المؤلفون: JP Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Jean-Christophe Andrez, Girish Bankar, David Bogucki, Kristen Burford, Elaine Chang, Sultan Chowdhury, Richard Dean, Gina de Boer, Shannon Decker, Christoph Dehnhardt, Mandy Feng, Wei Gong, Michael Grimwood, Abid Hasan, Angela Hussainkhel, Qi Jia, Stephanie Lee, Jenny Li, Sophia Lin, Andrea Lindgren, Verner Lofstrand, Janette Mezeyova, Rostam Namdari, Karen Nelkenbrecher, Noah Gregory Shuart, Luis Sojo, Shaoyi Sun, Matthew Taron, Matthew Waldbrook, Diana Weeratunge, Steven Wesolowski, Aaron Williams, Michael Wilson, Zhiwei Xie, Rhena Yoo, Clint Young, Alla Zenova, Wei Zhang, Alison J Cutts, Robin P Sherrington, Simon N Pimstone, Raymond Winquist, Charles J Cohen, James R Empfield

المصدر: eLife, Vol 11 (2022)

مصطلحات موضوعية: epilepsy, SCN8A, NBI-921352, anti-seizure medicine, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/72468; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/ff1c4ccf767e411f85c1b12a0db8fe55

المؤلفون: J P, Johnson, Thilo, Focken, Kuldip, Khakh, Parisa Karimi, Tari, Celine, Dube, Samuel J, Goodchild, Jean-Christophe, Andrez, Girish, Bankar, David, Bogucki, Kristen, Burford, Elaine, Chang, Sultan, Chowdhury, Richard, Dean, Gina, de Boer, Shannon, Decker, Christoph, Dehnhardt, Mandy, Feng, Wei, Gong, Michael, Grimwood, Abid, Hasan, Angela, Hussainkhel, Qi, Jia, Stephanie, Lee, Jenny, Li, Sophia, Lin, Andrea, Lindgren, Verner, Lofstrand, Janette, Mezeyova, Rostam, Namdari, Karen, Nelkenbrecher, Noah Gregory, Shuart, Luis, Sojo, Shaoyi, Sun, Matthew, Taron, Matthew, Waldbrook, Diana, Weeratunge, Steven, Wesolowski, Aaron, Williams, Michael, Wilson, Zhiwei, Xie, Rhena, Yoo, Clint, Young, Alla, Zenova, Wei, Zhang, Alison J, Cutts, Robin P, Sherrington, Simon N, Pimstone, Raymond, Winquist, Charles J, Cohen, James R, Empfield

المصدر: eLife. 11

مصطلحات موضوعية: Neurons, Mice, Epilepsy, NAV1.6 Voltage-Gated Sodium Channel, Gain of Function Mutation, Mutation, Sodium, Animals, Rats, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::3cf389ce4c308fb570995099c2f50504
https://pubmed.ncbi.nlm.nih.gov/35234610

المؤلفون: Shaoyi, Sun, Qi, Jia, Alla Y, Zenova, Sophia, Lin, Angela, Hussainkhel, Janette, Mezeyova, Elaine, Chang, Samuel J, Goodchild, Zhiwei, Xie, Andrea, Lindgren, Gina, de Boer, Rainbow, Kwan, Kuldip, Khakh, Luis, Sojo, Paul, Bichler, J P, Johnson, James R, Empfield, Charles J, Cohen, Christoph M, Dehnhardt, Richard, Dean

المصدر: Bioorganicmedicinal chemistry letters. 45

مصطلحات موضوعية: Structure-Activity Relationship, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, Humans, NAV1.5 Voltage-Gated Sodium Channel

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::72ffd93fb821803255bea0175c7110a5
https://pubmed.ncbi.nlm.nih.gov/34044121

المؤلفون: Thilo, Focken, Kristen, Burford, Michael E, Grimwood, Alla, Zenova, Jean-Christophe, Andrez, Wei, Gong, Michael, Wilson, Matt, Taron, Shannon, Decker, Verner, Lofstrand, Sultan, Chowdhury, Noah, Shuart, Sophia, Lin, Samuel J, Goodchild, Clint, Young, Maegan, Soriano, Parisa K, Tari, Matthew, Waldbrook, Karen, Nelkenbrecher, Rainbow, Kwan, Andrea, Lindgren, Gina, de Boer, Stephanie, Lee, Luis, Sojo, Robert J, DeVita, Charles J, Cohen, Steven S, Wesolowski, J P, Johnson, Christoph M, Dehnhardt, James R, Empfield

المصدر: Journal of medicinal chemistry. 62(21)

مصطلحات موضوعية: Central Nervous System, Models, Molecular, Epilepsy, Hep G2 Cells, Amides, Madin Darby Canine Kidney Cells, Mice, Structure-Activity Relationship, Dogs, Protein Domains, NAV1.6 Voltage-Gated Sodium Channel, Animals, Humans, Protein Isoforms, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::83cdc1c0cbb195dcbc6825acef82c33c
https://pubmed.ncbi.nlm.nih.gov/31525968

