng Chen, Inder Chaudhary, James Joseph Gibbons, Ker Yu, Efren Guillermo Delos Santos, Tarek S. Mansour, Irwin Hollander, Semiramis Ayral-Kaloustian
المصدر: Journal of Medicinal Chemistry. 53:2636-2645
مصطلحات موضوعية: Models, Molecular, Cell Survival, Morpholines, Mice, Nude, Protein Serine-Threonine Kinases, Pharmacology, Binding, Competitive, Inhibitory Concentration 50, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, chemistry.chemical_compound, Adenosine Triphosphate, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Structure–activity relationship, Phosphatidylinositol, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Molecular Structure, Triazines, Kinase, Akt/PKB signaling pathway, TOR Serine-Threonine Kinases, Intracellular Signaling Peptides and Proteins, Survival Analysis, Xenograft Model Antitumor Assays, In vitro, Protein Structure, Tertiary, Models, Chemical, chemistry, Biochemistry, Area Under Curve, Mutation, Molecular Medicine, Female, Protein Binding
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المؤلفون: James Joseph Gibbons, Ker Yu, Robert T. Abraham
المصدر: Seminars in Oncology. 36:S3-S17
مصطلحات موضوعية: P70-S6 Kinase 1, mTORC1, Biology, Models, Biological, mTORC2, Neoplasms, Drug Discovery, medicine, Animals, Humans, PI3K/AKT/mTOR pathway, Cell Proliferation, Sirolimus, Antibiotics, Antineoplastic, Everolimus, Cell growth, TOR Serine-Threonine Kinases, RPTOR, Hematology, Cell biology, Oncology, Protein Biosynthesis, Protein Kinases, Signal Transduction, medicine.drug
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المؤلفون: James Joseph Gibbons, Ker Yu, Boris Shor, Robert T. Abraham
المصدر: Cell Cycle. 8:3831-3837
مصطلحات موضوعية: mTORC1, Mechanistic Target of Rapamycin Complex 1, Protein Serine-Threonine Kinases, Biology, Pharmacology, mTORC2, Humans, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Sirolimus, Antibiotics, Antineoplastic, Cell growth, TOR Serine-Threonine Kinases, RPTOR, Intracellular Signaling Peptides and Proteins, Proteins, Cell Biology, Drug development, Multiprotein Complexes, Protein Biosynthesis, Proto-Oncogene Proteins c-akt, Signal Transduction, Transcription Factors, Developmental Biology
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المؤلفون: Li Di, Arie Zask, Mark Edward Ruppen, Judy Lucas, Mairead Young, Jianyao Wang, Michael Cinque, Inder Chaudhary, Christine Gaydos, Semiramis Ayral-Kaloustian, Tarek S. Mansour, Ker Yu, Jianxin Gu, James Joseph Gibbons
المصدر: Journal of Medicinal Chemistry. 53:452-459
مصطلحات موضوعية: Molecular Conformation, Mice, Nude, Antineoplastic Agents, Protein Serine-Threonine Kinases, Pharmacology, Wortmannin, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Stability, In vivo, Drug Discovery, Tumor Cells, Cultured, medicine, Animals, Humans, Protein Kinase Inhibitors, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Sirolimus, Kinase, TOR Serine-Threonine Kinases, Intracellular Signaling Peptides and Proteins, Stereoisomerism, Biological activity, Prodrug, Xenograft Model Antitumor Assays, Kidney Neoplasms, Rats, Androstadienes, chemistry, Biochemistry, Drug Design, Molecular Medicine, medicine.drug
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المؤلفون: David Malwitz, Irwin Hollander, Kevin J. Curran, Arie Zask, John W. Ellingboe, Lourdes Toral-Barza, Yongbo Hu, Weiguo Zhang, Pawel Nowak, Joshua Kaplan, Natasja Brooijmans, Matthew Gregory Bursavich, Derek C. Cole, Jeroen C. Verheijen, James Joseph Gibbons, Ker Yu
المصدر: Journal of Medicinal Chemistry. 52:7081-7089
مصطلحات موضوعية: Models, Molecular, Cell growth, Kinase, Angiogenesis, Chemistry, TOR Serine-Threonine Kinases, High-throughput screening, RPTOR, Molecular Conformation, mTORC1, Binding, Competitive, mTORC2, Substrate Specificity, Molecular Weight, Inhibitory Concentration 50, Pyrimidines, Biochemistry, Cell Line, Tumor, Drug Discovery, Humans, Molecular Medicine, Protein Kinase Inhibitors, Protein Kinases, PI3K/AKT/mTOR pathway, Signal Transduction
