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المؤلفون: Peter M. Ihnat, Katherine Taylor, Chakravarthy Nachu Narasimhan, Dingjiang Liu, Valentyn Antochshuk, Jason E. Fernandez, Kapil Gupta, Daniel Dix, Eric Routhier, Elaine S.E. Stokes, Truong Nobel T, Sorina Morar-Mitrica, Fleming Michael, James K. Kranz, Diluzio Willow, Christine Wurth, George Crotts, Bing He, Monica L. Adams, Tanvir Tabish
المصدر: Journal of pharmaceutical sciences. 107(2)
مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Process management, Drug Industry, Computer science, Best practice, Chemistry, Pharmaceutical, Pharmaceutical Science, 01 natural sciences, Risk Assessment, Quality by Design, Biopharmaceutics, 03 medical and health sciences, Robustness (computer science), 010608 biotechnology, Critical to quality, Humans, Technology, Pharmaceutical, Good manufacturing practice, Intersectoral Collaboration, Clinical Trials as Topic, Design of experiments, 030104 developmental biology, Biopharmaceutical, Pharmaceutical Preparations, Drug Design, Drug product
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061474570a3b0f2fc78623421fb44679
https://pubmed.ncbi.nlm.nih.gov/29074375 -
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المؤلفون: Matthew J. Todd, Marina I. Nelen, Celine Schalk-Hihi, Jose C. Clemente, James K. Kranz, Christopher M. Flores, Lawrence C. Kuo, Diane M. Maguire, Erica L Nulton, Sui-Po Zhang
المصدر: SLAS Discovery. 17:629-640
مصطلحات موضوعية: Cannabinoid receptor, High-throughput screening, Arachidonic Acids, Plasma protein binding, Biochemistry, Glycerides, Substrate Specificity, Analytical Chemistry, Inhibitory Concentration 50, Catalytic Domain, High-Throughput Screening Assays, medicine, Humans, Enzyme Inhibitors, Enzyme Assays, chemistry.chemical_classification, biology, Hydrolysis, Active site, Monoacylglycerol Lipases, Monoacylglycerol lipase, Kinetics, Enzyme, Solubility, chemistry, Mechanism of action, biology.protein, Molecular Medicine, medicine.symptom, Endocannabinoids, Protein Binding, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05db4e32fcae5283a2c28027f6dc8703
https://doi.org/10.1177/1087057112441012 -
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المؤلفون: Frank A. Lewandowski, Li Liu, Jose Clemente, Charles H. Reynolds, Bruce L. Grasberger, Renee L. DesJarlais, Mark J. Macielag, Celine Schalk-Hihi, Christopher M. Flores, Mcdonnell Mark E, Richard S. Alexander, Shariff Bayoumy, Hongchang Ma, Ingrid Deckman, Diane M. Maguire, Keli C. Dzordzorme, Robyn L. Miller, Tara Mezzasalma Haarlander, Carsten Schubert, Lawrence C. Kuo, James K. Kranz, Cindy Milligan
المصدر: Protein Science. 20:670-683
مصطلحات موضوعية: biology, Chemistry, Stereochemistry, Glyceride, Plasma protein binding, Biochemistry, Monoacylglycerol lipase, chemistry.chemical_compound, Monomer, Membrane, Catalytic cycle, Static electricity, biology.protein, Lipase, Molecular Biology
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المؤلفون: James K. Kranz, Kendra K. Frederick, A. Joshua Wand
المصدر: Biochemistry. 45:9841-9848
مصطلحات موضوعية: Models, Molecular, Calmodulin, Protein Conformation, Stereochemistry, Entropy, Biochemistry, chemistry.chemical_compound, Molecular recognition, Amide, Ca2+/calmodulin-dependent protein kinase, Side chain, Animals, Amino Acid Sequence, Myosin-Light-Chain Kinase, Nuclear Magnetic Resonance, Biomolecular, biology, Titrimetry, Hydrogen Bonding, Conformational entropy, Calcium-Calmodulin-Dependent Protein Kinase Type 1, chemistry, Calcium-Calmodulin-Dependent Protein Kinases, biology.protein, Signal transduction, Peptides, Chickens, Protein Binding, Entropy (order and disorder)
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المصدر: Biochemistry. 41:14158-14166
