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1دورية أكاديمية
المؤلفون: Farida Omarova, Jan Rosing, Rogier M. Bertina, Elisabetta Castoldi
المصدر: Thrombosis Update, Vol 2, Iss , Pp 100022- (2021)
مصطلحات موضوعية: Factor XI, Thrombin, Phospholipids, Exosites, Ionic strength, Diseases of the circulatory (Cardiovascular) system, RC666-701
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Elisabetta Castoldi, Lisbeth F.A. Maurissen, Daniela Tormene, Luca Spiezia, Sabrina Gavasso, Claudia Radu, Tilman M. Hackeng, Jan Rosing, Paolo Simioni
المصدر: Haematologica, Vol 95, Iss 9 (2010)
مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5
وصف الملف: electronic resource
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المساهمون: Biochemie, RS: Carim - B03 Cell biochemistry of thrombosis and haemostasis, RS: Carim - B01 Blood proteins & engineering
المصدر: Thrombosis Research, 207, 143-149. Elsevier Science
مصطلحات موضوعية: D-DIMER LEVEL, medicine.medical_specialty, TFPI, FACTOR PATHWAY INHIBITOR, 1ST, Protein S, Pathogenesis, Tissue factor, Prothrombinase, Internal medicine, CARDIOVASCULAR RISK-FACTORS, medicine, THROMBIN GENERATION, Risk factor, COAGULATION-FACTORS, PLASMA, biology, business.industry, Smoking, ORAL-CONTRACEPTIVES, Contraceptives, Thrombosis, PROTHROMBINASE, Hematology, medicine.disease, APC resistance, Endocrinology, biology.protein, business, Protein C, medicine.drug, Hormone
وصف الملف: application/pdf
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المؤلفون: Jan Rosing, Marie Mawet, Maud Jost, Christine Klipping, Catherine Maillard, Jonathan Douxfils, Jean-Michel Foidart, I.J.M. Duijkers, Virginie Kinet
المساهمون: RS: Carim - B01 Blood proteins & engineering, Biochemie
المصدر: Contraception, 102(6), 396-402. Elsevier Science
مصطلحات موضوعية: Ethinyl Estradiol, activated protein c resistance, chemistry.chemical_compound, 0302 clinical medicine, Sex hormone-binding globulin, Sex Hormone-Binding Globulin, Medicine, Levonorgestrel, 030212 general & internal medicine, RISK, 030219 obstetrics & reproductive medicine, biology, Estetrol, Obstetrics and Gynecology, Middle Aged, Contraceptives, Oral, Combined, Contraception, Androstenes, Female, medicine.drug, Adult, VENOUS THROMBOSIS, medicine.medical_specialty, Adolescent, medicine.drug_class, PROFILE, Young Adult, 03 medical and health sciences, Drospirenone, Ethinylestradiol, Internal medicine, Humans, CYCLE, Menstrual Cycle, Hemostasis, levonorgestrel, business.industry, Estrogens, medicine.disease, Endocrinology, Reproductive Medicine, chemistry, Estrogen, biology.protein, Activated protein C resistance, business
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المؤلفون: Paolo Simioni, Tilman M. Hackeng, Peter van Doorn, Joost C. M. Meijers, Jan Rosing, Saskia Middeldorp, Elena Campello, Elisabetta Castoldi
المساهمون: RS: Carim - B01 Blood proteins & engineering, Biochemie, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, ARD - Amsterdam Reproduction and Development, Experimental Vascular Medicine
المصدر: Thrombosis and Haemostasis, 120(1), 55-64. Georg Thieme Verlag
Thrombosis and haemostasis, 120(1), 55-64. Schattauer GmbHمصطلحات موضوعية: MECHANISM, Heterozygote, Lipoproteins, Population, PROTEIN-S, Peptide, FACTOR PATHWAY INHIBITOR, Protein S, CONTRIBUTES, FACTOR-XA, INITIATION, Thrombin, Tissue factor pathway inhibitor, Prothrombinase, medicine, Factor V Leiden, THROMBIN-CATALYZED ACTIVATION, COFACTOR, Humans, education, Blood Coagulation, chemistry.chemical_classification, education.field_of_study, factor V, biology, Homozygote, Factor V, Hematology, PROTHROMBINASE, Blood Coagulation Disorders, medicine.disease, Molecular biology, Peptide Fragments, chemistry, Factor Va, factor V-short, Factor Xa, Mutation, Proteolysis, factor V Leiden, biology.protein, tissue factor pathway inhibitor, INACTIVATION, Blood Coagulation Tests, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a54bea56a743f5729adadbf71987a3