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المؤلفون: David Malwitz, David J. Richard, Kristine Svenson, Lourdes Toral-Barza, Natasja Brooijmans, Ker Yu, Kevin J. Curran, Jeroen C. Verheijen, Judy Lucas, Arie Zask, Pawel Nowak, Joshua Kaplan, Weiguo Zhang, Robert T. Abraham, Irwin Hollander, Joel Bard, James Joseph Gibbons, Semiramis Ayral-Kaloustian, Tarek S. Mansour
المصدر: Journal of Medicinal Chemistry. 52:5013-5016
مصطلحات موضوعية: Models, Molecular, Allosteric regulation, Regulator, Mice, Nude, Antineoplastic Agents, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, Adenosine Triphosphate, In vivo, Cell Line, Tumor, Microsomes, Drug Discovery, Animals, Class Ib Phosphatidylinositol 3-Kinase, Urea, Cytotoxicity, PI3K/AKT/mTOR pathway, chemistry.chemical_classification, Binding Sites, biology, Chemistry, TOR Serine-Threonine Kinases, Intracellular Signaling Peptides and Proteins, Xenograft Model Antitumor Assays, Isoenzymes, Pyrimidines, Enzyme, Biochemistry, Enzyme inhibitor, Drug Design, biology.protein, Cancer research, Pyrazoles, Molecular Medicine, Carbamates, Signal transduction
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المؤلفون: Nan Zhang, James Joseph Gibbons, Nguyen Thai Hiep, Danielle Vitale, Semiramis Ayral-Kaloustian, Carl F. Beyer, Richard Hernandez
المصدر: Cancer Chemotherapy and Pharmacology. 64:681-689
مصطلحات موضوعية: Cancer Research, Paclitaxel, GTP', Stereochemistry, Antineoplastic Agents, Guanosine triphosphate, Toxicology, Microtubules, Radioligand Assay, chemistry.chemical_compound, Biopolymers, Tubulin, Microtubule, Humans, Pharmacology (medical), Cytoskeleton, Pharmacology, biology, Hydrocarbons, Halogenated, Depolymerization, Chemistry, Triazoles, Flow Cytometry, Cold Temperature, Cevipabulin, Oncology, Vincristine, biology.protein, Phosphorylation, Guanosine Triphosphate, HeLa Cells
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المؤلفون: Kathryn A. Saraf, Ramzi Ayyad, Kaapjoo Park, Scott A. Jelinsky, Wenshan Hao, James Joseph Gibbons, Magda Asselin, Derek C. Cole, Jun Xu, Chao-Pei Betty Chang
المصدر: Journal of Medicinal Chemistry. 51:4115-4121
مصطلحات موضوعية: STAT3 Transcription Factor, chemistry.chemical_classification, Magnetic Resonance Spectroscopy, biology, Chemistry, Carboxylic acid, Esters, Caspase 3, Quinolones, Stat3 Signaling Pathway, Biochemistry, Cell Line, Tumor, hemic and lymphatic diseases, Drug Discovery, STAT protein, biology.protein, Humans, Molecular Medicine, Phosphorylation, Signal transduction, STAT3, Chromatography, High Pressure Liquid, STAT5, Signal Transduction
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المؤلفون: Nguyen Thai Hiep, Danielle Vitale, Judy Lucas, Nan Zhang, Carl F. Beyer, James Joseph Gibbons, Richard Hernandez, Semiramis Ayral-Kaloustian, Carolyn Discafani
المصدر: Cancer Research. 68:2292-2300
مصطلحات موضوعية: Cancer Research, Mice, Nude, Antineoplastic Agents, Biology, Microtubules, Mice, chemistry.chemical_compound, Nude mouse, Tubulin, In vivo, Cell Line, Tumor, medicine, Animals, Humans, Cytotoxicity, Hydrocarbons, Halogenated, Biological activity, Triazoles, biology.organism_classification, Xenograft Model Antitumor Assays, Vinblastine, Oncology, Biochemistry, Paclitaxel, chemistry, Cell culture, Carcinoma, Squamous Cell, biology.protein, Female, Drug Screening Assays, Antitumor, HeLa Cells, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fae0fc496b1b25ddde519260b68cb36
https://doi.org/10.1158/0008-5472.can-07-1420 -
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المؤلفون: Chris Liang, Heather A. Wakelee, George R. Blumenschein, Leora Horn, Jon P. Gockerman, Christine M. Lovly, Gary Dukart, Corey A. Carter, James Joseph Gibbons, Jeffrey R. Infante, K. Harrow, Karen L. Reckamp
المصدر: Journal of Thoracic Oncology. 11:S36-S37
مصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, endocrine system, medicine.drug_class, business.industry, non-small cell lung cancer (NSCLC), medicine.disease, ALK inhibitor, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Glucocorticoid receptor, Oncology, In vivo, Cell culture, 030220 oncology & carcinogenesis, polycyclic compounds, Cancer research, medicine, Adenocarcinoma, Anaplastic lymphoma kinase, business, hormones, hormone substitutes, and hormone antagonists, Dexamethasone, medicine.drug
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