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المؤلفون: Mark Munson, James Pribish, Lim Sungtaek, Maniar Sachin, Bradford H. Hirth, Robert H. Barker, Jiang John Z, Yong Mi Choi-Sledeski, Sukanthini Thurairatnam, Kwon Yon Musick, Elina Makino, John E. Macor
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Arylsulfatase A, biology, Chemistry, Organic Chemistry, Neurodegeneration, Pharmacology, medicine.disease, Biochemistry, Metachromatic leukodystrophy, UGT8, medicine.anatomical_structure, In vivo, Lysosome, Drug Discovery, biology.protein, medicine, Substrate reduction therapy, Arylsulfatase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0e9cd71be8f13535f7151488851852
https://europepmc.org/articles/PMC7549271/ -
2Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III
المؤلفون: Andrew Hebert, Paul Erdman, Maniar Sachin, Anlai Wang, Alexandre Gross, Elina Tserlin, Claude Barberis, Vinod F. Patel, Jiang John Z, Mark Czekaj, Mikhail Levit, James Pribish, Frank Sun, Matthieu Barrague, Luke Fire, Shih-Min A. Huang
المصدر: Bioorganicmedicinal chemistry letters. 29(3)
مصطلحات موضوعية: Indoles, Clinical Biochemistry, hERG, Compound 17, Pharmaceutical Science, Antineoplastic Agents, 01 natural sciences, Biochemistry, Part iii, Mice, Structure-Activity Relationship, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Drug Discovery, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, Cell Proliferation, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Neoplasms, Experimental, Combinatorial chemistry, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Pim kinases, biology.protein, Molecular Medicine, Tumor growth inhibition, Drug Screening Assays, Antitumor
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المؤلفون: Sachin Maniar, Anlai Wang, James Pribish, Shih-Min A. Huang, Andrew Hebert, Mikhail Levit, Jinyu Liu, Claude Barberis, Luke Fire, Elina Tserlin, Paul Erdman, Vinod F. Patel, Mark Czekaj, Joseph D. Batchelor, Frank Sun
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127625
مصطلحات موضوعية: Indoles, Pyrrolidines, Clinical Biochemistry, hERG, Pharmaceutical Science, Antineoplastic Agents, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Mice, Piperidines, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Tumor growth, Protein Kinase Inhibitors, Molecular Biology, PK/PD models, Aza Compounds, biology, 010405 organic chemistry, Chemistry, Kinase, Organic Chemistry, Cancer, Stereoisomerism, medicine.disease, Xenograft Model Antitumor Assays, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Permeability (electromagnetism), biology.protein, Cancer research, Molecular Medicine, Tumor growth inhibition, Protein Binding
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4
المؤلفون: James Pribish, Claude Barberis, Liduo Shen, Mark Czekaj, Neil Moorcroft, Mikhail Levit, Elina Tserlin, Anlai Wang, Andrew Hebert, Sandra Moreno-Mazza, Matthieu Barrague, Tahir Majid, Joseph D. Batchelor, Paul Erdman, Alexandre Gross
المصدر: Bioorganicmedicinal chemistry letters. 27(20)
مصطلحات موضوعية: 0301 basic medicine, Indoles, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 0302 clinical medicine, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, Drug Discovery, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, PK/PD models, ADME, Kinase, Chemistry, Organic Chemistry, Hit to lead, Combinatorial chemistry, Rats, Enzyme Activation, 030104 developmental biology, 030220 oncology & carcinogenesis, Microsomes, Liver, Molecular Medicine, Identification (biology), Half-Life
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المؤلفون: Keith Sides, James Pribish, Magali Mathieu, Sam Rebello, Gregory H. Merriman, Henry W. Pauls, Guyan Liang, Xin Chen, Julian Levell, Jennifer Cairns, Isabelle Morize, Brian Whitely, Joseph T. Tsay, Aldous Suzanne C, Sébastien Maignan
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1049-1054
مصطلحات موضوعية: Models, Molecular, Library design, Proteases, Molecular model, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Tryptase, Pharmacology, Crystallography, X-Ray, Biochemistry, Small Molecule Libraries, Serine, Structure-Activity Relationship, Drug Discovery, Hydrolase, medicine, Animals, Combinatorial Chemistry Techniques, Humans, Mast Cells, Enzyme Inhibitors, Molecular Biology, Serine protease, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Mast cell, Recombinant Proteins, Rats, medicine.anatomical_structure, biology.protein, Molecular Medicine, Tryptases