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1
المؤلفون: Emily J. Hanan, Marie-Gabrielle Braun, Robert A. Heald, Calum MacLeod, Connie Chan, Saundra Clausen, Kyle A. Edgar, Charles Eigenbrot, Richard Elliott, Nicholas Endres, Lori S. Friedman, Emily Gogol, Xiao-Hui Gu, Rebecca Hong Thibodeau, Philip S. Jackson, James R. Kiefer, Jamie D. Knight, Michelle Nannini, Raman Narukulla, Amanda Pace, Jodie Pang, Hans E. Purkey, Laurent Salphati, Deepak Sampath, Stephen Schmidt, Steve Sideris, Kyung Song, Swathi Sujatha-Bhaskar, Mark Ultsch, Heidi Wallweber, Jianfeng Xin, SiewKuen Yeap, Amy Young, Yu Zhong, Steven T. Staben
المصدر: Journal of medicinal chemistry. 65(24)
مصطلحات موضوعية: Phosphatidylinositol 3-Kinases, Class I Phosphatidylinositol 3-Kinases, Cell Line, Tumor, Drug Discovery, Mutation, Molecular Medicine, Humans, Female, Breast Neoplasms, Phosphoinositide-3 Kinase Inhibitors
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2
المؤلفون: Charles Eigenbrot, Robert Heald, Bryan K. Chan, Michael D. Lainchbury, Timothy P. Heffron, Hans E. Purkey, Hank La, Philip Stephen Jackson, Stephen P. Schmidt, Gabriele Schaefer, Emily Chan, Marian C. Bryan, Ivana Yen, Jamie D. Knight, Daniel J. Burdick, Yuan Chen, Lily Shao, Richard L. Elliott, Jennafer Dotson, Shiva Malek, Christine Yu, Krista K. Bowman, Steve Sideris, Hanan Emily, Shumei Wang, Saundra Clausen, Siew Kuen Yeap, Eileen Mary Seward, Trisha Dela Vega
المصدر: Journal of medicinal chemistry. 59(19)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Lung Neoplasms, Mutant, Antineoplastic Agents, Crystallography, X-Ray, 03 medical and health sciences, T790M, Mice, 0302 clinical medicine, In vivo, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Discovery, Animals, Humans, Epidermal growth factor receptor, Binding site, Lung, Protein Kinase Inhibitors, EGFR inhibitors, Cell Proliferation, biology, Chemistry, Point mutation, Molecular biology, In vitro, respiratory tract diseases, ErbB Receptors, 030104 developmental biology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, biology.protein, Molecular Medicine
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3
المؤلفون: Krista K. Bowman, Hans E. Purkey, Bryan K. Chan, Michael D. Lainchbury, Belen Dominguez-Fernandez, Robert Heald, Eileen Mary Seward, Stephen P. Schmidt, Mark Merchant, Lily Shao, Kuen Yeap, Saundra Clausen, Emily Chan, Daniel J. Burdick, Yuan Chen, Charles Eigenbrot, Gabriele Schaefer, Steve Sideris, Philip Stephen Jackson, Samuel Edward Mann, Ivana Yen, Richard L. Elliott, Kyle Mortara, Timothy P. Heffron, Hank La, Marian C. Bryan, Christine Yu, Shiva Malek, Jamie D. Knight, Hanan Emily, Shumei Wang
المصدر: Journal of medicinal chemistry. 58(22)
مصطلحات موضوعية: Models, Molecular, Lung Neoplasms, Mutant, Antineoplastic Agents, Pharmacology, In Vitro Techniques, medicine.disease_cause, Substrate Specificity, T790M, Structure-Activity Relationship, Dogs, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Discovery, medicine, Structure–activity relationship, Potency, Animals, Humans, Epidermal growth factor receptor, chemistry.chemical_classification, Mutation, biology, Chemistry, Kinase, Stereoisomerism, Genes, erbB-1, Lipids, Xenograft Model Antitumor Assays, respiratory tract diseases, Rats, ErbB Receptors, Macaca fascicularis, Enzyme, Drug Design, Gene Knockdown Techniques, biology.protein, Microsomes, Liver, Molecular Medicine
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4
