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1
المؤلفون: Brian G. Hartl, Randy Steinkampf, T C Major, Joan A. Keiser, Tawny K. Dahring, H. D. Hollis Showalter, Gina H. Lu, Alan J. Kraker, Robert L. Panek, Hussein Hallak, Brian L. Batley, Zhipei Wu, Bill J. Roberts, Sylvester Klutchko, Sandra J. Patmore, William L. Elliott, Laura A. Bradford, Wayne D. Klohs, Annette Marian Doherty, James Marino Hamby, Diane H. Boschelli
المصدر: Journal of Medicinal Chemistry. 41:4365-4377
مصطلحات موضوعية: Male, Platelet-derived growth factor, Pyrimidine, Pyridones, Transplantation, Heterologous, Biological Availability, Mice, Nude, Muscle, Smooth, Vascular, CSK Tyrosine-Protein Kinase, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Growth factor receptor, Drug Discovery, Tumor Cells, Cultured, Animals, Humans, Receptors, Platelet-Derived Growth Factor, Enzyme Inhibitors, Phosphorylation, Rats, Wistar, biology, 3T3 Cells, Protein-Tyrosine Kinases, Receptors, Fibroblast Growth Factor, Rats, Pyrimidines, src-Family Kinases, chemistry, Biochemistry, Enzyme inhibitor, Fibroblast growth factor receptor, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, Signal transduction, Tyrosine kinase, Platelet-derived growth factor receptor
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2
المصدر: Journal of Medicinal Chemistry. 41:1752-1763
مصطلحات موضوعية: Models, Molecular, Insecta, Molecular model, Pyrimidine, Protein Conformation, Pyridines, Stereochemistry, Molecular Sequence Data, In Vitro Techniques, Crystallography, X-Ray, CSK Tyrosine-Protein Kinase, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Cyclic AMP, Animals, Humans, Protease Inhibitors, Receptors, Platelet-Derived Growth Factor, Amino Acid Sequence, Binding site, Protein kinase A, biology, Hydrogen Bonding, Protein-Tyrosine Kinases, Cyclic AMP-Dependent Protein Kinases, Receptors, Fibroblast Growth Factor, ErbB Receptors, Pyrimidines, src-Family Kinases, Biochemistry, chemistry, Docking (molecular), Enzyme inhibitor, biology.protein, Molecular Medicine, Baculoviridae, Chickens, Tyrosine kinase, Platelet-derived growth factor receptor, Protein Binding
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3
المؤلفون: Aneesa Amar, Gina H. Lu, Alan J. Kraker, H. D. Hollis Showalter, James Marino Hamby, Barvian Mark Robert, Brian G. Hartl, Robert L. Panek
المصدر: Bioorganic & Medicinal Chemistry Letters. 7:2903-2908
مصطلحات موضوعية: Platelet-derived growth factor, biology, Chemistry, Fibroblast growth factor receptor 1, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Fibroblast growth factor, Biochemistry, Small molecule, chemistry.chemical_compound, Enzyme inhibitor, Fibroblast growth factor receptor, embryonic structures, Drug Discovery, biology.protein, Molecular Medicine, Signal transduction, Molecular Biology, Tyrosine kinase
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4
المؤلفون: Wayne D. Klohs, James Marino Hamby, Alan J. Kraker, David W. Fry, Cindy Shen, Aneesa Amar, Robert L. Panek, Gina H. Lu, Barvian Mark Robert, Connolly Cleo, Mel C. Schroeder, Annette Marian Doherty
المصدر: Bioorganic & Medicinal Chemistry Letters. 7:2415-2420
مصطلحات موضوعية: Platelet-derived growth factor, biology, Pyrimidine, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, chemistry, Fibroblast growth factor receptor, Enzyme inhibitor, Drug Discovery, biology.protein, Molecular Medicine, Signal transduction, Tyrosine, Molecular Biology, Tyrosine kinase, Platelet-derived growth factor receptor
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5
المؤلفون: Elizabeth A. Lunney, A M Doherty, B. A. Steinbaugh, James Stanley Kaltenbronn, Aurash Shahripour, Mark Stephen Plummer, James Marino Hamby, Tomi K. Sawyer, Christine Humblet, Harriet W. Hamilton
المصدر: Journal of Medicinal Chemistry. 38:2893-2905
مصطلحات موضوعية: Molecular model, Stereochemistry, Isostere, Peptidomimetic, Phenylalanine, Peptide, Heptanes, Structure-Activity Relationship, chemistry.chemical_compound, Renin, Drug Discovery, Side chain, Animals, Binding site, chemistry.chemical_classification, Binding Sites, Dipeptide, Molecular Structure, biology, Chemistry, Hydrogen Bonding, Stereoisomerism, Haplorhini, Amides, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine
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6
المؤلفون: John C. Hodges, James Marino Hamby, Sylvester Klutchko
المصدر: Bioorganic & Medicinal Chemistry Letters. 4:57-62
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Carboxylic acid, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Tetrahydroisoquinoline derivatives, Inhibitory postsynaptic potential, Biochemistry, Chemical synthesis, Angiotensin II, chemistry, Drug Discovery, Molecular Medicine, Molecular Biology, Angiotensin II Receptor Binding
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7
المصدر: Synthetic Communications. 23:971-983
مصطلحات موضوعية: Nucleophile, Stereochemistry, Chemistry, Organic Chemistry, polycyclic compounds, Moiety, chemistry.chemical_element, Ring (chemistry), Carbon
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8
المصدر: ChemInform. 24
مصطلحات موضوعية: chemistry, Nucleophile, Stereochemistry, chemistry.chemical_element, General Medicine, Ring (chemistry), Carbon
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9
المؤلفون: James Marino Hamby, John C. Hodges, Sylvester Klutchko
المصدر: ChemInform. 25
مصطلحات موضوعية: Chemistry, Stereochemistry, Tetrahydroisoquinoline derivatives, General Medicine, Inhibitory postsynaptic potential, Angiotensin II Receptor Binding
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10
المؤلفون: Amy Mae Bunker, Ila Sircar, James Marino Hamby, Joan A. Keiser, J. Iii Quin, C. R. Kostlan, John C. Hodges, Jeremy J. Edmunds, Robert L. Panek, S. J. Kesten, J. G. Topliss, R. T. Winters, C. J. C. Connolly
المصدر: ChemInform. 24
مصطلحات موضوعية: chemistry.chemical_classification, Biphenyl, chemistry.chemical_compound, Angiotensin receptor, chemistry, Design synthesis, TRIF, Carboxylic acid, Imidazole, General Medicine, Medicinal chemistry, Alkyl