المؤلفون: Dheeraj Malhotra, Raphael Bernier, Stephen Sanders, James R. Empfield, Kevin J. Bender, Geoffrey S. Pitt, Arthur J. Campbell, Wendy K. Chung, William A. Catterall, Rikke S. Møller, Alfred L. George, Joerg F. Hipp, Jennifer Tjernagel, John Millichap, Evangelos Kiskinis, Florence F. Wagner, Cora Taylor, Dennis Lal, John E. Spiro, Leah F. Schust, Jeffrey R. Cottrell, Thomas S. Otis, Angie L. Auldridge, Steven Petrou, Omar Khwaja

المصدر: Trends in neurosciences, vol 41, iss 7
Sanders, S J, Campbell, A J, Cottrell, J R, Moller, R S, Wagner, F F, Auldridge, A L, Bernier, R A, Catterall, W A, Chung, W K, Empfield, J R, George, A L, Hipp, J F, Khwaja, O, Kiskinis, E, Lal, D, Malhotra, D, Millichap, J J, Otis, T S, Petrou, S, Pitt, G, Schust, L F, Taylor, C M, Tjernagel, J, Spiro, J E & Bender, K J 2018, ' Progress in Understanding and Treating SCN2A-Mediated Disorders ', Trends in Neurosciences, vol. 41, no. 7, pp. 442-456 . https://doi.org/10.1016/j.tins.2018.03.011

مصطلحات موضوعية: 0301 basic medicine, Intellectual and Developmental Disabilities (IDD), Autism, autism spectrum disorder, Neurodegenerative, Article, Infantile seizures, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Neurodevelopmental disorder, Dravet syndrome, Intellectual disability, medicine, Genetics, Animals, Humans, 2.1 Biological and endogenous factors, Psychology, Aetiology, Neurodevelopmental Disorders/drug therapy, NAV1.2 Voltage-Gated Sodium Channel, Neurology & Neurosurgery, neurodevelopment, business.industry, General Neuroscience, NAV1.2 Voltage-Gated Sodium Channel/genetics, Neurosciences, medicine.disease, Na(V)1.2, Axon initial segment, neurodevelopmental disorder, Brain Disorders, developmental delay, 030104 developmental biology, Mental Health, Autism spectrum disorder, Neurodevelopmental Disorders, intellectual disability, Neurological, epilepsy, Cognitive Sciences, business, Neuroscience, 030217 neurology & neurosurgery, Gene Discovery, Na1.2, sodium channel

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368f22a1be36996d1c034e8fc9066f8a
https://escholarship.org/uc/item/1b1284bd

المؤلفون: James R. Empfield, Michael P Clark

نوع المادة: eBook.

الموضوعات: Chemistry, Toxicology, Biochemistry

تصنيفات: SCIENCE / Chemistry / Clinical, MEDICAL / Pharmacology

المؤلفون: James R. Empfield, Michael P Clark

المصدر: Topics in Medicinal Chemistry ISBN: 9783662439135
Reducing Drug Attrition

مصطلحات موضوعية: Drug, medicine.medical_specialty, business.industry, media_common.quotation_subject, medicine, Attrition, Intensive care medicine, business, medicine.disease, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e864fc299ac32e73298589e371735faf
https://doi.org/10.1007/978-3-662-43914-2

المؤلفون: Amos B. Smith, James R. Empfield

المصدر: Chemical and Pharmaceutical Bulletin. 47:1671-1678

مصطلحات موضوعية: Chemistry, Stereochemistry, Drug Discovery, Phyllanthoside, Total synthesis, General Chemistry, General Medicine, Combinatorial chemistry, Stereocenter

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7cfa52ebef4715e7239153d73f7f76aa
https://doi.org/10.1248/cpb.47.1671

المؤلفون: James R, Empfield, Paul D, Leeson

المصدر: IDrugs : the investigational drugs journal. 13(12)

مصطلحات موضوعية: Drug Industry, Research Design, Models, Organizational, Drug Discovery, Drug Evaluation, Preclinical, Animals, Humans, Pharmacokinetics, Efficiency, Organizational

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::24ef6299b112b361beafece8aada93a9
https://pubmed.ncbi.nlm.nih.gov/21154145

المؤلفون: James R. Empfield, Diane H. Boschelli, Franklin A. Davis, Amos B. Smith, Michael C. Weismiller, Bang Chi Chen

المصدر: ChemInform. 22

مصطلحات موضوعية: Hydroxylation, chemistry.chemical_compound, Chemistry, Yield (chemistry), Sodium, Enantioselective synthesis, Organic chemistry, chemistry.chemical_element, General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3024d14aa16a86147f8ce8dbd28e88b3
https://doi.org/10.1002/chin.199112343