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1
المؤلفون: Robert A. Giacobbe, Adam B. Shapiro, Jason Thresher, Alita A. Miller, Boudewijn Dejonge, Michael D. Huband, William F. Penwell, David E. Ehmann, Rong-Fang Gu, Robert E. McLaughlin, Ning Gao
المصدر: Antimicrobial Agents and Chemotherapy. 59:1680-1689
مصطلحات موضوعية: Acinetobacter baumannii, Penicillin binding proteins, Drug resistance, Biology, Microbiology, Drug Resistance, Multiple, Bacterial, polycyclic compounds, medicine, Penicillin-Binding Proteins, Pharmacology (medical), Mechanisms of Action: Physiological Effects, Pathogen, Pharmacology, organic chemicals, Sulbactam, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, biology.organism_classification, Anti-Bacterial Agents, Multiple drug resistance, Infectious Diseases, bacteria, Antibacterial activity, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5dcd27449195d8495fe9e1e9aad358
https://doi.org/10.1128/aac.04808-14 -
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المؤلفون: David E. Ehmann, Jason Thresher, Asha S. Nayar, Ning Gao, Folkert Reck, Adam B. Shapiro, Thomas J. Dougherty
المصدر: Antimicrobial Agents and Chemotherapy. 59:331-337
مصطلحات موضوعية: Topoisomerase IV, Morpholines, Mutant, Microbial Sensitivity Tests, Biology, medicine.disease_cause, DNA gyrase, Microbiology, Bacterial Proteins, Mechanisms of Resistance, Drug Resistance, Bacterial, Escherichia coli, medicine, Topoisomerase II Inhibitors, Pharmacology (medical), Naphthyridines, Pharmacology, Mutation, Pseudomonas aeruginosa, Escherichia coli Proteins, Infectious Diseases, DNA Gyrase, biology.protein, Topoisomerase-II Inhibitor, Type II topoisomerase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2632fda9d5d600daf271f08bf6541e
https://doi.org/10.1128/aac.04077-14 -
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المؤلفون: Mark Cornebise, James D. Whiteaker, Laurel Hajec, Ning Gao, Jason Thresher, Pamela Hill, Peter Doig, D. Bryan Prince, Amanda Haixi Li, Philip L. Ross, Sushmita D. Lahiri, Nelson B. Olivier, Sarah M. McLeod, Folkert Reck, Michael R. Hale
المصدر: Protein Expression and Purification. 104:57-64
مصطلحات موضوعية: Lipopolysaccharide, Protein Conformation, Gene Expression, Biology, Crystallography, X-Ray, medicine.disease_cause, Catalysis, Mass Spectrometry, Amidohydrolases, Lipid A, chemistry.chemical_compound, Bacterial Proteins, Biosynthesis, Protein purification, Escherichia coli, medicine, Pseudomonas aeruginosa, Escherichia coli Proteins, Zinc, chemistry, Biochemistry, Efflux, Multidrug Resistance-Associated Proteins, Bacterial outer membrane, Chromatography, Liquid, Biotechnology
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4
المؤلفون: Kerry E. Murphy-Benenato, Michael R. Hale, Philip L. Ross, Nelson B. Olivier, Ning Gao, Allison Laura Choy, Matthew D. Miller, Jason Thresher
المصدر: ACS Medicinal Chemistry Letters. 5:1213-1218
مصطلحات موضوعية: Aquifex aeolicus, chemistry.chemical_compound, biology, Chemistry, Stereochemistry, Hydrogen bond, Organic Chemistry, Drug Discovery, Hydrolase, Tetrahydropyran, Crystal structure, biology.organism_classification, Biochemistry
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المؤلفون: Ning Gao, Rong-Fang Gu, Jason Thresher, Adam B. Shapiro
المصدر: Analytical Biochemistry. 463:15-22
مصطلحات موضوعية: Boron Compounds, Penicillin binding proteins, Acylation, Recombinant Fusion Proteins, Biophysics, Fluorescence Polarization, Penicillins, Biochemistry, chemistry.chemical_compound, Bacterial Proteins, Biosynthesis, polycyclic compounds, medicine, Penicillin-Binding Proteins, Mecillinam, Molecular Biology, Integral membrane protein, Cell Biology, biochemical phenomena, metabolism, and nutrition, Fusion protein, Kinetics, chemistry, Pseudomonas aeruginosa, Electrophoresis, Polyacrylamide Gel, Peptidoglycan, Fluorescence anisotropy, medicine.drug
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المؤلفون: Janelle Comita-Prevoir, Thomas F. Durand-Reville, Robert A. Giacobbe, Camilo Velez-Vega, Brendan Chen, Alita A. Miller, Robert E. McLaughlin, Tiffany Palmer, Boudewijn L. M. de Jonge, Ning Gao, Nicole M. Carter, Adam B. Shapiro, Samir H. Moussa, Nelson B. Olivier, John P. Mueller, Jason Thresher, John O'Donnell, Hoan Huynh, Beth Andrews, Satenig Guler, Tommasi Ruben A, Sushmita D. Lahiri, Sarah M. McLeod, Neil Bifulco, Joseph V. Newman, David E. Ehmann