https://doi.org/10.1055/s-0039-1700516 -
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المؤلفون: Marie-Christine Alessi, Jan Rosing, Guillaume Mourey, Pierre-Emmanuel Morange, Marjorie Poggi, Elisabetta Castoldi, M. Christella L. G. D. Thomassen, Tilman M. Hackeng, Manal Ibrahim-Kosta, Alexandra Fournel, Catherine P.M. Hayward, Nathalie Hezard, Kanin Wichapong
المساهمون: Hôpital de la Timone [CHU - APHM] (TIMONE), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Department of Biochemistry, Maastricht University [Maastricht], Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Canadian Institutes of Health Research (CIHR)MOP 133474, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Biochemie, RS: Carim - B01 Blood proteins & engineering, RS: Carim - B03 Cell biochemistry of thrombosis and haemostasis
المصدر: Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, 2021, 19 (5), pp.1186-1199. ⟨10.1111/jth.15274⟩
Journal of Thrombosis and Haemostasis, Wiley, 2021, 19 (5), pp.1186-1199. ⟨10.1111/jth.15274⟩
Journal of Thrombosis and Haemostasis, 19(5), 1186-1199. Wileyمصطلحات موضوعية: factor V deficiency, Factor V Deficiency, compared with normal FVa, has both pro- and anticoagulant functions. Objective We investigated an FV-deficient patient (FV:C 3%, 030204 cardiovascular system & hematology, Thrombophilia, but also a lower rate of APC-catalyzed inactivation in the presence of protein S. Conclusions FVBesancon induces a hypercoagulable state via quantitative (markedly decreased FV level) and qualitative (phospholipid-binding defect) effects that affect anticoagulant pathways (anticoagulant activities of FV, Background Coagulation factor V (FV), 03 medical and health sciences, 0302 clinical medicine, Tissue factor pathway inhibitor, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Prothrombinase, V-max) of prothrombin activation, medicine, FVa inactivation, Humans, predicting impaired binding of FV(a) to phospholipids. Recombinant FVBesancon was hardly secreted, Platelet, phospholipids, indicating that this mutation is responsible for the patient's FV deficiency. Model system experiments performed using highly diluted plasma as a source of FV showed that, FVa(Besancon) has slightly (<= 1.5-fold) unfavorable kinetic parameters (K-m, biology, Chemistry, Homozygote, present in plasma and platelets, Factor V, Hematology, medicine.disease, Molecular biology,
FVBesancon) that favors a "closed conformation" of the C2 domain, Mutation, biology.protein, activated protein C resistance, tissue factor pathway inhibitor alpha level) more strongly than the prothrombinase activity of FVa. A possible specific role of platelet FV cannot be excluded, venous thrombosis, Blood Coagulation Tests, Activated protein C resistance, thrombin generation in the patient's platelet-rich plasma (PRP) was higher than in control PRP and extremely resistant to activated protein C (APC). This was partially attributable to the complete abolition of the APC-cofactor activity of FV and a marked reduction of plasma tissue factor pathway inhibitor antigen and activity. The patient was homozygous for a novel missense mutation (Ala2086Asp, Protein C, FV:Ag 4%) paradoxically presenting with recurrent venous thrombosis (11 events) instead of bleeding. Methods/Results Thrombophilia screening revealed only heterozygosity for the F2 20210G>A mutation. Although thrombin generation in the patient's platelet-poor plasma was suggestive of a hypocoagulable state, medicine.drug وصف الملف: application/pdf
