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1
المؤلفون: Shuangying Liu, Xiaotian Zhu, Angela Toms, Yongjin Xu, David C. Dalgarno, Rory Dodd, Lois Parillon, Yihan Wang, Scott Wardwell, Tim Clackson, Jiwei Qi, Anna Kohlmann, Yaoyu Ning, Hyun Gyung Jang, Xiaohui Lu, Lisi Cai, Qurish K. Mohemmad, Rongsong Xu, Dong Zou, Sen Zhang, William C. Shakespeare, Timothy A. Dwight, Narayana I. Narasimhan, Qihong Xu, Rana Anjum, Lauren Moran, Tianjun Zhou, Frank Wang, Mathew Thomas, Wei-Sheng Huang, Jeffrey A. Keats, Feng Li, Jan Romero, Victor M. Rivera
المصدر: Journal of medicinal chemistry. 59(10)
مصطلحات موضوعية: 0301 basic medicine, Lung Neoplasms, Brigatinib, Cell Survival, Phosphines, Molecular Conformation, Administration, Oral, Antineoplastic Agents, Mice, SCID, Bioinformatics, 03 medical and health sciences, Mice, Structure-Activity Relationship, 0302 clinical medicine, Organophosphorus Compounds, hemic and lymphatic diseases, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Discovery, medicine, Anaplastic lymphoma kinase, Animals, Humans, Anaplastic Lymphoma Kinase, Lung cancer, Protein Kinase Inhibitors, ADME, Cell Proliferation, chemistry.chemical_classification, Dose-Response Relationship, Drug, Kinase, Chemistry, Receptor Protein-Tyrosine Kinases, Neoplasms, Experimental, medicine.disease, Lymphoma, Rats, 030104 developmental biology, Enzyme, Pyrimidines, Protein kinase domain, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Female, Drug Screening Assays, Antitumor
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2
المؤلفون: Xiaotian Zhu, Dong Zou, Chester A. Metcalf, Raji Sundaramoorthi, Frank Wang, Feng Li, Jan Romero, John Iuliucci, Lois Commodore, Shuangying Liu, Wei-Sheng Huang, Lisi Cai, Qihong Xu, Jeff Keats, Tim Clackson, David C. Dalgarno, Joseph Snodgrass, Jiwei Qi, Yihan Wang, Victor M. Rivera, Mathew Thomas, Ingrid Chen, Tianjun Zhou, Yaoyu Ning, David Wen, Tomi K. Sawyer, Karin Russian, William C. Shakespeare, Marc I Broudy, Scott Wardwell
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3743-3748
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Mutant, Fusion Proteins, bcr-abl, Administration, Oral, Pharmaceutical Science, Carboxamide, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Drug Discovery, medicine, Animals, Molecular Biology, Aniline Compounds, Molecular Structure, biology, Chemistry, Organic Chemistry, Ponatinib, Biological activity, medicine.disease, In vitro, Rats, Disease Models, Animal, Cyclization, Enzyme inhibitor, Alkynes, Mutation, biology.protein, Molecular Medicine, Linker, Toluene, Chronic myelogenous leukemia
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3
المؤلفون: Yaoyu Ning, Chester A. Metcalf, Lois Commodore, Jan Romero, Scott Wardwell, Tomi K. Sawyer, Yihan Wang, Qurish K. Mohemmad, Scott Paul Lentini, Ingrid Chen, Victor M. Rivera, Karin Russian, Geetha Banda, Sasmita Das, Narayana I. Narasimhan, Xiaotian Zhu, Raji Sundaramoorthi, Lisi Cai, Tianjun Zhou, Jeff Keats, Frank Wang, Tim Clackson, Qihong Xu, Jiwei Qi, David Wen, Joseph Snodgrass, Shuangying Liu, William C. Shakespeare, R. Mathew Thomas, Marc I Broudy, John Iuliucci, Wei-Sheng Huang, David C. Dalgarno, Dong Zou
المصدر: Journal of Medicinal Chemistry. 53:4701-4719
مصطلحات موضوعية: Models, Molecular, Mutant, Fusion Proteins, bcr-abl, Administration, Oral, Antineoplastic Agents, Mice, SCID, Pharmacology, Crystallography, X-Ray, Mice, chemistry.chemical_compound, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Drug Discovery, medicine, Animals, Kinase activity, Benzamide, Protein Kinase Inhibitors, ADME, Kinase, Chemistry, Imidazoles, breakpoint cluster region, Myeloid leukemia, medicine.disease, Rats, Pyridazines, Leukemia, Blood-Brain Barrier, Mutation, Molecular Medicine, Drug Screening Assays, Antitumor
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4دورية أكاديمية
المؤلفون: Wei-Sheng Huang, Chester A. Metcalf, Raji Sundaramoorthi, Yihan Wang, Dong Zou, R. Mathew Thomas, Xiaotian Zhu, Lisi Cai, David Wen, Shuangying Liu, Jan Romero, Jiwei Qi, Ingrid Chen, Geetha Banda, Scott P. Lentini, Sasmita Das, Qihong Xu, Jeff Keats, Frank Wang, Scott Wardwell
المصدر: Journal of Medicinal Chemistry; Jun2010, Vol. 53 Issue 12, p4701-4719, 19p