يعرض 1 - 10 نتائج من 93 نتيجة بحث عن '"Jan Kehler"', وقت الاستعلام: 1.05s تنقيح النتائج
  1. 1
    دورية أكاديمية
    From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group.

    المؤلفون: Sigrid Marie Blom, Mario Rottländer, Jan Kehler, Christoffer Bundgaard, Nicole Schmitt, Henrik Sindal Jensen

    المصدر: PLoS ONE, Vol 9, Iss 6, p e100209 (2014)

    مصطلحات موضوعية: Medicine, Science

    وصف الملف: electronic resource

    Relation: http://europepmc.org/articles/PMC4067310?pdf=render; https://doaj.org/toc/1932-6203

    URL الوصول: https://doaj.org/article/13c242eb117543f791c6da46c8b50c06

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  2. 2
    Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia

    المؤلفون: Lars Kyhn Rasmussen, Jan Kehler, Elin Eneberg, Todor V. Gerdjikov, Jesper F. Bastlund, Jessica Hayes, Morten Langgård, Bettina Laursen

    المصدر: Neuropharmacology. 186

    مصطلحات موضوعية: 0301 basic medicine, Serial reaction time, Phosphodiesterase Inhibitors, Phencyclidine, Prefrontal Cortex, Nucleus accumbens, Impulsivity, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, medicine, Premovement neuronal activity, Animals, Prefrontal cortex, Pharmacology, business.industry, Phosphodiesterase, medicine.disease, Cyclic Nucleotide Phosphodiesterases, Type 1, Rats, Disease Models, Animal, 030104 developmental biology, Schizophrenia, Hallucinogens, Conditioning, Operant, Female, medicine.symptom, business, Neuroscience, Goals, 030217 neurology & neurosurgery, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b597c388792164dc058ff27f11820f7f
    https://pubmed.ncbi.nlm.nih.gov/33444639

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  3. 3
    Debenzylative Cycloetherification as a Synthetic Tool in the Diastereoselective Synthesis of 3,6-Disubstituted Hexahydro-2

    المؤلفون: Alejandro, Castán, Ramón, Badorrey, José A, Díez, Claus T, Christoffersen, Lars K, Rasmussen, Jan, Kehler, Ralf, Köhler, José A, Gálvez, María D, Díaz-de-Villegas

    المصدر: The Journal of organic chemistry. 85(9)

    مصطلحات موضوعية: Structure-Activity Relationship, Phosphodiesterase Inhibitors, Phosphoric Diester Hydrolases, Humans, Pyrroles, Melanoma, Cell Proliferation

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::57c3c0319bc75bcaf7501e2b68074278
    https://pubmed.ncbi.nlm.nih.gov/32248689

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  4. 4
    Debenzylative cycloetherification as a synthetic tool in the diastereoselective synthesis of 3,6-Disubstituted Hexahydro-2H-furo[3,2-b]pyrroles, PDE1 enzyme inhibitors with an antiproliferative effect on melanoma cells

    المؤلفون: Ralf Köhler, José María Abad Díez, Lars Kyhn Rasmussen, María D. Díaz-de-Villegas, Jan Kehler, Claus Tornby Christoffersen, Alejandro Castán, José A. Gálvez, Ramón Badorrey

    المساهمون: Gobierno de Aragón

    المصدر: Digital.CSIC. Repositorio Institucional del CSIC
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    مصطلحات موضوعية: chemistry.chemical_classification, 010405 organic chemistry, Stereochemistry, Melanoma, Organic Chemistry, PDE1, 010402 general chemistry, medicine.disease, 01 natural sciences, 0104 chemical sciences, Enzyme, chemistry, medicine, Antiproliferative effect

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04d1dd40bc2fd5623e30b52a4b5d555
    http://hdl.handle.net/10261/220552

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  5. 5
    Phosphodiesterase 1 bridges glutamate inputs with NO- and dopamine-induced cyclic nucleotide signals in the striatum

    المؤلفون: Oliver Griesbeck, Dahdjim Betolngar, Jan Kehler, Liliana R. V. Castro, Charlotte Hougaard, Pierre Vincent, Jun Yang, Élia Mota, Arne Fabritius, Claus Tornby Christoffersen, Jacob Nielsen

    المساهمون: Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing (B2A), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Tools for Bio-Imaging [Martinsried, Germany], Max Planck Institute for Neurobiology [Martinsried, Germany], H. Lundbeck A/S [Valby, Denmark], Hunan Agricultural University [Changsha], OG and PV received a funding for cooperation from 'Bayerisch-Französisches Hochschulzentrum'., Vincent, Pierre, Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

    المصدر: Cerebral Cortex
    Cerebral Cortex, 2019, Epub ahead of print. ⟨10.1093/cercor/bhz041⟩
    Cerebral Cortex, Oxford University Press (OUP), 2019, Epub ahead of print. ⟨10.1093/cercor/bhz041⟩

