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1
المؤلفون: Xuena Lin, Kelli Kuhen, Tao Wu, Elizabeth A. Winzeler, Christoph Fischli, Chun Li, Kerstin Gagaring, Jared Ek, Tiffany Chuan, Suresh B. Lakshminarayana, Rachel Borboa, Thomas Hollenbeck, Arnab K. Chatterjee, Fenghua Liu, Thierry T. Diagana, Richard Glynne, Caroline Francek, Reto Brun, Advait Nagle, John Isbell, Bo Liu, Christopher Caldwell, David C. Tully, David Plouffe, Tove Tuntland, Philip B. Alper, Suzanne Skolnik, Jonathan Chang, Jianling Wang, Matthias Rottmann, Zhong Chen
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Plasmodium falciparum, Biological Availability, Pharmacology, Article, Piperazines, Antimalarials, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Antimalarial Agent, Malaria, Falciparum, Rats, Wistar, Mice, Inbred BALB C, biology, Imidazoles, biology.organism_classification, In vitro, Rats, Piperazine, chemistry, Molecular Medicine, Caco-2 Cells
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2
المؤلفون: Chun Li, Véronique Dartois, Jeanette Wu, Suzanne Skolnik, Thierry T. Diagana, Thomas H. Keller, Advait Nagle, David Plouffe, Maria Tan, Matthias Rottmann, Xuena Lin, Arnab K. Chatterjee, Jonathan Chang, Elizabeth A. Winzeler, Suresh B. Lakshminarayana, Fenghua Liu, Kerstin Gagaring, John Isbell, Tao Wu, William Tan, Christopher Caldwell, Richard Glynne, Zhong Chen, Christoph Fischli, David C. Tully, Anne Goh, Tove Tuntland, Min Low Kang, Nicole Y. Ye, Jared Ek, Reto Brun, Hui Qing Ang, Rachel Borboa, Thomas Hollenbeck, Jianling Wang, Peiting Zeng, Kelli L. Kuhen, Caroline Francek
المصدر: Journal of medicinal chemistry. 54(14)
مصطلحات موضوعية: Plasmodium berghei, Plasmodium falciparum, Drug Resistance, Parasitemia, Pharmacology, Piperazines, Cell Line, chemistry.chemical_compound, Antimalarials, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, parasitic diseases, medicine, Benzene Derivatives, Potency, Animals, Humans, Amino Acids, Mice, Inbred BALB C, Aniline Compounds, biology, Chemistry, Imidazoles, Hit to lead, medicine.disease, biology.organism_classification, Malaria, Rats, Drug development, Molecular Medicine, Female, Lead compound
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3
المؤلفون: Jonathan Chang, David Plouffe, Tove Tuntland, Tao Wu, Tomoyo Sakata, Kelli Kuhen, Nathanael S. Gray, Zhong Chen, John Isbell, David C. Tully, Elizabeth A. Winzeler, Arnab K. Chatterjee, Steven Howard, Xianming Deng, Susan Simerson, Jared Ek, Advait Nagle, Kerstin Henson, Francisco Adrian
المصدر: Bioorganicmedicinal chemistry letters. 20(14)
مصطلحات موضوعية: Pyrimidine, Stereochemistry, Clinical Biochemistry, Plasmodium falciparum, Pharmaceutical Science, Antimalarial, Drug resistance, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Antimalarials, Structure-Activity Relationship, In vivo, parasitic diseases, Drug Discovery, Potency, Structure–activity relationship, Animals, Molecular Biology, 030304 developmental biology, 0303 health sciences, biology, 010405 organic chemistry, Drug discovery, Organic Chemistry, biology.organism_classification, 3. Good health, 0104 chemical sciences, 1H-Imidazol-2-yl-pyrimidine-4,6-diamines, Pyrimidines, chemistry, Drug development, Molecular Medicine
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4
المؤلفون: Jared Ek, Steven Howard, Kerstin Henson, Advait Nagle, Jonathan Chang, Tao Wu, Arnab K. Chatterjee, Zhong Chen, Susan Simerson, Elizabeth A. Winzeler, David Plouffe, Tove Tuntland, Francisco Adrian, Kelli Kuhen, Nathanael S. Gray, Tomoyo Sakata, Rachel Borboa, John Isbell, David C. Tully, Xianming Deng
