المؤلفون: Jeremy L. Jenkins, Katrin Volkmann, Shelly Meeusen, Prisca Liberali, Karyn Colman, Ludivine Challet Meylan, Michael B. Stadler, Ilya Lukonin, Janine E. Baaten, Denise Serra, Rui Zhao, Francisca Maurer

المصدر: Nature

مصطلحات موضوعية: Male, 0301 basic medicine, Transcription, Genetic, Receptors, Retinoic Acid, Retinoic acid, Tretinoin, Biology, Retinoid X receptor, Article, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Organoid, Animals, Homeostasis, Regeneration, Intestinal Mucosa, Vitamin A, Multidisciplinary, Sequence Analysis, RNA, Cell Differentiation, Phenotype, Intestinal epithelium, Cell biology, Intestines, Mice, Inbred C57BL, Organoids, Enterocytes, 030104 developmental biology, Nuclear receptor, chemistry, 030220 oncology & carcinogenesis, Enterocyte differentiation, Stem cell, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aef2914c3fb4511271adaf18a1eeeef
https://doi.org/10.1038/s41586-020-2776-9

المؤلفون: Bo Liu, Sukwon Ha, H. Michael Petrassi, Kate Jacobsen, George Harb, W. Perry Gordon, Bryan Laffitte, Thanh Lam, Qihui Jin, Yong Jia, Janine E. Baaten, Minhua Qiu, Robert Hill, Shelly Meeusen, Shanshan Yan, Badry Bursulaya, Valentina Molteni, Anwesh Kamireddy, Lisa Deaton, Jianfeng Pan, You-Qing Zhang, Loren Jon, Michael DiDonato, Yahu A. Liu, Shifeng Pan, Andrew M. Schumacher, Tingting Mo, Yefen Zou, Xiaoyue Zhang, Weijun Shen, Karyn Colman, Richard Glynne, Xueshi Hao, Peter McNamara, Vân Nguyen-Tran, Zhicheng Wang, Sheryll Espinola, Bao Nguyen, Tom Y.-H. Wu, Jing Li, Qiang Ding

المصدر: Journal of Medicinal Chemistry. 63:2958-2973

مصطلحات موضوعية: Male, Indoles, DYRK1A, medicine.medical_treatment, Disease, Protein Serine-Threonine Kinases, Pharmacology, 01 natural sciences, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, In vivo, Insulin-Secreting Cells, Diabetes mellitus, Insulin Secretion, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Rats, Wistar, Cells, Cultured, Cell Proliferation, 030304 developmental biology, Diphtheria toxin, Aza Compounds, 0303 health sciences, Type 1 diabetes, Chemistry, Insulin, Protein-Tyrosine Kinases, medicine.disease, In vitro, Rats, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Diabetes Mellitus, Type 1, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222e5ae5085b8fd7b08c90167919a793
https://doi.org/10.1021/acs.jmedchem.9b01624

المؤلفون: Zhihong Huang, Bryan Laffitte, Yefen Zou, Weijun Shen, Ganesh Bhat, Bo Liu, Qiang Ding, Shanshan Yan, Yahu A. Liu, Richard Glynne, Tom Y.-H. Wu, Robert Hill, Matthew S. Tremblay, Shelly Meeusen, Valentina Molteni, Jing Li, Xueshi Hao, Van Nguyen-Tran, Yong Jia, Janine E. Baaten

المصدر: ACS Omega, Vol 4, Iss 2, Pp 3571-3581 (2019)

مصطلحات موضوعية: lcsh:Chemistry, Type 1 diabetes, lcsh:QD1-999, Apoptosis, Chemistry, General Chemical Engineering, Cancer research, medicine, General Chemistry, medicine.disease, Cell survival

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fe07c592dcafca39f735aad8a46b7e
https://doi.org/10.1021/acsomega.8b03050

المؤلفون: W. Perry Gordon, Tove Tuntland, Shelly Meeusen, Leah Clemmer, Sara Da Ros, Laura Bordone, Robert Hill, Thomas Hollenbeck, John W. Fathman, Kenneth Ng, Sheryll Espinola, Xiaohui He, Bo Liu, John Nelson, Maya Iskandar, Xue-Feng Zhu, Vân Nguyen-Tran, Andreas Kreusch, David C.S. Huang, Songchun Jiang, Yong Jia, Badry Bursulaya, Janine E. Baaten, Jian Shi, Mu-Yun Gao, Tao Jiang, Barun Okram, Glen Spraggon, Pierre-Yves Michellys, Hong Liu

