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المؤلفون: Meredith S. Eno, Jason D. Brubaker, John E. Campbell, Chris De Savi, Timothy J. Guzi, Brett D. Williams, Douglas Wilson, Kevin Wilson, Natasja Brooijmans, Joseph Kim, Ayşegül Özen, Emanuele Perola, John Hsieh, Victoria Brown, Kristina Fetalvero, Andrew Garner, Zhuo Zhang, Faith Stevison, Rich Woessner, Jatinder Singh, Yoav Timsit, Caitlin Kinkema, Clare Medendorp, Christopher Lee, Faris Albayya, Alena Zalutskaya, Stefanie Schalm, Thomas A. Dineen
المصدر: Journal of medicinal chemistry. 65(14)
مصطلحات موضوعية: ErbB Receptors, Lung Neoplasms, Drug Resistance, Neoplasm, Carcinoma, Non-Small-Cell Lung, Drug Discovery, Mutation, Molecular Medicine, Humans, Protein Kinase Inhibitors
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المؤلفون: Elena Garralda, Joseph L. Kim, Michael Palmer, Wei Hu, Kevin J. Wilson, Michael Sheets, Douglas Wilson, Marcia S. Brose, Vivek Subbiah, Christoph Lengauer, Justin F. Gainor, Sai-Hong Ignatius Ou, Michelle Maynard, Beni B. Wolf, Paul Fleming, Erica Evans, Jason D. Brubaker, Matthew H. Taylor, Rami Rahal, Mimi I. Hu, Lori J. Wirth, Lucian DiPietro, Stephen D. Miller, Qiongfang Cao, Timothy Guzi
المصدر: Cancer Discovery. 8:836-849
مصطلحات موضوعية: 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, endocrine system, endocrine system diseases, medicine.medical_treatment, Receptor tyrosine kinase, Targeted therapy, Papillary thyroid cancer, 03 medical and health sciences, 0302 clinical medicine, In vivo, Carcinoma, Medicine, neoplasms, Thyroid cancer, biology, business.industry, Medullary thyroid cancer, Cancer, medicine.disease, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, biology.protein, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::aa86a49748bd34657ea36b58384cc476
https://doi.org/10.1158/2159-8290.cd-18-0338 -
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المؤلفون: Craig C. Correll, Robert G. Aslanian, Li Xiao, Rema Bitar, Wei Zhou, John W. Butcher, Charles G. Garlisi, Joshua Close, Rachel N. Maccoss, Joon Jung, Scott Crawford, Kevin M. Maloney, Purakkattle Biju, Anandan Palani, Xianhai Huang, Xiaoxin Yang, Kevin D. McCormick, Scott Peterson, Hongjun Zhang, Diane Rindgen, Ying Huang, Alexei V. Buevich, Ning Shao, Li Dong, Phieng Siliphaivanh, Jason D. Brubaker, Michelle Martinez, Hongchen Qiu, François G. Gervais, Ravi P. Nargund, Zhidan Liu
المصدر: ACS Medicinal Chemistry Letters. 9:679-684
مصطلحات موضوعية: 0301 basic medicine, Drug, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, medicine.drug_class, media_common.quotation_subject, Organic Chemistry, Pharmacology, medicine.disease, Receptor antagonist, 01 natural sciences, Biochemistry, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, Pharmacokinetics, Drug Discovery, medicine, Antagonism, Crth2 antagonist, Receptor, media_common, Asthma, Tricyclic
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المؤلفون: Kevin W. Johnson, Peter Fuller, Sujal V. Deshmukh, Fang He, Peter Goldenblatt, Lauren Dorosh, Hongbo Zeng, Jason D. Brubaker, Luis E. Torres, Tony Siu, Fiona Elwood, Charles A. Lesburg, Sangita B. Patel, Duan Liu, Elma Kadic, Christopher J. Dinsmore, Xavier Fradera, Lynsey Shaffer, Jonathan R. Young, Lily Y. Moy, Feng Shi, Carla Alpert, Joel A. Klappenbach, Joshua Close, Rafael Fernandez, Hongshi Yu, Nathan Bays, Dawn M. Mampreian
المصدر: Journal of Medicinal Chemistry. 60:9676-9690
مصطلحات موضوعية: 0301 basic medicine, Halogenation, Stereochemistry, medicine.drug_class, Carboxamide, Pyrazole, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, Ligand efficiency, Chemistry, Drug discovery, Janus Kinase 1, Ligand (biochemistry), Rats, Bioavailability, Molecular Docking Simulation, 030104 developmental biology, Pyran, Pyrazoles, Molecular Medicine
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المؤلفون: Tina Zimmermann, Steven Bench, Andrea Romagnani, Klaus P. Hoeflich, Carsten Wolter, Michael Sheets, Kerrie Faia, Kerry-Ann Bright, Timothy LaBranche, Marion Dorsch, Alberto Toso, Gordon Heidkamp, James R. Bischoff, Alison Ribeiro, Joshua Close, Marina Bacac, Felix Scheuplein, Nisha Perez, Caitlin Utt, Emanuele Perola, Jan Eckmann, Kristina Fetalvero, Stefan Gross, Qiongfang Cao, Debora Paduraru, Grace O. Silva, Chaoyang Ye, Marly I. Roche, Luke Green, Erin O’Hearn, Tary Traore, Weifan Weng, Jason D. Brubaker, Joseph Kim, Michael Burke, Sylvia Herter, Chandra Miduturu, Erik Gerson, Tim Guzi, Rich Woessner
المصدر: Cancer Research. 81:1717-1717