مصطلحات موضوعية: Conformational change, biology, Calmodulin, Chemistry, biology.organism_classification, Biochemistry, law.invention, Crystallography, Protein structure, law, Helix, Biophysics, biology.protein, Paramecium, Electron paramagnetic resonance, Linker, Heteronuclear single quantum coherence spectroscopy
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المؤلفون: Andrew L. Lee, Kim A. Sharp, James K. Kranz, A. Joshua Wand, Xiang Jin Song
المصدر: Biochemistry. 41:13814-13825
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Calmodulin, Protein Conformation, Entropy, Biochemistry, Heat capacity, Nuclear magnetic resonance, Protein structure, Cluster (physics), Side chain, Animals, Myosin-Light-Chain Kinase, Residual entropy, Binding Sites, biology, Chemistry, Temperature, Water, Muscle, Smooth, Peptide Fragments, Kinetics, Amplitude, Chemical physics, biology.protein, Thermodynamics, Calcium, Chickens, Protein Binding, Entropy (order and disorder)
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المؤلفون: A. Joshua Wand, James K. Kranz, Eun Kyung Lee, Angus C. Nairn
المصدر: Journal of Biological Chemistry. 277:16351-16354
مصطلحات موضوعية: chemistry.chemical_classification, animal structures, Calmodulin, biology, Kinase, Stereochemistry, Chemical shift, Context (language use), Peptide, Cell Biology, Biochemistry, Enzyme, chemistry, Heteronuclear molecule, biology.protein, Protein kinase A, Molecular Biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::887d891fb55d905eaefb632ca404cb0b
https://doi.org/10.1074/jbc.c200139200 -
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المؤلفون: A. Joshua Wand, Peter F. Flynn, James K. Kranz, Ernesto J. Fuentes
المصدر: Biochemistry. 41:2599-2608
مصطلحات موضوعية: Calmodulin, Molecular Sequence Data, Hydrostatic pressure, Biochemistry, chemistry.chemical_compound, Molecular recognition, Amide, Bound state, Pressure, Animals, Amino Acid Sequence, Myosin-Light-Chain Kinase, Nuclear Magnetic Resonance, Biomolecular, biology, Intermolecular force, Recombinant Proteins, Crystallography, Spectrometry, Fluorescence, chemistry, Heteronuclear molecule, biology.protein, Thermodynamics, Chickens, Two-dimensional nuclear magnetic resonance spectroscopy, Protein Binding
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المؤلفون: Wendy Liu, Peter F. Flynn, Ernesto J. Fuentes, M McCormick, Wand Aj, James K. Kranz
المصدر: Biochemistry. 40:14744-14753
مصطلحات موضوعية: Models, Molecular, biology, Protein Conformation, Anabaena, Stereochemistry, Flavodoxin, Cyanobacteria, biology.organism_classification, Resonance (chemistry), Biochemistry, Recombinant Proteins, Protein Structure, Tertiary, chemistry.chemical_compound, Protein structure, Bacterial Proteins, Deuterium, chemistry, Amide, biology.protein, Side chain, Nuclear Magnetic Resonance, Biomolecular, Oxidation-Reduction, Protein secondary structure
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المؤلفون: Felix W. Wehrli, Ari D. Goldberg, Ravinder Reddy, John S. Leigh, Umamaheswar Duvvuri, A. Joshua Wand, S.W. Englander, Linh Hoang, James K. Kranz
المصدر: Proceedings of the National Academy of Sciences. 98:12479-12484
مصطلحات موضوعية: Cartilage, Articular, Magnetic Resonance Spectroscopy, Molecular Sequence Data, Context (language use), Low frequency, Matrix (biology), Nuclear magnetic resonance, medicine, Animals, Amino Acid Sequence, Multidisciplinary, biology, Chemistry, Cartilage, Relaxation (NMR), Water, Nuclear magnetic resonance spectroscopy, Biological Sciences, medicine.anatomical_structure, Proteoglycan, biology.protein, Biophysics, Cattle, Proteoglycans, Collagen, Protons, Dispersion (chemistry)
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23564c468169e679e80265d6e8f42407
https://doi.org/10.1073/pnas.221471898