المصدر: Bioorganic & Medicinal Chemistry Letters
مصطلحات موضوعية: Cellular assay, Kinase, medicine.drug_class, Clinical Biochemistry, Plasmodium falciparum, Pharmaceutical Science, Carboxamide, Resistant strains, 01 natural sciences, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, Antimalarials, Mice, In vivo, Drug Discovery, medicine, Animals, Humans, Pharmacokinetics, Kinase activity, Enzyme Inhibitors, Benzamide, Molecular Biology, 030304 developmental biology, ComputingMethodologies_COMPUTERGRAPHICS, 0303 health sciences, biology, 010405 organic chemistry, Cellular Assay, Organic Chemistry, Phosphotransferases, biology.organism_classification, In vitro, 3. Good health, 0104 chemical sciences, Malaria, Cyclic amines, chemistry, Benzamides, Molecular Medicine, Directed Molecular Evolution
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المؤلفون: John Isbell, Christina Guintu, Ken Micklash, Jim Mainquist, Shumei Jiang, and Andrew Brailsford, Darcy Shave, Jared Ek, Matthew Rynd, Dimitri Petrov, Yingyao Zhou, Jim Yuchen Chang, Bradley J. Backes, Mark Richard Weselak
المصدر: Journal of combinatorial chemistry. 7(2)
مصطلحات موضوعية: Sample handling, Quality Control, Chromatography, Autoanalysis, Chemistry, High-throughput screening, General Chemistry, Robotics, Mass Spectrometry, Pharmaceutical Preparations, Liquid chromatography–mass spectrometry, Combinatorial Chemistry Techniques, Indicators and Reagents, Throughput (business), Chromatography, High Pressure Liquid
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6
المؤلفون: Jennifer L. Harris, Takashi Nakai, Jun Li, Bradley J. Backes, H. Michael Petrassi, Christine Tumanut, Brian T. Masick, Jennifer A. Williams, Jared Ek
المصدر: Bioorganicmedicinal chemistry letters. 15(12)
مصطلحات موضوعية: Models, Molecular, Proteases, Proteolysis, medicine.medical_treatment, Clinical Biochemistry, Molecular Sequence Data, Pharmaceutical Science, Cleavage (embryo), Biochemistry, Substrate Specificity, Serine, Thrombin, Coumarins, Drug Discovery, medicine, Combinatorial Chemistry Techniques, Humans, Computer Simulation, Amino Acid Sequence, Threonine, Molecular Biology, Fluorescent Dyes, Protease, medicine.diagnostic_test, Chemistry, Caspase 3, Organic Chemistry, Caspases, Molecular Medicine, Oligopeptides, medicine.drug, Cysteine
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7
المؤلفون: Jared Ek, Jennifer L. Harris, Daniel E. Mason, Eric C. Peters
المصدر: Biochemistry. 43(21)
مصطلحات موضوعية: Stereochemistry, Molecular Sequence Data, Peptide, Mass spectrometry, Biochemistry, Mass Spectrometry, Substrate Specificity, Inhibitory Concentration 50, Ubiquitin, Peptide Library, Hydrolase, Carbon-Nitrogen Lyases, Combinatorial Chemistry Techniques, ISOPEPTIDASE T, Amino Acid Sequence, Peptide library, Cellular proteins, chemistry.chemical_classification, biology, Kinetics, Enzyme, chemistry, biology.protein, Peptides, Ubiquitin Thiolesterase
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8دورية أكاديمية
المؤلفون: Tao Wu, Advait Nagle, Kelli Kuhen, Kerstin Gagaring, Rachel Borboa, Caroline Francek, Zhong Chen, David Plouffe, Anne Goh, Suresh B. Lakshminarayana, Jeanette Wu, Hui Qing Ang, Peiting Zeng, Min Low Kang, William Tan, Maria Tan, Nicole Ye, Xuena Lin, Christopher Caldwell, Jared Ek
المصدر: Journal of Medicinal Chemistry; Jul2011, Vol. 54 Issue 14, p5116-5130, 15p