    مصطلحات موضوعية: Male, Dopamine, Cognitive Neuroscience, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Glutamic Acid, PDE1, Nitric Oxide, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, Cyclic nucleotide, chemistry.chemical_compound, 0302 clinical medicine, medicine, Animals, Rats, Wistar, 030304 developmental biology, Neurons, 0303 health sciences, Neuronal Plasticity, Chemistry, Glutamate receptor, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Phosphodiesterase, Long-term potentiation, Cyclic Nucleotide Phosphodiesterases, Type 1, Corpus Striatum, Rats, Cell biology, Mice, Inbred C57BL, nervous system, Synaptic plasticity, NMDA receptor, Nucleotides, Cyclic, 030217 neurology & neurosurgery, medicine.drug

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f58574bad650f7c419ae1faba3dcbb1
    https://hdl.handle.net/21.11116/0000-0006-E090-921.11116/0000-0006-E091-821.11116/0000-0005-BCFD-B

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  6. 6
    Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs

    المؤلفون: Rasmus P. Clausen, Claus H. Jensen, Sara Björk Sigurdardóttir, Kenneth T. Kongstad, David E. Gloriam, Petrine Wellendorph, Mia Nittegaard-Nielsen, Christina Birkedahl Falk-Petersen, Francesco Bavo, Yongsong Tian, Jan Kehler, Kasper Harpsøe, Jacob Krall, Stine B. Vogensen, Bente Frølund, Anne S. Haugaard

    المصدر: Journal of Medicinal Chemistry. 60:9022-9039

    مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Carboxylic Acids, Molecular Conformation, Hydroxybutyrates, Cyclopentanes, Ligands, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, γ-Hydroxybutyric acid, Drug Discovery, T-HCA, Binding site, Binding Sites, 010405 organic chemistry, Chemistry, Ligand, 0104 chemical sciences, Molecular hybridization, Design synthesis, Crotonates, Drug Design, Molecular Medicine, Pharmacophore, 030217 neurology & neurosurgery

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371f91bb7a8a910a778dba45c5ffc706
    https://doi.org/10.1021/acs.jmedchem.7b01351

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  7. 7
    PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries

    المؤلفون: Jacob Nielsen, Thomas Dalsgaard, Dorte Clausen, Lasse Folkersen, Lars Kyhn Rasmussen, Makhala M. Khammy, Claus Tornby Christoffersen, Peter Hjørringgaard Larsen, Morten Grunnet, Jan Kehler, Christian Aalkjaer

    المصدر: British Journal of Pharmacology. 174:4186-4198

    مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Gene isoform, medicine.medical_specialty, Vascular smooth muscle, Vasodilation, In situ hybridization, PDE1, Biology, Cell biology, 03 medical and health sciences, Cyclic nucleotide, chemistry.chemical_compound, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Internal medicine, medicine, Myocyte, Mesenteric arteries

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bed48d77c724ef4e0d3657e422ae2bcb
    https://doi.org/10.1111/bph.14034

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  8. 8
    Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats

    المؤلفون: Ulf Simonsen, Christoffer Bundgaard, Tomas Mow, Susie Mogensen, Estéfano Pinilla, Morten Grunnet, Jan Kehler, Morten Laursen, Claus Tornby Christoffersen, Lilliana Beck, Jakob S. Knudsen, Elise R. Hedegaard

    المصدر: British Journal of Pharmacology. 174:2563-2575

    مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Aorta, Endothelium, Chemistry, Phosphodiesterase, Vasodilation, 030204 cardiovascular system & hematology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Blood pressure, Mean blood pressure, medicine.artery, medicine, Mesenteric arteries, Phenylephrine, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bdd379087ddb01a34b9b4760977398c2
    https://doi.org/10.1111/bph.13868

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  9. 9
    Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties ofN-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2AReceptor Agonist

    المؤلفون: Sebastian Leth-Petersen, Hans Bräuner-Osborne, Christoffer Bundgaard, John D. McCorvy, Jesper L. Kristensen, Jan Kehler, Anders A. Jensen, Terry P. Kenakin, Gudrun Liebscher

    المصدر: Journal of Pharmacology and Experimental Therapeutics. 361:441-453

    مصطلحات موضوعية: 0301 basic medicine, Pharmacology, chemistry.chemical_classification, Agonist, Ketanserin, medicine.drug_class, 25CN-NBOH, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, In vivo, medicine, Molecular Medicine, Efflux, Receptor, Inositol phosphate, 030217 neurology & neurosurgery, Mesulergine, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::35e10d89ac28ecf5f871e1557a08469c
    https://doi.org/10.1124/jpet.117.239905

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  10. 10
    Ortho lithiation-in situ borylation of substituted morpholine benzamides

    المؤلفون: Jan Kehler, Morten Lysen, Jesper L. Kristensen, Anna Cederbalk

    المصدر: Tetrahedron. 73:1576-1582

    مصطلحات موضوعية: In situ, 010405 organic chemistry, Chemistry, Organic Chemistry, Regioselectivity, 010402 general chemistry, 01 natural sciences, Biochemistry, Borylation, 0104 chemical sciences, chemistry.chemical_compound, Morpholine, Drug Discovery, Organic chemistry, A kinase

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6c296a63832bc5ee4474ab30ba3452a6
    https://doi.org/10.1016/j.tet.2017.02.002

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