-
1
المؤلفون: Rakesh Nagilla, Sharada Manns, Eugene L. Stewart, Marlys Hammond, Tram H. Hoang, Scott K. Thompson, Walter Trizna, Chaya Duraiswami, Eugene T. Grygielko, Thuy B. Tran, James S. Frazee, Kevin P. Madauss, Johnson Latisha C, Shawn P. Williams, Lindsay E. Glace, David G. Washburn, Jeffrey D. Bray
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:4664-4668
مصطلحات موضوعية: Agonist, medicine.drug_class, Stereochemistry, Clinical Biochemistry, hERG, Administration, Oral, Pharmaceutical Science, Pharmacology, Biochemistry, Partial agonist, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Progesterone receptor, medicine, Animals, Humans, Pyrrolidinones, Molecular Biology, Binding Sites, biology, Organic Chemistry, Haplorhini, Ether-A-Go-Go Potassium Channels, Rats, Nuclear receptor, chemistry, biology.protein, Molecular Medicine, Receptors, Progesterone, Lead compound
-
2
المؤلفون: Stephen R. Petteway, Thaddeus A. Tomaszek, Lum Robert T, Lucinda A. Ivanoff, James S. Frazee, Thomas D. Meek, John G. Gleason, Michael G. Darcy, Dennis M. Lambert, Scott K. Thompson, Annabellee V. Fernandez, Brian W. Metcalf, Edmund J. Sternberg, Jane F. Morris, Alecia M. Eppley
المصدر: Bioorganic & Medicinal Chemistry Letters. 4:2441-2446
مصطلحات موضوعية: Protease, biology, Chemistry, Isostere, Stereochemistry, Peptidomimetic, medicine.medical_treatment, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, In vitro, HIV-1 protease, Drug Discovery, medicine, biology.protein, Molecular Medicine, Peptide bond, Molecular Biology
-
3
المؤلفون: A. M. Eppley, Edmund J. Sternberg, Thomas D. Meek, A. V. Fernandez, John G. Gleason, S. R. Jun. Petteway, D. M. Lambert, Brian W. Metcalf, Jane F. Morris, Scott K. Thompson, Michael G. Darcy, James S. Frazee, T. A. Jun. Tomaszek, Lucinda A. Ivanoff, Lum Robert T
المصدر: ChemInform. 26
مصطلحات موضوعية: HIV-1 protease, biology, Chemistry, Isostere, Stereochemistry, biology.protein, Triazole derivatives, Peptide bond, General Medicine
-
4
المؤلفون: Eugene T. Grygielko, Patrick Stoy, Eugene L. Stewart, Tram H. Hoang, Johnson Latisha C, Jaclyn R. Patterson, Marlys Hammond, Qing Lu, Linda S. Barton, Rakesh Nagilla, David G. Washburn, Shawn P. Williams, Lara S. Kallander, Jeffrey D. Bray, Leonard M. Azzarano, Scott K. Thompson, Chaya Duraiswami, James S. Frazee, Kevin P. Madauss, Nicholas J. Laping, Xiaoping Xu
المصدر: Bioorganicmedicinal chemistry letters. 20(1)
مصطلحات موضوعية: ERG1 Potassium Channel, Pyrrolidines, medicine.drug_class, Stereochemistry, Clinical Biochemistry, hERG, Endometriosis, Pharmaceutical Science, Carboxamide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Partial agonist, Pyrrolidine, chemistry.chemical_compound, In vivo, Drug Discovery, Progesterone receptor, medicine, Animals, Humans, Receptor, Molecular Biology, Sulfonamides, Binding Sites, biology, Chemistry, Organic Chemistry, Ether-A-Go-Go Potassium Channels, Rats, biology.protein, Molecular Medicine, Female, Carbamates, Receptors, Progesterone
-
5
المؤلفون: Marlys Hammond, David G. Washburn, Angela Smallwood, Tram H. Hoang, Nicholas J. Laping, Rebecca Trejo, Hiroko Nakamura, James S. Frazee, Martha S. Head, Scott K. Thompson, Kendra E. Hightower, Charlene Wu, Rakesh Nagilla, Jaclyn R. Patterson, Melanie Nord, Walter Trizna, Baoguang Zhao, Sharada Manns, Leonard M. Azzarano, Christine G. Schnackenberg
المصدر: Bioorganicmedicinal chemistry letters. 19(15)
مصطلحات موضوعية: Stereochemistry, Carboxylic acid, Chemistry, Pharmaceutical, Clinical Biochemistry, Glucuronidation, Molecular Conformation, Pharmaceutical Science, Administration, Oral, Biological Availability, Protein Serine-Threonine Kinases, Biochemistry, Immediate-Early Proteins, chemistry.chemical_compound, Acetic acid, Inhibitory Concentration 50, Structure-Activity Relationship, Glucuronic Acid, Drug Discovery, Animals, Carboxylate, Enzyme Inhibitors, Molecular Biology, Glucocorticoids, Protein Kinase Inhibitors, Benzoic acid, chemistry.chemical_classification, biology, Bicyclic molecule, Organic Chemistry, Glucuronic acid, Rats, chemistry, Models, Chemical, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine
-
6
المؤلفون: Eugene T. Grygielko, Shawn P. Williams, Lindsay E. Glace, Jeffrey D. Bray, Chaya Duraiswami, James S. Frazee, Kevin P. Madauss, David G. Washburn, Tram H. Hoang, Leahann Lapinski, Walter Trizna, Nicholas J. Laping, Scott K. Thompson
المصدر: Bioorganicmedicinal chemistry letters. 19(16)
مصطلحات موضوعية: Agonist, Pyrrolidines, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Crystallography, X-Ray, Biochemistry, Partial agonist, Pyrrolidine, chemistry.chemical_compound, Drug Discovery, Progesterone receptor, medicine, Animals, Computer Simulation, Molecular Biology, Hormone binding protein, Binding Sites, Organic Chemistry, Rational design, Protein Structure, Tertiary, Rats, chemistry, Nuclear receptor, Estrogen, Drug Design, Models, Animal, Molecular Medicine, Receptors, Progesterone
-
7
المؤلفون: Richard M. Edwards, Stephen A. Douglas, M Gellai, A Gao, Russell D. Cousins, J D Leber, A. Lago, Eliot H. Ohlstein, James S. Frazee, Ponnal Nambi
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 91(17)
مصطلحات موضوعية: Neointima, Endothelin Receptor Antagonists, Male, Time Factors, medicine.drug_class, Blood Pressure, CHO Cells, Pharmacology, In Vitro Techniques, Pulmonary Artery, Gerbil, Transfection, Binding, Competitive, Muscle, Smooth, Vascular, Rats, Sprague-Dawley, Radioligand Assay, In vivo, Heart Rate, Cricetinae, Rats, Inbred SHR, medicine, Animals, Humans, Cloning, Molecular, Receptor, Aorta, Multidisciplinary, Molecular Structure, Chemistry, Endothelin receptor antagonist, Endothelins, Hemodynamics, Receptor antagonist, Recombinant Proteins, Mesenteric Arteries, Rats, Kinetics, Carotid Arteries, Vasoconstriction, Drug Design, Indans, Vascular Resistance, Rabbits, medicine.symptom, Endothelin receptor, Muscle Contraction, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc8fb7c87a068c46e67967a75d472b8
https://pubmed.ncbi.nlm.nih.gov/8058755 -
8
المؤلفون: William E. Bondinell, Frederic W. Chapin, James S. Frazee, Gerald R. Girard, Kenneth G. Holden, Carl Kaiser, Cynthia Maryanoff, Carl D. Perchonock, George W. Gessner, J. P. Hieble, Leonard M. Hillegass, Robert G. Pendleton, John L. Sawyer
المصدر: Drug metabolism reviews. 14(4)
مصطلحات موضوعية: Chemical Phenomena, Epinephrine, Chemistry, Pyridines, Phenylethanolamine N-Methyltransferase, Epinephrine biosynthesis, Administration, Oral, Isoquinolines, Phenylethanolamine N-methyltransferase, Biochemistry, Depression, Chemical, Tetrahydroisoquinolines, Animals, Humans, Pharmacology (medical), Potential source, General Pharmacology, Toxicology and Pharmaceutics
-
9
المؤلفون: Fadia E. Ali, William E. Bondinell, Penelope A. Dandridge, James S. Frazee, Eleanor Garvey, Gerald R. Girard, Carl Kaiser, Thomas W. Ku, John J. Lafferty, George I. Moonsammy, Hye-Ja Oh, Julia A. Rush, Paulette E. Setler, Orum D. Stringer, Joseph W. Venslavsky, Beth W. Volpe, Libby M. Yunger, Charles L. Zirkle
المصدر: Journal of medicinal chemistry. 28(5)
مصطلحات موضوعية: Male, Alkylation, medicine.medical_treatment, Central nervous system, Carboxylic Acids, Administration, Oral, In Vitro Techniques, Norepinephrine, Drug Discovery, medicine, Animals, Gamma-aminobutyric acid uptake, Neurotransmitter Uptake Inhibitors, Amino Acids, gamma-Aminobutyric Acid, chemistry.chemical_classification, Chemistry, Glutamate Decarboxylase, Brain, Rats, Inbred Strains, Stereoisomerism, Receptors, GABA-A, In vitro, Amino acid, Rats, Receptors, Neurotransmitter, Orally active, Anticonvulsant, medicine.anatomical_structure, Biochemistry, Mechanism of action, 4-Aminobutyrate Transaminase, Molecular Medicine, GABA Uptake Inhibitors, medicine.symptom, Synaptosomes