المصدر: ACS Medicinal Chemistry Letters. 8:1048-1053

مصطلحات موضوعية: 0301 basic medicine, Kinase, Organic Chemistry, Pattern recognition receptor, Biology, Biochemistry, digestive system diseases, RIPK2, Serine, 03 medical and health sciences, 030104 developmental biology, In vivo, NOD2, Drug Discovery, Tyrosine kinase, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c03b4d7782a1105eb048003151bbcc2
https://doi.org/10.1021/acsmedchemlett.7b00258

المؤلفون: Richard Glynne, Bryan Laffitte, Peter McNamara, George Harb, Weidong Wang, V. Deshmukh, Matthew S. Tremblay, Charles Y. Cho, You Qing Zhang, Ann E. Herman, Peter G. Schultz, Jonathan G. Swoboda, Janine E. Baaten, Weijun Shen, Tom Y.-H. Wu, Christophe M. Filippi, Jing Li, Qihui Jin, Anwesh Kamireddy, Xu Wu

المصدر: Journal of the American Chemical Society. 135:1669-1672

مصطلحات موضوعية: Cell, Drug Evaluation, Preclinical, IκB kinase, Biochemistry, Catalysis, Cell Line, Islets of Langerhans, Mice, Structure-Activity Relationship, Colloid and Surface Chemistry, medicine, Animals, Humans, Urea, Inducer, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Cell growth, Chemistry, General Chemistry, Small molecule, Molecular biology, High-Throughput Screening Assays, Molecular Weight, medicine.anatomical_structure, Mechanism of action, Cell culture, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bd49122d522040efaa9a74797d00bd
https://doi.org/10.1021/ja309304m

المؤلفون: Adam L. Orr, Renata L.S. Goncalves, Edward K. Ainscow, H. Michael Petrassi, Irina V. Perevoshchikova, Martin D. Brand, Douglas C Quackenbush, Leonardo Vargas, Stephen J Attle, Shelly Meeusen, Carolina N. Turk, Jing Li, Janine E. Baaten, Jason T. Matzen, Victoria J. Dardov

المصدر: Nature chemical biology

مصطلحات موضوعية: Male, Antimycin A, Oxidative phosphorylation, Mitochondrion, Biology, medicine.disease_cause, Article, Oxidative Phosphorylation, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Electron Transport Complex III, 0302 clinical medicine, Adenosine Triphosphate, Superoxides, Insulin-Secreting Cells, medicine, Animals, Humans, Rats, Wistar, Molecular Biology, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Reactive oxygen species, Dose-Response Relationship, Drug, Superoxide, Cell Biology, Free Radical Scavengers, Hydrogen Peroxide, High-Throughput Screening Assays, Mitochondria, Rats, Oxidative Stress, HEK293 Cells, Pyrimidines, chemistry, Biochemistry, Coenzyme Q – cytochrome c reductase, Retrograde signaling, Pyrazoles, Female, 030217 neurology & neurosurgery, Oxidative stress, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e479961fe97e19cf3ff3afb0c5b3dfc
https://pubmed.ncbi.nlm.nih.gov/26485078

المؤلفون: Jing Li, Weidong Wang, Tom Wu, Jonathan G. Swoboda, Bryan A. Laffitte, Peter G. Schultz, Richard Glynne, Christophe M. Filippi, Qihui Jin, Weijun Shen, George Harb, Matthew S. Tremblay, Ann E. Herman, Charles Y. Cho, Eric C. Peters, Xu Wu, Janine E. Baaten, You Qing Zhang, Anwesh Kamireddy, Peter McNamara, V. Deshmukh

المصدر: Journal of the American Chemical Society. 135:4573-4573

مصطلحات موضوعية: Colloid and Surface Chemistry, Chemistry, High-throughput screening, General Chemistry, Computational biology, Biochemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dc271046574af3349f5003ca28b5f875
https://doi.org/10.1021/ja401118g