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المؤلفون: Robert F. A. Zwaal, Edouard M. Bevers, Jan Rosing
المصدر: Phospholipid-Binding Antibodies ISBN: 9780429278129
مصطلحات موضوعية: Chemical engineering, Chemistry, Scientific method
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2240ae3c80b7a379321b07efa69abe1e
https://doi.org/10.1201/9780429278129-3 -
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المؤلفون: Elisabetta Castoldi, Peter van Doorn, Connie Duckers, Paolo Simioni, Tilman M. Hackeng, Jan Rosing
المساهمون: Biochemie, Promovendi CD, RS: CARIM - R1.01 - Blood proteins & engineering
المصدر: Thrombosis and Haemostasis, 118(7), 1194-1202. Georg Thieme Verlag
مصطلحات موضوعية: Male, 0301 basic medicine, Glycosylation, 030204 cardiovascular system & hematology, FACTOR PATHWAY INHIBITOR, COFACTOR ACTIVITY, FACTOR-XA, chemistry.chemical_compound, 0302 clinical medicine, Protein Isoforms, RISK, biology, Chemistry, Thrombin, Factor V, Hematology, Middle Aged, Phenotype, Coagulation, thrombin generation, Factor Xa, tissue factor pathway inhibitor, Female, Blood Coagulation Tests, Antibody, Adult, Gene isoform, VENOUS THROMBOSIS, Adolescent, Lipoproteins, Phospholipid, COAGULATION, Thromboplastin, ACTIVATED PROTEIN-C, Young Adult, 03 medical and health sciences, Tissue factor pathway inhibitor, TISSUE FACTOR PATHWAY, Prothrombinase, R2 haplotype, Humans, Blood Coagulation, phospholipids, factor V, PROTHROMBINASE, Molecular biology, ALPHA, 030104 developmental biology, Haplotypes, biology.protein, Protein Processing, Post-Translational
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3add7c8325def3f6faac8c14ad55d13
https://cris.maastrichtuniversity.nl/en/publications/11034a32-8c88-4717-bad1-dd99a77f7fe2 -
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المؤلفون: Jean-Michel Foidart, Rogerio A. Lobo, Ulysse Gaspard, Jonathan Douxfils, Céline Bouvy, Maud Jost, Jan Rosing, Mélanie Taziaux
المصدر: Maturitas. 152:69
مصطلحات موضوعية: medicine.medical_specialty, Postmenopausal women, medicine.drug_class, business.industry, Obstetrics and Gynecology, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Estetrol, Endocrinology, chemistry, Coagulation, Estrogen, Internal medicine, medicine, business, Protein C, medicine.drug
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المساهمون: Promovendi CD, Biochemie, RS: CARIM - R1.01 - Blood proteins & engineering, Ondersteunend personeel CD
المصدر: Journal of Thrombosis and Haemostasis, 15(1), 140-149. Wiley
مصطلحات موضوعية: 0301 basic medicine, factor Xa, B-DOMAIN, COAGULATION, Plasma protein binding, 030204 cardiovascular system & hematology, TFPI, FACTOR-XA, 03 medical and health sciences, Tissue factor, 0302 clinical medicine, Thrombin, Tissue factor pathway inhibitor, Prothrombinase, medicine, THROMBIN-CATALYZED ACTIVATION, Binding site, RELEASE, prothrombinase complex, TEXAS BLEEDING DISORDER, factor V, ANTICOAGULANT ACTIVITY, biology, Chemistry, Factor V, Hematology, PROTHROMBINASE, Molecular biology, thrombin, 030104 developmental biology, biology.protein, tissue factor pathway inhibitor, PROTEIN-C, Protein C, medicine.drug