المؤلفون: Jamie D. Knight, Lyn H. Jones, Richard D. Kelsey, Alan Armstrong
المصدر: Organic Letters. 7:713-716
مصطلحات موضوعية: Models, Molecular, Primary (chemistry), Scope (project management), Aziridines, Organic Chemistry, General Medicine, Pyrazole, Biochemistry, Oxaziridine, chemistry.chemical_compound, Hydrazines, chemistry, Electrophilic amination, Solvents, Pyrazoles, Organic chemistry, Amines, Physical and Theoretical Chemistry, Amination
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5
المؤلفون: Matthew Rudd, Paul Wright, Matthew J. Tozer, Jonathan W. Steed, S. Barret Kalindjian, Susan E. Gibson, Jerome O. Jones, Nello Mainolfi, Jamie D. Knight
المصدر: Tetrahedron. 60:6945-6958
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Hydrocarbon, chemistry, Stereochemistry, Heck reaction, Organic Chemistry, Drug Discovery, Amino acid residue, Biochemistry, Cyclophane, Amino acid
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6
المؤلفون: Jamie D. Knight, Amit Kumar, Peter B. Wyatt, Stephanos Ghilagaber
المصدر: Tetrahedron Letters. 43:6991-6994
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Organic chemistry, Aziridine, Histidine methyl ester, Ring (chemistry), Biochemistry, Sodium cyanide, Histidine
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7
المؤلفون: Richard S. Cooke, Alan Armstrong, Graham R. Cumming, Jamie D. Knight, Ian D. Edmonds, Stephen E. Shanahan
المصدر: Chinese Journal of Chemistry. 23:1270-1272
مصطلحات موضوعية: Primary (chemistry), Chemistry, Heteroatom, Organic chemistry, chemistry.chemical_element, Reactivity (chemistry), General Chemistry, Combinatorial chemistry, Nitrogen, Amination
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8
المؤلفون: Lily Shao, Gabriele Schaefer, Belen Dominguez-Fernandez, Krista K. Bowman, Robert Heald, Jamie D. Knight, Timothy P. Heffron, Christine Yu, Mark Merchant, Stephen P. Schmidt, Kuen Yeap, Kyle Mortara, Charles Eigenbrot, Hank La, Michael Lainchbury, Ivana Yen, Daniel J. Burdick, Eileen Mary Seward, Yuan Chen, Saundra Clausen, Bryan K. Chan, Shiva Malek, Richard L. Elliott, Hanan Emily, Shumei Wang, Hans E. Purkey, Philip Stephen Jackson, Marian C. Bryan, Emily Chan, Samuel Edward Mann, Steve Sideris
المصدر: Journal of Medicinal Chemistry. 59:2848-2848
مصطلحات موضوعية: Lead (geology), Biochemistry, Chemistry, Epidermal Growth Factor Receptor Inhibitors, Drug Discovery, Mutant, Molecular Medicine, Combinatorial chemistry
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9
المؤلفون: Jerome O. Jones, Jamie D. Knight, Susan E. Gibson, Matthew J. Tozer, Jonathan W. Steed, S. Barret Kalindjian
المصدر: ChemInform. 33
مصطلحات موضوعية: Stereochemistry, Chemistry, Solid-state, General Medicine, Amino acid residue
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10
المؤلفون: Lily Shao, Emily J. Hanan, Yuan Chen, Robert L. Yauch, Gabriele Schaefer, Timothy P. Heffron, S. Sideris, Emily Chan, Shiva Malek, Jamie D. Knight, Stephen Schmidt
المصدر: Cancer Research. 74:1735-1735
مصطلحات موضوعية: Cancer Research, biology, business.industry, Pharmacology, respiratory tract diseases, T790M, Gefitinib, Oncology, Protein kinase domain, Cancer research, medicine, biology.protein, Erlotinib, Epidermal growth factor receptor, business, Protein kinase B, Tyrosine kinase, medicine.drug, EGFR inhibitors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7facd37df816786d6b9ebf343c89850c
https://doi.org/10.1158/1538-7445.am2014-1735