مصطلحات موضوعية: Cancer Research, Melanoma, CD3, medicine.medical_treatment, T-cell receptor, Biology, medicine.disease, Immune system, Oncology, Cancer immunotherapy, Cancer research, medicine, biology.protein, Cytokine secretion, Kinase activity, CD8
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0eb54e4cfffcf5824710a2a61ff8ed1c
https://doi.org/10.1158/1538-7445.am2021-1717 -
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المؤلفون: Vivek, Subbiah, Justin F, Gainor, Rami, Rahal, Jason D, Brubaker, Joseph L, Kim, Michelle, Maynard, Wei, Hu, Qiongfang, Cao, Michael P, Sheets, Douglas, Wilson, Kevin J, Wilson, Lucian, DiPietro, Paul, Fleming, Michael, Palmer, Mimi I, Hu, Lori, Wirth, Marcia S, Brose, Sai-Hong Ignatius, Ou, Matthew, Taylor, Elena, Garralda, Stephen, Miller, Beni, Wolf, Christoph, Lengauer, Timothy, Guzi, Erica K, Evans
المصدر: Cancer discovery. 8(7)
مصطلحات موضوعية: Mice, Inbred BALB C, Lung Neoplasms, Pyridines, Proto-Oncogene Proteins c-ret, Mice, Nude, Antineoplastic Agents, Xenograft Model Antitumor Assays, Article, Carcinoma, Neuroendocrine, Mice, Pyrimidines, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Neoplasms, Mutation, Animals, Humans, Pyrazoles, Thyroid Neoplasms, Protein Kinase Inhibitors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::eec07db5df6b7d30c144f60995259458
https://pubmed.ncbi.nlm.nih.gov/29967074 -
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المؤلفون: Graham Smith, Michael D. Altman, Larissa Rakhilina, Dietrich Steinhuebel, Jason D. Brubaker, Craig R. Gibeau, John Maclean, Ruojing Yang, Erin F. Mulrooney, Hongmin Chen, James Baker, Charles A. Lesburg, Jeremy Presland, Lily Y. Moy, Melanie A. Kleinschek, Yiping Chen, Thierry O. Fischmann, Jongwon Lim, Erica Leccese
المصدر: ACS Medicinal Chemistry Letters. 6:683-688
مصطلحات موضوعية: Serine/threonine-specific protein kinase, Pyrimidine, medicine.drug_class, Stereochemistry, Kinase, Organic Chemistry, Carboxamide, Pyrazole, IRAK4, Biochemistry, Pyrazolopyrimidine, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Kinase activity
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المؤلفون: Jie Zhang-Hoover, Chaomin Li, Erin F. Mulrooney, Christian Fischer, Alan B. Northrup, Melanie A. Kleinschek, Jeremy Presland, Brian M. Andresen, Anthony Donofrio, Jason D. Brubaker, Matthew Lloyd Childers, Thierry O. Fischmann, Jongwon Lim, Alexander Hicks, Sue Jin, James Baker, Lilly Y. Moy, Hongmin Chen, Antoaneta S. Necheva, Luis E. Torres, Ruojing Yang, Michael D. Altman, Craig R. Gibeau, Duan Liu, Heidi Ferguson, Charles A. Lesburg, John Maclean, Erica Leccese, Faruk Mansoor, Graham Smith, Sam Kattar, Yiping Chen, Larissa Rakhilina
المصدر: Bioorganicmedicinal chemistry letters. 27(12)
مصطلحات موضوعية: Models, Molecular, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Inflammation, Pharmacology, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, Quinazoline, medicine, Animals, Kinase activity, Molecular Biology, Protein Kinase Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Kinase, Interleukin-6, Organic Chemistry, Imidazoles, TLR7, IRAK4, 0104 chemical sciences, High-Throughput Screening Assays, Rats, 010404 medicinal & biomolecular chemistry, Disease Models, Animal, Interleukin-1 Receptor-Associated Kinases, Rats, Inbred Lew, Quinazolines, Molecular Medicine, medicine.symptom
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المؤلفون: Timothy J. Guzi, Jason D. Brubaker, Beni B. Wolf, Christoph Lengauer, Douglas Wilson, Timothy LaBranche, Michelle Maynard, Lucian Dipietro, Joseph L. Kim, Wei Hu, Kevin J. Wilson, Michael Sheets, Erica Evans, Qiangfang Cao, Rami Rahal
المصدر: Clinical Cancer Research. 24:B01-B01
مصطلحات موضوعية: endocrine system, congenital, hereditary, and neonatal diseases and abnormalities, Cancer Research, endocrine system diseases, Cabozantinib, Kinase, business.industry, Autophosphorylation, Cancer, Vandetanib, medicine.disease, chemistry.chemical_compound, Oncology, chemistry, In vivo, Cancer research, medicine, Kinase activity, business, neoplasms, Tyrosine kinase, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7582d1a9009506fec4f3ba67c77d8769
https://doi.org/10.1158/1557-3265.aacriaslc18-b01 -
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المؤلفون: Philip J. Hamzik, Jason D. Brubaker
المصدر: Organic Letters. 12:1116-1119
مصطلحات موضوعية: Geminal, Organic Chemistry, Sulfonium Compounds, Ring (chemistry), Oxetane, Biochemistry, Combinatorial chemistry, Carbonyl group, chemistry.chemical_compound, chemistry, Ethers, Cyclic, Oxetan-3-tert-butylsulfinimine, Organic chemistry, Reactivity (chemistry), Imines, Bioisostere, Physical and Theoretical Chemistry
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