المصدر: Nature microbiology. 2
مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), Acinetobacter baumannii, Models, Molecular, Gram-negative bacteria, medicine.drug_class, 030106 microbiology, Immunology, Antibiotics, Drug Evaluation, Preclinical, Drug resistance, beta-Lactams, Applied Microbiology and Biotechnology, Microbiology, beta-Lactamases, 03 medical and health sciences, Mice, Dogs, Enterobacteriaceae, Drug Resistance, Multiple, Bacterial, Gram-Negative Bacteria, Genetics, medicine, Animals, Humans, Penicillin-Binding Proteins, Vaborbactam, biology, Cell Biology, biology.organism_classification, Antimicrobial, Virology, Rats, Carbapenems, Sulbactam, Drug Design, Antibacterial activity, Gram-Negative Bacterial Infections, beta-Lactamase Inhibitors, Azabicyclo Compounds, Acinetobacter Infections
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المؤلفون: Jason Thresher, Amy Kutschke, Richard A. Alm, Wei Yang, Ning Gao, Philip L. Ross, Michele Johnstone, Pamela Hill, Michael R. Hale, Bryan Prince, Sushmita D. Lahiri, Matthew D. Miller
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:2362-2367
مصطلحات موضوعية: Lipopolysaccharides, Models, Molecular, Lipopolysaccharide, Protein Conformation, Stereochemistry, Clinical Biochemistry, Amino Acids, Cyclic, Pharmaceutical Science, Hydroxamic Acids, medicine.disease_cause, Biochemistry, Uridine Diphosphate, Amidohydrolases, Lipid A, Structure-Activity Relationship, chemistry.chemical_compound, Biosynthesis, Drug Discovery, medicine, Amino Acid Sequence, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, Wild type, Pathogenic bacteria, biology.organism_classification, Anti-Bacterial Agents, Amino acid, chemistry, Drug Design, Molecular Medicine, Bacterial outer membrane, Hydrophobic and Hydrophilic Interactions, Bacteria
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المؤلفون: Philip L. Ross, Gunther Kern, Stephania Livchak, Jason Thresher, Beth Andrews, Wei Yang, Adam B. Shapiro, Ning Gao
المصدر: SLAS Discovery. 18:341-347
مصطلحات موضوعية: High-throughput screening, Drug Evaluation, Preclinical, Fluorescence Polarization, Peptide binding, Peptide, Ligands, Binding, Competitive, Biochemistry, Analytical Chemistry, Lipid A, Inhibitory Concentration 50, Catalytic Domain, Acyl Carrier Protein, Escherichia coli, Enzyme Inhibitors, chemistry.chemical_classification, Uridine Diphosphate N-Acetylglucosamine, biology, Active site, Molecular biology, High-Throughput Screening Assays, Acyl carrier protein, chemistry, biology.protein, Molecular Medicine, Peptides, Bacterial outer membrane, Myristic Acids, Acyltransferases, Fluorescence anisotropy, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414ddc9fd857be4a035ae45e30bb46b4
https://doi.org/10.1177/1087057112462062 -
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المؤلفون: Haris Jahic, David E. Ehmann, Stephania Livchak, Ce Feng Liu, Jason Thresher, Hongming Wang
المصدر: Biochemical Pharmacology. 84:654-660
مصطلحات موضوعية: Adenosine, DNA Ligases, Calorimetry, Biology, Biochemistry, chemistry.chemical_compound, Mutant protein, Drug Discovery, medicine, Enzyme Inhibitors, Mode of action, DNA Primers, Pharmacology, chemistry.chemical_classification, DNA ligase, Base Sequence, Isothermal titration calorimetry, Molecular biology, Anti-Bacterial Agents, Kinetics, Streptococcus pneumoniae, Enzyme, chemistry, Mutagenesis, Site-Directed, Antibacterial activity, DNA, medicine.drug
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المؤلفون: Haris Jahic, Laurel Hajec, Adam B. Shapiro, Jason Thresher, Swati Prasad, David E. Ehmann, Ning Gao
المصدر: SLAS Discovery. 15:1088-1098
مصطلحات موضوعية: Oligonucleotides, Fluorescence Polarization, Biology, Biochemistry, DNA gyrase, Analytical Chemistry, chemistry.chemical_compound, Plasmid, Topoisomerase II Inhibitors, Magnesium, Electrophoresis, Agar Gel, DNA, Superhelical, Oligonucleotide, Topoisomerase, Assay, Hydrogen-Ion Concentration, Molecular biology, High-Throughput Screening Assays, DNA Topoisomerases, Type I, chemistry, Biocatalysis, Biophysics, biology.protein, Nucleic Acid Conformation, Molecular Medicine, DNA supercoil, Topoisomerase-II Inhibitor, DNA, Plasmids, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e1b59e7ecb2492a4f0adefd9e6bbab
https://doi.org/10.1177/1087057110378624